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21. 发明申请

US20120289882A1 INTRA-ATRIAL IMPLANTS HAVING VARIABLE THICKNESSES TO ACCOMODATE VARIABLE THICKNESS IN SEPTUM 有权
标题翻译：具有可变厚度的内部植入物可以在SEPTUM中保存可变厚度
公开(公告)号：US20120289882A1
公开(公告)日：2012-11-15
申请号：US13471415
申请日：2012-05-14
申请人： Edward McNamara , David Celermajer , Stephen J. Forucci , Hiroatsu Sugimoto
发明人： Edward McNamara , David Celermajer , Stephen J. Forucci , Hiroatsu Sugimoto
IPC分类号： A61M1/00
摘要： The invention is a septal implant that can accommodate variable thicknesses of the patient's atrial septum as well the variable thicknesses of septums across a population. The invention is able to accomplish this result by having flexible annular flanges that define a gap into which the septum fits. Due to the flexible nature of the annular flanges, the gap is adjustable.
摘要翻译：本发明是可以适应患者房间隔的可变厚度的隔膜植入物以及跨越群体的隔膜的可变厚度。本发明能够通过具有限定间隔配合的间隙的柔性环形凸缘来实现该结果。由于环形凸缘的灵活性，间隙可调节。

22. 发明申请

US20110190874A1 DEVICES AND METHODS FOR REDUCING VENOUS PRESSURE 有权
标题翻译：用于降低呼吸压力的装置和方法
公开(公告)号：US20110190874A1
公开(公告)日：2011-08-04
申请号：US13016290
申请日：2011-01-28
申请人： David Celermajer , Michael W. Sutherland , Edward McNamara
发明人： David Celermajer , Michael W. Sutherland , Edward McNamara
IPC分类号： A61F2/82
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2250/0029 , A61F2250/0036
摘要： Devices and method are disclosed for reducing pressure in a patient's vena cava and in the right atrium of a patient's heart. A valve is implanted in the inferior vena cava (IFC) between the patient's renal veins and hepatic veins. When pressure in a patient's IFC reaches high levels, i.e., the pressure differential across the valve reaches high levels, the valve automatically closes or begins to close. The closing is caused by the pressure of the patient's blood moving one or more flaps in the valve to a closed or near-closed position. This prevents excessive pressure in the upper or superior vena cava and the right atrium of the patient's heart. The device also includes a pressure relief feature that opens and allows retrograde flow of blood if the pressure differential exceeds a yet higher pressure.
摘要翻译：公开了用于减轻患者的心脏腔内和右心房中的压力的装置和方法。瓣膜植入患者的肾静脉和肝静脉之间的下腔静脉（IFC）。当患者IFC中的压力达到高水平时，即跨过阀门的压差达到高水平时，阀门自动关闭或开始关闭。关闭是由于患者血液中的一个或多个瓣片移动到闭合或接近闭合位置的压力引起的。这可以防止患者心脏的上腔静脉和上腔静脉和右心房的压力过大。该装置还包括压力释放特征，如果压力差超过更高的压力，该压力释放特征将打开并允许血液逆行流动。

23. 发明授权

US09277995B2 Devices and methods for reducing venous pressure 有权
标题翻译：降低静脉压的装置和方法
公开(公告)号：US09277995B2
公开(公告)日：2016-03-08
申请号：US13016290
申请日：2011-01-28
申请人： David Celermajer , Michael W. Sutherland , Edward McNamara
发明人： David Celermajer , Michael W. Sutherland , Edward McNamara
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2250/0029 , A61F2250/0036
摘要： Devices and method are disclosed for reducing pressure in a patient's vena cava and in the right atrium of a patient's heart. A valve is implanted in the inferior vena cava (IFC) between the patient's renal veins and hepatic veins. When pressure in a patient's IFC reaches high levels, i.e., the pressure differential across the valve reaches high levels, the valve automatically closes or begins to close. The closing is caused by the pressure of the patient's blood moving one or more flaps in the valve to a closed or near-closed position. This prevents excessive pressure in the upper or superior vena cava and the right atrium of the patient's heart. The device also includes a pressure relief feature that opens and allows retrograde flow of blood if the pressure differential exceeds a yet higher pressure.
摘要翻译：公开了用于减轻患者的心脏腔内和右心房中的压力的装置和方法。瓣膜植入患者的肾静脉和肝静脉之间的下腔静脉（IFC）。当患者IFC中的压力达到高水平时，即跨过阀门的压差达到高水平时，阀门自动关闭或开始关闭。关闭是由于患者血液中的一个或多个瓣片移动到闭合或接近闭合位置的压力引起的。这可以防止患者心脏的上腔静脉和上腔静脉和右心房的压力过大。该装置还包括压力释放特征，如果压力差超过更高的压力，该压力释放特征将打开并允许血液逆行流动。

24. 发明申请

US20050095591A1 Diagnostic assay 审中-公开
公开(公告)号：US20050095591A1
公开(公告)日：2005-05-05
申请号：US10489623
申请日：2001-09-12
申请人： Richard Christopherson , Christobal Dos Remedios , David Celermajer
发明人： Richard Christopherson , Christobal Dos Remedios , David Celermajer
IPC分类号： G01N33/53 , G01N33/543 , G01N33/569 , G01N33/68 , G01N37/00 , G06F19/00 , C12Q1/68
CPC分类号： G01N33/6893 , G01N2800/324 , Y02A90/24
摘要： The present invention relates generally to a diagnostic device including a prognostic assay for parameters which are indicative of a condition or event associated with the systemic vasculature. More particularly, the present invention provides an assay to detect parameters associated with a vascular disease including cardiovascular, stroke, pulmonary, renovascular, cerebrovascular, thrombotic or generalized arterial or venous condition or event including acute coronary syndrome such as but not limited to acute myocardial infarction, heart failure, atheromoma or a thrombotic condition. The identification of these parameters or more particularly a pattern of parameters enables the diagnosis of a condition or event or the determination of the risk of development of a condition or event associated to the systemic vasculature. Still more particularly, the present invention is directed to a diagnostic device comprising a set of members wherein one or more of said members has or have specific or generic binding partners in a biological sample from an animal including human subject wherein the pattern of binding of the members to the binding partners is indicative, predictive or otherwise associated with a likelihood of a condition or event within the systemic vasculature. The absence of detection of specific or generic binding partners is also of indicative or predictive value. This is particularly important in cases where patients are unable to communicate advice to a physician on their own condition, such as during surgery or for patients in a coma. It is also useful in determining the risk of a vascular disease including cardiovascular, stroke, pulmonary, renovascular, cerebrovascular, thrombotic or generalized arterial or venous conditions or events in a healthy subject or a subject entering into an exposure to risk such as surgery or chemotherapy. The present invention is useful inter alia for the identification and/or quantitation of biochemical markers of conditions or events in the systemic vasculature such as heart disease, heart disorders, infections of the heart, stroke and thrombosis as well as the determination of a risk of development of these conditions including the absence of disorders or absence of risk of the development of a disorder. The assessment of such conditions may be made in a clinical setting, as part of triage, as part of a routine testing protocol and/or as a laboratory procedure.

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