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21. 发明申请

US20130131594A1 BALLOON CATHETER WITH EXTERNAL DELIVERY TUBE 有权
标题翻译：带外部输送管的气压管
公开(公告)号：US20130131594A1
公开(公告)日：2013-05-23
申请号：US13813221
申请日：2011-08-03
申请人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
发明人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
IPC分类号： A61M25/10 , A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0032 , A61M25/0097 , A61M25/1002 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/105 , A61M2025/1086
摘要： A balloon catheter (10) having a shaft (16), a balloon (14), and an external delivery tube (12) is disclosed. Methods of using the balloon catheter having an external delivery tube are also disclosed. In one example, the balloon catheter is an agent delivery catheter including a catheter body extending between catheter proximal and distal portions. An inflatable balloon assembly (100) is coupled with the catheter body. An agent delivery assembly (102) is coupled with the catheter body and the inflatable balloon assembly. The agent delivery assembly includes a delivery lumen (32) extending through the catheter body, and an agent delivery tube extending along an exterior balloon surface (64). The agent delivery tube includes at least one delivery orifice (70) directed outside of the exterior balloon surface. The agent delivery assembly is isolated from fluid communication with the inflatable balloon assembly.
摘要翻译：公开了一种具有轴（16），气球（14）和外部输送管（12）的球囊导管（10）。还公开了使用具有外部输送管的气囊导管的方法。在一个示例中，气囊导管是包括在导管近端部分和远端部分之间延伸的导管主体的药剂输送导管。可充气球囊组件（100）与导管主体联接。药剂输送组件（102）与导管主体和可充气球囊组件联接。药剂输送组件包括延伸穿过导管主体的递送腔（32）和沿外部气囊表面（64）延伸的药剂输送管。药剂输送管包括指向外气囊表面外部的至少一个输送孔（70）。药剂输送组件与可充气球囊组件的流体连通隔离。

22. 发明授权

US08439878B2 Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities 有权
标题翻译：溶血性血栓切除术导管带有自充气近端球囊药物输注能力
公开(公告)号：US08439878B2
公开(公告)日：2013-05-14
申请号：US12338376
申请日：2008-12-18
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC分类号： A61M5/178
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22065
摘要： A thrombectomy catheter with a self-inflating proximal balloon having drug infusion capabilities is described. A self-inflating balloon is formed from an inflatable thin walled section of a flexible catheter tube. The self-inflating balloon includes a plurality of outflow orifices located about the peripheral circumference thereof and located proximal to an inflow gap interposed between a fluid jet emanator and the self-inflating balloon. The self-inflating balloon is inflated and expanded by internal operating pressures by proximal composite flow of fluid from the fluid jet emanator and entrained fluid from the inflow gap to uniformly space and position the outflow orifices of the self-inflating balloon in close proximity to the thrombus or vessel walls of a blood vessel. The thrombectomy catheter may be used for, among other things, thrombectomies, embolectomies, thrombus or vessel dilation, and for the delivery of drugs to a thrombus or vessel site.
摘要翻译：描述了具有药物输注能力的具有自充气近端球囊的血栓切除术导管。自充气气囊由柔性导管的可膨胀薄壁部分形成。自膨胀气囊包括多个位于其周边周围的流出孔，位于流体喷射发生器和自膨胀气囊之间的入口间隙附近。自充气气球通过内部操作压力通过来自流体喷射发生器的流体的近似复合流动和来自流入间隙的夹带的流体膨胀和膨胀，以将自膨胀气囊的流出孔均匀地间隔并定位在紧邻血栓或血管壁。血栓切除术导管可以用于血栓切除术，静脉血栓栓塞，血栓或血管扩张，以及用于将药物递送至血栓或血管部位。

23. 发明申请

US20090156983A1 RHEOLYTIC THROMBECTOMY CATHETER WITH SELF-INFLATING DISTAL BALLOON 有权
标题翻译：具有自动离子气球的流变色谱柱导管
公开(公告)号：US20090156983A1
公开(公告)日：2009-06-18
申请号：US12336750
申请日：2008-12-17
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22067 , A61B2017/22068 , A61B2017/22084
摘要： The devices of the present disclosure are rheolytic thrombectomy catheters with a self-inflating distal balloon. A self-inflating balloon is located distal to an inflow gap or orifice and distal to a fluid jet emanator, which self-inflating balloon is inflated and expanded by the utilization of internal operating forces consisting of forwardly directed high velocity fluid jet streams and/or entrained thrombus particulate therein. The self-inflating balloon, when inflated, impinges on the wall of the blood vessel to isolate sections of the blood vessel distal and proximal to the inflated balloon in order to prevent flow of thrombus particulate, fluids and the like distal to the self-inflating balloon and to provide a stagnant nonflow region proximal to the self-inflating balloon. The devices of the present disclosure also provide for a uniform spacing of the catheter tube with respect to the thrombus and/or wall of the blood vessel.
摘要翻译：本公开的装置是具有自充气远端气囊的溶血性血栓切除术导管。自充气球囊位于流入间隙或孔口的远侧并且远离流体射流喷射器，该自膨胀球囊通过利用由向前定向的高速流体射流和/或组合的内部操作力而膨胀和膨胀其中夹带血栓颗粒。充气气囊充气时会撞击到血管壁上，以将血管的远端和近侧的血管部分隔开，以防止血栓微粒，流体等远离自膨胀的流动并且提供靠近自充气气球的停滞的非流动区域。本公开的装置还提供导管管相对于血管的血栓和/或壁的均匀间隔。

24. 发明授权

US09005163B2 Balloon catheter with external delivery tube 有权
标题翻译：气球导管与外部输送管
公开(公告)号：US09005163B2
公开(公告)日：2015-04-14
申请号：US13813221
申请日：2011-08-03
申请人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
发明人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
IPC分类号： A61M29/00 , A61M25/10 , A61F2/958 , A61M25/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0032 , A61M25/0097 , A61M25/1002 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/105 , A61M2025/1086
摘要： A balloon catheter having a shaft, a balloon, and an external delivery tube, as well as methods of use thereof. In one example, the balloon catheter is an agent delivery catheter including a catheter body extending between catheter proximal and distal portions. An inflatable balloon assembly is coupled with the catheter body. An agent delivery assembly, which is coupled with the catheter body and the inflatable balloon assembly, includes a delivery lumen extending through the catheter body and an agent delivery tube extending along an exterior balloon surface. The agent delivery tube includes at least one delivery orifice directed outside of the exterior balloon surface. The agent delivery assembly is isolated from fluid communication with the inflatable balloon assembly.
摘要翻译：具有轴，球囊和外部输送管的气囊导管及其使用方法。在一个示例中，气囊导管是包括在导管近端部分和远端部分之间延伸的导管主体的药剂输送导管。可充气球囊组件与导管主体相连。与导管主体和可充气球囊组件联接的药剂输送组件包括延伸穿过导管主体的输送腔和沿着外气囊表面延伸的药剂输送管。药剂输送管包括指向外部气囊表面外部的至少一个输送孔。药剂输送组件与可充气球囊组件的流体连通隔离。

25. 发明授权

US08303538B2 Rheolytic thrombectomy catheter with self-inflating distal balloon 有权
标题翻译：具有自充气远端气球的溶血性血栓切除术导管
公开(公告)号：US08303538B2
公开(公告)日：2012-11-06
申请号：US12336750
申请日：2008-12-17
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC分类号： A61M29/00
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22067 , A61B2017/22068 , A61B2017/22084
摘要： The devices of the present disclosure are rheolytic thrombectomy catheters with a self-inflating distal balloon. A self-inflating balloon is located distal to an inflow gap or orifice and distal to a fluid jet emanator, which self-inflating balloon is inflated and expanded by the utilization of internal operating forces consisting of forwardly directed high velocity fluid jet streams and/or entrained thrombus particulate therein. The self-inflating balloon, when inflated, impinges on the wall of the blood vessel to isolate sections of the blood vessel distal and proximal to the inflated balloon in order to prevent flow of thrombus particulate, fluids and the like distal to the self-inflating balloon and to provide a stagnant nonflow region proximal to the self-inflating balloon. The devices of the present disclosure also provide for a uniform spacing of the catheter tube with respect to the thrombus and/or wall of the blood vessel.
摘要翻译：本公开的装置是具有自充气远端气囊的溶血性血栓切除术导管。自充气球囊位于流入间隙或孔口的远侧并且远离流体射流喷射器，该自膨胀球囊通过利用由向前定向的高速流体射流和/或组合的内部操作力而膨胀和膨胀其中夹带血栓颗粒。充气气囊充气时会撞击到血管壁上，以将血管的远端和近侧的血管部分隔开，以防止血栓微粒，流体等远离自膨胀的流动并且提供靠近自充气气球的停滞的非流动区域。本公开的装置还提供导管管相对于血管的血栓和/或壁的均匀间隔。

26. 发明授权

US06945951B1 Thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06945951B1
公开(公告)日：2005-09-20
申请号：US09930796
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B17/22 , A61B17/32 , A61M1/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

27. 发明授权

US06805684B2 Thrombectomy catheter and system 失效
公开(公告)号：US06805684B2
公开(公告)日：2004-10-19
申请号：US09930795
申请日：2001-08-16
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

28. 发明授权

US06676627B1 Crossflow thrombectomy catheter and system 失效
标题翻译：血栓切除导管及系统
公开(公告)号：US06676627B1
公开(公告)日：2004-01-13
申请号：US09417395
申请日：1999-10-13
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61B1720
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.
摘要翻译：交叉流血栓切除术导管和用于从血管或其他体腔破裂和去除血栓或其他材料的系统。从导管远端的环形环喷射发生器或其他喷射发射器发射的高速盐水喷射器通过流入孔夹带流体，并且流动阻力产生背压，该背压驱动跨径流通过径向流出孔，并周向地将正常和牵引力施加在血管或其它体腔中的血栓形成沉积物或病变上，从而分离和输送通过流入孔夹带的血栓颗粒，于是高速喷射器将血栓颗粒浸入，排气腔或再次通过外流孔再循环。

29. 发明授权

US06764483B1 Thrombectomy catheter and system 失效
公开(公告)号：US06764483B1
公开(公告)日：2004-07-20
申请号：US09915875
申请日：2001-07-26
申请人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
发明人： Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , John B. Bridgeman , Debra M. Kozak , Rosemary C. Beaupre , Mark L. Jenson , Cindy M. Setum , Robert C. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B17/3203 , A61M1/0084
摘要： Cross stream thrombectomy catheter and system for fragmentation and removal of thrombus or other material from blood vessels or other body cavities. High velocity saline jets emitted from a toroidal loop jet emanator or other jet emanator in a catheter distal end entrain fluid through inflow orifices, and with flow resistances create a back-pressure which drives cross stream streams through outflow orifices in a radial direction and thence radially and circumferentially to apply normal and drag forces on thrombotic deposits or lesions in the blood vessel or other body cavity, thereby breaking apart and transporting thrombus particles to be entrained through the inflow orifices, whereupon the high velocity jets macerate the thrombus particles which then transit an exhaust lumen or recirculate again via the outflow orifices.

30. 发明授权

US06224570B1 Rheolytic thrombectomy catheter and method of using same 有权
标题翻译：溶血性血栓切除术导管及其使用方法
公开(公告)号：US06224570B1
公开(公告)日：2001-05-01
申请号：US09188633
申请日：1998-11-09
申请人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
发明人： Hieu V. Le , Michael J. Bonnette , John Edward Morris , Steven E. Wiesel , Debra M. Kozak , Cindy M. Setum , Robert G. Dutcher
IPC分类号： A61M5178
CPC分类号： A61B17/32037 , A61B2090/034
摘要： A rheolytic thrombectomy catheter and method of using same to remove thrombus from a body vessel or other body cavity. Several embodiments are disclosed. All embodiments include an outer catheter having a lumen and an inner high pressure tube of a size to enable it to be passed through the lumen of the catheter. The distal end of the inner high pressure tube extends beyond the distal end of the catheter and carries a jet cap for directing one or more jets of saline proximally toward the distal end of the catheter. In some embodiments, the catheter has a distally located inwardly directed stationary stop and the inner high pressure tube includes a distally located outwardly directed transitional stop for engaging the inwardly directed stationary stop to thereby position the jet cap at a defined distance from the distal end of the catheter. In other embodiments, a stationary stop is located at the proximal end of the catheter and a transitional stop is carried on the proximal end of the inner high pressure tube. In the embodiments having the stationary and transitional stops located proximally, the inner high pressure tube includes a flow director at its distal end. In use, thrombus is dislodged, entrained, and broken into pieces by the saline jets and evacuated proximally through the lumen of the catheter.
摘要翻译：一种溶解性血栓切除术导管及其使用方法，从身体血管或其他体腔去除血栓。公开了几个实施例。所有实施例包括具有内腔和内部高压管的外导管，其尺寸使其能够穿过导管的内腔。内部高压管的远端延伸超过导管的远端，并且携带用于将一个或多个盐水向近端引导到导管的远端的喷射帽。在一些实施例中，导管具有远侧定位的向内指向的固定止动件，并且内部高压管包括远侧定位的向外指向的过渡止动件，用于接合向内指向的固定止动件，从而将喷射盖定位在距离导管。在其他实施例中，静止止动件位于导管的近端处，并且过渡停止件承载在内部高压管的近端上。在具有位于近侧的静止和过渡止动件的实施例中，内部高压管在其远端包括导流器。在使用中，血栓被移出，夹带并通过盐水喷射器破碎成碎片，并通过导管的内腔向近端排出。

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