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21. 发明专利

DK118553B 未知
公开(公告)号：DK118553B
公开(公告)日：1970-09-07
申请号：DK352665
申请日：1965-07-09
申请人： HOECHST AG
发明人： SCHMIDT F
IPC分类号： A61K31/17 , A61K31/64 , A61P3/08 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02 , C07C127/22 , C07C143/82 , C07D27/50

22. 发明专利

SE323662B 未知
公开(公告)号：SE323662B
公开(公告)日：1970-05-11
申请号：SE1495565
申请日：1965-11-19
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , SCHMIDT F , WEYER R , MUTH K
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D327/06 , C07D335/02 , C07C143/833

23. 发明专利

ZA7305332B BENZENESULFONYL-UREAS AND PROCESSES FOR PREPARING THEM 未知
公开(公告)号：ZA7305332B
公开(公告)日：1974-07-31
申请号：ZA7305332
申请日：1973-08-06
申请人： HOECHST AG
发明人： WEYER R , AUMUELLER W , HITZEL V , SCHMIDT F
IPC分类号： C07D239/26 , C07C311/58 , C07C311/59 , C07C311/60 , C07D213/75 , C07D215/38 , C07D239/42 , C07D263/58 , C07D277/82 , C07D
CPC分类号： C07D213/75 , C07D215/38 , C07D239/42 , C07D263/58 , C07D277/82 , Y10S514/866

24. 发明专利

SE358637B 未知
公开(公告)号：SE358637B
公开(公告)日：1973-08-06
申请号：SE395271
申请日：1971-05-18
申请人： HOECHST AG
发明人： MUTH K , AUMUELLER W , WEYER R , WEBER H , SCHMIDT F
IPC分类号： A61K31/17 , A61K31/64 , A61P3/08 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02 , C07C143/84

25. 发明专利

DK123865B 未知
公开(公告)号：DK123865B
公开(公告)日：1972-08-14
申请号：DK627167
申请日：1967-12-14
申请人： HOECHST AG
发明人： SCHMIDT F
IPC分类号： C07C311/59 , A61K31/64 , C07C311/58 , C07C143/78

26. 发明专利

SE345661B 未知
公开(公告)号：SE345661B
公开(公告)日：1972-06-05
申请号：SE483865
申请日：1965-04-13
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , SCHMIDT F , WEYER R , MUTH K
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02 , C07C143/82
摘要： The invention comprises compounds of formula wherein R is H or (optionally Ph substituted) C1- 4 alkyl; R1 is (a) C2- 8 alkyl, alkenyl or mercaptoalkyl, (b) C4- 8 alkoxyalkyl*, alkylmercaptoalkyl* or alkylsulphonylalkyl* (alkyl* at least C2), (c) phenyl-C1- 4 alkyl or -cyclopropyl, (d) cyclohexyl-C1- 4 alkyl, cycloheptyl-methyl or -ethyl, or cyclooctylmethyl, (e) C1- 2 endoalkylene-cyclohexyl, -cyclohexenyl, -cyclohexylmethyl or -cyclohexenylmethyl, (f) C1- 4-alkyl- or -alkoxy-cyclohexyl, (g) C5- 8 cycloalkyl, (h) cyclohexenyl or cyclohexenylmethyl, (i) a C4- 5+O or S heterocyclic nucleus which may be bound to the adjacent N by a methylene group; X is (i) C4- 11 alkyl, alkenyl, alkoxyalkyl, alkylmercaptoalkyl, cycloalkoxyalkyl, cycloalkylmercaptoalkyl, cycloalkylalkoxyalkyl or cycloalkylalkylmercaptoalkyl, (ii) (C4- 8 ring) cycloalkyl, cycloalkenyl, cycloalkyl-C1- 4 alkyl, cycloalkenyl-C1- 4 alkyl, C1- 4 alkyl-cycloalkyl or C1- 4 alkyl-cycloalkenyl, (iii) C1- 2 endoalkylene-cyclohexyl or -cyclohexenyl, (iv) alkyl, cycloalkyl or cycloalkylalkyl mono- or disubstituted by Cl, Br or CN; Y is a C1- 4 hydrocarbon radical. A large number of such compounds (with m.p.s.) are listed in the Specification. The compounds are prepared by (a) synthesizing the sulphonylurea group from compounds or oxidizing corresponding sulphonylthioureas sulphinylureas or sulphonylureas, (b) acylating corresponding aminoalkylphenylenesulphonylureas or (c) hydrogenating the corresponding compounds in which X is unsaturated. The above compounds are stated to possess blood sugar lowering properties and may be applied, as such or as salts, in the form of tablets containing the usual adjuncts such as talc, starch, lactose, tragacanth and Mg stearate.

27. 发明专利

SE344061B 未知
公开(公告)号：SE344061B
公开(公告)日：1972-03-27
申请号：SE1738867
申请日：1967-12-19
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , WEYER R , MUTH K , SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07C143/833

28. 发明专利

NO123569B 未知
公开(公告)号：NO123569B
公开(公告)日：1971-12-13
申请号：NO16406766
申请日：1966-07-26
申请人： HOECHST AG
发明人： WEBER H , AUMUELLER W , WEYER R , MUTH K , SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/58 , C07C311/59 , C07D309/14

29. 发明专利

SE339222B 未知
公开(公告)号：SE339222B
公开(公告)日：1971-10-04
申请号：SE3968
申请日：1968-01-03
申请人： HOECHST AG
发明人： MUTH K , AUMUELLER W , WEBER H , WEYER R , SCHMIDT F
IPC分类号： C07C311/59 , A61K31/64 , C07C311/58 , C07C143/833

30. 发明专利

DK121116B 未知
公开(公告)号：DK121116B
公开(公告)日：1971-09-13
申请号：DK343966
申请日：1966-07-01
申请人： HOECHST AG
发明人： SCHMIDT F
IPC分类号： A61K31/64 , C07C67/00 , C07C301/00 , C07C303/36 , C07C303/40 , C07C311/54 , C07C311/58 , C07D335/02 , C07C143/78
摘要： The invention comprises compounds of formula wherein R is H or (optionally Ph substituted) C1- 4 alkyl; R1 is (a) C2- 8 alkyl, alkenyl or mercaptoalkyl, (b) C4- 8 alkoxyalkyl*, alkylmercaptoalkyl* or alkylsulphonylalkyl* (alkyl* at least C2), (c) phenyl-C1- 4 alkyl or -cyclopropyl, (d) cyclohexyl-C1- 4 alkyl, cycloheptyl-methyl or -ethyl, or cyclooctylmethyl, (e) C1- 2 endoalkylene-cyclohexyl, -cyclohexenyl, -cyclohexylmethyl or -cyclohexenylmethyl, (f) C1- 4-alkyl- or -alkoxy-cyclohexyl, (g) C5- 8 cycloalkyl, (h) cyclohexenyl or cyclohexenylmethyl, (i) a C4- 5+O or S heterocyclic nucleus which may be bound to the adjacent N by a methylene group; X is (i) C4- 11 alkyl, alkenyl, alkoxyalkyl, alkylmercaptoalkyl, cycloalkoxyalkyl, cycloalkylmercaptoalkyl, cycloalkylalkoxyalkyl or cycloalkylalkylmercaptoalkyl, (ii) (C4- 8 ring) cycloalkyl, cycloalkenyl, cycloalkyl-C1- 4 alkyl, cycloalkenyl-C1- 4 alkyl, C1- 4 alkyl-cycloalkyl or C1- 4 alkyl-cycloalkenyl, (iii) C1- 2 endoalkylene-cyclohexyl or -cyclohexenyl, (iv) alkyl, cycloalkyl or cycloalkylalkyl mono- or disubstituted by Cl, Br or CN; Y is a C1- 4 hydrocarbon radical. A large number of such compounds (with m.p.s.) are listed in the Specification. The compounds are prepared by (a) synthesizing the sulphonylurea group from compounds or oxidizing corresponding sulphonylthioureas sulphinylureas or sulphonylureas, (b) acylating corresponding aminoalkylphenylenesulphonylureas or (c) hydrogenating the corresponding compounds in which X is unsaturated. The above compounds are stated to possess blood sugar lowering properties and may be applied, as such or as salts, in the form of tablets containing the usual adjuncts such as talc, starch, lactose, tragacanth and Mg stearate.

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