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21. 发明授权

US07857819B2 Implant tool for use with a microstimulator 失效
标题翻译：用于微型刺激仪的植入物工具
公开(公告)号：US07857819B2
公开(公告)日：2010-12-28
申请号：US11565564
申请日：2006-11-30
申请人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
发明人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36071
摘要： A stimulation system is described that includes an implantable microstimulator. A tail may be coupled to a distal end of the implantable microstimulator. In one embodiment, the stimulation system includes an implantation tool that includes an insertion cannula, a handle, a bushing, and a detachable blunt dissector tip. The bushing is situated within the insertion cannula and may position the implantable microstimulator longitudinally within the insertion cannula when the implantable microstimulator is placed within the insertion cannula. The detachable blunt dissector tip may be attached to the tail of the implantable microstimulator. The stimulation system may further comprise an end cap that includes an upper portion and a base portion conformable over at least a portion of curved tissue. An open trough extends through the base upper portions and may be configured to guide the implantation tool through the tissue at various angles.
摘要翻译：描述了包括可植入微型刺激器的刺激系统。尾部可以联接到可植入微型刺激器的远端。在一个实施例中，刺激系统包括植入工具，其包括插入套管，手柄，衬套和可拆卸的钝性解剖器尖端。衬套位于插入套管内，并且当可植入微型刺激器放置在插入套管内时，可以将可植入的微型刺激器纵向定位在插入套管内。可拆卸的钝性解剖器尖端可以附接到可植入微型刺激器的尾部。所述刺激系统还可以包括端盖，所述端盖包括在至少一部分弯曲组织上的上部和基部。开口槽延伸穿过基底上部，并且可构造成以各种角度引导植入工具穿过组织。

22. 发明申请

US20100076535A1 LEADS WITH NON-CIRCULAR-SHAPED DISTAL ENDS FOR BRAIN STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 审中-公开
标题翻译：用于脑刺激系统的非圆形远端的引线及其制造和使用方法
公开(公告)号：US20100076535A1
公开(公告)日：2010-03-25
申请号：US12237888
申请日：2008-09-25
申请人： Anne M. Pianca , Courtney Lane , James C. Makous , Andrew DiGiore , Ellis Garai
发明人： Anne M. Pianca , Courtney Lane , James C. Makous , Andrew DiGiore , Ellis Garai
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/0472 , A61N1/0529 , A61N1/36082
摘要： A lead is configured and arranged for brain stimulation. The lead includes a proximal end and a distal end. The proximal end includes a plurality of terminals disposed at the proximal end. The distal end has a non-circular transverse cross-sectional shape and includes a plurality of electrodes disposed at the distal end. A plurality of conductive wires electrically couple at least one of the plurality of electrodes to at least one of the plurality of terminals.
摘要翻译：铅的配置和排列用于脑刺激。引线包括近端和远端。近端包括设置在近端的多个端子。前端具有非圆形横截面形状，并且包括设置在远端的多个电极。多个导线将多个电极中的至少一个电连接到多个端子中的至少一个。

23. 发明授权

US09387319B2 System for permanent electrode placement utilizing microelectrode recording methods 有权
标题翻译：使用微电极记录方法的永久电极放置系统
公开(公告)号：US09387319B2
公开(公告)日：2016-07-12
申请号：US13196402
申请日：2011-08-02
申请人： Anne M. Pianca
发明人： Anne M. Pianca
IPC分类号： A61N1/00 , A61N1/05 , A61B5/04
CPC分类号： A61N1/0529 , A61B5/04001 , A61N1/0539 , Y10S439/909
摘要： A lead stimulation/recording system is provided, which is a combination of a permanent DBS stimulating lead and a recording microelectrode. The DBS lead has a lumen extending from the proximal to the distal end of the lead, the lumen having an opening on each end of the lead. The microelectrode is configured and dimensioned to be insertable into the DBS lead from either the distal or proximal opening of the DBS lead, thereby permitting the microelectrode to be placed before, concurrently with, or after placement of the DBS lead. In addition, the system may be used with known microelectrode recording systems and methods of inserting the electrodes, such as the five-at-a-time method, the dual-microdrive method, or the single microdrive method.
摘要翻译：提供铅刺激/记录系统，其是永久DBS刺激引线和记录微电极的组合。 DBS引线具有从引线的近端延伸到远端的内腔，管腔在引线的每一端具有开口。微电极的构造和尺寸被设计成从DBS导线的远端或近端开口插入到DBS引线中，从而允许微电极放置在放置DBS引线之前，同时或之后。此外，该系统可以与已知的微电极记录系统和插入电极的方法一起使用，例如五次方法，双微型驱动方法或单个微驱动方法。

24. 发明授权

US08712542B2 Deposited conductive layers for leads of implantable electric stimulation systems and methods of making and using 失效
标题翻译：用于可植入电刺激系统的引线的沉积的导电层以及制造和使用的方法
公开(公告)号：US08712542B2
公开(公告)日：2014-04-29
申请号：US12264526
申请日：2008-11-04
申请人： David Michael McMorrow , Anne M. Pianca
发明人： David Michael McMorrow , Anne M. Pianca
IPC分类号： A61N1/00 , H01B7/00 , H01B11/02
CPC分类号： A61N1/0553 , A61N1/3752 , A61N1/3787
摘要： An implantable lead includes an inner core substrate. A plurality of conductors that include at least one layer of at least one conductive material are deposited on the inner core substrate. A patterned insulator layer is disposed over the conductors such that at least two regions of each conductor remain exposed through the insulator. A patterned terminal layer defines a plurality of separated terminals that are deposited at a proximal end of the lead. At least one terminal is electrically coupled to each conductor via at least one of the exposed regions of the at least one conductor. A patterned electrode layer defines a plurality of separated electrodes that are deposited at a distal end of the lead. At least one electrode is electrically coupled to each conductor via at least one of the exposed regions of the at least one conductor.
摘要翻译：可植入引线包括内芯基板。包括至少一层至少一种导电材料的多个导体沉积在内芯基板上。在导体上设置有图案化的绝缘体层，使得每个导体的至少两个区域保持暴露于绝缘体中。图案化的端子层限定沉积在引线的近端处的多个分离的端子。至少一个端子经由至少一个导体的暴露区域中的至少一个电耦合到每个导体。图案化电极层限定沉积在引线的远端的多个分离的电极。至少一个电极经由至少一个导体的暴露区域中的至少一个电耦合到每个导体。

25. 发明授权

US08244377B1 Fixation arrangements for implantable leads and methods of making and using 失效
标题翻译：可植入引线的固定安排和制造和使用方法
公开(公告)号：US08244377B1
公开(公告)日：2012-08-14
申请号：US11863034
申请日：2007-09-27
申请人： Anne M. Pianca , Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru
发明人： Anne M. Pianca , Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/057
摘要： An implantable member has a body with a distal end portion and either a fixation portion of the body disposed near the distal end portion or a fixation device attached to a tip of the distal end portion of the body. The fixation portion can include at least one surface feature of the body that facilitates fixation of the implantable member within tissue when implanted.
摘要翻译：可植入构件具有主体，其具有设置在远端部附近的远端部分和本体的固定部分，或固定装置附接到主体的远端部分的尖端。固定部分可以包括主体的至少一个表面特征，其有助于植入时在植入组织内固定可植入构件。

26. 发明授权

US08204595B2 Lead assembly for implantable microstimulator 有权
标题翻译：可植入微型激励器的导线组件
公开(公告)号：US08204595B2
公开(公告)日：2012-06-19
申请号：US12207184
申请日：2008-09-09
申请人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
发明人： Anne M. Pianca , Todd K. Whitehurst , James P. McGivern
IPC分类号： A61N1/375
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly for a small implantable medical device (a.k.a, microdevice 10) provides means to attach a remote electrode to microdevice, which means inhibit fluid ingress when microdevice is not attached to lead assembly. Microdevices may provide either or both tissue stimulation and sensing. Known microdevices include spaced apart electrodes on the outer surface of the microdevice. Lead assembly includes an insulated lead including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode at the distal end of the lead and electrically connected to the at least one conductor, and a connector attached to the proximal end of the lead and adapted to be removably connectable to microdevice. Connector includes at least one contact to electrically connect at least one device electrode on microdevice to at least one conductor, thereby electrically connecting at least electrode and the at least one electrode at the distal end of lead. Lead assembly is configured to inhibit fluid ingress into the connector. A number of embodiments of the invention, capable of inhibiting fluid ingress into connector, are taught.
摘要翻译：用于小型可植入医疗装置（a.k.a，微器件10）的引线组件提供将远程电极附接到微器件的装置，这意味着当微器件未附接到引线组件时抑制流体进入。微器件可以提供组织刺激和感测之一或两者。已知的微器件在微器件的外表面上包括间隔开的电极。引线组件包括绝缘引线，其包括近端和远端，其间具有至少一个导体; 在所述引线的远端处的至少一个电极并且电连接到所述至少一个导体，以及连接到所述引线的近端并适于可移除地连接到微器件的连接器。连接器包括至少一个接触件，用于将微器件上的至少一个器件电极电连接到至少一个导体，由此至少电极和至少一个电极在铅的远端处电连接。引线组件被配置为抑制流体进入连接器。教导了能够抑制流体进入连接器的本发明的许多实施例。

27. 发明申请

US20110118815A1 ELECTRODE ARRAY ASSEMBLY AND METHOD OF MAKING SAME 有权
标题翻译：电极阵列组件及其制造方法
公开(公告)号：US20110118815A1
公开(公告)日：2011-05-19
申请号：US13013599
申请日：2011-01-25
申请人： Janusz A. Kuzma , Anne M. Pianca
发明人： Janusz A. Kuzma , Anne M. Pianca
IPC分类号： A61N1/05 , H05K13/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A lead assembly and a method of making a lead are provided. The method of making a multi-contact lead assembly comprises placing monofilament placed in the void spaces not occupied by the plurality of conductor wires and, in one embodiment, thermally fusing the monofilament to the like material spacer by applying heat just below the melting temperature of the monofilament and spacer material. Alternatively, the monofilament and spacer may be of different materials and heat is applied to cause at least one material to thermally reflow or melt. The conductive contacts may be located at either the distal end and/or proximal end of the lead. Oversized spacers may be used in order to provide extra material to fill voids during the thermal fusion/reflow process.
摘要翻译：提供引线组件和引线的方法。制造多接触引线组件的方法包括放置放置在未被多根导线占据的空隙空间中的单丝，并且在一个实施例中，通过施加刚好低于熔融温度单丝和间隔材料。或者，单丝和间隔件可以是不同的材料，并且施加热量以使至少一种材料热回流或熔化。导电触点可以位于引线的远端和/或近端处。可以使用超大间隔物，以便在热熔/回流过程期间提供额外的材料以填充空隙。

28. 发明授权

US07004948B1 Cranial sealing plug 有权
公开(公告)号：US07004948B1
公开(公告)日：2006-02-28
申请号：US10052331
申请日：2002-01-18
申请人： Anne M. Pianca , Carla M. Mann , Tom Xiaohai He , Michael Dogali
发明人： Anne M. Pianca , Carla M. Mann , Tom Xiaohai He , Michael Dogali
IPC分类号： A61B19/00 , A61B5/04 , A61N1/00
CPC分类号： A61N1/0539 , A61B17/3462 , A61B90/11 , A61B2017/3419 , A61B2090/103 , A61F2/2875 , A61N1/0534
摘要： Various embodiments of a burr hole plug assembly offer significant improvements for allowing lead and/or cannula access through a burr hole drilled through a patient's skull in connection with a Deep Brain Stimulation system, and subsequent sealing of such burr hole. The various burr hole plug assemblies described: (a) accommodate various burr hole sizes and provide a secure fit in the burr hole; (b) accommodate various locations for lead positioning and adjustment; (c) allow the lead to remain in a static position when the burr hole plug assembly is placed; (d) protect the lead from fracture at the exit location of the plug; (e) remain flush with the skull to avoid skin erosion and to eliminate unsightly flange protrusion from the patients' skull; (f) adequately hold the lead in place over time; and (g) provide a selection of various types of burr hole plug assemblies and sizes for use by the implanting surgeon, thereby eliminating the need for surgeons to resort to custom plugs and plug assemblies made in the operating room specifically to fit a given patient.

29. 发明授权

US06389320B1 Implantable stimulation lead adaptable for stylet or guidewire placement 失效
标题翻译：植入式刺激引线适用于探针或导丝放置
公开(公告)号：US06389320B1
公开(公告)日：2002-05-14
申请号：US09411749
申请日：1999-10-01
申请人： Anne M. Pianca
发明人： Anne M. Pianca
IPC分类号： A61N105
CPC分类号： A61N1/056
摘要： An implantable stimulation lead is readily adaptable for stylet placement or guidewire lead placement. The implantable lead includes at its distal end an implanting guide structure which includes a rigid member having a through bore. A plug is dimensioned to be received within the through bore and a retaining mechanism releasably retains the plug within the through bore. When the plug is retained within the through bore, the lead is adapted for stylet placement and when the plug is released from the through bore, the lead is adapted for guidewire lead placement. In a preferred embodiment, the distal electrode of the lead provides the rigid member of the implanting guide structure. After the lead is positioned by guidewire lead placement, the proximal end of the lead may be sealed with a plug or the plug of the implanting guide structure or new plug may be replaced or placed in the lead to prevent blood flow through the lead.
摘要翻译：植入式刺激引线易于适用于探针放置或导丝引线放置。可植入引线在其远端包括植入引导结构，其包括具有通孔的刚性构件。插头的尺寸设计成容纳在通孔内，并且保持机构将插塞可释放地保持在通孔内。当插头保持在通孔内时，引线适用于探针放置，并且当插头从通孔中释放时，引线适于引导导线放置。在优选实施例中，引线的远端电极提供植入引导结构的刚性构件。在引线通过导线引线放置定位之后，引线的近端可以用塞子密封，或者植入引导结构的插塞或新塞子可以被替换或放置在引线中以防止血液通过引线。

30. 发明授权

US09220811B2 Implantable or insertable medical devices 有权
标题翻译：可植入或可插入的医疗器械
公开(公告)号：US09220811B2
公开(公告)日：2015-12-29
申请号：US12563641
申请日：2009-09-21
申请人： Edward Holman Overstreet , Anne M. Pianca , Janusz A. Kuzman , Aditya Pandit , Shaina Brito , Robert E. Richard , Kerri DiPietro , Frederick H. Strickler , Mark Boden , Lan Pham , William Orinski
发明人： Edward Holman Overstreet , Anne M. Pianca , Janusz A. Kuzman , Aditya Pandit , Shaina Brito , Robert E. Richard , Kerri DiPietro , Frederick H. Strickler , Mark Boden , Lan Pham , William Orinski
IPC分类号： A61L27/18 , A61L27/34 , A61L27/54 , C08G77/20 , A61N1/05
CPC分类号： A61L27/54 , A61L27/18 , A61L27/34 , A61L2300/222 , A61L2300/602 , A61N1/0534 , A61N1/0541 , A61N1/0551 , C08L83/06
摘要： In various aspects, the present invention is directed to implantable neurostimulation leads and methods for their formation. In various additional aspects, the present invention is directed to medical devices having silicone-containing regions with overlying polymeric layers and to methods of forming the same.
摘要翻译：在各个方面，本发明涉及可植入的神经刺激引线及其形成方法。在各种附加方面，本发明涉及具有含有覆盖聚合物层的含硅氧烷的区域的医疗装置及其形成方法。

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