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21. 发明专利

AU5191390A AGENTS FOR DIAGNOSING AND TREATING MELANOMAS, AROMATIC HALOGENATED DERIVATIVES USABLE AS SUCH AGENTS AND THEIR PREPARATION 未知
公开(公告)号：AU5191390A
公开(公告)日：1990-09-05
申请号：AU5191390
申请日：1990-02-14
申请人： INST NAT SANTE RECH MED
发明人： MOREAU MARIE-FRANCE , MICHELOT JOSETTE , VEYRE ANNIE , MADELMONT JEAN-CLAUDE , GODENECHE DENISE , LABARRE PIERRE , PARRY DANIEL , MEYNIEL GASTON
IPC分类号： A61K31/165 , A61K31/18 , A61K31/63 , A61K49/00 , A61K51/00 , A61K51/04 , A61P35/00 , C07B59/00 , C07C217/10 , C07C217/20 , C07C231/02 , C07C233/40 , C07C233/78 , C07C237/06 , C07C309/69 , C07C309/73 , C07C311/13 , C07C311/18 , C07C317/28 , C07C323/25
摘要： PCT No. PCT/FR90/00107 Sec. 371 Date Aug. 6, 1991 Sec. 102(e) Date Aug. 6, 1991 PCT Filed Feb. 14, 1990 PCT Pub. No. WO90/09170 PCT Pub. Date Aug. 23, 1990. (I) The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z-CONH-, Z-O-, Z-S(O)-n1 group, n1 being equal to 0,1,2 or 3, a Z-SO2-NH- Z-NHCO- group, Z being a bond, a -CH2- or -CH(C6H5)- group, n is an integer between 2 and 4, and R1 and R2 each denote a hydrogen atom, a C1 to C6 alkyl group or a C6 to C12 aryl or aralkyl group, these compounds possibly being labelled by radioisotopes chosen from 123I, 123I, 123I, 75Br, 77Br, 18F, or 11C or by stable isotopes chosen from 13C and 19F, as well as their addition salts with pharmaceutically acceptable acids. The invention also concerns the use of these compounds to manufacture an agent for diagnosing and/or treating malignant melanomas.

22. 发明专利

ES2394274T3 Análogos marcados de halobenzamidas como radiofármacos 未知
公开(公告)号：ES2394274T3
公开(公告)日：2013-01-30
申请号：ES07805258
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , CHAVIGNON OLIVER , TEULADE JEAN-CLAUDE , MOINS NICOLE
IPC分类号： C07D471/04 , A61K31/165 , C07D209/42 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68
摘要： Compuesto de fórmula (I): en la que R1 representa un radionúclido, Ar es un grupo heteroarílico, m es un número entero que varía de 2 a 4, R2 y R3 representan, independientemente entre sí, un átomo de hidrógeno, un grupo alquilo (C1-C6) o un grupo alquenilo (C1-C6), en el que el grupo heteroarilo es un anillo aromático de 5 ó 6 miembros, que comprende 1 ó 2 átomos de nitrógeno, o un núcleo aromático bi- o tricíclico que comprende de 1 a 4 átomos de nitrógeno o que comprende un átomo de azufre, presentando al menos uno de los anillos 6 miembros anulares, presentando el otro anillo o anillos condensados 5 ó 6 miembros anulares, siendo posible que dicho grupo heteroarílico esté monosustituido por: - un átomo de halógeno opcionalmente marcado, - un grupo alcoxi (C1-C4), - un grupo alquilo (C1-C4), - un grupo oxo, o - un grupo anilino, el cual puede estar en sí mismo sustituido por entre 1 y 3 grupos, que se pueden seleccionar de entre un grupo alquilo (C1-C4) o un grupo alcoxi (C1-C4), un grupo hidroxilo, un átomo de halógeno o un grupo NHRe, en el que Re representa un hidrógeno, o un grupo CORa, un grupo COORa o un 20 grupo SO2Ra, en los que Ra representa un grupo arilo o un grupo alquilo (C1-C10) opcionalmente sustituido con un grupo oxo; y en la que R1 está enlazado con el núcleo aromático como tal, o, cuando el sustituyente del núcleo aromático es un grupo anilino, R1 puede estar enlazado con el grupo fenilo del grupo anilino, y en la que Ar se selecciona de entre un grupo piridilo, fenazinilo, naftiridinilo, indolilo, imidazopiridilo, bencimidazolilo, quinolilo, quinolonilo, isoquinolilo, quinoxalinilo, benzotienilo, acridinilo o acridonilo, siendo posible que dicho grupo esté monosustituido por un grupo metilo, un grupo metoxi o un átomo de halógeno opcionalmente marcado, y un grupo acridinilo sustituido por un grupo anilino el cual puede estar en sí mismo sustituido por entre 1 y 3 grupos que se pueden seleccionar de entre un grupo alquilo (C1-C4) o alcoxi (C1-C4), un grupo hidroxilo, un átomo de halógeno o un grupo NHRc, en el que Re representa un hidrógeno, o un grupo CORa, un grupo COORa o un 30 grupo SO2Ra, en los que Ra representa un grupo arilo o un grupo alquilo (C1-C10) opcionalmente sustituido por un grupo oxo, y sus sales de adición con ácidos farmacéuticamente aceptables, para su uso en una composición radiofarmacéutica en el diagnóstico y/o el tratamiento del melanoma.

23. 发明专利

AU2007278041B9 Labelled analogues of halobenzamides as radiopharmaceuticals 未知
公开(公告)号：AU2007278041B9
公开(公告)日：2012-11-22
申请号：AU2007278041
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , MOINS NICOLE , TEULADE JEAN-CLAUDE , CHAVIGNON OLIVIER
IPC分类号： C07D209/42 , A61K31/165 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68 , C07D471/04
摘要： The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

24. 发明专利

AU2007278041B2 Labelled analogues of halobenzamides as radiopharmaceuticals 未知
公开(公告)号：AU2007278041B2
公开(公告)日：2012-08-16
申请号：AU2007278041
申请日：2007-07-27
申请人： INST NAT SANTE RECH MED , UNIV CLERMONT AUVERGNE
发明人： MADELMONT JEAN-CLAUDE , CHEZAL JEAN-MICHEL , MOINS NICOLE , TEULADE JEAN-CLAUDE , CHAVIGNON OLIVIER
IPC分类号： C07D209/42 , A61K31/165 , C07D215/54 , C07D217/26 , C07D219/06 , C07D233/62 , C07D235/24 , C07D237/26 , C07D333/68 , C07D471/04
摘要： The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.

25. 发明专利

BR0116424A 未知
公开(公告)号：BR0116424A
公开(公告)日：2006-02-21
申请号：BR0116424
申请日：2001-12-21
申请人： SERVIER LAB , INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , VIDAL AURELIEN , MOUNETOU EMMANUELLE , RAPP MARYSE , MAURIZIS JEAN-CLAUDE , RENARD PIERRE , CAIGNARD DANIEL-HENRI , BIZOT-ESPIARD JEAN-GUY
IPC分类号： A61K31/5415 , A61P19/02 , A61P19/08 , A61P29/00 , A61P43/00 , C07D279/02 , C07D417/12 , A61K31/54
摘要： wherein: represents a single or double bond, R1 represents a hydrogen atom or a hydroxy, alkoxy, acyloxy, alkylsulphonyloxy, arylsulphonyloxy or arylalkoxy group, R2 represents a hydrogen atom or an alkyl group, R3 and R4, which may be identical or different, each represent a hydrogen atom, a halogen atom or an alkyl, hydroxy or alkoxy group, Ak represents an alkylene chain, R5, R6 and R7, which may be identical or different, each represent an alkyl group, or R5, R6 and R7, taken together with the nitrogen atom carrying them, form a saturated or unsaturated nitrogen-containing heterocycle, X represents a halogen atom, and its optical isomers when they exist. Medicaments.

26. 发明专利

ES2231222T3 DERIVADOS DE AMONIO CUATERNARIO, SU PROCEDIMIENTO DE PRODUCCION Y SU USO EN FARMACIA. 未知
公开(公告)号：ES2231222T3
公开(公告)日：2005-05-16
申请号：ES00945979
申请日：2000-06-22
申请人： INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07H15/26
摘要： Compuestos de fórmula (Ia) ó (Ib): **(Fórmula)** en la cual: M representa una molécula utilizable para la terapia o el diagnóstico de las patologías debidas a una afección del cartílago, R1, R2, R3, idénticos o diferentes, representan un grupo alquilo (C1-C6) lineal o ramificado, o R1, R2, R3 tomados conjuntamente con el átomo de nitrógeno que los contiene forman un heterociclo nitrogenado saturado o insaturado, X representa una cadena alquileno (C1-C6) lineal o ramificado, en la que uno o varios grupos -CH2- son reemplazados eventualmente por un átomo de azufre, de oxígeno, un grupo -NR- (en el que R representa un grupo alquilo (C1-C6) lineal o ramificado) un grupo -CO-, un grupo -CO-NH-, un grupo -CO2-, un grupo -SO- o un grupo -SO2-, Hal representa un átomo de halógeno, o **(Fórmula)** R4 representa un grupo alquilo (C1-C6) lineal o ramificado, Hal representa un átomo de halógeno **(Fórmula)** representa una molécula utilizable para la terapia o el diagnóstico de las patologías debidas auna afección del cartílago, quedando entendido que el átomo de nitrógeno puede estar incluido eventualmente en un sistema heterocíclico nitrogenado saturado o insaturado, o encajado en un doble enlace.

27. 发明专利

PL353032A1 NOVEL QUATERNARY AMMONIUM DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL USE 未知
公开(公告)号：PL353032A1
公开(公告)日：2003-10-06
申请号：PL35303200
申请日：2000-06-22
申请人： SERVIER LAB , INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07H15/26
摘要： A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R 1 , R 2 and R 3 represent alkyl, or R 1 , R 2 and R 3 together with the nitrogen atom carrying them, form a heterocycle, X represents a (C 1 -C 6 )alkylene chain in which one or more -CH 2 - groups are optionally replaced by sulphur, oxygen, or -NR-, -CO-, -CO-NH-, -CO 2 -, -SO- or -SO 2 -, n represents 0 or 1, Hal represents halogen, or, R 4 represents alkyl, Hal represents halogen, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond.

28. 发明专利

ZA200109850B Quaternay ammonium derivatives, method for preparing same and pharmaceutical use. 未知
公开(公告)号：ZA200109850B
公开(公告)日：2003-02-26
申请号：ZA200109850
申请日：2001-11-29
申请人： SERVIER LAB , INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07D , C07C , C07H , C07F , A61K , A61P
摘要： A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R 1 , R 2 and R 3 represent alkyl, or R 1 , R 2 and R 3 together with the nitrogen atom carrying them, form a heterocycle, X represents a (C 1 -C 6 )alkylene chain in which one or more -CH 2 - groups are optionally replaced by sulphur, oxygen, or -NR-, -CO-, -CO-NH-, -CO 2 -, -SO- or -SO 2 -, n represents 0 or 1, Hal represents halogen, or, R 4 represents alkyl, Hal represents halogen, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond.

29. 发明专利

NO20016267A 未知
公开(公告)号：NO20016267A
公开(公告)日：2002-01-30
申请号：NO20016267
申请日：2001-12-20
申请人： INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07H15/26
CPC分类号： C07D409/06 , C07C237/20 , C07D259/00 , C07D279/02 , C07D417/12 , C07F13/005 , C07H5/06 , Y10S436/811

30. 发明专利

NO20016267D0 未知
公开(公告)号：NO20016267D0
公开(公告)日：2001-12-20
申请号：NO20016267
申请日：2001-12-20
申请人： INST NAT SANTE RECH MED
发明人： MADELMONT JEAN-CLAUDE , GIRAUD ISABELLE , NICOLAS COLETTE , MAURIZIS JEAN-CLAUDE , RAPP MARYSE , OLLIER MONIQUE , RENARD PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： A61K31/165 , A61K31/4045 , A61K31/5415 , A61K31/555 , A61K31/7008 , A61K49/00 , A61K51/00 , A61P19/00 , C07C231/12 , C07C237/20 , C07D259/00 , C07D279/02 , C07D409/06 , C07D417/12 , C07F13/00 , C07H5/06 , C07H15/12 , C07D
摘要： A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, R 1 , R 2 and R 3 represent alkyl, or R 1 , R 2 and R 3 together with the nitrogen atom carrying them, form a heterocycle, X represents a (C 1 -C 6 )alkylene chain in which one or more -CH 2 - groups are optionally replaced by sulphur, oxygen, or -NR-, -CO-, -CO-NH-, -CO 2 -, -SO- or -SO 2 -, n represents 0 or 1, Hal represents halogen, or, R 4 represents alkyl, Hal represents halogen, represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, wherein the nitrogen atom may optionally be included in a saturated or unsaturated nitrogen-containing heterocyclic system, or included in a double bond.

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