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21. 发明授权

US08470203B2 Fabrication of polyaniline nanofiber dispersions and films 有权
标题翻译：聚苯胺纳米纤维分散体和薄膜的制备
公开(公告)号：US08470203B2
公开(公告)日：2013-06-25
申请号：US12724252
申请日：2010-03-15
申请人： Richard B. Kaner , Dan Li , Jiaxing Huang
发明人： Richard B. Kaner , Dan Li , Jiaxing Huang
IPC分类号： H01B1/00 , C08G73/00 , B05D5/12
CPC分类号： C08G73/0266 , D01D5/38 , D01D5/40 , D01F6/76
摘要： A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.
摘要翻译：用于形成稳定的聚苯胺纳米纤维胶体的新方法使用静电排斥来保持纳米纤维的分散并防止在纳米纤维合成期间的聚集。胶体悬浮液直接由溶液中的反应物形成，保持在约1.0至约4.0的pH和约10℃至约100℃的温度，同时最小或不搅拌。还阐述了通过自组装形成聚苯胺纳米纤维超薄膜的新方法。

22. 发明申请

US20130138004A1 OFF-LINE SENSING METHOD AND ITS APPLICATIONS IN DETECTING UNDERSENSING, OVERSENSING, AND NOISE 有权
标题翻译：离线感测方法及其在检测过程中的应用，监测和噪声
公开(公告)号：US20130138004A1
公开(公告)日：2013-05-30
申请号：US13483387
申请日：2012-05-30
申请人： Yanting Dong , Shijie Zhang , Deepa Mahajan , Chenguang Liu , Dan Li , Yayun Lin , Derek D. Bohn
发明人： Yanting Dong , Shijie Zhang , Deepa Mahajan , Chenguang Liu , Dan Li , Yayun Lin , Derek D. Bohn
IPC分类号： A61B5/04 , A61N1/39
CPC分类号： A61B5/04012 , A61B5/0245 , A61B5/042 , A61B5/0452 , A61B5/7217 , A61N1/3704 , A61N1/3937
摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.
摘要翻译：一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。多遍处理确定心电图的至少第一个通道的位置。然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

23. 发明授权

US08447390B2 Detecting hemodynamic stability during arrhythmia using the changes in atrial activation 有权
公开(公告)号：US08447390B2
公开(公告)日：2013-05-21
申请号：US13650376
申请日：2012-10-12
申请人： Dan Li , Arjun D. Sharma
发明人： Dan Li , Arjun D. Sharma
IPC分类号： A61B5/0464
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3962
摘要： Detected changes in atrial activation can be used to discriminate between hemodynamically stable and hemodynamically unstable tachyarrhythmias.

24. 发明授权

US08412325B2 High-energy anti-tachycardia therapy 有权
标题翻译：高能抗心动过速治疗
公开(公告)号：US08412325B2
公开(公告)日：2013-04-02
申请号：US12419074
申请日：2009-04-06
申请人： Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Dan Li
发明人： Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Dan Li
IPC分类号： A61N1/362
CPC分类号： A61N1/3621 , A61N1/3906
摘要： Embodiments of the invention are related to medical devices and methods for delivery high-energy anti-tachycardia therapy to a subject, amongst other things. In an embodiment, the invention includes a medical device including a controller module configured to administer a plurality of electrical pulses to a patient in response to a detected tachycardia, the electrical pulses comprising an amplitude of greater than 3 Volts and less than 40 Volts, the controller configured to modulate the amplitude of the electrical pulses. In an embodiment, the invention includes a method of treating a tachyarrhythmia including administering a first series of electrical pulses to a patient with an implantable medical device, the electrical pulses including an amplitude of greater than 8 Volts and less than 40 Volts, the first series of electrical pulses having an interval of less than about 600 ms in between individual pulses. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及用于向对象递送高能抗心动过速疗法的医疗装置和方法。在一个实施例中，本发明包括医疗装置，其包括控制器模块，其被配置为响应于检测到的心动过速向患者施加多个电脉冲，所述电脉冲包括大于3伏且小于40伏的振幅，控制器被配置为调制电脉冲的幅度。在一个实施方案中，本发明包括治疗快速性心律失常的方法，包括用可植入医疗装置向患者施用第一系列电脉冲，所述电脉冲包括大于8伏且小于40伏特的振幅，第一系列在各个脉冲之间具有小于约600ms的间隔的电脉冲。本文还包括其它实施例。

25. 发明授权

US08401628B2 Sensing vector configuration in ICD to assist arrhythmia detection and annotation 有权
标题翻译：感应ICD中的矢量配置，以协助心律失常检测和注释
公开(公告)号：US08401628B2
公开(公告)日：2013-03-19
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/024
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译：一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，其通信耦合到心脏信号感测电路。所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

26. 发明申请

US20120296383A1 METHOD AND DEVICE FOR PROVIDING ANTI-TACHYARRHYTHMIA THERAPY 审中-公开
标题翻译：用于提供抗TACHYARRHYTHMIA治疗的方法和装置
公开(公告)号：US20120296383A1
公开(公告)日：2012-11-22
申请号：US13569208
申请日：2012-08-08
申请人： Dan Li
发明人： Dan Li
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3605 , A61N1/36114 , A61N1/36564 , A61N1/3962
摘要： Various system embodiments comprise at least one sensor input adapted to receive at least one sensed signal associated with a tachyarrhythmia, a feature set extractor adapted to extract at least two features from the at least one sensed signal associated with the tachyarrhythmia, a feature set generator adapted to form a feature set using the at least two features extracted by the feature set extractor, at least one generator adapted for use to selectively apply an anti-tachycardia pacing (ATP) therapy and a neural stimulation (NS) therapy, and a controller adapted to respond to the feature set. The controller is adapted to initiate the NS therapy when the feature set corresponds to criteria for applying the NS therapy to modify the tachyarrhythmia, and initiate the ATP therapy to terminate the modified tachyarrhythmia. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于接收与快速性心律失常相关联的至少一个感测信号的至少一个传感器输入，适于从与快速性心律失常相关联的至少一个感测信号中提取至少两个特征的特征集提取器，适于以使用由所述特征集提取器提取的所述至少两个特征来形成特征集合，适于用于选择性地应用抗心动过速起搏（ATP）治疗和神经刺激（NS）治疗）的至少一个发生器，以及适于以响应功能集。当特征集合对应于应用NS治疗来修改快速性心律失常的标准时，控制器适于启动NS治疗，并且启动ATP治疗以终止改变的快速性心律失常。本文提供了其它方面和实施例。

27. 发明授权

US08301267B2 Method and apparatus for sensing mechanical energy of an implantable lead 有权
标题翻译：用于感测可植入引线的机械能的方法和装置
公开(公告)号：US08301267B2
公开(公告)日：2012-10-30
申请号：US12876426
申请日：2010-09-07
申请人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
发明人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
IPC分类号： A61N1/05
CPC分类号： A61B5/02158 , A61B5/02133 , A61B5/02405 , A61N1/36514 , A61N1/36578
摘要： An apparatus comprises an implantable sensor and a signal analyzer circuit communicatively coupled to the implantable sensor. The implantable sensor is configured for coupling to an implantable lead and the implantable sensor provides an electrical vibration sensor signal representative of mechanical vibration of the implantable lead. The signal analyzer circuit is configured to determine a baseline of the vibration sensor signal, detect a change in the vibration sensor signal from the baseline vibration sensor signal, and provide an indication of the change to a user or process.
摘要翻译：一种装置包括可植入传感器和通信地耦合到可植入传感器的信号分析器电路。可植入传感器被配置为联接到可植入引线，并且可植入传感器提供表示可植入引线的机械振动的电振动传感器信号。信号分析器电路被配置为确定振动传感器信号的基线，从基线振动传感器信号检测振动传感器信号的变化，并且向用户或过程提供变化的指示。

28. 发明授权

US08255049B2 Method and device for providing anti-tachyarrhythmia therapy 有权
标题翻译：提供抗快速性心律失常治疗的方法和装置
公开(公告)号：US08255049B2
公开(公告)日：2012-08-28
申请号：US11382120
申请日：2006-05-08
申请人： Dan Li
发明人： Dan Li
IPC分类号： A61N1/372
CPC分类号： A61N1/3621 , A61N1/3605 , A61N1/36114 , A61N1/36564 , A61N1/3962
摘要： Various system embodiments comprise at least one sensor input adapted to receive at least one sensed signal associated with a tachyarrhythmia, a feature set extractor adapted to extract at least two features from the at least one sensed signal associated with the tachyarrhythmia, a feature set generator adapted to form a feature set using the at least two features extracted by the feature set extractor, at least one generator adapted for use to selectively apply an anti-tachycardia pacing (ATP) therapy and a neural stimulation (NS) therapy, and a controller adapted to respond to the feature set. The controller is adapted to initiate the NS therapy when the feature set corresponds to criteria for applying the NS therapy to modify the tachyarrhythmia, and initiate the ATP therapy to terminate the modified tachyarrhythmia. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括适于接收与快速性心律失常相关联的至少一个感测信号的至少一个传感器输入，适于从与快速性心律失常相关联的至少一个感测信号中提取至少两个特征的特征集提取器，适于以使用由所述特征集提取器提取的所述至少两个特征来形成特征集合，适于用于选择性地应用抗心动过速起搏（ATP）治疗和神经刺激（NS）治疗）的至少一个发生器，以及适于以响应功能集。当特征集合对应于应用NS治疗来修改快速性心律失常的标准时，控制器适于启动NS治疗，并且启动ATP治疗以终止改变的快速性心律失常。本文提供了其它方面和实施例。

29. 发明授权

US08239011B2 Atrial arrhythmia detection and discrimination based on intracardiac impedance 有权
标题翻译：基于心内阻力的房性心律失常检测和鉴别
公开(公告)号：US08239011B2
公开(公告)日：2012-08-07
申请号：US12757125
申请日：2010-04-09
申请人： Dan Li
发明人： Dan Li
IPC分类号： A61B5/02
CPC分类号： A61B5/0464 , A61B5/6846 , A61B5/7264
摘要： An apparatus comprises an implantable impedance sensing circuit configured to sense an atrial impedance signal when coupled to a plurality of implantable electrodes, and an impedance signal analyzer circuit configured to detect a sudden change in a characteristic of the sensed atrial impedance signal that indicates atrial tachyarrhythmia. The impedance signal analyzer circuit classifies the atrial tachyarrhythmia indication as ST when the detected sudden change satisfies an ST threshold value of the characteristic, classifies the atrial tachyarrhythmia indication as AT when the detected sudden change satisfies an AT threshold value of the characteristic that is different from the ST threshold value, classifies the atrial tachyarrhythmia indication as AF when the detected sudden change satisfies an AF threshold value of the characteristic that is different from the ST and AT amplitude threshold values, and provides a classification of the tachyarrhythmia to a user or process.
摘要翻译：一种装置包括可植入阻抗感测电路，其配置成当耦合到多个可植入电极时感测心房阻抗信号，以及阻抗信号分析器电路，被配置为检测所述感测的心房阻抗信号的特征突然变化，其指示房性快速性心律失常。阻抗信号分析仪电路将检测到的突发性变化满足特征的ST阈值时，将房性快速性心律失常指示分类为ST，当检测到的突变变得满足不同于特征的特征的AT阈值时，将心房快速性心律失常指示分类为AT ST阈值，当检测到的突然变化满足与ST和AT振幅阈值不同的特征的AF阈值时，将心房快速性心律失常指示分类为AF，并且向用户或过程提供快速性心律失常的分类。

30. 发明授权

US08103963B2 Graphical user interface, display control device, display method, and program 有权
标题翻译：图形用户界面，显示控制设备，显示方式和程序
公开(公告)号：US08103963B2
公开(公告)日：2012-01-24
申请号：US12191640
申请日：2008-08-14
申请人： Takuo Ikeda , Hidenori Karasawa , Kazuto Mugura , Mayu Irimajiri , Shinji Kimura , Yoshiyasu Kubota , Takashi Kitao , Shogo Sato , Dan Li
发明人： Takuo Ikeda , Hidenori Karasawa , Kazuto Mugura , Mayu Irimajiri , Shinji Kimura , Yoshiyasu Kubota , Takashi Kitao , Shogo Sato , Dan Li
IPC分类号： G06F3/048 , G06F7/00
CPC分类号： G09G5/14 , G09G2340/12 , G09G2340/145 , H04M1/72552 , H04M1/72566 , H04M1/72586 , H04M2250/60
摘要： There is provided a graphical user interface that is displayed within one screen of a display device. The graphical user interface includes a matrix-shaped display area that is partitioned along a first axis by types of content and partitioned along a second axis by units of time. Items of information on the content that is processed within a specified unit of time are displayed within the matrix-shaped display area, closed together along the second axis.
摘要翻译：提供了在显示设备的一个屏幕内显示的图形用户界面。图形用户界面包括按照内容类型沿着第一轴分割的矩阵状显示区域，并且沿着第二轴以时间为单位分割。在规定时间内处理的内容的信息项显示在矩形显示区域内，沿着第二轴关闭在一起。

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