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21. 发明申请

US20100317946A1 Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction 有权
标题翻译：使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震
公开(公告)号：US20100317946A1
公开(公告)日：2010-12-16
申请号：US12797781
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
IPC分类号： A61B5/145 , A61B5/0402
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译：用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

22. 发明申请

US20100317943A1 Active Noise Cancellation in an Optical Sensor Signal 有权
标题翻译：光传感器信号中的主动噪声消除
公开(公告)号：US20100317943A1
公开(公告)日：2010-12-16
申请号：US12797831
申请日：2010-06-10
申请人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis
发明人： Jonathan L. Kuhn , David A. Anderson , Can Cinbis
IPC分类号： A61B5/145
CPC分类号： A61B5/1459 , A61B5/1495
摘要： A medical device system and associated method are used for monitoring tissue oxygenation. An optical sensor produces a signal corresponding to tissue light attenuation. A processor receives the optical sensor signal and computes a first measure of light attenuation at a first light wavelength and a second measure of light attenuation at a second light wavelength. In one embodiment, noise cancellation circuitry receives the first measure and the second measure and generates a guessed ratio of the first and second measures. Using the first measure, the second measure and the guessed ratio, the noise cancellation circuitry provides a peak output power when the guessed ratio corresponds to an actual ratio of the first and second measures.
摘要翻译：医疗器械系统和相关方法用于监测组织氧合。光学传感器产生对应于组织光衰减的信号。处理器接收光学传感器信号并且计算第一光波长处的光衰减的第一测量值和在第二光波长处的光衰减的第二测量值。在一个实施例中，噪声消除电路接收第一测量和第二测量并产生第一和第二测量的猜测比率。使用第一测量，第二测量和猜测比率，当猜测比率对应于第一和第二测量的实际比率时，噪声消除电路提供峰值输出功率。

23. 发明申请

US20100196874A1 METHOD OF DRUG DESIGN 审中-公开
标题翻译：药物设计方法
公开(公告)号：US20100196874A1
公开(公告)日：2010-08-05
申请号：US12519018
申请日：2007-12-13
申请人： Elena V. Gazina , Steven Petrou , David N. Harrison , David A. Anderson
发明人： Elena V. Gazina , Steven Petrou , David N. Harrison , David A. Anderson
IPC分类号： C12Q1/70 , C12Q1/48 , C12N7/01 , G06F17/50
CPC分类号： G01N33/56983 , C12N9/127 , G01N2333/085 , G01N2333/9125
摘要： The description discloses that amiloride-like compounds inhibit enterovirus RNA replication by interaction with RNA dependent RNA polymerase (RdRP). The description discloses in silico and in vitro methods of screening for inhibitors of RdRP activity, amiloride-resistant enterovirus variants and amiloride-like compounds.
摘要翻译：该描述公开了阿米洛利类化合物通过与RNA依赖性RNA聚合酶（RdRP）的相互作用来抑制肠道病毒RNA复制。该描述公开了用于筛选RdRP活性抑制剂，阿米洛利抗性肠病毒变体和阿米洛利样化合物的硅和体外方法。

24. 发明申请

US20100179444A1 IMPLANTABLE MEDICAL DEVICE WITH ADAPTIVE SIGNAL PROCESSING AND ARTIFACT CANCELLATION 有权
标题翻译：具有自适应信号处理和人工取消的可植入医疗器械
公开(公告)号：US20100179444A1
公开(公告)日：2010-07-15
申请号：US12687946
申请日：2010-01-15
申请人： Richard J. O'Brien , D. Curtis Deno , David A. Anderson , David R. Bloem
发明人： Richard J. O'Brien , D. Curtis Deno , David A. Anderson , David R. Bloem
IPC分类号： A61B5/0402 , G08B23/00
CPC分类号： A61B5/0205 , A61B5/1455 , A61B5/7207 , A61N1/3718 , A61N1/3925 , G06K9/00503 , G06K9/6247 , G06K2009/00939
摘要： A medical device having a sensor sensing an n-dimensional signal during a first known variable condition and during a second known variable condition different from the first known variable condition, a processor performing principal component analysis (PCA) on the sensed n-dimensional signal to generate a first template corresponding to a principal component of variation associated with the first known variable condition and a second template corresponding to a principal component of variation associated with the second known variable condition, a storage device storing the first template and the second template, and a controller detecting a patient condition in response to the stored templates.
摘要翻译：一种医疗装置，其具有在第一已知可变条件期间和在与第一已知可变条件不同的第二已知可变条件期间感测n维信号的传感器，处理器对所感测的n维信号执行主分量分析（PCA）生成对应于与第一已知可变条件相关联的变化的主成分的第一模板和对应于与第二已知可变条件相关联的变化的主成分的第二模板，存储第一模板和第二模板的存储装置，以及响应于所存储的模板检测患者状况的控制器。

25. 发明授权

US07679554B1 Communications link time transfer to improve navigation system accuracy 有权
标题翻译：通信链路时间传输，提高导航系统的准确性
公开(公告)号：US07679554B1
公开(公告)日：2010-03-16
申请号：US12167897
申请日：2008-07-03
申请人： Patrick Y Hwang , Bernard A. Schnaufer , David A. Anderson , Gary A. McGraw
发明人： Patrick Y Hwang , Bernard A. Schnaufer , David A. Anderson , Gary A. McGraw
IPC分类号： G01S5/14 , G01S1/00
CPC分类号： G01S19/15 , G01S19/235 , G01S19/41
摘要： A method and apparatus for improving differential navigation accuracy uses time transfer over a two-way communications link. The communications link transmits an overall time offset between a differential reference station and a remote user. A differential navigation position solution is modified at the remote user with the overall time offset to improve the differential navigation accuracy. A first time offset between a first communications device and a first navigation receiver at the remote user is determined. A second time offset between the first communications device at the remote user and a second communications device at the differential reference station is determined. A third time offset between the second communications device and a second navigation receiver at the differential reference station is determined. An overall time offset from the first time offset, the second time offset, and the third time offset is computed and used to improve the differential navigation accuracy.
摘要翻译：用于改善差分导航精度的方法和装置使用双向通信链路上的时间传递。通信链路传输差分参考站和远程用户之间的整体时间偏移。差分导航位置解决方案在远程用户处被修改，具有总时间偏移量，以提高差分导航精度。确定远程用户的第一通信设备和第一导航接收器之间的第一时间偏移。确定远程用户的第一通信设备与差分参考站处的第二通信设备之间的第二时间偏移。确定第二通信设备和差分参考站处的第二导航接收机之间的第三次偏移。计算出与第一时间偏移，第二时间偏移和第三时间偏移的总体时间偏移，并用于提高差分导航精度。

26. 发明申请

US20090030334A1 IMPLANTABLE HEART SOUND SENSOR WITH NOISE CANCELLATION 有权
标题翻译：具有噪声消除的可植入心脏声音传感器
公开(公告)号：US20090030334A1
公开(公告)日：2009-01-29
申请号：US11781734
申请日：2007-07-23
申请人： David A. Anderson , Can Cinbis
发明人： David A. Anderson , Can Cinbis
IPC分类号： A61B5/02
CPC分类号： A61N1/36514 , A61B7/003 , A61B7/006 , A61B7/008 , A61B2562/0204 , A61N1/36578 , A61N1/3702
摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.
摘要翻译：植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。

27. 发明授权

US09867990B2 Determination of dipole for tissue conductance communication 有权
公开(公告)号：US09867990B2
公开(公告)日：2018-01-16
申请号：US12915788
申请日：2010-10-29
申请人： Can Cinbis , David A. Anderson , Michael A. Reinert , Xiaonan Shen , James K. Carney , Michael B. Terry
发明人： Can Cinbis , David A. Anderson , Michael A. Reinert , Xiaonan Shen , James K. Carney , Michael B. Terry
IPC分类号： A61N1/40 , A61N1/372 , A61B5/00 , A61N1/08 , H04B13/00
CPC分类号： A61N1/37217 , A61B5/0028 , A61N1/08 , H04B13/005
摘要： Aspects of the present disclosure include a medical device system including an implantable medical device and an external device with three or more electrodes configured to contact a patient's skin. The external device either transmits or receives a test signal to or from the implantable medical device using a plurality of possible receive dipoles, where each possible receive dipole is formed by a pair of electrodes. A signal quality monitor, either at the implantable medical device or at the external device, measures a signal quality for the possible receive dipoles.

28. 发明授权

US09126049B2 Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction 有权
$Shock reduction using absolute calibrated tissue oxygen saturation and total hemoglobin volume fraction$
标题翻译：使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震
公开(公告)号：US09126049B2
公开(公告)日：2015-09-08
申请号：US12797781
申请日：2010-06-10
申请人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
发明人： Jonathan L. Kuhn , Can Cinbis , David A. Anderson , James K. Carney
IPC分类号： A61B5/00 , A61N1/362 , A61B5/02 , A61B5/145 , A61B5/1459 , A61N1/365 , A61N1/39 , A61B5/0215 , A61B5/042 , A61B5/11
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device for detecting and treating an arrhythmia includes an optical sensor adapted for positioning adjacent to a blood-perfused tissue volume. In one embodiment for controlling arrhythmia therapies delivered by the device, the optical sensor is controlled to emit light in response to detecting an arrhythmia, detect light scattered by the volume of blood perfused tissue including measuring an optical sensor output signal corresponding to the intensity of scattered light for at least four spaced-apart wavelengths, and compute a volume-independent measure of tissue oxygen saturation from the detected light. The hemodynamic status of the arrhythmia is detected in response to the measure of tissue oxygen saturation.
摘要翻译：用于检测和治疗心律失常的可植入医疗装置包括适于邻近于血液灌注的组织体积定位的光学传感器。在用于控制由装置传送的心律失常治疗的一个实施例中，响应于检测到心律失常，控制光学传感器发光，检测由血液灌注组织的体积散射的光，包括测量对应于散射强度的光学传感器输出信号用于至少四个间隔波长的光，并且从检测到的光计算组织氧饱和度的体积独立测量。响应于组织氧饱和度的测量，检测心律失常的血液动力学状态。

29. 发明授权

US08617082B2 Heart sounds-based pacing optimization 有权
标题翻译：基于心音的起搏优化
公开(公告)号：US08617082B2
公开(公告)日：2013-12-31
申请号：US13111260
申请日：2011-05-19
申请人： Xusheng Zhang , Aleksandre T. Sambelashvili , David A. Anderson , Zhendong Song
发明人： Xusheng Zhang , Aleksandre T. Sambelashvili , David A. Anderson , Zhendong Song
IPC分类号： A61B5/02
CPC分类号： A61N1/36578 , A61B5/0006 , A61B5/04017 , A61B5/0452 , A61B5/4848 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： An implantable medical device receives both heart sound and electrogram signals. A processor within the implantable medical device extracts physiologically relevant information from both the heart sound signal and the electrogram signal. Based on the extracted physiologically relevant information a set of pacing parameters is evaluated. In certain examples, the values of the pacing parameters may be changed by the implantable medical device in response to the physiologically relevant information extracted from the heart sound signal and the electrogram signal.
摘要翻译：可植入医疗设备接收心音和电描记信号。可植入医疗装置内的处理器从心音信号和电描记图信号中提取生理相关信息。基于提取的生理相关信息，评估一组起搏参数。在某些示例中，响应于从心脏声音信号和电描记图信号提取的生理学相关信息，可由可植入医疗装置改变起搏参数的值。

30. 发明申请

US20120043094A1 Packoff With Internal Lockdown Mechanism 有权
标题翻译：包装内部锁定机制
公开(公告)号：US20120043094A1
公开(公告)日：2012-02-23
申请号：US12858952
申请日：2010-08-18
申请人： David A. Anderson , James Sinnott
发明人： David A. Anderson , James Sinnott
IPC分类号： E21B23/00 , E21B19/00
CPC分类号： E21B33/04
摘要： A packoff is located within a wellhead housing and a casing hanger. The packoff has an internal ratchet ring that engages a threaded profile on the exterior of the casing hanger thereby allowing installation of the packoff to be achieved by simply stabbing the packoff over the protruding neck of the casing hanger. This ratchet ring significantly reduces the rotation required during installation, decreasing potential for damage to seals. The casing hanger has an external lock ring that is inwardly biased. During installation of the packoff, the packoff acts to activate the lock ring to thereby force it outward. The lock ring is forced outward and into a recess formed in the interior of the wellhead housing. The lock ring and the ratchet ring locks the packoff and casing hanger into place with the wellhead housing without the need of external lockdown screws, thereby minimizing leak paths.
摘要翻译：包装位于井口外壳和套管吊架内。包装具有内部棘轮环，其接合套管悬挂架的外部上的螺纹轮廓，从而允许通过简单地将包装物穿过套管悬挂器的突出颈部来实现的包装的安装。该棘轮环显着减少了安装过程中所需的旋转，降低了对密封件损坏的可能性。套管悬挂器具有向内偏置的外部锁定环。在包装的安装期间，包装用于启动锁定环从而将其强制向外。锁环被迫向外并进入形成在井口壳体内部的凹槽中。锁环和棘轮环将包装和套管挂钩与井口外壳锁定在一起，而不需要外部锁定螺钉，从而最小化泄漏路径。

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