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1. 发明授权

US10537304B2 Hand wand for ultrasonic cosmetic treatment and imaging 有权
公开(公告)号：US10537304B2
公开(公告)日：2020-01-21
申请号：US12996616
申请日：2009-06-05
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61B8/08
摘要： Embodiments of the invention provide a dermatological cosmetic treatment and imaging system and method. In some embodiments, the system (20) includes a hand wand (100) with at least one finger activated controller (150, 160), and a removable transducer module (200) having an ultrasound transducer (280). In some embodiments, the system (20) can include a control module (300) that is coupled to the hand wand (100) and has a graphical user interface (310) for controlling the removable transducer module (200), and an interface (130) coupling the hand wand (100) to the control module (300). The interface (130) may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the cosmetic treatment system (20) may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.

2. 发明授权

US08641622B2 Method and system for treating photoaged tissue 有权
标题翻译：光电组织治疗方法及系统
公开(公告)号：US08641622B2
公开(公告)日：2014-02-04
申请号：US13230498
申请日：2011-09-12
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B5/682 , A61B5/6842 , A61B8/08 , A61B8/0858 , A61B8/12 , A61B8/13 , A61B8/4209 , A61B8/4281 , A61B8/4455 , A61B8/4483 , A61B8/461 , A61B8/483 , A61B8/546 , A61B17/320068 , A61H23/0245 , A61H2201/5007 , A61N7/00 , A61N2007/0008 , A61N2007/0034 , A61N2007/0052 , A61N2007/027 , G01S15/8909
摘要： A method and system for ultrasound treatment of photoaged tissue are provided. An exemplary method and system are configured for first, ultrasound imaging of the region of interest for localization of the treatment area, second, delivery of ultrasound energy at a depth and pattern to achieve the desired therapeutic effects, and third to monitor the treatment area during and after therapy to assess the results and/or provide feedback. The exemplary treatment method and system can be configured for producing arrays of sub-millimeter and larger zones of thermal ablation to treat the epidermal, superficial dermal, mid-dermal and deep dermal components of photoaged tissue.
摘要翻译：提供了一种用于光电组织超声处理的方法和系统。一种示例性方法和系统被配置用于首先对感兴趣区域的超声成像进行治疗区域的定位，其次，以深度和图案递送超声能量以获得期望的治疗效果，第三，监测治疗区域的治疗区域并在治疗后评估结果和/或提供反馈。可以将示例性治疗方法和系统配置用于产生亚毫米和更大的热消融区域阵列，以治疗光化组织的表皮，浅表皮肤，中间皮肤和深层真皮成分。

3. 发明授权

US08366622B2 Treatment of sub-dermal regions for cosmetic effects 有权
标题翻译：治疗亚皮肤区域的化妆品效果
公开(公告)号：US08366622B2
公开(公告)日：2013-02-05
申请号：US13444336
申请日：2012-04-11
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin , Brian D. O'Connor
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin , Brian D. O'Connor
IPC分类号： A61B7/02
CPC分类号： A61N7/02 , A61B5/682 , A61B5/6842 , A61B8/08 , A61B8/0858 , A61B8/12 , A61B8/13 , A61B8/4209 , A61B8/4281 , A61B8/4455 , A61B8/4483 , A61B8/461 , A61B8/483 , A61B8/546 , A61B17/320068 , A61H23/0245 , A61H2201/5007 , A61N7/00 , A61N2007/0008 , A61N2007/0034 , A61N2007/0052 , A61N2007/027 , G01S15/8909
摘要： A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
摘要翻译：公开了一种用于无创面部提升和深层组织紧固的方法和系统。配置了用于成像，监测和热损伤以处理SMAS区域的示例性方法和处理系统。根据示例性实施例，示例性方法和系统被配置为通过首先对感兴趣区域进行成像以对治疗区域和周围结构进行定位来处理SMAS区域;其次，在深度，分布处输送超声能量，时间和能量水平，以达到预期的治疗效果，第三是监测治疗前，治疗期间和治疗后的治疗区域，以计划和评估结果和/或提供反馈。

4. 发明授权

US07846096B2 Method for monitoring of medical treatment using pulse-echo ultrasound 有权
标题翻译：使用脉冲回波超声检查治疗方法
公开(公告)号：US07846096B2
公开(公告)日：2010-12-07
申请号：US10721034
申请日：2003-11-24
申请人： T. Douglas Mast , Waseem Faidi , Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： T. Douglas Mast , Waseem Faidi , Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/12 , A61B8/14 , A61B8/4488 , A61B8/5207 , A61B8/5238 , A61B8/5276 , A61B10/0233 , A61B17/22012 , A61B17/2202 , A61B17/29 , A61B17/320092 , A61B2090/378 , A61B2090/3784 , A61B2090/3929 , A61B2090/3975 , A61N7/022 , A61N2007/0078 , G01S15/899
摘要： A method for ultrasound imaging of anatomical tissue. A first signal is received from a first imaging ultrasound wave which has been reflected from a location in the anatomical tissue during a first time period. A second signal is received from a second imaging ultrasound wave which has been reflected from the location in the anatomical tissue during a later second time period, following a discrete medical treatment. The second signal is subtracted from the first signal to form a difference signal. The difference signal may be scaled, spatially filtered, then used to generate an indication, the indication showing the effect of the medical treatment in the location in the anatomical tissue.
摘要翻译：解剖组织超声成像的方法。从第一时间段内从解剖组织中的位置反射的第一成像超声波接收第一信号。在离散的医疗处理之后，在稍后的第二时间段内已经从解剖组织中的位置反射的第二成像超声波接收第二信号。从第一信号中减去第二信号以形成差分信号。差分信号可以被缩放，空间过滤，然后用于产生指示，该指示表示在解剖组织中的位置处的医疗的影响。

5. 发明申请

US20100256490A1 MEDICAL SYSTEM HAVING AN ULTRASOUND SOURCE AND AN ACOUSTIC COUPLING MEDIUM 审中-公开
标题翻译：具有超声波源和声学耦合介质的医疗系统
公开(公告)号：US20100256490A1
公开(公告)日：2010-10-07
申请号：US12818261
申请日：2010-06-18
申请人： Inder Raj S. Makin , T. Douglas Mast , Michael H. Slayton , Peter G. Barthe , Jeffrey D. Messerly , Waseem Faidi , Megan M. Runk
发明人： Inder Raj S. Makin , T. Douglas Mast , Michael H. Slayton , Peter G. Barthe , Jeffrey D. Messerly , Waseem Faidi , Megan M. Runk
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/4272 , A61B8/12 , A61B8/4281 , A61B8/4444 , A61B8/546 , A61B2017/2253 , A61N7/00 , A61N7/022 , A61N2007/0052
摘要： An ultrasound medical system has an end effector including a medical ultrasound transducer and an acoustic coupling medium. The acoustic coupling medium has a transducer-proximal surface and a transducer-distal surface. The medical ultrasound transducer is positioned to emit medical ultrasound through the acoustic coupling medium from the transducer-proximal surface to the transducer-distal surface. The end effector is adapted to change a property (such as the shape and/or the temperature) of the acoustic coupling medium during emission, and/or between emissions, of medical ultrasound from the medical ultrasound transducer during a medical procedure on a patient. In one example, such changes are used to change the focus and/or beam angle of the emitted ultrasound during the medical procedure.
摘要翻译：超声波医疗系统具有包括医用超声波换能器和声耦合介质的末端执行器。声耦合介质具有换能器近侧表面和换能器远侧表面。医疗超声换能器被定位成通过声耦合介质从换能器近端表面到换能器远侧表面发射医用超声波。端部执行器适于在医疗超声波换能器在患者的医疗过程期间改变声学耦合介质在发射期间和/或发射之间的医疗超声波的性质（例如形状和/或温度）。在一个示例中，这样的改变用于在医疗过程期间改变发射的超声的焦点和/或束角。

6. 发明授权

US07806839B2 System and method for ultrasound therapy using grating lobes 有权
标题翻译：使用栅瓣的超声治疗系统和方法
公开(公告)号：US07806839B2
公开(公告)日：2010-10-05
申请号：US10867170
申请日：2004-06-14
申请人： T. Douglas Mast , Waseem Faidi , Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
发明人： T. Douglas Mast , Waseem Faidi , Inder Raj S. Makin , Peter G. Barthe , Michael H. Slayton
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00
CPC分类号： A61N7/022 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095 , A61N2007/027
摘要： A system and method for medical treatment of tissue using ultrasound. The system comprises a probe having an array of transducer elements, an ultrasound waveform generator adapted to generate at least one electrical ultrasound signal, and a plurality of phase controls, each coupled to the ultrasound waveform generator and adapted to generate from the electrical ultrasound signal a phase-shifted drive signal that is coupled to an associated transducer element. The drive signal is effective to control grating lobe foci emitted by the array. The method employs the system.
摘要翻译：一种使用超声波治疗组织的系统和方法。该系统包括具有换能器元件阵列的探头，适于产生至少一个电超声波信号的超声波波形发生器，以及多个相位控制器，每个相位控制器耦合到超声波波形发生器，并适于从电超声波信号耦合到相关联的换能器元件的相移驱动信号。驱动信号有效地控制由阵列发射的光栅叶片焦点。该方法采用该系统。

7. 发明申请

US20090216159A1 METHOD AND SYSTEM FOR COMBINED ULTRASOUND TREATMENT 审中-公开
标题翻译：用于组合超声治疗的方法和系统
公开(公告)号：US20090216159A1
公开(公告)日：2009-08-27
申请号：US12437726
申请日：2009-05-08
申请人： Michael H. Slayton , Inder Raj S. Makin , Peter G. Barthe
发明人： Michael H. Slayton , Inder Raj S. Makin , Peter G. Barthe
IPC分类号： A61N7/02 , A61N7/00
CPC分类号： A61H23/0245 , A61B8/4472 , A61B8/483 , A61H2201/5007 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0073 , A61N2007/0078
摘要： A non-invasive method and system for combined ultrasound treatment are provided. An exemplary combined ultrasound treatment system comprises a transducer configured to deliver ultrasound energy to provide two or more energy effects to a region of interest. The energy effects facilitate the initiation of one or more responses in the region of interest. In accordance with an exemplary embodiment of the present invention, a transducer is configured to deliver energy over varying temporal and/or spatial distributions in order to provide energy effects and initiate responses in a region of interest.
摘要翻译：提供了一种用于组合超声治疗的非侵入性方法和系统。示例性组合超声治疗系统包括被配置为递送超声能量以向感兴趣区域提供两个或更多个能量效应的换能器。能量效应有助于在感兴趣的区域启动一个或多个反应。根据本发明的示例性实施例，换能器被配置为在不同的时间和/或空间分布上传递能量，以便在感兴趣的区域中提供能量效应并启动响应。

8. 发明授权

US07473250B2 Ultrasound medical system and method 有权
标题翻译：超声医疗系统及方法
公开(公告)号：US07473250B2
公开(公告)日：2009-01-06
申请号：US10850984
申请日：2004-05-21
申请人： Inder Raj S. Makin , T. Douglas Mast , Michael H. Slayton , Peter G. Barthe , Jeffrey D. Messerly , Waseem Faidi , Megan M. Runk , Brian D. O'Connor , Christopher J. Park , Paul M. Jaeger
发明人： Inder Raj S. Makin , T. Douglas Mast , Michael H. Slayton , Peter G. Barthe , Jeffrey D. Messerly , Waseem Faidi , Megan M. Runk , Brian D. O'Connor , Christopher J. Park , Paul M. Jaeger
IPC分类号： A61B18/18
CPC分类号： A61B5/4836 , A61B5/053 , A61B8/13 , A61B8/4281 , A61B8/4483 , A61B17/2202 , A61B18/06 , A61B18/08 , A61B18/12 , A61B18/1815 , A61B2090/378 , A61N7/00
摘要： An ultrasound medical system includes an interstitial end effector. The interstitial end effector is interstitially insertable into patient tissue, includes at least one medical-treatment ultrasound transducer, and includes at least one end-effector-tissue-track ablation device. One method for ultrasonically treating a lesion in a patient includes the steps of obtaining the interstitial end effector and inserting it into the patient creating a tissue track which is surrounded by patient tissue and which ends at the distal end of the inserted interstitial end effector. Other steps include ultrasonically ablating the lesion using the at-least-one medical-treatment ultrasound transducer, using the at-least-one end-effector-tissue-track ablation device to ablate the patient tissue surrounding the tissue track along substantially the entire tissue track, and withdrawing the end effector from the patient.
摘要翻译：超声波医疗系统包括间质末端执行器。间质末端效应器在间质中可插入患者组织中，包括至少一个医疗超声换能器，并且包括至少一个末端效应器 - 组织 - 轨道消融装置。用于超声治疗患者病变的一种方法包括以下步骤：获得间隙末端执行器并将其插入患者中，从而产生组织轨迹，所述组织轨道被患者组织包围，并且在组织轨迹的末端处被插入插入的末端执行器。其他步骤包括使用至少一个医疗超声换能器超声波消融损伤，使用至少一个末端效应器 - 组织道消融装置沿着基本上整个组织消融围绕组织轨迹的患者组织跟踪并从患者中取出末端执行器。

9. 发明授权

US09566454B2 Method and sysem for non-ablative acne treatment and prevention 有权
标题翻译：非烧蚀性痤疮治疗和预防的方法和系统
公开(公告)号：US09566454B2
公开(公告)日：2017-02-14
申请号：US11738682
申请日：2007-04-23
申请人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
发明人： Peter G. Barthe , Michael H. Slayton , Inder Raj S. Makin
IPC分类号： A61N7/02 , A61B17/00 , A61B17/22 , A61B18/00 , A61N7/00 , A61B8/00 , A61M37/00
CPC分类号： A61N7/02 , A61B8/4272 , A61B2017/00747 , A61B2017/22008 , A61B2018/00666 , A61M37/0092 , A61N7/00 , A61N2007/0008 , A61N2007/0078
摘要： A method and system for non-ablative acne treatment and prevention is disclosed. The method utilizes ultrasound energy which is targeted at a region of interest to treat existing acne and prevent future acne from forming. The application of ultrasound energy causes numerous physiological effects that treat acne. Some of these physiological effects comprise reducing sebum, increasing perfusion at the region of interest, denaturing proteins at the region of interest, creating an uninhabitable environment at the region of interest, initiating programmed cell death at the region of interest and the initiation of mechanical effects at the region of interest.
摘要翻译：公开了一种用于非烧蚀性痤疮治疗和预防的方法和系统。该方法利用针对感兴趣区域的超声能量来治疗现有的痤疮并防止将来的痤疮形成。超声能量的应用导致许多治疗痤疮的生理效应。这些生理作用中的一些包括减少皮脂，增加感兴趣区域的灌注，在感兴趣的区域变性蛋白质，在感兴趣的区域产生不适宜的环境，在感兴趣的区域启动程序性细胞死亡并引发机械效应在感兴趣的地区。

10. 发明授权

US09216276B2 Methods and systems for modulating medicants using acoustic energy 有权
标题翻译：使用声能调节药物的方法和系统
公开(公告)号：US09216276B2
公开(公告)日：2015-12-22
申请号：US12116810
申请日：2008-05-07
申请人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
发明人： Michael H. Slayton , Peter G. Barthe , Inder Raj S. Makin
IPC分类号： A61M37/00 , A61N7/00 , A61N7/02 , A61B19/00 , A61B8/00
CPC分类号： A61M37/0092 , A61B8/4281 , A61B2090/378 , A61M2037/0007 , A61M2205/3375 , A61N7/00 , A61N7/02 , A61N2007/0008 , A61N2007/0043 , A61N2007/0056
摘要： This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
摘要翻译：本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。在示例性实施例中，本文公开的方法和系统能够调制多层组织。在示例性实施例中，能量是声能（例如，超声）。在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合形式或能量吸收器如冷却。首先通过扩散，循环和/或注射将药物引入感兴趣的区域。用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

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