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21. 发明申请

US20090216159A1 METHOD AND SYSTEM FOR COMBINED ULTRASOUND TREATMENT 审中-公开
标题翻译：用于组合超声治疗的方法和系统
公开(公告)号：US20090216159A1
公开(公告)日：2009-08-27
申请号：US12437726
申请日：2009-05-08
申请人： Michael H. Slayton , Inder Raj S. Makin , Peter G. Barthe
发明人： Michael H. Slayton , Inder Raj S. Makin , Peter G. Barthe
IPC分类号： A61N7/02 , A61N7/00
CPC分类号： A61H23/0245 , A61B8/4472 , A61B8/483 , A61H2201/5007 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0073 , A61N2007/0078
摘要： A non-invasive method and system for combined ultrasound treatment are provided. An exemplary combined ultrasound treatment system comprises a transducer configured to deliver ultrasound energy to provide two or more energy effects to a region of interest. The energy effects facilitate the initiation of one or more responses in the region of interest. In accordance with an exemplary embodiment of the present invention, a transducer is configured to deliver energy over varying temporal and/or spatial distributions in order to provide energy effects and initiate responses in a region of interest.
摘要翻译：提供了一种用于组合超声治疗的非侵入性方法和系统。示例性组合超声治疗系统包括被配置为递送超声能量以向感兴趣区域提供两个或更多个能量效应的换能器。能量效应有助于在感兴趣的区域启动一个或多个反应。根据本发明的示例性实施例，换能器被配置为在不同的时间和/或空间分布上传递能量，以便在感兴趣的区域中提供能量效应并启动响应。

22. 发明授权

US09566454B2 Method and sysem for non-ablative acne treatment and prevention 有权
标题翻译：非烧蚀性痤疮治疗和预防的方法和系统
公开(公告)号：US09566454B2
公开(公告)日：2017-02-14
申请号：US11738682
申请日：2007-04-23
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61N7/02 , A61B17/00 , A61B17/22 , A61B18/00 , A61N7/00 , A61B8/00 , A61M37/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B2017/00747 , A61B2017/22008 , A61B2018/00666 , A61M37/0092 , A61N7/00 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
摘要翻译：公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。超声能量的应用导致许多治疗痤疮的生理效应。这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应在感兴趣的地区。

23. 发明授权

US09216276B2 Methods and systems for modulating medicants using acoustic energy 有权
标题翻译：使用声能调节药物的方法和系统
公开(公告)号：US09216276B2
公开(公告)日：2015-12-22
申请号：US12116810
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61M37/00 , A61N7/00 , A61N7/02 , A61B19/00 , A61B8/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

24. 发明授权

US09011336B2 Method and system for combined energy therapy profile 有权
标题翻译：联合能量治疗方案和系统
公开(公告)号：US09011336B2
公开(公告)日：2015-04-21
申请号：US12116845
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61B8/00 , A61N7/00 , A61N7/02 , A61B18/14 , A61B18/20 , A61B19/00 , A61B17/22
CPC分类号： A61N7/022 , A61B8/4281 , A61B18/14 , A61B18/20 , A61B34/30 , A61B2017/22024 , A61B2017/22028 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
摘要翻译：公开了一种用组合治疗方案处理组织的方法和系统。在一个示例性实施例中，使用超声能量来治疗感兴趣区域内的组织的许多深度，并且改变超声能量的空间和时间属性以进行更有效的治疗。本发明的方法和系统被配置为从表面上向下处理所有的组织，而不是备用的中间组织。

25. 发明申请

US20120330222A1 METHODS FOR TREATMENT OF HYPERHIDROSIS 有权
标题翻译：治疗高血压的方法
公开(公告)号：US20120330222A1
公开(公告)日：2012-12-27
申请号：US13603159
申请日：2012-09-04
申请人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B18/04 , A61M37/00
CPC分类号： A61N7/02 , A61B8/4281 , A61B17/320068 , A61B2018/00005 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0078
摘要： Methods for ultrasound treatment of hyperhidrosis are provided. Various methods and systems for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, thermal and/or ablative energy can be deposited at the particular depth at which the sweat gland population is located below the skin surface. Ultrasound and non-ultrasound treatments for hyperhidrosis are provided.
摘要翻译：提供超声治疗多汗症的方法。用于针对性治疗汗腺的各种方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用集中的，未聚焦的，或通过控制各种空间和时间参数来散焦超声波。结果，热汗和/或烧蚀能量可以沉积在汗腺群体位于皮肤表面下方的特定深度处。提供超声和非超声治疗多汗症。

26. 发明申请

US20120197120A1 METHODS FOR TREATMENT OF SWEAT GLANDS 有权
标题翻译：施肥方法
公开(公告)号：US20120197120A1
公开(公告)日：2012-08-02
申请号：US13444485
申请日：2012-04-11
申请人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61M37/00 , A61B8/00
CPC分类号： A61N7/02 , A61B8/4281 , A61B17/320068 , A61B2018/00005 , A61N7/00 , A61N2007/0004 , A61N2007/0052 , A61N2007/0078
摘要： A method and system for ultrasound treatment of sweat glands are provided. An exemplary method and system for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound through control of various spatial and temporal parameters. As a result, ablative energy can be deposited at the particular depth at which the aberrant sweat gland population is located below the skin surface.
摘要翻译：提供了一种用于汗腺超声处理的方法和系统。用于针对性治疗汗腺的示例性方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用聚焦，通过控制各种空间和时间参数，不聚焦或散焦超声波。因此，可以在异常汗腺群体位于皮肤表面下方的特定深度沉积烧蚀能量。

27. 发明授权

US07530356B2 Method and system for noninvasive mastopexy 有权
标题翻译：无创乳腺炎的方法和系统
公开(公告)号：US07530356B2
公开(公告)日：2009-05-12
申请号：US11163155
申请日：2005-10-06
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61B8/00 , A61B18/04
CPC分类号： A61N7/02 , A61B8/0825 , A61B8/14 , A61B8/4281 , A61B8/429 , A61B8/4483 , A61B8/461 , A61B8/483 , A61B18/04 , A61B18/18 , A61B2018/00333 , A61B2018/00577 , A61B2018/00642 , A61B2018/00791 , A61B2018/00904 , A61B2018/00994 , A61N2007/0052 , G01S7/52046 , G01S15/8909
摘要： Methods and systems for noninvasive mastopexy through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a deep tissue region, such as a region comprising muscular fascia and ligaments. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth from 1 mm to 4 cm with a conformal selective deposition of ultrasound energy without damaging an intervening tissue in the range of frequencies from 1 to 15 MHz. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.
摘要翻译：提供了通过用超声波深部组织收紧进行非侵入性手术的方法和系统。示例性方法和系统包括治疗性超声系统，其被配置为向深部组织区域（例如包括肌肉筋膜和韧带的区域）提供超声治疗。根据各种示例性实施例，治疗性超声系统可以被配置为通过适形选择性沉积超声能量来实现从1mm到4cm的深度，而不损害在1至15MHz的频率范围内的介入组织。此外，治疗性超声还可以与超声成像或成像/监测能力组合，或者单独配置成像，治疗和监测系统或其任何一体化的结合。

28. 发明申请

US20080281255A1 METHODS AND SYSTEMS FOR MODULATING MEDICANTS USING ACOUSTIC ENERGY 有权
标题翻译：使用声学能量调制药物的方法和系统
公开(公告)号：US20080281255A1
公开(公告)日：2008-11-13
申请号：US12116810
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61N7/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

29. 发明授权

US07247141B2 Intra-cavitary ultrasound medical system and method 有权
标题翻译：腔内超声医疗系统及方法
公开(公告)号：US07247141B2
公开(公告)日：2007-07-24
申请号：US10795680
申请日：2004-03-08
申请人： Inder Raj S. Makin , Yoav Avidor , Michael H. Slayton , Peter G. Barthe
发明人： Inder Raj S. Makin , Yoav Avidor , Michael H. Slayton , Peter G. Barthe
IPC分类号： A61B8/00
CPC分类号： A61B17/42 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B17/2202 , A61B2017/2253 , A61B2017/4216
摘要： A method for medically employing ultrasound within a body cavity of a patient. An end effector is obtained having a medical ultrasound transducer assembly. A biocompatible hygroscopic substance is obtained having a non-expanded anhydrous state and having an expanded and fluidly-loculated hydrated state. The end effector, including the transducer assembly, and the substance in substantially its anhydrous state are inserted into a body cavity (such as endoscopically inserted into a uterus) of a patient. The transducer assembly is used to medically image and/or medically treat patient tissue (such as stopping blood flow to, and/or ablating, a uterine fibroid). A system for medically employing ultrasound includes the end effector and the substance. In another system, the end effector includes the substance. The substance in its hydrated state expands inside the body cavity providing acoustic coupling between the wall of the body cavity and the transducer assembly.
摘要翻译：一种在患者体腔内医用超声波的方法。获得具有医学超声换能器组件的端部执行器。获得具有未膨胀无水状态并且具有膨胀和流动位置的水合状态的生物相容性吸湿性物质。末端执行器（包括换能器组件）和基本上其无水状态的物质插入患者的体腔（例如内窥镜插入子宫中）。换能器组件用于医疗图像和/或医学上治疗患者组织（例如阻止血液流向和/或消融子宫肌瘤）。用于医学使用超声波的系统包括末端执行器和物质。在另一系统中，末端执行器包括物质。其水合状态的物质在体腔内扩张，提供体腔壁与换能器组件之间的声耦合。

30. 发明申请

US20140243713A1 Methods and Systems for Generating Thermal Bubbles for Improved Ultrasound Imaging and Therapy 有权
标题翻译：用于产生热气泡以改善超声成像和治疗的方法和系统
公开(公告)号：US20140243713A1
公开(公告)日：2014-08-28
申请号：US14270859
申请日：2014-05-06
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/4281 , A61B8/4472 , A61B8/48 , A61B2018/00005 , A61B2018/00642 , A61N5/0616 , A61N5/10 , A61N2007/0039 , A61N2007/0043 , A61N2007/0056 , A61N2007/006 , A61N2007/0065 , A61N2007/0073
摘要： A method and system uniquely capable of generating thermal bubbles for improved ultrasound imaging and therapy. Several embodiments of the method and system contemplates the use of unfocused, focused, or defocused acoustic energy at variable spatial and/or temporal energy settings, in the range of about 1 kHz-100 MHz, and at variable tissue depths. The unique ability to customize acoustic energy output and target a particular region of interest makes possible highly accurate and precise thermal bubble formation. In an embodiment, the energy is acoustic energy. In other embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents (including monopolar and bipolar radio-frequency current). In an embodiment, the energy is various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling.
摘要翻译：一种独特地产生热气泡以改进超声成像和治疗的方法和系统。该方法和系统的几个实施例考虑在约1kHz-100MHz的范围内和在可变组织深度处的可变空间和/或时间能量设置下使用未聚焦，聚焦或散焦的声能。定制声能输出和瞄准特定感兴趣区域的独特能力使得高精度和精确的热气泡形成成为可能。在一个实施例中，能量是声能。在其他实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流（包括单极性和双极性射频电流）。在一个实施例中，能量是声能，电磁能和其它能量形式或诸如冷却的能量吸收器的各种组合。

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