专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US4605673A 7H-dibenzo(a,c,)cyclohepten-5-one-(7) derivatives 失效
标题翻译： 7,7-二苯并（a，c）环庚烯-5-酮（7）衍生物
公开(公告)号：US4605673A
公开(公告)日：1986-08-12
申请号：US562690
申请日：1983-12-19
申请人： Gerhard Satzinger , Edgar Fritschi , Manfred Herrmann
发明人： Gerhard Satzinger , Edgar Fritschi , Manfred Herrmann
IPC分类号： A61K31/135 , A61K31/445 , A61P25/24 , A61P25/26 , C07C51/363 , C07C51/373 , C07C51/56 , C07C55/07 , C07C63/72 , C07C65/34 , C07C67/00 , C07C213/00 , C07C217/12 , C07C225/18 , C07D295/088 , C07D295/116 , C07F9/54
CPC分类号： C07D295/088 , C07C51/363 , C07C51/373 , C07C51/56 , C07C55/07 , C07C63/72 , C07C65/34 , C07D295/116 , C07F9/5407
摘要： The invention is concerned with 7H-dibenzo(a,c)-cyclohepten-5-one-(7) derivatives of general formula I ##STR1## wherein R.sup.1 and R.sup.2 can be the same or different, a hydrogen atom, an alkyl radical containing 1 to 3 carbon atoms, or, together with the nitrogen atom to which they are attached form a heterocyclic ring containing 3 to 6 carbon atoms,n is 2 or 3R.sup.3 is a hydrogen atom or a halogen atom andX is either a methylene radical or an oxygen atomand the pharmacologically acceptable salts thereof with inorganic and organic acids.The invention is furthermore concerned with analogous processes for the preparation thereof and their application for controlling psychic diseases and gastric and/or intestinal ulcers.
摘要翻译：本发明涉及通式Ⅰ的7H-二苯并（a，c） - 环庚烯-5-酮 - （7）衍生物，其中R1和R2可以相同或不同，氢原子，含有1〜3个碳原子的烷基，或与它们所连接的氮原子一起形成含有3〜6个碳原子的杂环，n为2或3，R3为氢原子或卤原子，X为亚甲基或氧原子，以及其与无机酸和有机酸的药理学上可接受的盐。本发明还涉及其制备方法的类似方法及其用于控制心理疾病和胃和/或肠溃疡的应用。

22. 发明授权

US4425350A 5,6,6a,7-Tetrahydro-4H-dibenz(de,g)-isoquinoline derivatives, and their use for treating central nervous system disorders 失效
标题翻译： 5,6,6a，7-四氢-4H-二苯并（de，g） - 异喹啉衍生物及其用于治疗中枢神经系统疾病的用途
公开(公告)号：US4425350A
公开(公告)日：1984-01-10
申请号：US251000
申请日：1981-04-03
申请人： Johannes Hartenstein , Edgar Fritschi
发明人： Johannes Hartenstein , Edgar Fritschi
IPC分类号： A61K31/47 , A61K31/473 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D221/18 , C07D491/06 , C07D217/04 , C07D217/06
CPC分类号： C07D491/06 , C07D221/18
摘要： The present invention provides compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and are hydroxy, straight or branched-chain alkoxy of from 1 to 5 carbon atoms, phenoxy, benzyloxy, two adjacent groups may be methylenedioxy, or hydrogen provided R.sub.4 and R.sub.5 are not simultaneously hydrogen; R.sub.6 is hydrogen, straight or branched-chain alkyl of from 1 to 5 carbon atoms, straight or branched-chain alkenyl of from 2 to 5 carbon atoms, cycloalkylalkyl of from 4 to 7 carbon atoms, alkoxy carbonyl of from 2 to 6 carbon atoms, trifluoroacetyl, aralkyl of from 5 to 11 carbon atoms, or acyl which is derived from an aliphatic, araliphatic or aromatic carboxylic acid of from 1 to 11 carbon atoms; and the pharmaceutically acceptable salts thereof; excluding 5,6,6a,7-tetrahydro-1-hydroxy-2,9,10trimethoxy-5-methyl-4H-dibenz(de,g)-isoquinoline and 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-5-methyl-4H-dibenz(de,g)isoquinoline.The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for treating diseases of the central nervous system.
摘要翻译：本发明提供以下通式的化合物：其中R 1，R 2，R 3，R 4和R 5可以相同或不同，为1至5个碳原子的羟基，直链或支链烷氧基，苯氧基，苄氧基，两个相邻的基团可以是亚甲二氧基，或者提供的氢，R4和R5不同时为氢; R 6是氢，具有1至5个碳原子的直链或支链烷基，2至5个碳原子的直链或支链烯基，4至7个碳原子的环烷基烷基，2至6个碳原子的烷氧基羰基具有5至11个碳原子的三氟乙酰基，芳烷基或衍生自具有1至11个碳原子的脂族，芳脂族或芳族羧酸的酰基; 及其药学上可接受的盐; 不包括5,6,6a，7-四氢-1-羟基-2,9,10-三甲氧基-5-甲基-4H-二苯并（de，g） - 异喹啉和5,6,6a，7-四氢-1,2， 9,10-四甲氧基-5-甲基-4H-二苯并（de，g）异喹啉。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。此外，本发明涉及这些化合物用于治疗中枢神经系统疾病的用途。

23. 发明授权

US5284872A Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof 失效
标题翻译：硝基链烷酸衍生物，其制备方法，含有衍生物的药物组合物及其药物用途
公开(公告)号：US5284872A
公开(公告)日：1994-02-08
申请号：US681876
申请日：1991-04-05
申请人： Klaus Sandrock , Eike Noack , Edgar Fritschi , Ralf Kanzler , Martin Feelisch
发明人： Klaus Sandrock , Eike Noack , Edgar Fritschi , Ralf Kanzler , Martin Feelisch
IPC分类号： C07C323/59 , C07C327/34 , A61K31/21 , A61K31/16
CPC分类号： C07C327/34 , C07C323/59
摘要： New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a thio ester thereof, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, coronary dilation, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.
摘要翻译：通过将硝酸链烷酸与含硫氨基酸或肽缩合形成的新的有机硝酸盐化合物，随后将所得产物与氨基酸N-酰基氨基酸，肽或N-酰基肽反应，生成硫代酯，其防止硝酸盐耐受性或克服现有的耐受性，并且其可用于治疗心脏疾病，包括循环系统疾病，冠状动脉扩张，高血压，心脏功能不全和用于扩张外周血管。

24. 发明授权

US4605552A Calcium-antagonist compositions intended for inhalation and process for their manufacture 失效
标题翻译：用于吸入和加工制造的钙拮抗剂组合物
公开(公告)号：US4605552A
公开(公告)日：1986-08-12
申请号：US631049
申请日：1984-07-16
申请人： Edgar Fritschi
发明人： Edgar Fritschi
IPC分类号： A61K9/00 , A61K9/72 , A61K31/55 , A61K45/06 , A61K45/08 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/10 , C07D281/10 , A61L9/04
CPC分类号： A61K9/008 , A61K31/55
摘要： Pharmaceutical compositions for administration by inhalation, wherein calcium-antagonists are employed as the active substances, e.g., metered-sprays of calcium-antagonists, in particular of diltiazem and a process for their manufacture are described.
摘要翻译：描述了通过吸入给药的药物组合物，其中使用钙拮抗剂作为活性物质，例如钙拮抗剂的计量喷雾剂，特别是地尔硫卓的计量喷雾剂及其制备方法。

25. 发明授权

US4105795A Antispasmodic substituted sulphoximides 失效
标题翻译：解痉取代的磺酰亚胺
公开(公告)号：US4105795A
公开(公告)日：1978-08-08
申请号：US719970
申请日：1976-09-02
申请人： Manfred Haake , Reinhold Pothmann , Kurt H. Ahrens , Edgar Fritschi
发明人： Manfred Haake , Reinhold Pothmann , Kurt H. Ahrens , Edgar Fritschi
IPC分类号： A61K31/175 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/435 , A61K31/535 , A61P25/04 , C07C67/00 , C07C325/00 , C07C381/00 , C07D295/13 , C07D327/08 , C07D333/44 , C07D335/12 , A61K31/16 , A61K31/445 , C07C145/00 , C07D295/08
CPC分类号： C07D295/13 , C07D327/08 , C07D335/12
摘要： This invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 independently represent groups selected from the group consisting of straight chain alkyl groups; branched chain alkyl groups; aryl groups; optionally substituted aryl groups and the groups required to complete a ring system together with the sulphur atom;R.sup.3 and R.sup.4 independently represent groups selected from the group consisting of hydrogen; straight chain alkyl groups; branched chain alkyl groups and optionally substituted aryl groups;R.sup.5 and R.sup.6 independently represent groups selected from the group consisting of alkyl groups and the groups required to complete a heterocyclic ring together with the nitrogen atom; the groupR.sup.7 represents a group selected from the group consisting of hydrogen; straight chain alkyl groups and branched chain alkyl groups;X represents an anion of a physiologically acceptable acid andn represents a number selected from the group consisting of 0 and 1.The compounds show pharmacological activity, for example, as spasmolytics and broncholytics.
摘要翻译：本发明提供通式I（I）的化合物，其中R 1和R 2独立地表示选自直链烷基的基团; 支链烷基; 芳基; 任选取代的芳基和与硫原子一起完成环系所需的基团; R3和R4独立地表示选自氢，直链烷基; 支链烷基和任选取代的芳基; R5和R6独立地表示选自烷基和与氮原子一起完成杂环所需的基团的基团; 基团R7表示选自氢的基团; 直链烷基和支链烷基; X表示生理上可接受的酸的阴离子，N表示从0和1组所选择的数字。

26. 发明授权

US4180578A 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use 失效
标题翻译： 2,4-二氨基-5-（4'-甲硫基）苄基嘧啶，化合物，组合物和使用方法
公开(公告)号：US4180578A
公开(公告)日：1979-12-25
申请号：US891266
申请日：1978-03-29
申请人： Edgar Fritschi , Walter Liebenow , Jaroslav Prikryl
发明人： Edgar Fritschi , Walter Liebenow , Jaroslav Prikryl
IPC分类号： C07D239/48 , C07D239/49 , C07D295/145 , A61K31/505
CPC分类号： C07D239/49 , C07D295/145
摘要： A compound selected from a 2,4-diamino-5-thiobenzylpyrimidine of the formula: ##STR1## in which R is selected from hydrogen, alkyl, lower alkoxy, and halogen and R' is alkyl; and pharmacologically acceptable acid addition salts thereof. These compounds have an anti-bacterial action and are sulphonamide potentiators.
摘要翻译：选自下式的2,4-二氨基-5-硫代苄基嘧啶的化合物：其中R选自氢，烷基，低级烷氧基和卤素，R'是烷基; 及其药理学上可接受的酸加成盐。这些化合物具有抗菌作用，并且是磺酰胺增效剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式