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21. 发明授权

US08114382B2 Myelin detection using benzofuran derivatives 有权
标题翻译：使用苯并呋喃衍生物的髓磷脂检测
公开(公告)号：US08114382B2
公开(公告)日：2012-02-14
申请号：US12211854
申请日：2008-09-17
申请人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Cristina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K49/00
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

22. 发明申请

US20110142759A1 AGENTS AND METHODS FOR THE IMAGING OF MYELIN BASIC PROTEIN 有权
标题翻译：用于成像MYELIN基础蛋白的试剂和方法
公开(公告)号：US20110142759A1
公开(公告)日：2011-06-16
申请号：US13031349
申请日：2011-02-21
申请人： Rong Zhang , Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Victoria Eugenia Cotero , Bruce Fletcher Johnson
发明人： Rong Zhang , Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Victoria Eugenia Cotero , Bruce Fletcher Johnson
IPC分类号： A61K51/04 , C07D213/89 , C07C311/40 , C07D241/04 , A61P43/00 , C12Q1/02
CPC分类号： A61K49/10 , A61K51/04
摘要： The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
摘要翻译：本发明涉及能够与受试者中的髓磷脂碱性蛋白结合的试剂。还提供了用于检测髓鞘相关神经病变的方法，其包括鉴定处于或伴有髓磷脂相关神经病的风险的受试者，向受试者施用特异性结合髓磷脂碱性蛋白的试剂，以及通过检测来测定受试者的髓鞘形成该主体中存在的代理人。还提供了含有用于检测髓磷脂碱性蛋白质的试剂或其衍生物的试剂盒。

23. 发明申请

US20100068140A1 MYELIN DETECTION USING BENZOFURAN DERIVATIVES 有权
标题翻译：使用苯唑嘌呤衍生物进行MYELIN检测
公开(公告)号：US20100068140A1
公开(公告)日：2010-03-18
申请号：US12211854
申请日：2008-09-17
申请人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
发明人： Christina Abucay Tan Hehir , Stephen Johnson Lomnes , Kenneth Michael Fish , Tiberiu Mircea Siclovan , Michael Christopher Montalto , Tunchiao Hubert Lam
IPC分类号： A61K51/04
CPC分类号： G01N33/60 , A61K49/10 , A61K51/0419 , G01N33/6896 , G01N2800/285 , Y10T436/14 , Y10T436/20 , Y10T436/200833
摘要： The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.
摘要翻译：本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物检测髓磷脂的方法及其在样品中的局部浓度的定量测量。在一个实施方案中，髓鞘蛋白检测的方法包括鉴定患有髓磷脂相关神经病的风险或被诊断患有髓磷脂相关神经病的受试者，所述苯并呋喃化合物或所述化合物的衍生物肠胃外给药，以及通过检测受试者中的结合来确定受试者的髓鞘形成例子。在一个实施方案中，本发明提供了一种在哺乳动物组织的手术领域中成像有髓组织的方法，包括使手术部位与化合物的苯并呋喃化合物或放射性同位素衍生物接触并检测手术部位的结合的步骤。在另一个实施方案中，提供了一种脊髓和脊髓神经根组织成像方法，其包括非肠道给药苯并呋喃化合物的放射性同位素衍生物和检测椎管内的放射性同位素衍生物和椎间孔的步骤。还提供了定量苯并呋喃化合物或其衍生物的结合方法。

24. 发明授权

US06608163B2 Polycarbonate copolymers having improved hydrolytic stability 有权
标题翻译：具有改善的水解稳定性的聚碳酸酯共聚物
公开(公告)号：US06608163B2
公开(公告)日：2003-08-19
申请号：US09764795
申请日：2001-01-17
申请人： Christian Maria Emile Bailly , Tiberiu Mircea Siclovan
发明人： Christian Maria Emile Bailly , Tiberiu Mircea Siclovan
IPC分类号： C08G6400
CPC分类号： C08G64/06 , C08G64/12
摘要： The present invention provides polycarbonate copolymers having improved hydrolytic stability, solvent resistance, or combinations thereof. In particular, certain of the copolymers of the invention have improved resistance to dilute caustic solution. Thus, the copolymers of the present invention are particularly useful as structural elements in applications where such elements routinely come in contact with caustic solutions, such as in automatic dishwashing equipment. Preferred comonomers include 4,4′-biphenol, bis-(4-hydroxyphenyl)terephthalamide (“BHPT”), and a bisimide bisphenol obtained by reacting Bisphenol A dianhydride (BPADA) with 4,4′-isopropylidene phenol aniline. The comonomers are utilized along with 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A) in concentrations in a range between about 1 and about 50 weight percent of the repeating units in the polycarbonate.
摘要翻译：本发明提供了具有改进的水解稳定性，耐溶剂性或其组合的聚碳酸酯共聚物。特别地，本发明的某些共聚物具有改进的对苛性碱溶液的耐受性。因此，本发明的共聚物特别可用作这些元素常规地与苛性碱溶液接触的应用中的结构元件，例如在自动洗碗设备中。优选的共聚单体包括4,4'-联苯酚，双 - （4-羟基苯基）对苯二甲酰胺（“BHPT”）和通过双酚A二酐（BPADA）与4,4'-异亚丙基苯酚苯胺反应获得的双酰亚胺双酚。共聚单体与聚碳酸酯中重复单元的约1至约50重量％之间的浓度与2,2-双（4-羟基苯基）丙烷（双酚A）一起使用。

25. 发明授权

US6143839A Weatherable blends of polycarbonates with arylate polymers 有权
标题翻译：聚碳酸酯与芳基化聚合物的耐候性共混物
公开(公告)号：US6143839A
公开(公告)日：2000-11-07
申请号：US152877
申请日：1998-09-14
申请人： Jimmy Lynn Webb , Randall Lee Carter , Tiberiu Mircea Siclovan , James Edward Pickett
发明人： Jimmy Lynn Webb , Randall Lee Carter , Tiberiu Mircea Siclovan , James Edward Pickett
IPC分类号： C08K3/00 , C08K5/00 , C08L67/03 , C08L69/00
CPC分类号： C08L69/00
摘要： Weatherability of polycarbonates, or of blends of polycarbonates with other polymers such as polyesters, is improved by incorporating therein a thermoplastic arylate polymer comprising units derived from a resorcinol or alkylresorcinol isophthalate-terephthalate. These units may be combined with units derived from a resorcinol or alkylresorcinol ester of a C.sub.4-12 aliphatic, alicyclic or mixed aliphatic-alicyclic dicarboxylic acid, such as sebacic acid.
摘要翻译：通过在其中加入包含衍生自间苯二酚或间苯二酚间苯二甲酸酯 - 对苯二甲酸酯的单元的热塑性芳基化合物聚合物来改善聚碳酸酯或聚碳酸酯与其它聚合物如聚酯的共混物的耐候性。这些单元可以与衍生自C4-12脂族，脂环族或混合脂族 - 脂环族二羧酸如癸二酸的间苯二酚或烷基间苯二酚酯的单元组合。

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