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21. 发明申请

US20080070299A1 Synthetic nucleic acid molecule compositions and methods of preparation 有权
公开(公告)号：US20080070299A1
公开(公告)日：2008-03-20
申请号：US11825304
申请日：2007-07-05
申请人： Keith Wood , Monika Wood , Brian Almond , Aileen Paguio , Frank Fan
发明人： Keith Wood , Monika Wood , Brian Almond , Aileen Paguio , Frank Fan
IPC分类号： C12N15/53 , C12N15/85 , C12N5/06
CPC分类号： C07K14/43595 , C07K2319/00 , C12N15/65 , C12N15/70
摘要： A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.

22. 发明申请

US20080026407A1 Covalent tethering of functional groups to proteins 有权
标题翻译：官能团共价结合蛋白质
公开(公告)号：US20080026407A1
公开(公告)日：2008-01-31
申请号：US11786792
申请日：2007-04-12
申请人： Keith Wood , Dieter Klaubert , Georgyi Los , Robert Bulleit , Mark McDougall , Chad Zimprich
发明人： Keith Wood , Dieter Klaubert , Georgyi Los , Robert Bulleit , Mark McDougall , Chad Zimprich
IPC分类号： C12Q1/02 , C07C233/00 , C07C271/06 , C07D209/00 , C07D209/34 , G01N33/573 , C07D221/00 , C07D311/02 , C07D311/82 , C07D403/00
CPC分类号： C12Q1/34 , C07C217/08 , C07C271/16 , C07D209/48 , C07D233/64 , C07D311/78 , C07D311/82 , C07D405/06 , C07D493/10 , C07D495/04 , C07F5/022 , C12N9/14 , C12N9/86 , C12Y308/01005 , G01N33/5005 , G01N33/58 , Y10S436/80
摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
摘要翻译：提供任选融合到感兴趣的蛋白质的突变体水解酶。突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定。还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。

23. 发明申请

US20070087400A1 Covalent tethering of functional groups to proteins and substrates therefor 审中-公开
标题翻译：官能团共价结合到蛋白质和底物上
公开(公告)号：US20070087400A1
公开(公告)日：2007-04-19
申请号：US11509796
申请日：2006-08-24
申请人： Aldis Darzins , Lance Encell , Tonny Johnson , Dieter Klaubert , Georgyi Los , Mark McDougall , Keith Wood , Monika Wood , Chad Zimprich
发明人： Aldis Darzins , Lance Encell , Tonny Johnson , Dieter Klaubert , Georgyi Los , Mark McDougall , Keith Wood , Monika Wood , Chad Zimprich
IPC分类号： C12Q1/26 , C12P21/06 , C07H21/04 , C12N9/16 , C12N9/88 , C12N1/21
CPC分类号： C12Q1/34 , B82Y30/00
摘要： A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein.
摘要翻译：提供任选融合到感兴趣的蛋白质的突变体水解酶。突变体水解酶能够与相应的非突变（野生型）水解酶的底物形成键，其比野生型水解酶和底物之间形成的键更稳定，并且相对于野生型水解酶具有至少两个氨基酸取代野生型水解酶。还提供了包含一个或多个官能团的水解酶的底物，以及使用本发明的突变体水解酶和底物的方法。还提供能够与底物形成稳定结合的融合蛋白和表达融合蛋白的细胞。

24. 发明申请

US20060281124A1 DEVICE AND METHOD FOR PURIFICATION OF BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于净化生物材料的装置和方法
公开(公告)号：US20060281124A1
公开(公告)日：2006-12-14
申请号：US11466945
申请日：2006-08-24
申请人： Steven Ekenberg , Keith Wood , Laurie Engel
发明人： Steven Ekenberg , Keith Wood , Laurie Engel
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/558
CPC分类号： C12N15/1017 , G01N33/54333
摘要： An apparatus, method and kit for isolating a biomolecule from a sample. The sample comprises a complex biological material, which includes insoluble matter. Some embodiments of the apparatus and kit include a reservoir and means for capturing the biomolecule either contained within or coupled to the reservoir. The reservoir can have an inner surface, and can be adapted to contain the sample. The apparatus can further include least one of a filter positioned between the means for capturing the biomolecule and at least a portion of the inner surface of the reservoir, and an aperture defined in the inner surface of the reservoir. Some embodiments of the method include combining the sample with a solid phase that is adapted to capture the biomolecule, removing the insoluble matter from the sample, and removing the biomolecule from the solid phase.
摘要翻译：用于从样品中分离生物分子的装置，方法和试剂盒。样品包括复杂的生物材料，其包括不溶性物质。装置和试剂盒的一些实施方案包括储存器和用于捕获包含在储存器中或耦合到储存器的生物分子的装置。储存器可以具有内表面，并且可以适于容纳样品。设备还可以包括位于用于捕获生物分子的装置和储存器的内表面的至少一部分之间的过滤器中的至少一个以及限定在储存器的内表面中的孔。该方法的一些实施方案包括将样品与适于捕获生物分子的固相组合，从样品中除去不溶物质，以及从固相中除去生物分子。

25. 发明申请

US20060127988A1 Synthetic nucleic acid molecule compositions and methods of preparation 审中-公开
标题翻译：合成核酸分子组合物和制备方法
公开(公告)号：US20060127988A1
公开(公告)日：2006-06-15
申请号：US11316042
申请日：2005-12-22
申请人： Keith Wood , Monika Gruber , Yao Zhuang , Aileen Paguio
发明人： Keith Wood , Monika Gruber , Yao Zhuang , Aileen Paguio
IPC分类号： C12P19/34 , C07H21/04 , C12N15/63
CPC分类号： C12N9/0069 , C12N15/67
摘要： A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
摘要翻译：制备在特定宿主细胞中表达时具有降低的不适当或非预期转录特征的合成核酸分子的方法。

26. 发明申请

US20060051827A1 Method for increasing luminescence assay sensitivity 有权
公开(公告)号：US20060051827A1
公开(公告)日：2006-03-09
申请号：US10991759
申请日：2004-11-18
申请人： Erika Hawkins , John Centanni , Jacqueline Sankbeil , Keith Wood
发明人： Erika Hawkins , John Centanni , Jacqueline Sankbeil , Keith Wood
IPC分类号： C12Q1/66
CPC分类号： C12Q1/66 , G01N33/582 , G01N2333/90241 , Y10S435/968 , Y10S435/975
摘要： A method for increasing the sensitivity of a bio-luminescent assay comprising carrying out the assay in the presence of an organic compound that reduces luminescence that is not dependent on the presence of an analyte by at least about 10 fold, and that reduces, maintains, or increases the luminescence that is dependent on the presence of an analyte.

27. 发明申请

US20050153310A1 Luciferase biosensor 有权
标题翻译：萤光素酶生物传感器
公开(公告)号：US20050153310A1
公开(公告)日：2005-07-14
申请号：US10957433
申请日：2004-10-01
申请人： Frank Fan , Martin Lewis , John Shultz , Keith Wood , Braeden Butler
发明人： Frank Fan , Martin Lewis , John Shultz , Keith Wood , Braeden Butler
IPC分类号： C07H21/04 , C12N5/06 , C12N9/02 , C12N9/06 , C12Q1/66 , C12Q1/68
CPC分类号： C12N9/0069 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C12Q1/66 , G01N2500/04
摘要： A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
摘要翻译：提供了一种环境敏感的报告蛋白的改良甲壳质萤光素酶蛋白。

28. 发明申请

US20050048592A1 Kits for detection of ATP 有权
标题翻译：用于检测ATP的试剂盒
公开(公告)号：US20050048592A1
公开(公告)日：2005-03-03
申请号：US10895596
申请日：2004-07-21
申请人： Keith Wood , Rita Hannah , Richard Moravec
发明人： Keith Wood , Rita Hannah , Richard Moravec
IPC分类号： C12N9/02 , C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/26 , C12Q1/66 , C12Q1/68
CPC分类号： C12Q1/66 , C12Q1/008
摘要： Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase inhibitors.
摘要翻译：用于检测ATP的存在，用于测量ATP浓度以及使用包含ATP依赖性酶和一种或多种ATP酶抑制剂的组合物检测活细胞的方法和试剂盒。

29. 发明申请

US20050026171A1 Luciferase-based assays 有权
标题翻译：基于荧光素酶的测定
公开(公告)号：US20050026171A1
公开(公告)日：2005-02-03
申请号：US10746995
申请日：2003-12-23
申请人： Erika Hawkins , James Cali , Samuel Ho , Martha O'Brien , Richard Somberg , Robert Bulleit , Keith Wood
发明人： Erika Hawkins , James Cali , Samuel Ho , Martha O'Brien , Richard Somberg , Robert Bulleit , Keith Wood
IPC分类号： C12Q1/66 , C12Q1/68
CPC分类号： C12Q1/66
摘要： A method and kit is provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minize interference by at least about 10% relative to an assay not having tolerance enhancement agent.
摘要翻译：提供了一种方法和试剂盒，用于增强测定试剂对测定样品中化合物的耐受性，测定试剂包括荧光素酶。该方法包括使荧光素酶与容许增强剂接触，其量足以基本上保护荧光素酶活性免受化合物的干扰，并且相对于不具有耐受性增强剂的测定法将干扰减小至少约10％。

30. 发明授权

US06722665B1 MESC seal, O-ring carrier 有权
标题翻译： MESC密封，O型圈载体
公开(公告)号：US06722665B1
公开(公告)日：2004-04-20
申请号：US10067489
申请日：2002-02-04
申请人： Christopher W. Burkhart , Keith Wood
发明人： Christopher W. Burkhart , Keith Wood
IPC分类号： F16J1502
CPC分类号： F16J15/122 , F16J15/061 , H01L21/67126
摘要： A sealing assembly is provided for sealing retractable opposing planar surfaces of processing modules each having sealable cavities for the fabrication of semiconductor wafers. The sealing assembly may include an inner frame adapted to be concentrically positioned within a central opening of an outer frame. The outer frame may include lifting tabs attached to an upper portion such that the lifting tabs are graspable to removably position the sealing assembly between the opposing planar surfaces of the processing modules. An O-ring, which may include an elastomeric material, is adapted to fit about a circumference of the inner frame. The opposing surfaces of the processing modules define an opening therebetween which accepts the sealing assembly. The opposing surfaces of the modules are retractably movable towards one another thereby coupling the O-ring between the opposing planar surfaces to provide a seal.
摘要翻译：提供密封组件用于密封处理模块的可缩回的相对平面表面，每个表面具有用于制造半导体晶片的可密封空腔。密封组件可以包括适于同心地定位在外框架的中心开口内的内框架。外框架可以包括附接到上部的提升翼片，使得提升翼片可握住以将密封组件可移除地定位在处理模块的相对的平面之间。可以包括弹性体材料的O形环适于围绕内框架的圆周。处理模块的相对表面在其间限定开口，该开口接受密封组件。模块的相对表面可向彼此可向地可靠地移动，从而在相对的平面之间连接O形环以提供密封。

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