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21. 发明授权

US08121692B2 Method and apparatus for neural stimulation with respiratory feedback 有权
标题翻译：呼吸反馈神经刺激的方法和装置
公开(公告)号：US08121692B2
公开(公告)日：2012-02-21
申请号：US11468595
申请日：2006-08-30
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

22. 发明申请

US20090076363A1 Adherent Device with Multiple Physiological Sensors 有权
标题翻译：具有多个生理传感器的粘附装置
公开(公告)号：US20090076363A1
公开(公告)日：2009-03-19
申请号：US12209273
申请日：2008-09-12
申请人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/04
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient for an extended period comprises a breathable tape. The breathable tape comprises a porous material with an adhesive coating to adhere the breathable tape to a skin of the patient. At least one electrode is affixed to the breathable tape and capable of electrically coupling to a skin of the patient. A printed circuit board is connected to the breathable tape to support the printed circuit board with the breathable tape when the tape is adhered to the patient. Electronic components electrically are connected to the printed circuit board and coupled to the at least one electrode to measure physiologic signals of the patient. A breathable cover and/or an electronics housing is disposed over the circuit board and electronic components and connected to at least one of the electronics components, the printed circuit board or the breathable tape.
摘要翻译：用于长时间监视患者的附着装置包括透气带。透气带包括具有粘合剂涂层以将透气带粘附到患者皮肤的多孔材料。至少一个电极固定在透气带上并且能够电耦合到患者的皮肤。印刷电路板连接到透气带上，以便当带子粘附到患者时，用透气带支撑印刷电路板。电气部件电连接到印刷电路板并且耦合到至少一个电极以测量患者的生理信号。透气盖和/或电子壳体设置在电路板和电子部件上方并连接到电子部件，印刷电路板或透气带中的至少一个。

23. 发明申请

US20090076342A1 Adherent Multi-Sensor Device with Empathic Monitoring 审中-公开
标题翻译：具有同步监测的粘附多传感器设备
公开(公告)号：US20090076342A1
公开(公告)日：2009-03-19
申请号：US12209271
申请日：2008-09-12
申请人： Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/6833 , A61B2560/0412
摘要： A system and methods are provided for physiological monitoring and prediction. The system includes a detecting system and a remote monitoring system. The detecting system includes, (i) an adherent device with a plurality of sensors that provide an indication of at least one physiological event of a patient, the adherent device being coupled to the patient's thorax and (ii) a wireless communication device coupled to the plurality of sensors and configured to transfer patient data directly or indirectly from the plurality of sensors to a remote monitoring system. The remote monitoring system is coupled to the wireless communication device. Logic resources may be provided at the remote monitoring system to determine the physiological event of the patient.
摘要翻译：提供了一种用于生理监测和预测的系统和方法。该系统包括检测系统和远程监控系统。所述检测系统包括：（i）具有多个传感器的粘附装置，所述多个传感器提供患者的至少一个生理事件的指示，所述粘附装置耦合到患者的胸部，以及（ii）耦合到所述患者的胸部的无线通信装置多个传感器并且被配置为将患者数据直接或间接地从多个传感器传送到远程监视系统。远程监控系统耦合到无线通信设备。可以在远程监控系统处提供逻辑资源以确定患者的生理事件。

24. 发明申请

US20080058892A1 METHOD AND APPARATUS FOR NEURAL STIMULATION WITH RESPIRATORY FEEDBACK 有权
标题翻译：用呼吸反馈神经刺激的方法和装置
公开(公告)号：US20080058892A1
公开(公告)日：2008-03-06
申请号：US11468595
申请日：2006-08-30
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。

25. 发明申请

US20080058873A1 METHOD AND APPARATUS FOR CONTROLLING NEURAL STIMULATION DURING DISORDERED BREATHING 有权
标题翻译：用于控制异常呼吸期间神经刺激的方法和装置
公开(公告)号：US20080058873A1
公开(公告)日：2008-03-06
申请号：US11468603
申请日：2006-08-30
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/18
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

26. 发明授权

US08039727B2 Method and apparatus for shunt for in vivo thermoelectric power system 有权
标题翻译：用于体内热电电力系统分流的方法和装置
公开(公告)号：US08039727B2
公开(公告)日：2011-10-18
申请号：US11681995
申请日：2007-03-05
申请人： Blair Erbstoeszer , Kristofer J. James
发明人： Blair Erbstoeszer , Kristofer J. James
IPC分类号： H01L35/30 , H01L35/02 , A61N1/39 , A61N1/00
CPC分类号： A61N1/3785 , H01L35/30
摘要： One embodiment of the present subject matter includes an apparatus with a first housing portion which is thermally conductive and which has a first case opening; a second housing portion which is thermally conductive and which has a second case opening, the second case opening being hermetically sealed to the first case opening, with the first housing portion and the second housing portion at least partially defining an interior volume; cardiac rhythm management electronics disposed in the interior volume; a thermal shunt disposed in the interior volume; and a thermoelectric energy converter disposed in the interior volume and adjacent the thermal shunt, the thermoelectric energy converter having a first pole and a second pole, with the first pole thermally connected to the first housing portion, and the second pole thermally connected to the shunt.
摘要翻译：本主题的一个实施例包括具有第一壳体部分的装置，其具有导热性并且具有第一壳体开口; 第二壳体部分，其是导热的并且具有第二壳体开口，所述第二壳体开口被气密地密封到所述第一壳体开口，所述第一壳体部分和所述第二壳体部分至少部分地限定内部空间; 设置在内部体积中的心律管理电子装置; 设置在内部容积中的热分流器; 以及设置在所述内部体积中并且与所述热分流相邻的热电能量转换器，所述热电能量转换器具有第一极和第二极，所述第一极热连接到所述第一壳体部分，所述第二极热连接到所述分流器。

27. 发明申请

US20110060380A1 RESPIRATORY RECTIFICATION 有权
标题翻译：呼吸恢复
公开(公告)号：US20110060380A1
公开(公告)日：2011-03-10
申请号：US12557084
申请日：2009-09-10
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译：一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。

28. 发明授权

US06647294B2 High-side energy delivery through a single-quadrant thyristor triggered with a current-limiting switch 有权
公开(公告)号：US06647294B2
公开(公告)日：2003-11-11
申请号：US09966643
申请日：2001-09-28
申请人： Mark Vane , Kristofer J. James
发明人： Mark Vane , Kristofer J. James
IPC分类号： A61N139
CPC分类号： A61N1/3981 , A61N1/3956
摘要： A cardiac rhythm management system includes an implantable cardiac rhythm management device that includes a defibrillation energy delivery circuit. The defibrillation energy delivery circuit provides high side energy delivery through a single-quadrant thyristor switch that is triggered by a current-limiting transistor switch. The defibrillation energy delivery circuit requires fewer electronic components, reducing the size and/or cost of the implantable cardiac rhythm management device. For example, the single-quadrant thyristor, designed to conduct and latch in only one quadrant (e.g., quadrant III) and having appropriate dV/dt and voltage blocking capabilities, may eliminate the need for additional series-coupled semiconductor devices. In another example, current-limiting is designed into, or inherent in, the semiconductor device triggering the single-quadrant thyristor, thereby eliminating the need for additional current-limiting circuits.

29. 发明授权

US09999768B2 Respiratory rectification 有权
公开(公告)号：US09999768B2
公开(公告)日：2018-06-19
申请号：US13529770
申请日：2012-06-21
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.

30. 发明授权

US08233987B2 Respiratory rectification 有权
标题翻译：呼吸整治
公开(公告)号：US08233987B2
公开(公告)日：2012-07-31
申请号：US12557084
申请日：2009-09-10
申请人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
发明人： Mark Gelfand , Kristofer J. James , Randy W. Westlund , Antonis Panteleon , Todd P. Goblish , Mark C. Lynn
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/3611 , A61N1/36171
摘要： A means for treating breathing disorders by stimulating respiratory muscles or nerves to entrain respiratory systems while leaving respiratory drive intact. Embodiments of the invention employ frequency analysis to determine if appropriate stimulation energy is being applied.
摘要翻译：一种通过刺激呼吸肌或神经夹带呼吸系统同时使呼吸驱动完好无损来治疗呼吸障碍的手段。本发明的实施例采用频率分析来确定是否正在施加适当的刺激能量。

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