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21. 发明专利

EA039356B1 БИСПЕЦИФИЧЕСКИЕ К EGFR/c-Met АНТИТЕЛА 未知
公开(公告)号：EA039356B1
公开(公告)日：2022-01-18
申请号：EA201891597
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12N15/63
摘要： Биспецифическиек EGFR и/или c-Met антителаи способыполученияи применениямолекул. Рецепторэпидермальногофакторароста (EGFR, ErbB1 или HERI) представляетсобойтрансмембранныйгликопротеинтипа I массой 170 кДа, кодируемыйпротоонкогеномс-ErbB1. EGFR являетсячленомсемействачеловеческихрецепторовэпидермальныхфакторовроста (HER), которыепредставляютсобойрецепторныетирозинкиназы (RTK), включающего HER2 (ErbB2), HER3 (ErbB3) и HER4 (ErbB4). Сигнализация EGFR инициируетсясвязываниемлигандов, закоторымследуетиндукцияконформационногоизменения, гомодимеризацияилигетеродимеризациярецепторас другимичленамисемейства ErbB.

22. 发明专利

NZ708352A Bispecific egfr/c-met antibodies 未知
公开(公告)号：NZ708352A
公开(公告)日：2019-10-25
申请号：NZ70835213
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE , MOORES SHERI
IPC分类号： C07K16/28 , A61K39/395
摘要： Bispecific EGFR/c-Met antibodies and methods making and using the molecules. Epidermal growth factor receptor (EGFR, ErbBI or HERI) is a Type I transmembmne glycoprotein of 170 kDa thai is encoded by the c-erbBI proto-oncogene. EGFR is a member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTK) which includes HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4). EGFR signaling is initiated by ligand binding followed by induction of conformational change, homodimerizalion or heterodimerization of the receptor with other ErbB family members. Exemplified here is bispecific EM1-mAb comprising the EGFR binding arm of mAb E1-F405L (modified from 2F8) and the c-Met binding arm of mAb M1-K409R (modified from 069) useful for treating tumours harbouring EGFR and/or c-Met mutations or amplifications.

23. 发明专利

RS58192B1 BISPECIFIČNA EGFR/C-MET ANTITELA 未知
公开(公告)号：RS58192B1
公开(公告)日：2019-03-29
申请号：RSP20181488
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00 , A61K31/437 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K33/24 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28

24. 发明专利

PL2922872T3 BISPECYFICZNE PRZECIWCIAŁA PRZECIWKO EGFR/C-MET 未知
公开(公告)号：PL2922872T3
公开(公告)日：2019-03-29
申请号：PL13856592
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00 , A61K31/437 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K33/24 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28

25. 发明专利

LT2922872T BISPECIFINIAI EGFR/C-MET ANTIKŪNAI 未知
公开(公告)号：LT2922872T
公开(公告)日：2018-12-27
申请号：LT13856592
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00 , A61K31/437 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K33/24 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28

26. 发明专利

AU2013347962B2 Bispecific EGFR/c-Met antibodies 未知
公开(公告)号：AU2013347962B2
公开(公告)日：2018-10-25
申请号：AU2013347962
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00
摘要： Bispecific EGFR/c-Met antibodies and methods making and using the molecules. Epidermal growth factor receptor (EGFR, ErbBI or HERI) is a Type I transmembmne glycoprotein of 170 kDa thai is encoded by the c-erbBI proto-oncogene. EGFR is a member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTK) which includes HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4). EGFR signaling is initiated by ligand binding followed by induction of conformational change, homodimerizalion or heteromdimerization of the receptor with other ErbB family members.

27. 发明专利

PE20151181A1 ANTICUERPOS EGFR/C-MET BIESPECIFICOS 未知
公开(公告)号：PE20151181A1
公开(公告)日：2015-08-19
申请号：PE2015000666
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00
摘要： Anticuerpos EGFR/c-Met biespecificos y metodos para hacer y usar las moleculas. El receptor del factor de crecimiento epidermico (EGFR, ErbBI o HERI) es una glucoproteina de transmembrana tipo I de 170 kDa que es codificada por el protooncogen c-erbBI. EGFR es un miembro de la familia del receptor del factor de crecimiento epidermico humano (HER) de receptores tirosina quinasas (RTK) que incluyen HER2 (ErbB2), HER3 (ErbB3) y HER4 (ErbB4). La senalizacion de EGFR es iniciada por la union a un ligando seguida de la induccion del cambio conformacional, homodimerizacion o heterodimerizacion del receptor con otros miembros de la familia ErbB

28. 发明专利

HUE052548T2 Bispecifikus EGFR/C-MET-ellenanyagok 未知
公开(公告)号：HUE052548T2
公开(公告)日：2021-05-28
申请号：HUE18199421
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00 , A61K33/24 , A61K45/06 , A61P35/00 , C07K16/28

29. 发明专利

AU2021202394A1 Bispecific EGFR/c-Met antibodies 未知
公开(公告)号：AU2021202394A1
公开(公告)日：2021-05-20
申请号：AU2021202394
申请日：2021-04-20
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , SCHUURMAN JANINE , PARREN PAUL
IPC分类号： C07K16/00
摘要： Figure IA. NO: 18 LPAPKNLVVSEVTEDSLRLSWNDP-HGFYDSFLIQYQESEKVGEAINLTVPGSERSYDLTG (60) 19 LPAPKNLVVSEVTEDSLRLSWrYD-RDGY SFLIQYQESEKVGEAINLTVPGSERSYDLTG 20 LPAPKNLVVSEVTEDSLRLSW3YN-GDHE SFLIQYQESEKVGEAINLTVPGSERSYDLTG 21 LPAPKNLVVSEVTEDSLRLSW DP-RGFY GSFLIQYQESEKVGFAINLTVPGSERSYDLTG 22 LPAPKNLVVSEVTEDSLRLSWrWP-YADL'SFLIQYQESEKVGRAINLTVPGSERSYDLTG 23 LPAPKNLVVSEVTEDSLRLSW YN-GDHF2SFLIQYQESEKVGEAINLTVPGSERSYDLTG 24 LPAPKNLVVSEVTEDSLRLSW YDLGDHF SFLIQYQESEKVGEAINLTVPGSERSYDLTG 25 LPAPKNLVVSEVTEDSLRLSW DP-WAFY CSFLIQYQESEKVGEAINLTVPGSERSYDLTG 27 LPAPKNLVVSEVTEDSARLSW DP-WAFY SFLIQYQESEKVGEAIVLTVPGSERSYDLTG 29 LPAPKNLVVSEVTEDSLRLSW WP-YADL SFLIQYQESEKVGEAINLTVPGSERSYDLTG 107 LPAPKNLVVSEVTEDSARLSW DP-HGFY SFLIQYQESEKVGEAIVLTVPGSERSYDLTG 108 LPAPKNLVVSEVTEDSARLSW DP-WAFY SFLIQYQESEKVGEAIVLTVPGSERSYDLTG 109 LPAPKNLVVSEVTEDSARLSW DP-HAF SFLIQYQESEKVGEAIVLTVPGSERSYDLTG 110 LPAPKNLVVSEVTEDSARLSWEDP-HGFY SFLIQYQESEKVGEAIVLTVPGSERSYDLTG 18 LKPGTEYTVSIYGV INVYKDTNMRGI PLSAEFTT (94) 19 LKPGTEYTVSIYGV INVYKDTNMRG PLSAEFTT 20 LKPGTEYTVSIYGVINVYKDTNMRGIPLSAEFTT 21 LKPGTEYTVSIYGViNVYKDTNMRGIPLSAEFTT 22 LKPGTEYTVSIYGViNVYKDTNMRGIPLSAEFTT 23 LKPGTEYTVSIYGV NVYKDTNMRGI PLSAEFTT 24 LKPGTEYTVSIYGV NVYKDTNMRGI PLSAEFTT 25 LKPGTEYTVSIYGV JNVYKDTNMRGI PLSAEFTT 27 LKPGTEYTVSIYGV NVYKDTNMRGI PLSAIFTT 29 LKPGTEYTVSIYGV INVYKDTNMRGI PLSAEFTT 107 LKPGTEYTVSIYGV INVYKDTNMRGI PLSAIFTT 108 LKPGTEYTVSIYGV INVYKDTNIRGI PLSAIFTT 109 LKPGTEYTVSIYGV INVYKDTNIRGI PLSAIFTT 110 LKPGTEYTVSIYGV NVYKDTIRGI PLSAIFTT Bispecific EGFR/c-Met antibodies and methods making and using the molecules. Epidermal growth factor receptor (EGFR, ErbBI or HERI) is a Type I transmembmne glycoprotein of 170 kDa thai is encoded by the c-erbBI proto-oncogene. EGFR is a member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases (RTK) which includes HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4). EGFR signaling is initiated by ligand binding followed by induction of conformational change, homodimerizalion or heteromdimerization of the receptor with other ErbB family members.

30. 发明专利

SI3447069T1 Bispecifična protitelesa EGFR/C-MET 未知
公开(公告)号：SI3447069T1
公开(公告)日：2021-02-26
申请号：SI201331820
申请日：2013-11-21
申请人： JANSSEN BIOTECH INC
发明人： CHIU MARK , MOORES SHERI , NEIJSSEN JOOST , PARREN PAUL , SCHUURMAN JANINE
IPC分类号： C07K16/00 , A61K31/00 , A61K33/00 , A61K39/00 , A61K45/00 , A61P35/00

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