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21. 发明专利

SG11201911580QA FLUID CACHING 未知
公开(公告)号：SG11201911580QA
公开(公告)日：2020-01-30
申请号：SG11201911580Q
申请日：2019-01-10
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： COX-MURANAMI WESLEY , SEGALE DARREN , MILLER OLIVER , FOLEY JENNIFER , KHURANA TARUN KUMAR , CRIVELLI PAUL , WATTS GARY
IPC分类号： G01N35/08 , G01N35/02 , G01N37/00
摘要： An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.

22. 发明专利

CA3067426A1 FLOW CELL WITH INTEGRATED MANIFOLD 未知
公开(公告)号：CA3067426A1
公开(公告)日：2019-11-07
申请号：CA3067426
申请日：2019-04-30
申请人： ILLUMINA INC
发明人： LIN SZ-CHIN , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , KHURANA TARUN , CRIVELLI PAUL
IPC分类号： G01N35/08 , G01N37/00
摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

23. 发明专利

SG11201908310XA CARTRIDGE WITH LAMINATED MANIFOLD 未知
公开(公告)号：SG11201908310XA
公开(公告)日：2019-10-30
申请号：SG11201908310X
申请日：2019-01-31
申请人： ILLUMINA INC
发明人： SEGALE DARREN , TRAN HAI , CRIVELLI PAUL
IPC分类号： B01L3/00
摘要： 109 110 108 FIG. 1 N N kin O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 August 2019 (08.08.2019) WIPO I PCT 1111111111111101111111111111111011111010111111111111101111111111111111111111011110111111 (10) International Publication Number WO 2019/152677 Al (51) International Patent Classification: BOIL 3/00 (2006.01) (21) International Application Number: PCT/US2019/016097 (22) International Filing Date: 31 January 2019 (31.01.2019) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/626,022 03 February 2018 (03.02.2018) US 2020616 19 March 2018(19.03.2018) NL (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, CA 92122 (US). (72) Inventors: SEGALE, Darren; c/o Illumina Inc., 5200 Il- lumina Way, San Diego, CA 92122 (US). TRAN, Hai; c/ o Illumina Inc., 5200 Illumina Way, San Diego, CA 92122 (US). CRIVELLI, Paul; c/o Illumina Inc., 5200 Illumina Way, San Diego, CA 92122 (US). (74) Agent: MIKRUT, Jeffrey, J. et al.; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: CARTRIDGE WITH LAMINATED MANIFOLD (57) : A circuit with electrical interconnect for external electronic connection and sensor (s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor (s). The laminated manifold includes fluidic channel (s), an interface between the die and the fluidic channel (s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel (s), attaching sensor (s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel (s). [Continued on next page] W() 2019/152677 Al I 11111 0111E0 11101 111 11111M0101110111110HREHHIMEMMOHE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art. 21(3))

24. 发明专利

AU2021218096A1 Fluid Caching 未知
公开(公告)号：AU2021218096A1
公开(公告)日：2021-09-09
申请号：AU2021218096
申请日：2021-08-18
申请人： ILLUMINA CAMBRIDGE LTD , ILLUMINA INC
发明人： COX-MURANAMI WESLEY , SEGALE DARREN ROBERT , MILLER OLIVER JON , FOLEY JENNIFER OLIVIA , KHURANA TARUN KUMAR , CRIVELLI PAUL , WATTS GARY
IPC分类号： G01N35/08 , G01N35/02 , G01N37/00
摘要： An apparatus is disclosed, comprising: two or more fluid prime channels connected to a fluid inlet of a fluidic device; a flow control valve operatively associated with each fluid prime channel to control flow between the associated fluid prime channel and the fluid inlet; one or more outlet channels connected to a fluid outlet of the fluidic device; and a flow control valve operatively associated with each outlet channel to control flow between the fluid outlet and the associated outlet channel; a plate that is rotatable about an axis of rotation that is orthogonal to a surface of the plate, wherein the fluidic device is coupled to the plate; a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port formed through the plate; and a lid placed over the plurality of fluid compartments, wherein the lid includes valve actuators for opening and closing valves for controlling fluid flow from the fluid exit ports.

25. 发明专利

AU2019270818B2 Flow cell with flexible connection 未知
公开(公告)号：AU2019270818B2
公开(公告)日：2021-07-08
申请号：AU2019270818
申请日：2019-05-01
申请人： ILLUMINA INC
发明人： CRIVELLI PAUL , FOLEY JENNIFER , SEGALE DARREN , TAYLOR JAY , HAGE MATTHEW , DELATTRE CYRIL , RHEE MINSOUNG , LIU JEFFREY , COX-MURANAMI WESLEY , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： G01N35/02 , B81B3/00
摘要： An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

26. 发明专利

AU2019261940B2 Flow cell with integrated manifold 未知
公开(公告)号：AU2019261940B2
公开(公告)日：2021-07-08
申请号：AU2019261940
申请日：2019-04-30
申请人： ILLUMINA INC
发明人： LIN SZ-CHIN , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , KHURANA TARUN , CRIVELLI PAUL
IPC分类号： G01N35/08 , G01N37/00
摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

27. 发明专利

SG11202012551PA MULTI-VALVE FLUID CARTRIDGE 未知
公开(公告)号：SG11202012551PA
公开(公告)日：2021-01-28
申请号：SG11202012551P
申请日：2019-10-02
申请人： ILLUMINA INC
发明人： COX-MURANAMI WESLEY , OSMUS JAMES , CRIVELLI PAUL , DREWS BRADLEY KENT
IPC分类号： B01L3/00
摘要： An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.

28. 发明专利

PE20200275A1 CARTUCHO CON COLECTOR ESTRATIFICADO 未知
公开(公告)号：PE20200275A1
公开(公告)日：2020-02-04
申请号：PE2019001974
申请日：2019-01-31
申请人： ILLUMINA INC
发明人： SEGALE DARREN , TRAN HAI , CRIVELLI PAUL
IPC分类号： B01L3/00
摘要： Un circuito con una interconexion electrica para una conexion electronica externa y un sensor o sensores sobre un dado se combinan con un colector estratificado para entregar un reactivo liquido por encima de una superficie activa del sensor o sensores. El colector estratificado incluye un canal o canales fluidicos, estando sellada una superficie de contacto entre el dado y el canal o canales fluidicos. Tambien se divulga un metodo, incluyendo el metodo ensamblar un colector estratificado que incluye un canal o canales fluidicos, afianzar un sensor o sensores sobre un dado a un circuito, incluyendo el circuito una interconexion electrica, y afianzar una capa de planarizacion al circuito, incluyendo la capa de planarizacion un recorte para el dado. El metodo incluye adicionalmente colocar adhesivo de sellado en lados del dado, afianzar el colector estratificado al circuito, y sellar una superficie de contacto entre el dado y el canal o canales fluidicos.

29. 发明专利

AU2021218096B2 Fluid Caching 未知
公开(公告)号：AU2021218096B2
公开(公告)日：2022-10-20
申请号：AU2021218096
申请日：2021-08-18
申请人： ILLUMINA CAMBRIDGE LTD , ILLUMINA INC
发明人： COX-MURANAMI WESLEY , SEGALE DARREN ROBERT , MILLER OLIVER JON , FOLEY JENNIFER OLIVIA , KHURANA TARUN KUMAR , CRIVELLI PAUL , WATTS GARY
IPC分类号： G01N35/08 , G01N35/02 , G01N37/00
摘要： An apparatus is disclosed, comprising: two or more fluid prime channels connected to a fluid inlet of a fluidic device; a flow control valve operatively associated with each fluid prime channel to control flow between the associated fluid prime channel and the fluid inlet; one or more outlet channels connected to a fluid outlet of the fluidic device; and a flow control valve operatively associated with each outlet channel to control flow between the fluid outlet and the associated outlet channel; a plate that is rotatable about an axis of rotation that is orthogonal to a surface of the plate, wherein the fluidic device is coupled to the plate; a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port formed through the plate; and a lid placed over the plurality of fluid compartments, wherein the lid includes valve actuators for opening and closing valves for controlling fluid flow from the fluid exit ports.

30. 发明专利

BR112019020524B1 Cartucho com coletor laminado 未知
公开(公告)号：BR112019020524B1
公开(公告)日：2022-04-19
申请号：BR112019020524
申请日：2019-01-31
申请人： ILLUMINA INC
发明人： SEGALE DARREN , TRAN HAI , CRIVELLI PAUL
IPC分类号： B01L3/00
摘要： um circuito com interconexão elétrica para a conexão eletrônica externa e sensores em uma matriz são combinados com um coletor laminado para distribuir um reagente líquido sobre uma superfície ativa dos sensores. o coletor laminado inclui canais fluídicos, uma interface entre a matriz e os canais fluídicos sendo vedada. também é divulgado um método, o método incluindo montar um coletor laminado incluindo canais fluídicos, anexar sensores em uma matriz com um circuito, o circuito incluindo uma interconexão elétrica, e anexar uma camada de planarização com o circuito, a camada de planarização incluindo um recorte para a matriz. o método inclui ainda posicionar adesivo de vedação nas laterais da matriz, anexar o coletor laminado com o circuito e vedar uma interface entre a matriz e canais fluídicos.

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