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21. 发明申请

US20100309457A1 Wavefront Imaging Sensor 有权
标题翻译：波前成像传感器
公开(公告)号：US20100309457A1
公开(公告)日：2010-12-09
申请号：US12792177
申请日：2010-06-02
申请人： Xiquan Cui , Changhuei Yang
发明人： Xiquan Cui , Changhuei Yang
IPC分类号： G01J1/02
CPC分类号： G01J9/0215 , G02B21/0004 , G02B21/0092
摘要： Embodiments of the present invention relate to a wavefront imaging sensor (WIS) comprising an aperture layer having an aperture, a light detector having a surface and a transparent layer between the aperture layer and the light detector. The light detector can receive a light projection at the surface from light passing through the aperture. The light detector can also separately measure amplitude and phase information of a wavefront at the aperture based on the received light projection. The transparent layer has a thickness designed to locate the surface of the light detector approximately at a self-focusing plane in a high Fresnel number regime to narrow the light projection.
摘要翻译：本发明的实施例涉及一种波面成像传感器（WIS），其包括具有孔径的孔径层，具有表面的光检测器和在孔径层和光检测器之间的透明层。光检测器可以从穿过孔的光接收表面的光投影。光检测器还可以基于接收的光投射单独地测量孔径处的波前的幅度和相位信息。透明层具有设计成将光检测器的表面大致定位在高菲涅尔数状态的自聚焦平面上以使光投影变窄的厚度。

22. 发明申请

US20090225411A1 SCANNING ILLUMINATION MICROSCOPE 有权
标题翻译：扫描照明显微镜
公开(公告)号：US20090225411A1
公开(公告)日：2009-09-10
申请号：US12399823
申请日：2009-03-06
申请人： Xiquan Cui , Changhuei Yang
发明人： Xiquan Cui , Changhuei Yang
IPC分类号： G02B21/06
CPC分类号： G02B21/0024 , G02B21/0032 , G02B21/06
摘要： A microscopy method and configuration provides the ability to achieve wide field view and high resolution simultaneously. A beam array generator generates an M×N light beam array that illuminates a sample and an M×N sensor array. The sensor array obtains a whole microscopy image of the sample based on the light beam array. Each light beam of the array corresponds to one unique pixel sensor in the sensor array. A scanning of all light beams of the light beam array covers a whole area of the sample.
摘要翻译：显微镜方法和配置提供了同时实现宽视野和高分辨率的能力。光束阵列发生器产生照射样本的MxN光束阵列和MxN传感器阵列。传感器阵列基于光束阵列获得样品的整个显微镜图像。阵列的每个光束对应于传感器阵列中的一个独特的像素传感器。扫描光束阵列的所有光束覆盖样品的整个区域。

23. 发明授权

US09046680B2 Scanning illumination microscope 有权
标题翻译：扫描照明显微镜
公开(公告)号：US09046680B2
公开(公告)日：2015-06-02
申请号：US12399823
申请日：2009-03-06
申请人： Xiquan Cui , Changhuei Yang
发明人： Xiquan Cui , Changhuei Yang
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/0024 , G02B21/0032 , G02B21/06
摘要： A microscopy method and configuration provides the ability to achieve wide field view and high resolution simultaneously. A beam array generator generates an M×N light beam array that illuminates a sample and an M×N sensor array. The sensor array obtains a whole microscopy image of the sample based on the light beam array. Each light beam of the array corresponds to one unique pixel sensor in the sensor array. A scanning of all light beams of the light beam array covers a whole area of the sample.
摘要翻译：显微镜方法和配置提供了同时实现宽视野和高分辨率的能力。光束阵列发生器产生照射样本的M×N光束阵列和M×N传感器阵列。传感器阵列基于光束阵列获得样品的整个显微镜图像。阵列的每个光束对应于传感器阵列中的一个独特的像素传感器。扫描光束阵列的所有光束覆盖样品的整个区域。

24. 发明申请

US20120061554A1 QUANTITATIVE DIFFERENTIAL INTERFERENCE CONTRAST (DIC) MICROSCOPY AND PHOTOGRAPHY BASED ON WAVEFRONT SENSORS 有权
标题翻译：基于波形传感器的定量差分干涉对比（DIC）显微镜和摄影
公开(公告)号：US20120061554A1
公开(公告)日：2012-03-15
申请号：US13229741
申请日：2011-09-11
申请人： Xiquan Cui , Changhuei Yang , Guillermo J. Tearney
发明人： Xiquan Cui , Changhuei Yang , Guillermo J. Tearney
IPC分类号： H01L27/146 , G01J1/42 , H01L31/0232
CPC分类号： G02B21/0092 , G01J9/02 , G02B21/14 , H01L27/14643
摘要： Embodiments of the present invention relate to a wavefront sensor comprising a film and a photodetector. The film has one or more structured two dimensional apertures configured to convert a phase gradient of a wavefront into a measurable form. The photodetector is configured to receive the wavefront through the one or more 2D apertures and measure the phase gradient of the wavefront.
摘要翻译：本发明的实施例涉及一种包括膜和光电检测器的波前传感器。胶片具有一个或多个结构化的二维孔径，其被配置为将波前的相位梯度转换成可测量的形式。光电检测器被配置为通过一个或多个2D孔接收波前，并测量波前的相位梯度。

25. 发明申请

US20090225319A1 METHODS OF USING OPTOFLUIDIC MICROSCOPE DEVICES 审中-公开
标题翻译：使用光学显微镜装置的方法
公开(公告)号：US20090225319A1
公开(公告)日：2009-09-10
申请号：US12398098
申请日：2009-03-04
申请人： Lap Man Lee , Xiquan Cui , Changhuei Yang
发明人： Lap Man Lee , Xiquan Cui , Changhuei Yang
IPC分类号： G01N21/00
CPC分类号： G01N21/6458 , G01N15/1475 , G01N2015/008 , G01N2015/1497 , G01N2021/6439
摘要： An embodiment of a method comprises providing a fluid sample having objects to an optofluidic microscope device comprising a fluid channel and a light detector, and receiving time varying light data from the fluid sample. The embodiment of the method also comprises determining one or more characteristics of the objects based on the time varying light data, and determining one or more phenotypes associated with the objects based on the determined characteristics.
摘要翻译：一种方法的实施方案包括向具有流体通道和光检测器的光流体显微镜装置提供具有物体的流体样品，并从流体样品接收时变光数据。该方法的实施例还包括基于时变光数据确定对象的一个或多个特征，以及基于所确定的特征来确定与对象相关联的一个或多个表型。

26. 发明申请

US20120211644A1 LIGHT-FIELD PIXEL 有权
标题翻译：光场像素
公开(公告)号：US20120211644A1
公开(公告)日：2012-08-23
申请号：US13344523
申请日：2012-01-05
申请人： Guoan Zheng , Changhuei Yang
发明人： Guoan Zheng , Changhuei Yang
IPC分类号： G01J1/44
CPC分类号： G01J9/00
摘要： A light-field pixel for detecting a wavefront, the light-field pixel comprises an aperture layer, a light detector layer, and a processor. The aperture layer has a non-conventional aperture and a non-conventional aperture. The non-conventional aperture has a higher gradient of transmission at normal incidence than the conventional aperture. The light detector is configured to measure a first intensity of light through the non-conventional aperture and a second intensity of light through the conventional aperture. The processor is configured to detect the wavefront based on the first intensity normalized by the second intensity.
摘要翻译：用于检测波前的光场像素，所述光场像素包括孔径层，光检测器层和处理器。孔径层具有非常规孔径和非常规孔径。非常规孔径在常规孔径处具有较高的垂直入射梯度。光检测器被配置为测量通过非常规孔径的第一光强度和通过常规光圈的第二光强度。处理器被配置为基于由第二强度归一化的第一强度来检测波前。

27. 发明授权

US09743020B2 Super resolution optofluidic microscopes for 2D and 3D imaging 有权
公开(公告)号：US09743020B2
公开(公告)日：2017-08-22
申请号：US13069651
申请日：2011-03-23
申请人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
发明人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
IPC分类号： G01N15/14 , G02B21/36 , H04N5/349 , G06T3/40
CPC分类号： H04N5/349 , G01N15/147 , G01N15/1484 , G02B21/0008 , G02B21/36 , G06T3/4053
摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.

28. 发明授权

US09426429B2 Scanning projective lensless microscope system 有权
标题翻译：扫描投影镜头无显微镜系统
公开(公告)号：US09426429B2
公开(公告)日：2016-08-23
申请号：US13281287
申请日：2011-10-25
申请人： Guoan Zheng , Samuel Yang , Seung Ah Lee , Changhuei Yang
发明人： Guoan Zheng , Samuel Yang , Seung Ah Lee , Changhuei Yang
IPC分类号： H04N7/18 , G02B21/06 , G02B21/36
CPC分类号： H04N7/183 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H2001/0447
摘要： A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.
摘要翻译：一种扫描投影镜头无显微镜装置，包括一个样品表面，一个带有光元件的扫描照明源，在样品表面外部的光检测器和一个处理器。扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。

29. 发明授权

US09343494B2 Light guided pixel configured for emissions detection and comprising a guide layer with a wavelength selective filter material and a light detector layer 有权
标题翻译：配置用于发射检测的光引导像素，并且包括具有波长选择滤光器材料和光检测器层的引导层
公开(公告)号：US09343494B2
公开(公告)日：2016-05-17
申请号：US13411103
申请日：2012-03-02
申请人： Seung Ah Lee , Guoan Zheng , Benjamin Judkewitz , Shuo Pang , Jigang Wu , Changhuei Yang
发明人： Seung Ah Lee , Guoan Zheng , Benjamin Judkewitz , Shuo Pang , Jigang Wu , Changhuei Yang
IPC分类号： H01L27/146
CPC分类号： H01L27/14629 , H01L27/14621
摘要： A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.
摘要翻译：具有引导层和光检测器层的光引导像素。引导层具有光导。光检测器层具有接收光导通路的光检测元件。光导可以包括用于将发射引导到光检测元件的滤光器。

30. 发明申请

US20110234757A1 SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING 有权
标题翻译：超分辨率光学显微镜2D和3D成像
公开(公告)号：US20110234757A1
公开(公告)日：2011-09-29
申请号：US13069651
申请日：2011-03-23
申请人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
发明人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
IPC分类号： H04N13/02 , H04N7/18
CPC分类号： H04N5/349 , G01N15/147 , G01N15/1484 , G02B21/0008 , G02B21/36 , G06T3/4053
摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.
摘要翻译：超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。表面层具有二维光检测器阵列，其构造成当物体移动通过流体通道时，接收通过流体通道的光并采样一系列子像素偏移的投影框。超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。处理器被配置为使用超分辨率算法，并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

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