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21. 发明授权

US07074931B2 Process for asymmetric synthesis of substituted 1,4 -dihydropyridines 失效
标题翻译：不对称合成取代的1,4-二氢吡啶的方法
公开(公告)号：US07074931B2
公开(公告)日：2006-07-11
申请号：US10333669
申请日：2001-07-31
申请人： Ian Patel , Ian Ashworth , Daniel Levin
发明人： Ian Patel , Ian Ashworth , Daniel Levin
IPC分类号： C07D211/02 , C07D215/16
CPC分类号： C07D215/20
摘要： A process is described for reacting a vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound to form an 1,5-diketone which is converted to a 1,4-dihydropyridine. Asymmetric substituted 1,4-dihydropyridines are synthesized by the process by preparing an asymmetric vinylogous amide by reacting a 1,3-cyclohexanedione with a substantially homo-chiral phenylethylamine. Reaction of the asymmetric vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound forms an asymmetric 1,5-diketone. The 1,5-diketone is converted to an asymmetric substituted 1,4-dihydropyridine.
摘要翻译：描述了一种方法，用于在硅化合物存在下使乙烯基酰胺与α，β-不饱和酮反应，形成1,5-二酮，将其转化为1,4-二氢吡啶。不对称取代的1,4-二氢吡啶通过该方法通过使1,3-环己二酮与基本上同质的手性苯基乙胺反应制备不对称维生素酰胺来合成。在硅化合物存在下，不对称戊烯酰胺与α，β-不饱和酮的反应形成不对称的1,5-二酮。将1,5-二酮转化为不对称取代的1,4-二氢吡啶。

22. 发明授权

US06866680B2 Implantable stroke preventing device 失效
标题翻译：植入式中风防止装置
公开(公告)号：US06866680B2
公开(公告)日：2005-03-15
申请号：US09950027
申请日：2001-09-10
申请人： Yuval Yassour , Ofer Yodfat , Ygael Grad , Moshe Rosenfeld , Daniel Levin
发明人： Yuval Yassour , Ofer Yodfat , Ygael Grad , Moshe Rosenfeld , Daniel Levin
IPC分类号： A61F2/00 , A61F2/01 , A61F2/04 , A61F2/06 , A61F2/84 , A61F2/90
CPC分类号： A61F2/90 , A61F2/01 , A61F2/04 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2002/016 , A61F2002/018 , A61F2002/061 , A61F2002/065 , A61F2002/068 , A61F2230/0006 , A61F2230/0069 , A61F2250/0017 , A61F2250/0024
摘要： An implantable device for positioning in the vicinity of the bifurcation of the common carotid artery (CCA) into the internal carotid artery (ICA) and the external carotid artery (ECA), comprises a deflecting element suitable to deflect the flow of embolic material flowing in the CCS toward the ICA, into the ECA, without filtering.
摘要翻译：用于定位在颈总动脉（CCA）到颈内动脉（ICA）和外颈动脉（ECA）的分叉附近的可植入装置包括偏转元件，该偏转元件适于偏转流入的颈部动脉 CCS向ICA进入ECA，不进行过滤。

23. 发明授权

US06712834B2 Implantable blood filtering device 失效
标题翻译：可植入血液过滤装置
公开(公告)号：US06712834B2
公开(公告)日：2004-03-30
申请号：US09737092
申请日：2000-12-14
申请人： Yuval Yassour , Ofer Yodfat , Ygael Grad , Moshe Rosenfeld , Daniel Levin
发明人： Yuval Yassour , Ofer Yodfat , Ygael Grad , Moshe Rosenfeld , Daniel Levin
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61F2/958 , A61F2002/018 , A61F2002/8483 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： An implantable filtering device for implanting within an artery supplying blood to the brain, the device being made of bio-compatible material and comprising a filtering unit for entrapping plaque debris, and an anchoring member engageable with the walls of the carotid artery for anchoring said filtering unit at a fixed location with the artery. The filtering unit has a tapering shape extending between a wide inlet portion and a narrower outlet portion extending downstream, and a tap element fitted at the outlet portion for entrapping plaque debris.
摘要翻译：一种植入式过滤装置，用于植入在向大脑供血的动脉的动脉内，所述装置由生物相容的材料制成并且包括用于捕获斑块碎片的过滤单元，以及可与颈动脉壁接合的锚固构件，用于锚定所述过滤单位在固定位置与动脉。过滤单元具有在宽的入口部分和在下游延伸的较窄出口部分之间延伸的锥形形状，以及安装在出口部分处用于捕获斑块碎片的丝锥元件。

24. 发明授权

US4845285A Chemical process 失效
标题翻译：化学工艺
公开(公告)号：US4845285A
公开(公告)日：1989-07-04
申请号：US125103
申请日：1987-11-25
申请人： Colin Hardy , Tony R. Martin , Jerzy Czyzewski , Daniel Levin
发明人： Colin Hardy , Tony R. Martin , Jerzy Czyzewski , Daniel Levin
IPC分类号： C07C311/51 , C07C303/40 , C07C311/02
CPC分类号： C07C311/02
摘要： A process for preparing a compound of formula (II): ##STR1## or a tautomer or salt thereof in substantially pure form wherein R.sup.1 is C.sub.1-6 alkyl optionally substituted by one or more halogen atoms; R.sup.3 is hydrogen, fluorine, chlorine, bromine or iodine, C.sub.1-6 alkyl, trifluoromethyl or a cyano group; R.sup.4 is hydrogen, fluorine, chlorine, bromine, iodine or trifluoromethyl; R.sup.5 is fluorine, chlorine, bromine, iodine or trifluoromethyl; and R.sup.6 is hydrogen or C.sub.1-4 alkyl; which process comprises nitrating a compound of formula (III): ##STR2## or a salt thereof wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined above, in a solvent which is resistant to nitration under the desired reaction conditions and suitable for purification of the product of formula (II), heating the resultant solution to a temperature sufficient to at least partially dissolve the desired product and impurities and cooling the solution to precipitate the compound of formula (II) in substantially pure form.

25. 发明授权

US09499461B2 Pharmaceutical compositions comprising POH derivatives 有权
标题翻译：包含POH衍生物的药物组合物
公开(公告)号：US09499461B2
公开(公告)日：2016-11-22
申请号：US13818972
申请日：2011-08-26
申请人： Thomas Chen , Daniel Levin , Satish Puppali
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07D487/04 , C07D207/26 , C07D231/12 , C07C33/14 , A61K31/415 , A61K45/06 , A61K47/48 , A61N5/10 , A61K31/495 , A61K31/4188 , A61K31/045 , A61K31/4015 , C07B59/00
CPC分类号： C07C33/14 , A61K9/0043 , A61K31/045 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/495 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61N5/10 , C07B59/00 , C07B2200/05 , C07C2601/16 , C07D207/26 , C07D231/12 , C07D487/04
摘要： The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译：本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

26. 发明授权

US08530458B2 High-purity large-scale preparation of stannsoporfin 有权
公开(公告)号：US08530458B2
公开(公告)日：2013-09-10
申请号：US12968651
申请日：2010-12-15
申请人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
发明人： George S. Drummond , Robert Caroselli , Keith A. Cooke , Daniel Levin , David G. Roe , Christopher P. Boucher
IPC分类号： A01N55/02 , C07D487/22 , C07B47/00
CPC分类号： C07F7/2284 , A61K9/0019 , A61K31/555 , C07D487/22 , C07F7/003
摘要： Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.

27. 发明申请

US20130210877A1 PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES 有权
公开(公告)号：US20130210877A1
公开(公告)日：2013-08-15
申请号：US13818972
申请日：2011-08-26
申请人： Thomas Chen , Daniel Levin , Satish Puppali
发明人： Thomas Chen , Daniel Levin , Satish Puppali
IPC分类号： C07D487/04 , C07D207/26 , C07D231/12
CPC分类号： C07C33/14 , A61K9/0043 , A61K31/045 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/495 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61N5/10 , C07B59/00 , C07B2200/05 , C07C2601/16 , C07D207/26 , C07D231/12 , C07D487/04
摘要： The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

28. 发明申请

US20130203828A1 PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES 有权
标题翻译：包含POH衍生物的药物组合物
公开(公告)号：US20130203828A1
公开(公告)日：2013-08-08
申请号：US13566731
申请日：2012-08-03
申请人： Thomas Chen , Daniel Levin , Satish Pupalli
发明人： Thomas Chen , Daniel Levin , Satish Pupalli
IPC分类号： A61K47/48 , A61N5/10 , A61K45/06
CPC分类号： C07C33/14 , A61K9/0043 , A61K31/045 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/495 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61N5/10 , C07B59/00 , C07B2200/05 , C07C2601/16 , C07D207/26 , C07D231/12 , C07D487/04
摘要： The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译：本发明提供单萜或倍半萜衍生物，例如芳香醇衍生物。例如，紫苏醇衍生物可以是芳族醇氨基甲酸酯。紫苏醇衍生物可以是与治疗剂如化学治疗剂缀合的紫苏醇。本发明还提供了治疗诸如癌症的疾病的方法，其包括向患者递送治疗有效量的单萜（或倍半萜烯）衍生物的步骤。给药途径可以变化，并且可以包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

29. 发明申请

US20130058536A1 METHOD, SYSTEM AND COMPUTER READABLE MEDIUM EMBODYING A COMPUTER PROGRAM PRODUCT FOR DETERMINING A VEHICLE OPERATOR'S EXPECTATION OF A STATE OF AN OBJECT 有权
标题翻译：方法，系统和计算机可读介质确定计算机程序产品用于确定车辆操作者对物体状态的期望
公开(公告)号：US20130058536A1
公开(公告)日：2013-03-07
申请号：US13591890
申请日：2012-08-22
申请人： Daniel Levin , Gustav Markkula
发明人： Daniel Levin , Gustav Markkula
IPC分类号： G06K9/80
CPC分类号： B60K28/066 , A61B5/1128 , A61B5/18 , A61B5/6893 , B60W2540/22 , G08G1/168
摘要： The present invention generally relates to a method, a system and/or a computer readable program. An embodiment of the method includes acquiring an input signal indicative of the operator's expectation of the state of the object at a first point in time; determining a state of the object at a second later point in time based on the input signal; acquiring an input signal indicative of an estimated visual input of the operator at the second point in time; determining the operator's expectation of the state at the second point in time, based on the operator's expectation of the state of the object at the first point in time, and the estimated visual input and the state of the object at the second point in time; and providing an output signal indicative of the operator's expectation of the state at the second point in time.
摘要翻译：本发明一般涉及方法，系统和/或计算机可读程序。该方法的一个实施例包括获取指示操作者在第一时间点对对象状态的期望的输入信号; 基于所述输入信号，在稍后的时间点确定所述对象的状态; 在第二时间点获取指示操作者的估计视觉输入的输入信号; 基于操作者对第一时间点的对象状态的预期以及在第二时间点的对象的估计视觉输入和状态来确定操作者对第二时间点状态的预期; 以及提供指示操作者在第二时间点对状态的预期的输出信号。

30. 发明申请

US20130057671A1 METHOD FOR CLASSIFICATION OF EYE CLOSURES 有权
标题翻译：眼睛闭锁分类方法
公开(公告)号：US20130057671A1
公开(公告)日：2013-03-07
申请号：US13558780
申请日：2012-07-26
申请人： Daniel Levin , Lena Westervall , Susanna Leandersson , Peter Kronberg
发明人： Daniel Levin , Lena Westervall , Susanna Leandersson , Peter Kronberg
IPC分类号： H04N7/18
CPC分类号： G08B21/06 , A61B5/18 , A61B5/7221 , B60W40/08 , B60W2040/0827 , G06F19/00
摘要： The present invention generally relates to a method for improving the reliability of a portion of physiological data from an image sensor monitoring an operator positioned in an operator compartment of a vehicle. An embodiment of the method includes receiving, from the image sensor, physiological data including information relating to at least one of eye, face, head, arms and body motion of the operator, identifying an indication of at least an eyelid closure, eye movement or head movement of the operator based on the physiological data; comparing at least one of the physiological data and a lighting condition within the operator compartment with a set of rules for a current operator status; and classifying the type of eyelid closure, eye movement and/or head movement by correlating the identified eyelid closure, eye movement and/or head movement and a result of the comparison.
摘要翻译：本发明一般涉及一种用于提高来自监视位于车辆操作室中的操作员的图像传感器的一部分生理数据的可靠性的方法。该方法的实施例包括从图像传感器接收生理数据，其包括与操作者的眼睛，脸部，头部，手臂和身体运动中的至少一个有关的信息，识别至少一个眼睑闭合，眼睛运动或基于生理数据的操作员的头部运动; 将所述操作员室内的生理数据和照明条件中的至少一个与用于当前操作者状态的一组规则进行比较; 并通过将所识别的眼睑关闭，眼睛运动和/或头部移动与比较的结果相关联来分类眼睑闭合的类型，眼睛运动和/或头部运动。

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