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21. 发明申请

US20050227253A1 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 审中-公开
标题翻译：核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测
公开(公告)号：US20050227253A1
公开(公告)日：2005-10-13
申请号：US10990137
申请日：2004-11-15
申请人： Mary Faris , Rene Hubert , Arthur Raitano , Daniel Afar , Elana Levin , Pia Challita-Eid , Aya Jakobovits
发明人： Mary Faris , Rene Hubert , Arthur Raitano , Daniel Afar , Elana Levin , Pia Challita-Eid , Aya Jakobovits
IPC分类号： A61K38/17 , A61K39/00 , A61K39/38 , A61K39/395 , A61K48/00 , C07K14/47 , C12M1/34 , C12N15/12 , C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K14/47
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers,. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译：描述了一种新型基因（称为158P1D7）及其编码的蛋白质。虽然158P1D7在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。

22. 发明申请

US20050064445A1 Serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的蛇纹石跨膜抗原及其用途
公开(公告)号：US20050064445A1
公开(公告)日：2005-03-24
申请号：US10750262
申请日：2003-12-31
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N5/10 , C12N15/09 , C12P21/00 , C12P21/08 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two Intracellular loops. STRAP-1 protein expression Is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。这个家族中的两个蛋白质完全或主要地在前列腺中表达，也是在前列腺癌中，因此这个家族的成员被称为“前列腺的蛇纹石逆转膜抗原”。本文描述和表征了四种特定的人类STRAP。人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STRAP-1在某些其他人类癌症中高度过度表达。

23. 发明申请

US20050019870A1 Protein expressed in prostate cancer 有权
标题翻译：前列腺癌中表达的蛋白质
公开(公告)号：US20050019870A1
公开(公告)日：2005-01-27
申请号：US10936138
申请日：2004-09-07
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran
IPC分类号： A61K38/17 , C07K14/705 , G01N33/574 , A61K39/395 , C07H21/04
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/1709 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel prostate tumor associated gene (designated 24P4C12) and its encoded protein is described. 24P4C12 is highly expressed in prostate tissue xenografts, providing evidence that it is turned on in at least some prostate cancers. 24P4C12 provides a diagnostic and/or therapeutic target for prostate and other cancers.
摘要翻译：描述了一种新型前列腺肿瘤相关基因（称为24P4C12）及其编码的蛋白质。 24P4C12在前列腺组织异种移植物中高度表达，提供证据表明它在至少一些前列腺癌中被开启。 24P4C12提供了前列腺癌和其他癌症的诊断和/或治疗靶点。

24. 发明授权

US08257708B2 Antibodies against cancer antigen TMEFF2 and uses thereof 有权
标题翻译：针对癌抗原TMEFF2的抗体及其用途
公开(公告)号：US08257708B2
公开(公告)日：2012-09-04
申请号：US12892725
申请日：2010-09-28
申请人： Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
发明人： Vinay Bhaskar , Agustin De La Calle , Debbie Law , Ingrid Caras , Vanitha Ramakrishnan , Richard Murray , Daniel Afar , David Powers
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22
CPC分类号： C07K16/3069 , A61K47/6817 , A61K47/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/77
摘要： The invention relates to the identification and generation of antibodies that bind to TMEFF2 proteins which are involved in cancer. Further, the invention provides for the use of these antibodies in the treatment of cancer.
摘要翻译：本发明涉及与参与癌症的TMEFF2蛋白结合的抗体的鉴定和产生。此外，本发明提供了这些抗体在治疗癌症中的用途。

25. 发明申请

US20070270575A1 PROTEIN SHOWING ENHANCED EXPRESSION IN CANCER CELLS 有权
标题翻译：蛋白质显示癌细胞中增强的表达
公开(公告)号：US20070270575A1
公开(公告)日：2007-11-22
申请号：US11751621
申请日：2007-05-21
申请人： Aya Jakobovits , Mary Faris , Daniel Afar , Douglas Saffran , Rene Hubert , Mary Faris , Pia Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Daniel Afar , Douglas Saffran , Rene Hubert , Mary Faris , Pia Challita-Eid
IPC分类号： C07K14/00
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译：描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。

26. 发明申请

US20070148089A1 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的新型蛇纹石跨膜抗原及其用途
公开(公告)号：US20070148089A1
公开(公告)日：2007-06-28
申请号：US11542758
申请日：2006-10-03
申请人： Rene Hubert , Arthur Raitano , Douglas Saffran , Daniel Afar , Steven Mitchell , Mary Faris , Aya Jakobovits
发明人： Rene Hubert , Arthur Raitano , Douglas Saffran , Daniel Afar , Steven Mitchell , Mary Faris , Aya Jakobovits
IPC分类号： A61K51/00 , G01N33/574 , A01K67/027 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30 , C07K16/46
CPC分类号： C07K16/3069 , A61K38/00 , A61K39/00 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/28 , C07K2317/34 , C07K2319/00 , C07K2319/30 , C12Q1/6886 , C12Q2600/158 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2333/705
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两个蛋白质完全或主要地在前列腺中表达，也包括在前列腺癌中，因此该家族成员被称为“STEAP”（前列腺的六跨膜上皮抗原）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

27. 发明申请

US20070134253A1 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 审中-公开
公开(公告)号：US20070134253A1
公开(公告)日：2007-06-14
申请号：US11647988
申请日：2006-12-29
申请人： Daniel Afar , Rene Hubert , Atthur Raitano , Douglas Saffran , Stephen Mitchell
发明人： Daniel Afar , Rene Hubert , Atthur Raitano , Douglas Saffran , Stephen Mitchell
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/705 , C07K14/82 , C07K16/3038 , C07K16/3069 , C07K2317/34 , C07K2319/00 , C07K2319/30 , C12N2799/027 , G01N33/57434 , Y10S435/975
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

28. 发明申请

US20070104720A1 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
标题翻译：在人类癌症中表达的新型蛇纹石跨膜抗原及其用途
公开(公告)号：US20070104720A1
公开(公告)日：2007-05-10
申请号：US11580538
申请日：2006-10-12
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30 , C07K16/46
CPC分类号： C07K14/4748 , C07K14/705 , C07K14/723 , C07K16/28 , C07K16/3069 , C07K2317/34 , C07K2319/00 , Y10T436/143333
摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (SIX Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N— and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.
摘要翻译：描述了一种新型的细胞表面蛇纹石跨膜抗原家族。该家族中的两种蛋白质仅在或主要地在前列腺中表达，并且在前列腺癌中，因此该家族的成员被称为“STEAP”（前列腺的第六跨膜上皮原体）。本文描述和表征了四种特定的人STEAP。人类STEAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STEAP家族的原型成员STEAP-1似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。在结构上，STEAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STEAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。此外，STEAP-1在某些其他人类癌症中高度过度表达。

29. 发明申请

US20070041968A1 Methods of inducing an immune response 失效
标题翻译：诱导免疫反应的方法
公开(公告)号：US20070041968A1
公开(公告)日：2007-02-22
申请号：US11156231
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K48/00 , A61K39/395 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译：图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此，基因 2提供癌症的诊断，预后，预防和/或治疗靶点。图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。

30. 发明申请

US20050239122A1 Novel tumor antigen useful in diagnosis and therapy of prostate and colon cancer 审中-公开
标题翻译：用于诊断和治疗前列腺癌和结肠癌的新型肿瘤抗原
公开(公告)号：US20050239122A1
公开(公告)日：2005-10-27
申请号：US11147804
申请日：2005-06-07
申请人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
发明人： Daniel Afar , Rene Hubert , Kahan Leong , Arthur Raitano , Douglas Saffran , Stephen Mitchell , Aya Jakobovits , Mary Faris , Igor Vivanco
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/57419 , G01N33/57434 , G01N33/57488 , G01N2333/95
摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell membrane associated and secreted serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provided are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. The invention also provides prognostic and diagnostic methods of examining a biological sample for evidence of disregulated cellular growth by comparing the status of 20P1F12/TMPRSS2 in the biological sample to the status of 20P1F12/TMPRSS2 in a corresponding normal sample, wherein alterations in the status of 20P1F12/TMPRSS2 in the biological sample are associated with disregulated cellular growth. The invention further provides various therapeutic compositions and strategies for treating prostate cancer, including particularly, 20P1F12/TMPRSS2 polypeptide and anti-20P1F12/TMPRSS2 antibody therapy methods and compositions, cancer vaccines, and small molecule therapy.
摘要翻译：描述了衍生自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞膜相关和分泌的丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。所提供的组合物是结合20P1F12 / TMPRSS2蛋白和其多肽片段的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。本发明还提供了通过将生物样品中20P1F12 / TMPRSS2的状态与对应的正常样品中的20P1F12 / TMPRSS2的状态进行比较来检查生物样品以检测细胞生长失调的证据的预后和诊断方法，其中，生物样品中的20P1F12 / TMPRSS2与细胞生长失调有关。本发明还提供了治疗前列腺癌的各种治疗组合物和策略，特别包括20P1F12 / TMPRSS2多肽和抗-20P1F12 / TMPRSS2抗体治疗方法和组合物，癌症疫苗和小分子治疗。

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