专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US07486991B2 Baroreflex modulation to gradually decrease blood pressure 有权
公开(公告)号：US07486991B2
公开(公告)日：2009-02-03
申请号：US10746845
申请日：2003-12-24
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.

22. 发明申请

US20080051842A1 INTERMITTENT HIGH-ENERGY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 有权
标题翻译：间歇性高能量心脏刺激治疗效果
公开(公告)号：US20080051842A1
公开(公告)日：2008-02-28
申请号：US11466679
申请日：2006-08-23
申请人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

23. 发明申请

US20120123494A1 SYSTEM FOR ABATING NEURAL STIMULATION SIDE EFFECTS 有权
标题翻译：用于消除神经刺激侧面效应的系统
公开(公告)号：US20120123494A1
公开(公告)日：2012-05-17
申请号：US13356380
申请日：2012-01-23
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36132 , A61B5/02028 , A61B5/0205 , A61B5/08 , A61B5/4035 , A61B5/4047 , A61N1/3601 , A61N1/36114
摘要： Various system embodiments comprise a neural stimulation delivery system adapted to deliver a neural stimulation signal for use in delivering a neural stimulation therapy, a side effect detector, and a controller. The controller is adapted to control the neural stimulation delivery system, receive a signal indicative of detected side effect, determine whether the detected side enact is attributable to delivered neural stimulation therapy, and automatically titrate the neural stimulation therapy to abate the side effect. In various embodiments, the side effect detector includes a cough detector. In various embodiments, the controller is adapted to independently adjusting at least one stimulation parameter for at least one phase in the biphasic waveform as part of a process to titrate the neural stimulation therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于递送神经刺激疗法的神经刺激信号的神经刺激递送系统，副作用检测器和控制器。控制器适于控制神经刺激递送系统，接收指示检测到的副作用的信号，确定检测到的侧发生是否归因于递送的神经刺激治疗，并且自动滴定神经刺激疗法以减轻副作用。在各种实施例中，副作用检测器包括咳嗽检测器。在各种实施例中，控制器适于独立地调整两相波形中的至少一个相位的至少一个刺激参数，作为滴定神经刺激疗法的过程的一部分。本文提供了其它方面和实施例。

24. 发明授权

US08103341B2 System for abating neural stimulation side effects 有权
标题翻译：减轻神经刺激副作用的系统
公开(公告)号：US08103341B2
公开(公告)日：2012-01-24
申请号：US11467264
申请日：2006-08-25
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/00
CPC分类号： A61N1/36132 , A61B5/02028 , A61B5/0205 , A61B5/08 , A61B5/4035 , A61B5/4047 , A61N1/3601 , A61N1/36114
摘要： Various system embodiments comprise a neural stimulation delivery system adapted to deliver a neural stimulation signal for use in delivering a neural stimulation therapy, a side effect detector, and a controller. The controller is adapted to control the neural stimulation delivery system, receive a signal indicative of detected side effect, determine whether the detected side effect is attributable to delivered neural stimulation therapy, and automatically titrate the neural stimulation therapy to abate the side effect. In various embodiments, the side effect detector includes a cough detector. In various embodiments, the controller is adapted to independently adjusting at least one stimulation parameter for at least one phase in the biphasic waveform as part of a process to titrate the neural stimulation therapy. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于递送用于递送神经刺激疗法的神经刺激信号的神经刺激递送系统，副作用检测器和控制器。控制器适于控制神经刺激递送系统，接收指示检测到的副作用的信号，确定检测到的副作用是否归因于递送的神经刺激治疗，并且自动滴定神经刺激疗法以减轻副作用。在各种实施例中，副作用检测器包括咳嗽检测器。在各种实施例中，控制器适于独立地调整两相波形中的至少一个相位的至少一个刺激参数，作为滴定神经刺激疗法的过程的一部分。本文提供了其它方面和实施例。

25. 发明申请

US20100286738A1 INTERMITTENT HIGH-ENERGY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 审中-公开
标题翻译：间歇性高能量心脏刺激治疗效果
公开(公告)号：US20100286738A1
公开(公告)日：2010-11-11
申请号：US12838792
申请日：2010-07-19
申请人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Imad Libbus , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3622
摘要： A device and method for delivering high-energy electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The high-energy stimulation mimics the effects of exercise and improves symptoms even in patients who are exercise intolerant. The high-energy stimulation may be delivered on an intermittent basis either as pacing pulses in accordance with a programmed pacing mode and with a higher pacing pulse energy than used for conventional pacing or as low energy shock pulses.
摘要翻译：用于向心脏递送高能电刺激以改善心力衰竭患者的心脏功能的装置和方法。高能量刺激模拟运动的影响，即使在运动不耐受的患者中也能改善症状。高能量刺激可以间歇地作为起搏脉冲递送，或者作为起搏脉冲根据编程的起搏模式和较高的起搏脉冲能量而不是用于常规起搏或低能量冲击脉冲。

26. 发明申请

US20090143838A1 Baroreflex modulation to gradually decrease blood pressure 有权
标题翻译： Baroreflex调制逐渐降低血压
公开(公告)号：US20090143838A1
公开(公告)日：2009-06-04
申请号：US12321949
申请日：2009-01-27
申请人： Imad Libbus , Julio C. Spinelli
发明人： Imad Libbus , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36146 , A61N1/36564
摘要： An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及一种压力反射刺激器。刺激器的实施例包括脉冲发生器，以通过电极提供压力反射刺激信号和调制器。该调节剂调节压力反射刺激信号以增加压力反射刺激疗法预定的变化率，从而将全身血压降低到目标压力。本文提供了其他方面。

27. 发明授权

US08805501B2 Baroreflex stimulation to treat acute myocardial infarction 有权
标题翻译： Baroreflex刺激治疗急性心肌梗死
公开(公告)号：US08805501B2
公开(公告)日：2014-08-12
申请号：US13357932
申请日：2012-01-25
申请人： Imad Libbus
发明人： Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36117 , A61N1/36564
摘要： An aspect of the present subject relates to an implantable medical system. An embodiment of the system includes a baroreflex stimulator, a myocardial infarction detector, and a controller. The baroreflex stimulator applies a baroreflex stimulation signal through an electrode. The myocardial infarction detector detects an event indicative of myocardial infarction, The controller is connected to the baroreflex stimulator and to the myocardial infarction detector, and is adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction. Other aspects are provided herein.
摘要翻译：本发明的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心肌梗死检测器和控制器。压力反射刺激器通过电极施加压力反射刺激信号。心肌梗死检测器检测到指示心肌梗死的事件。控制器连接到压力反射刺激器和心肌梗塞检测器，并且适于对检测到的指示心肌梗塞的事件应用压力反射治疗。本文提供了其他方面。

28. 发明授权

US08755892B2 Systems for stimulating neural targets 有权
标题翻译：刺激神经靶点的系统
公开(公告)号：US08755892B2
公开(公告)日：2014-06-17
申请号：US11749500
申请日：2007-05-16
申请人： Badri Amurthur , Imad Libbus
发明人： Badri Amurthur , Imad Libbus
IPC分类号： A61N1/04 , A61N1/36
CPC分类号： A61N1/36017 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/026 , A61B5/14532 , A61B5/1455 , A61B5/4041 , A61B5/6815 , A61B5/6826 , A61B5/6838 , A61B8/06 , A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.
摘要翻译：本文公开了一种用于刺激人耳附近的神经靶的方法。根据实施例，将装置夹在患者耳垂上，该装置包括神经刺激电极。根据实施例，神经刺激信号被施加到电极以经皮刺激耳垂附近的神经靶。使用连接到该装置的传感器感测生理参数。根据实施例，响应于所感测的参数来调整神经刺激信号。使用的方法是多种治疗方案，包括抗高血压和心脏改善治疗。

29. 发明授权

US08571654B2 Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US08571654B2
公开(公告)日：2013-10-29
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

30. 发明授权

US08447397B2 Systems, devices and methods used in verifying neural stimulation capture 有权
标题翻译：用于验证神经刺激捕获的系统，设备和方法
公开(公告)号：US08447397B2
公开(公告)日：2013-05-21
申请号：US13460949
申请日：2012-05-01
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，早产性心室收缩（PVC）事件检测器，心率检测器，分析器和控制器。神经刺激器适于产生适于刺激自主神经靶标的刺激信号。分析器适于响应来自PVC事件检测器的PVC事件信号，产生作为PVC前心率数据和PVC后心率数据的函数的自主平衡指示器（ABI）。本文提供了其它方面和实施例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式