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21. 发明申请

US20100047213A1 CELL COMPOSITION AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：细胞组成及其制备方法
公开(公告)号：US20100047213A1
公开(公告)日：2010-02-25
申请号：US12544949
申请日：2009-08-20
申请人： Andy Zeitlin , Gregory Russotti , Shuyang He , Ajai Pal , Hong J. Chen , Thomas Brieva , Ryan Shorr , Brian Murphy
发明人： Andy Zeitlin , Gregory Russotti , Shuyang He , Ajai Pal , Hong J. Chen , Thomas Brieva , Ryan Shorr , Brian Murphy
IPC分类号： A61K35/12 , C12N5/02 , C12N5/071
CPC分类号： A01N1/0221
摘要： Provided herein are improved methods for the formulation of compositions comprising placental stem cells, and improved compositions and cell formulations produced thereby.
摘要翻译：本文提供了用于制备包含胎盘干细胞的组合物的改进方法，以及由此制备的改进的组合物和细胞制剂。

22. 发明授权

US07499828B2 Position determining apparatus and related method 失效
标题翻译：位置确定装置及相关方法
公开(公告)号：US07499828B2
公开(公告)日：2009-03-03
申请号：US11606248
申请日：2006-11-29
申请人： Mario Barton , Marius Filmalter , Eric Cramer , Dave Fugelso , David Cremer , Kyle Langenwalter , Brian Murphy , Richard Theriault , Evan McGee
发明人： Mario Barton , Marius Filmalter , Eric Cramer , Dave Fugelso , David Cremer , Kyle Langenwalter , Brian Murphy , Richard Theriault , Evan McGee
IPC分类号： G06F15/00 , G05D1/02
CPC分类号： A63B69/3614 , A63B24/0003 , A63B69/0002 , A63B69/3685 , A63B69/38 , A63B2024/0012 , A63B2102/24 , A63B2220/05 , A63B2220/806 , A63B2220/807
摘要： A system for determining the relative displacement of a rigid object is described herein. In one embodiment, the system includes three data sources positioned on an object. The data sources are configured to transmit data relating to positional displacement of the object. Each data source has predefined movement parameters based on the position of each data source on the object. In one embodiment, the system further includes a receiver unit configured to display positional information relating to the object based on the data received from each data source. The positional information represents a single valid solution set generated in part by eliminating positional movements that exceed the predefined movement parameters.
摘要翻译：这里描述了用于确定刚性物体的相对位移的系统。在一个实施例中，系统包括位于物体上的三个数据源。数据源被配置为发送与对象的位置偏移有关的数据。每个数据源基于对象上每个数据源的位置具有预定义的移动参数。在一个实施例中，系统还包括接收器单元，其被配置为基于从每个数据源接收的数据显示与对象相关的位置信息。位置信息表示通过消除超过预定移动参数的位置移动来部分生成的单个有效解集。

23. 发明申请

US20080300592A1 CATHETER DRIVER SYSTEM 有权
标题翻译：导管系统
公开(公告)号：US20080300592A1
公开(公告)日：2008-12-04
申请号：US12111119
申请日：2008-04-28
申请人： Barry Weitzner , Brian Murphy
发明人： Barry Weitzner , Brian Murphy
IPC分类号： A61B18/14
CPC分类号： A61M25/0133 , A61B18/14 , A61B18/1492 , A61B34/30 , A61B34/70 , A61B2017/003 , A61B2034/301 , A61B2034/742 , A61M25/0113 , A61M25/0147
摘要： An apparatus for performing medical procedures on an anatomical body includes an extension with an element near its distal end to be extended into the body, and a driver that moves the extension axially into the body, and that causes flexure of the distal end of the extension. The movement and flexure of the extension is driven by the driver from the proximal end of the extension, and an electronic controller directs the operation of the driver.
摘要翻译：用于在解剖体上执行医疗程序的装置包括具有靠近其远端延伸进入体内的元件的延伸部，以及使延伸部沿轴向移动到体内并使延伸部的远端弯曲的驱动器。延伸部的移动和弯曲由驱动器从延伸部的近端驱动，并且电子控制器引导驾驶员的操作。

24. 发明申请

US20080216887A1 Interconnect Technologies for Back Contact Solar Cells and Modules 审中-公开
标题翻译：用于背面接触太阳能电池和模块的互连技术
公开(公告)号：US20080216887A1
公开(公告)日：2008-09-11
申请号：US11963841
申请日：2007-12-23
申请人： Peter Hacke , David H. Meakin , James M. Gee , Sysavanh Southimath , Brian Murphy
发明人： Peter Hacke , David H. Meakin , James M. Gee , Sysavanh Southimath , Brian Murphy
IPC分类号： H01L31/05 , H01L31/18
CPC分类号： H01L31/022441 , H01L31/0516 , Y02E10/50 , Y10T29/49171
摘要： Methods and systems for interconnecting back contact solar cells. The solar cells preferably have reduced area busbars, or are entirely busbarless, and current is extracted from a variety of points on the interior of the cell surface. The interconnects preferably relieve stresses due to solder reflow and other thermal effects. The interconnects may be stamped and include external or internal structures which are bonded to the solder pads on the solar cell. These structures are designed to minimize thermal stresses between the interconnect and the solar cell. The interconnect may alternatively comprise porous metals such as wire mesh, wire cloth, or expanded metal, or corrugated or fingered strips. The interconnects are preferably electrically isolated from the solar cell by an insulator which is deposited on the cell, placed on the cell as a discrete layer, or laminated directly to desired areas of the interconnect.
摘要翻译：用于互连背接触太阳能电池的方法和系统。太阳能电池优选地具有减小的面积母线，或者完全无母线，并且电流从电池表面内部的各种点提取。互连优选地减轻由于焊料回流和其它热效应引起的应力。互连可以被冲压并且包括结合到太阳能电池上的焊盘的外部或内部结构。这些结构被设计成使互连和太阳能电池之间的热应力最小化。互连可以可选地包括多孔金属，例如金属丝网，金属丝布或多孔金属，或波纹状或指形条。互连优选地通过绝缘体与太阳能电池电隔离，所述绝缘体沉积在电池上，作为离散层放置在电池上，或者直接层压到互连的期望区域。

25. 发明申请

US20070176210A1 Semiconductor layer structure and method for fabricating a semiconductor layer structure 有权
标题翻译：半导体层结构及半导体层结构的制造方法
公开(公告)号：US20070176210A1
公开(公告)日：2007-08-02
申请号：US11702011
申请日：2007-02-02
申请人： Brian Murphy , Maik Haberlen , Jorg Lindner , Bernd Stritzker
发明人： Brian Murphy , Maik Haberlen , Jorg Lindner , Bernd Stritzker
IPC分类号： H01L27/10
CPC分类号： H01L21/02694 , H01L21/02381 , H01L21/02447 , H01L21/02532 , H01L21/02538 , H01L21/02551 , H01L21/02658 , H01L21/26506
摘要： Semiconductor layer structure and a method for producing a structure are provided, including a substrate made of semiconductor material, on which a layer made of a second semiconductor material is situated, furthermore a region (3) enriched with impurity atoms, which region is situated either in layer (2) or at a specific depth below the interface between layer (2) and substrate (1), additionally a layer (4) within the region (3) enriched with impurity atoms, which layer comprises cavities produced by ion implantation, furthermore at least one epitaxial layer (6) applied to layer (2) and also a defect region (5) comprising dislocations and stacking faults within the layer (4) comprising cavities, the at least one epitaxial layer (6) being largely crack-free, and a residual strain of the at least one epitaxial layer (6) being less than or equal to 1 GPa.
摘要翻译：提供半导体层结构和制造结构的方法，包括由半导体材料制成的基板，在其上设置由第二半导体材料制成的层，此外还包括富含杂质原子的区域（3），该区域位于在层（2）中或在层（2）和衬底（1）之间的界面下方的特定深度处，另外在区域（3）内富含杂质原子的层（4），该层包括通过离子注入产生的空穴，此外，施加到层（2）的至少一个外延层（6）还包括在包括空腔的层（4）内的位错和层叠缺陷的缺陷区域（5），所述至少一个外延层（6）所述至少一个外延层（6）的残余应变小于或等于1GPa。

26. 发明申请

US20070092534A1 Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses 有权
标题翻译：开发可用于减毒登革热病毒和嵌合登革热病毒的突变
公开(公告)号：US20070092534A1
公开(公告)日：2007-04-26
申请号：US11446050
申请日：2006-06-02
申请人： Stephen Whitehead , Brian Murphy , Kathryn Hanley , Joseph Blaney
发明人： Stephen Whitehead , Brian Murphy , Kathryn Hanley , Joseph Blaney
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
摘要翻译：开发了一个突变菜单，可用于微调登革病毒疫苗的衰减和生长特性。

27. 发明申请

US20060202310A1 Film or layer of semiconducting material, and process for producing the film or layer 有权
标题翻译：薄膜或半导体材料层，以及制造薄膜或层的方法
公开(公告)号：US20060202310A1
公开(公告)日：2006-09-14
申请号：US11384887
申请日：2006-03-20
申请人： Brian Murphy , Reinhold Wahlich , Rudiger Schmolke , Wilfried Von Ammon , James Moreland
发明人： Brian Murphy , Reinhold Wahlich , Rudiger Schmolke , Wilfried Von Ammon , James Moreland
IPC分类号： H01L29/06
CPC分类号： H01L21/3223 , H01L21/76251
摘要： SOI wafers are manufactured to have very thin device layers of high surface quality. The layer is ≦ 20 nm in thickness, has an HF density of ≦ 0.1/cm2, and a surface roughness of 0.2 nm RMS.
摘要翻译： SOI晶片被制造成具有非常薄的高表面质量的器件层。该层的厚度<20nm，HF密度<= 0.1 / CM <2>，表面粗糙度为0.2nm RMS。

28. 发明申请

US20060057158A1 Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines 失效
标题翻译：减毒，人 - 牛嵌合呼吸道合胞病毒疫苗的生产
公开(公告)号：US20060057158A1
公开(公告)日：2006-03-16
申请号：US11097946
申请日：2005-03-31
申请人： Ursula Buchholz , Peter Collins , Brian Murphy , Stephen Whitehead , Christine Krempl
发明人： Ursula Buchholz , Peter Collins , Brian Murphy , Stephen Whitehead , Christine Krempl
IPC分类号： A61K39/12 , C07H21/04 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/544 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/203
摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.
摘要翻译：嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段不同的RSV菌株。本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反义基因组。感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

29. 发明申请

US20060018927A1 Respiratory syncytial virus vaccines expressing protective antigens from promotor-proximal genes 有权
公开(公告)号：US20060018927A1
公开(公告)日：2006-01-26
申请号：US11054343
申请日：2005-02-08
申请人： Christine Krempl , Peter Collins , Brian Murphy , Ursula Buchholz , Stephen Whitehead
发明人： Christine Krempl , Peter Collins , Brian Murphy , Ursula Buchholz , Stephen Whitehead
IPC分类号： A61K39/155 , C12Q1/70 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2760/18622
摘要： Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift. In one embodiment, RSV glycoproteins are upregulated by shifting one or more glycoprotein-encoding genes to a more promoter-proximal position. Genes of interest for manipulation to create gene position-shifted RSV include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment that may be part of a gene or extragenic. A variety of additional mutations and nucleotide modifications are provided within the gene position-shifted RSV of the invention to yield desired phenotypic and structural effects.

30. 发明申请

US20050220767A1 Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 审中-公开
标题翻译：表达免疫调节分子的重组呼吸道合胞病毒的生产
公开(公告)号：US20050220767A1
公开(公告)日：2005-10-06
申请号：US10917984
申请日：2004-08-11
申请人： Peter Collins , Alexander Bukreyev , Brian Murphy , Stephen Whitehead
发明人： Peter Collins , Alexander Bukreyev , Brian Murphy , Stephen Whitehead
IPC分类号： C12N15/09 , A61K9/12 , A61K35/76 , A61K39/00 , A61K39/155 , A61K48/00 , A61P11/00 , A61P11/06 , A61P31/14 , A61P37/04 , C07K14/54 , C12N7/00 , C12N7/04 , C12N15/86 , A61K39/12
CPC分类号： C07K14/54 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N15/86 , C12N2760/18543 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译：提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。用于本发明的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白细胞介素5（IL-5），白介素6（IL-6）或白细胞介素18（IL- 18），肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。

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