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21. 发明授权

US06482221B1 Manipulatable delivery catheter for occlusive devices (II) 失效
标题翻译：闭塞装置的手术输送导管（II）
公开(公告)号：US06482221B1
公开(公告)日：2002-11-19
申请号：US09703468
申请日：2000-10-31
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61M2900
CPC分类号： A61M25/0147 , A61B17/12022 , A61B17/1204 , A61B17/12113 , A61B17/12136 , A61B17/1214 , A61B2017/1205 , A61M25/0053 , A61M25/0054 , A61M25/10 , A61M25/1006 , A61M2025/0034 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61M2025/0177 , A61M2025/018 , A61M2025/1052
摘要： This is in the general field of surgical instruments and is specifically a delivery catheter with a flexible, proximally-manipulated hinge or joint region. The inventive catheter may have a balloon region. The catheter may have a shaft of varying flexibility which contains several lumen. The inner, or delivery, lumen generally may be used with a guidewire to access target sites within the body via the flexible, small diameter vessels of the body. The delivery lumen may be also used for placement of occlusive materials, e.g., in an aneurysm. Inflation of the micro-balloon, located near the distal tip of the catheter, is effected using the inflation lumen. The push/pull wire lumen contains a wire, which when manipulated, flexes the catheter's distal tip. The push/pull wire tubing may have a variable thickness to aid in adjusting the degree of flexibility. Moreover, the delivery catheter may be capable of twisting in a helical or corkscrew-like manner for traversing certain vasculature. This may be accomplished by winding the push/pull wire within the catheter and fixedly attaching it. The catheter may further include an entry in the catheter wall to allow for the insertion of a guidewire; this may facilitate the rapid exchange of catheter devices as desired by the user.
摘要翻译：这是在外科器械的一般领域中，并且具体是具有柔性的，近端操作的铰链或接合区域的输送导管。本发明的导管可以具有气囊区域。该导管可具有包含若干内腔的具有不同柔性的轴。内部或输送腔通常可以与导丝一起使用以经由身体的柔性的小直径血管进入身体内的目标部位。输送腔也可以用于放置封闭材料，例如在动脉瘤中。位于导管远端顶端的微气囊的充气利用充气腔进行。推/拉线腔包含线，当被操纵时，其弯曲导管的远端。推/拉线管可以具有可变的厚度以有助于调节柔性程度。此外，输送导管可以以螺旋或类似螺旋状的方式扭转以穿过某些脉管系统。这可以通过将推/拉线缠绕在导管内并将其固定地附接来实现。导管还可以包括导管壁中的入口以允许插入导丝; 这可以促进用户期望的导管装置的快速交换。

22. 发明授权

US6139543A Flow apparatus for the disruption of occlusions 失效
标题翻译：用于堵塞的流动装置
公开(公告)号：US6139543A
公开(公告)日：2000-10-31
申请号：US120598
申请日：1998-07-22
申请人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson , Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang
发明人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson , Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang
IPC分类号： A61B18/20 , A61B17/00 , A61B18/22 , A61B18/24 , A61B18/26 , A61N5/06 , A61B18/18
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by mechanically disrupting the occlusive material.
摘要翻译：本发明包括用于通过由于在流体中吸收重复的辐射脉冲而产生的气泡的重复膨胀和塌缩来将流体从一个位置泵送到另一个位置的方法和装置。这种泵送现象可以用于通过用声波冲击和压力波来乳化闭塞或通过机械地破坏封闭材料来帮助去除身体通道中的全部或部分闭塞。

23. 发明授权

US09114038B2 Method of delivering a stent 有权
标题翻译：输送支架的方法
公开(公告)号：US09114038B2
公开(公告)日：2015-08-25
申请号：US11897821
申请日：2007-08-31
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61M25/09
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.
摘要翻译：本文描述了用于通过导管递送的导丝加载的支架。支架输送组件可以将支架输送并放置在身体的曲折区域内，所述曲折区域可以被引导线接近，但是对于支架置入导管是不可接近的。该组件包括一部分由可伸缩鞘覆盖的导丝和在该导丝的远端附近或其远端处的可径向扩张的支架。整个组件通过常规导管进行，或者可以单独使用。在任一情况下，当支架邻近体内的治疗部位时，护套向近侧缩回以暴露支架用于径向膨胀以与血管壁接触。无线电不透明的标记带可选地位于导线主体上的支架的两侧或两侧，以帮助视觉放置。组件可以可选地包括在导丝上的可膨胀气囊用于不同的治疗方式。

24. 发明授权

US08641748B2 Guidewire loaded stent for delivery through a catheter 失效
标题翻译：导丝加载支架用于通过导管输送
公开(公告)号：US08641748B2
公开(公告)日：2014-02-04
申请号：US11335205
申请日：2006-01-19
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.
摘要翻译：本文描述了用于通过导管递送的导丝加载的支架。支架输送组件可以将支架输送并放置在身体的曲折区域内，所述曲折区域可以被引导线接近，但是对于支架置入导管是不可接近的。该组件包括一部分由可伸缩鞘覆盖的导丝和在该导丝的远端附近或其远端处的可径向扩张的支架。整个组件通过常规导管进行，或者可以单独使用。在任一情况下，当支架邻近体内的治疗部位时，护套向近侧缩回以暴露支架用于径向膨胀以与血管壁接触。无线电不透明的标记带可选地位于导线主体上的支架的两侧或两侧，以帮助视觉放置。组件可以可选地包括在导丝上的可膨胀气囊用于不同的治疗方式。

25. 发明申请

US20120116429A1 ROTATIONAL THROMBECTOMY WIRE 有权
标题翻译：旋转色差线
公开(公告)号：US20120116429A1
公开(公告)日：2012-05-10
申请号：US13303339
申请日：2011-11-23
申请人： Marc-Alan Levine , Michael Leedle
发明人： Marc-Alan Levine , Michael Leedle
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/00778 , A61B2017/22038 , A61B2017/22094 , A61B2017/320008 , A61B2017/320733 , A61B2017/320766 , A61M25/0097 , A61M2025/0681
摘要： A rotational thrombectomy wire for breaking up vascular thrombus or other obstructive material having a core having a proximal region and a distal region and being rotatable by a motor. The distal region has a smaller diameter than the proximal region. A cable is coupled to the distal region of the core and extends distally thereof. A torque tube is positioned over the cable and a coil is positioned over a distal portion of the cable. A distal portion of the cable has a non-linear configuration. A first covering material is positioned over the coil.
摘要翻译：一种用于分解血管血栓或其它梗阻性材料的旋转血栓切除线，其具有具有近端区域和远侧区域并且可由马达旋转的芯。远侧区域具有比近侧区域更小的直径。电缆连接到芯的远侧区域并向远端延伸。扭矩管位于电缆上方，线圈位于电缆的远端部分上方。电缆的远端部分具有非线性配置。第一覆盖材料位于线圈上方。

26. 发明申请

US20070299501A1 Guidewire loaded stent for delivery through a catheter 失效
公开(公告)号：US20070299501A1
公开(公告)日：2007-12-27
申请号：US11897705
申请日：2007-08-31
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.

27. 发明申请

US20070299500A1 Guidewire loaded stent for delivery through a catheter 审中-公开
标题翻译：导丝加载支架用于通过导管输送
公开(公告)号：US20070299500A1
公开(公告)日：2007-12-27
申请号：US11897658
申请日：2007-08-31
申请人： Stephen Hebert , Marc-Alan Levine
发明人： Stephen Hebert , Marc-Alan Levine
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2/958 , A61F2002/9583 , A61M25/09 , A61M2025/09008 , A61M2025/09183
摘要： A guidewire loaded stent for delivery through a catheter is described herein. The stent delivery assembly can deliver and place a stent within tortuous regions of the body which are accessible to guidewires but inaccessible to stenting catheters. The assembly comprises a guidewire covered in part by a retractable sheath and a radially expandable stent near or at the distal end of the guidewire. The whole assembly is advanced through conventional catheters or it may be used alone. In either case, when the stent is adjacent to a treatment site within the body, the sheath is retracted proximally to expose the stent for radial expansion into contact with the vessel wall. Radio-opaque marker bands are optionally located on either side or both sides of the stent on the guidewire body to aid in visual placement. The assembly can optionally include an expandable balloon on the guidewire for different treatment modalities.
摘要翻译：本文描述了用于通过导管递送的导丝加载的支架。支架输送组件可以将支架输送并放置在身体的曲折区域内，所述曲折区域可以被引导线接近，但是对于支架置入导管是不可接近的。该组件包括一部分由可伸缩鞘覆盖的导丝和在该导丝的远端附近或其远端处的可径向扩张的支架。整个组件通过常规导管进行，或者可以单独使用。在任一情况下，当支架邻近体内的治疗部位时，护套向近侧缩回以暴露支架用于径向膨胀以与血管壁接触。无线电不透明的标记带可选地位于导线主体上的支架的两侧或两侧，以帮助视觉放置。组件可以可选地包括在导丝上的可膨胀气囊用于不同的治疗方式。

28. 发明授权

US06322576B1 Stable coil designs 失效
标题翻译：稳定线圈设计
公开(公告)号：US06322576B1
公开(公告)日：2001-11-27
申请号：US09018278
申请日：1998-02-04
申请人： Michael P. Wallace , Marc-Alan Levine , Delilah Yin Hui , Mary M. Chen , Liem Ho
发明人： Michael P. Wallace , Marc-Alan Levine , Delilah Yin Hui , Mary M. Chen , Liem Ho
IPC分类号： A61B1700
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00526 , A61B2017/00862 , A61B2017/00867
摘要： This is an implantable vaso-occlusive device. The device has a complex, three-dimensional structure in a relaxed configuration that may be used in the approximate shape of an anatomical cavity. It may be deployed in the approximate shape of a sphere, an ovoid, a clover, a box-like structure or other distorted spherical shape. The loops forming the relaxed configuration may pass through the interior of the structure. The device is a self-forming shape made from a pre-formed linear vaso-occlusion member. Fibers may be introduced onto the device and affixed to the pre-formed linear member. The constituent member may be also be covered with a fibrous braid. The device is typically introduced through a catheter. The device is passed axially through the catheter sheath and assumes its form upon exiting the catheter without further action. The invention also includes methods of winding the anatomically shaped vaso-occlusive device into appropriately shaped forms and annealing them to form various devices.
摘要翻译：这是一种植入式血管闭塞装置。该装置具有可以以解剖腔的近似形状使用的松弛构造中的复杂的三维结构。它可以以球体，卵球形，三叶草，盒状结构或其它变形球形的大致形状部署。形成松弛构型的环可以穿过结构的内部。该装置是由预先形成的线性血管闭塞构件制成的自形成形状。纤维可以引入到装置上并固定到预成形的线性构件上。构成部件也可以用纤维编织物覆盖。该装置通常通过导管引入。该装置轴向穿过导管护套，并且在离开导管时采取其形式，而无需进一步的动作。本发明还包括将解剖形状的血管闭塞装置卷绕成适当形状的形状并将其退火以形成各种装置的方法。

29. 发明授权

US06210400B1 Flexible flow apparatus and method for the disruption of occlusions 失效
标题翻译：柔性流动装置和堵塞方法
公开(公告)号：US06210400B1
公开(公告)日：2001-04-03
申请号：US09165435
申请日：1998-10-02
申请人： Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang , Quang Q. Tran , Victor C. Esch
发明人： Stephen J. Hebert , Marc-Alan Levine , Eduardo U. Sucgang , Quang Q. Tran , Victor C. Esch
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： Apparatus for pumping fluid from one location to another via generation of bubbles in fluid, and expansion and callapse thereof, are described. These apparatus deliver repetitive pulses of radiation to a fluid to form bubbles therein. The expansion and collapse of the bubbles cause fluid motion or pumping. This pumping can be used to facilitate removal of a total or partial occlusion in a body passage by a variety of mechanisms. The apparatus are flexible to facilitate use within a body passage.
摘要翻译：描述了用于通过在流体中产生气泡将流体从一个位置泵送到另一个位置的装置，以及其膨胀和回收。这些装置将重复的辐射脉冲输送到流体以在其中形成气泡。气泡的膨胀和破裂会导致流体运动或泵送。这种泵送可以用于通过各种机制促进身体通道中的全部或部分闭塞的去除。该装置是灵活的，以便于在身体通道内使用。

30. 发明授权

US09023070B2 Rotational thrombectomy wire coupler 有权
标题翻译：旋转血栓切除术线耦合器
公开(公告)号：US09023070B2
公开(公告)日：2015-05-05
申请号：US13456555
申请日：2012-04-26
申请人： Marc-Alan Levine , Nicholas Ciccarelli , Michael Leedle , John D. Leedle
发明人： Marc-Alan Levine , Nicholas Ciccarelli , Michael Leedle , John D. Leedle
IPC分类号： A61B17/22 , A61B17/3207 , A61B17/00 , A61B17/32 , A61B19/00
CPC分类号： A61B17/320758 , A61B2017/00398 , A61B2017/00477 , A61B2017/00734 , A61B2017/00876 , A61B2017/22038 , A61B2017/320032 , A61B2017/320733 , A61B2017/320775 , A61B2090/031
摘要： An assembly for breaking up vascular thrombus or other obstructive material including a motor housing having a motor, a motor shaft extending from the motor, a first housing positioned at a distal end of the motor shaft, a rotational thrombectomy wire and a second housing positioned at a proximal end of the wire. The first housing has a first magnet positioned therein and recessed from the distal edge of the first housing which has a first plurality of teeth. The second housing has a second magnet positioned therein and recessed from a proximal edge of the second housing which has a second plurality of teeth intermeshing with the first plurality of teeth when the wire is coupled to the motor shaft. The first and second plurality of teeth slip when a torque of the motor shaft exceeds a predetermined value.
摘要翻译：一种用于分解血管血栓或其他阻塞物质的组件，包括具有马达的马达壳体，从马达延伸的马达轴，位于马达轴远端的第一壳体，旋转血栓切除线和位于线的近端。第一壳体具有定位在其中的第一磁体并且具有第一多个齿的第一壳体的远端边缘凹陷。第二壳体具有定位在其中的第二磁体并且从第二壳体的近侧边缘凹入，当第二壳体与电动机轴联接时，该第二磁体具有与第一多个齿啮合的第二多个齿。当电动机轴的扭矩超过预定值时，第一和第二多个齿滑动。

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