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21. 发明申请

US20110137320A1 FASTENER HAVING TORQUE OPTIMIZED HEAD 审中-公开
标题翻译：具有扭矩优化头的紧固件
公开(公告)号：US20110137320A1
公开(公告)日：2011-06-09
申请号：US12852326
申请日：2010-08-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/58
CPC分类号： A61B17/888 , A61B17/8615 , A61B17/864 , A61B2017/00004
摘要： Disclosed is a medical fastener that can be mounted to a bone of a patient. The medical fastener can include a head portion comprising a recess having a first portion, a second tapered portion extending from the first portion, and a third cylindrical portion extending from the second tapered portion. A threaded body portion can extend from the head portion. The first portion and the second portion can have a Torx geometry or star-shaped configuration. Also disclosed is a driver usable to mount the medical fastener to the bone. The driver can include a tip that is complementary to the recess and an end that enables the driver to mount to a drill or other device that can rotate the driver.
摘要翻译：公开了可以安装到患者的骨骼上的医疗紧固件。医疗紧固件可以包括头部，头部包括具有第一部分的凹部，从第一部分延伸的第二锥形部分和从第二锥形部分延伸的第三圆柱形部分。螺纹体部分可以从头部延伸。第一部分和第二部分可以具有Torx几何形状或星形配置。还公开了可用于将医疗紧固件安装到骨头的驱动器。驱动器可以包括与凹部互补的尖端和使得驱动器能够安装到能够旋转驱动器的钻孔或其他装置的端部。

22. 发明授权

US07862541B2 Catheter having a soft distal tip 有权
标题翻译：导管具有软的远端
公开(公告)号：US07862541B2
公开(公告)日：2011-01-04
申请号：US11766662
申请日：2007-06-21
申请人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
发明人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0069 , A61M25/1006 , A61M25/1027 , A61M25/104 , A61M2025/0081 , A61M2025/1093 , Y10T29/49826
摘要： The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.
摘要翻译：本发明涉及一种导管，其具有可以以比现有技术中的导管低的成本制造的软远侧末端。在一个实施例中，通过将软套管连接到导管管的远端来产生导管。套管可在温度和压力条件下固定到导管上，导致套筒的近端相对于导管的外表面逐渐变细，避免或最小化导管插入轮廓中的不连续性，并且还使得内套管的壁与导管管的远端成锥形，避免或最小化导管内腔的不连续性。

23. 发明授权

US07717946B2 Polymeric plate bendable without thermal energy and methods of manufacture 失效
标题翻译：不含热能的聚合物板可弯曲和制造方法
公开(公告)号：US07717946B2
公开(公告)日：2010-05-18
申请号：US11146454
申请日：2005-06-06
申请人： Randolf von Oepen , Alexander Tschakaloff
发明人： Randolf von Oepen , Alexander Tschakaloff
IPC分类号： A61B17/80
CPC分类号： A61B17/8085 , A61B2017/00004 , A61B2017/00526 , Y10S606/907
摘要： An implantable plate for providing support to a bone of a subject when affixed thereto includes a polymeric body of a biocompatible polymer having a desired amount of polymer molecule orientation in a first direction so that the plate can be bent to conform with a contour of the bone of the subject. The polymeric body includes a top surface, a bottom surface, and at least one fastener portion. The fastener portion includes a recess and a fastener hold that is configured for receiving a fastener when affixed to the bone of the subject. A method of manufacturing the implantable plate includes: (1) injection molding a biocompatible polymeric composition into a polymeric body within an injection mold; (2) removing the polymeric body from the injection mold; and (3) forming at least one fastener hole within polymeric body.
摘要翻译：用于向被检体的骨骼提供支撑的可植入板，当固定在其上时包括具有在第一方向上具有所需量的聚合物分子取向的生物相容性聚合物的聚合体，使得该板能够弯曲以符合骨骼的轮廓的主题。聚合物主体包括顶表面，底表面和至少一个紧固件部分。紧固件部分包括凹部和紧固件保持件，其被构造成在固定到被检体的骨骼上时接收紧固件。制造可植入板的方法包括：（1）将生物相容性聚合物组合物注塑成注射模具内的聚合体; （2）从注射模具中取出聚合体; 和（3）在聚合物体内形成至少一个紧固件孔。

24. 发明申请

US20100081992A1 Expandable Member Formed Of A Fibrous Matrix For Intraluminal Drug Delivery 有权
标题翻译：用于腔内药物递送的纤维基质形成的可膨胀构件
公开(公告)号：US20100081992A1
公开(公告)日：2010-04-01
申请号：US12238627
申请日：2008-09-26
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61L29/16 , A61L2300/606 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , D01D5/0076
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements with a therapeutic agent incorporated therein. The therapeutic agent can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the therapeutic agent. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由其中结合有治疗剂的纤维元件基质形成的可扩张构件。治疗剂可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕治疗剂的保护性物质的第二涂层。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件具有分散在其中的治疗剂，并且将导管装置推进到期望的治疗部位。一旦在所需的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并将治疗剂递送到所需的治疗部位。

25. 发明申请

US20090318855A1 DEVICES AND METHODS FOR IMPROVING INTRAVASCULAR UPTAKE OF AGENTS 审中-公开
标题翻译：用于改善代谢物的血管内摄取的装置和方法
公开(公告)号：US20090318855A1
公开(公告)日：2009-12-24
申请号：US12145212
申请日：2008-06-24
申请人： Kevin J. Ehrenreich , Kim-Lien Nguyen , Randolf von Oepen , Gregory W. Chan , William Earl Webler, Jr. , Travis R. Yribarren
发明人： Kevin J. Ehrenreich , Kim-Lien Nguyen , Randolf von Oepen , Gregory W. Chan , William Earl Webler, Jr. , Travis R. Yribarren
IPC分类号： A61M1/00 , A61M25/10
CPC分类号： A61M25/1011 , A61M25/007 , A61M25/0082 , A61M2025/0096 , A61M2025/105 , A61M2025/1052
摘要： This invention is generally related to therapeutic treatment of a coronary vessel wall, and more particularly, to systems and methods for improving uptake of therapeutic agents within the endothelium for enhanced delivery of therapeutic agents to a treatment site. A medical device is provided that is capable of reducing the pressure applied to a vessel wall and delivering a therapeutic agent into the vessel wall. Also, methods are described for using the device to facilitate delivery and uptake of a therapeutic agent into the vessel wall.
摘要翻译：本发明通常涉及冠状血管壁的治疗处理，更具体地涉及用于改善内皮内治疗剂吸收的用于增强治疗剂递送至治疗部位的系统和方法。提供了能够降低施加到血管壁并将治疗剂输送到血管壁中的压力的医疗装置。此外，描述了使用该装置促进治疗剂递送和吸收到血管壁中的方法。

26. 发明申请

US20090270787A1 SYSTEMS AND METHODS FOR CREATING ENLARGED MIGRATION CHANNELS FOR THERAPEUTIC AGENTS WITHIN THE ENDOTHELIUM 审中-公开
标题翻译：用于在内皮细胞中产生治疗药物的扩增通道的系统和方法
公开(公告)号：US20090270787A1
公开(公告)日：2009-10-29
申请号：US12108167
申请日：2008-04-23
申请人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, JR. , Binh T. Nguyen , Mina Chow , Gregory W. Chan , Rachel Bright
发明人： Randolf von Oepen , Travis R. Yribarren , Kevin J. Ehrenreich , William E. Webler, JR. , Binh T. Nguyen , Mina Chow , Gregory W. Chan , Rachel Bright
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61B18/1492 , A61B18/24 , A61B2017/22051 , A61B2018/00238 , A61B2018/2272 , A61M2025/0024 , A61M2025/105 , A61M2025/1086
摘要： A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent.
摘要翻译：一种用于在冠状血管壁的治疗部位扩大内皮迁移通道的系统，以便能够增强治疗剂的递送。该系统包括放大剂，用于在冠状血管壁的治疗部位扩大内皮迁移通道。它还包括用于将放大剂递送到治疗部位的递送系统，以便扩大剂将被递送，从而扩大治疗部位的内皮迁移通道，并将治疗剂输送到递送部位。因此，治疗剂将被输送到治疗部位的扩大的移植通道中，用治疗剂治疗治疗部位。

27. 发明申请

US20080004568A1 CATHETER HAVING A SOFT DISTAL TIP 有权
标题翻译：导管带有一个软的距离
公开(公告)号：US20080004568A1
公开(公告)日：2008-01-03
申请号：US11766662
申请日：2007-06-21
申请人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
发明人： Andrew Jeffrey , Louise Balfe , Lorcan Coffey , Arik Zucker , Kay Unzicker , Zdravkica Dzakula , Ib Joergensen , Randolf von Oepen
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0069 , A61M25/1006 , A61M25/1027 , A61M25/104 , A61M2025/0081 , A61M2025/1093 , Y10T29/49826
摘要： The present invention relates to a catheter having a soft distal tip that can be manufactured at lower cost than catheters in the prior art. In one embodiment, the catheter is produced by coupling a soft sleeve to the distal end of a catheter tube. The sleeve may affixed to the catheter tube under temperature and pressure conditions that cause the proximal end of the sleeve to taper against the outer surface of the catheter tube, avoiding or minimizing discontinuities in the insertion profile of the catheter, and that also cause the inner wall of the sleeve to taper against the distal end of the catheter tube, avoiding or minimizing discontinuities in the lumen of the catheter.
摘要翻译：本发明涉及一种导管，其具有可以以比现有技术中的导管低的成本制造的软远侧末端。在一个实施例中，通过将软套管连接到导管管的远端来产生导管。套管可在温度和压力条件下固定到导管上，导致套筒的近端相对于导管的外表面逐渐变细，避免或最小化导管插入轮廓中的不连续性，并且还使得内套管的壁与导管管的远端成锥形，避免或最小化导管内腔的不连续性。

28. 发明申请

US20060078493A1 Methods and apparatus for localized administration of inhibitory moieties to a patient 审中-公开
标题翻译：局部给予患者抑制性部位的方法和装置
公开(公告)号：US20060078493A1
公开(公告)日：2006-04-13
申请号：US10015274
申请日：2001-12-11
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61K51/00
CPC分类号： A61F2/82 , A61F2210/0095 , A61K47/6957 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/44 , A61N5/1002
摘要： Methods and devices are provided for the localized administration to a patient of moieties effective for inhibiting unwanted cellular growth, including restenosis of an artery treated with a stent implant for blockage of blood flow by an atherosclerotic lesion. After implantation of a medical device capable of moiety-binding, moieties effective at inhibiting unwanted cellular growth are administered locally to a patient. In this manner the deleterious side-effects of systemic administration of moieties are avoided. Upon localized administration, the moieties bind the medical device, rendering the medical device itself capable of inhibiting unwanted cellular growth. According to an embodiment, after implantation of a stent, radioactive moieties specific for receptors immobilized on the stent surface are locally administered using a balloon perfusion catheter. The moieties bind specifically the receptors, becoming immobilized thereto, thereby rendering the stent radioactive and effective for inhibiting restenosis.
摘要翻译：提供了方法和装置，用于局部给予患者有效抑制不想要的细胞生长的部分，包括用支架植入物治疗的动脉再狭窄，以通过动脉粥样硬化病变阻塞血流。在植入能够进行部分结合的医疗器械后，有效地抑制不想要的细胞生长的部位在局部给予患者。以这种方式，避免了全身给药部分的有害副作用。局部给药后，该部分结合医疗装置，使医疗装置本身能够抑制不需要的细胞生长。根据一个实施方案，在植入支架后，使用球囊灌注导管局部施用对固定在支架表面上的受体特异的放射性部分。这些部分特异性地结合受体，变得固定在其上，从而使支架放射性并且有效地抑制再狭窄。

29. 发明授权

US06652573B2 Radial expansible stent for implanting in body vessels 有权
标题翻译：用于植入体内的径向可扩张支架
公开(公告)号：US06652573B2
公开(公告)日：2003-11-25
申请号：US09312083
申请日：1999-05-15
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054
摘要： A radial expansible stent for implanting in a blood vessel in the region of a vessel branch has a hollow cylindrical element, and the hollow cylindrical element at least over a portion is provided with a plurality of radial openings having edges, the edges at least locally being strip-shaped and forming shaped formations.
摘要翻译：用于植入血管分支区域中的血管的径向可膨胀支架具有中空圆柱形元件，并且至少在一部分上方的中空圆柱形元件设置有多个具有边缘的径向开口，所述边缘至少局部地条形和成形形状。

30. 发明申请

US20180133454A1 DELIVERY CATHETER DISTAL CAP 审中-公开
公开(公告)号：US20180133454A1
公开(公告)日：2018-05-17
申请号：US15662014
申请日：2017-07-27
申请人： Randolf von Oepen , Sean A. McNiven , Ken C. Salvador
发明人： Randolf von Oepen , Sean A. McNiven , Ken C. Salvador
IPC分类号： A61M39/20 , A61M39/10 , A61M25/01 , A61F2/24
CPC分类号： A61M25/0147 , A61F2/2427 , A61F2/2436 , A61F2/2466 , A61F2/95 , A61F2002/9505 , A61F2002/9511 , A61M39/10
摘要： An intravascular device delivery system includes a distal end cap to connect an elongated member of the intravascular device delivery system to an intravascular device. The distal end cap includes at least one connection member radially movable relative to the distal end cap that is configured to engage with a complimentary recess in the intravascular device.

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