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21. 发明申请

US20050123536A1 Treatment of immunological disorders using anti-dc30 antibodies 审中-公开
标题翻译：使用抗dc30抗体治疗免疫疾病
公开(公告)号：US20050123536A1
公开(公告)日：2005-06-09
申请号：US10496628
申请日：2002-11-20
申请人： Che-Leung Law , Kerry Klussman , Alan Wahl , Peter Senter , Svetlana Doronina , Brian Toki
发明人： Che-Leung Law , Kerry Klussman , Alan Wahl , Peter Senter , Svetlana Doronina , Brian Toki
IPC分类号： A61K48/00 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K47/48 , A61P1/16 , A61P5/14 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/14 , A61P27/16 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/39541 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/24 , C07K2317/31 , C07K2317/565 , A61K2300/00
摘要： The present invention relates to methods for the treatment of immunological disorders other than cancer, comprising administering proteins characterized by their ability to bind to CD30 and exert a cytostatic or cytotoxic effect on an activated lymphocyte. Such proteins include monoclonal antibodies AC10 and IleFi1. AC10 and HeFi-1 derivatives, and antibodies that compete with AC10 and HeFi-1 for binding to CD30. Other such proteins include multivalent anti-CD30 antibodies and anti-CD30 antibodies conjugated to cytotoxic agents. Treatment modalities with antibodies of the invention are also provided.
摘要翻译：本发明涉及用于治疗除癌症以外的免疫学疾病的方法，其包括施用以其结合CD30的能力为特征的蛋白质，并对活化的淋巴细胞施加细胞抑制或细胞毒性作用。这些蛋白质包括单克隆抗体AC10和IleFi1。 AC10和HeFi-1衍生物，以及与AC10和HeFi-1竞争结合CD30的抗体。其他这样的蛋白质包括多价抗CD30抗体和与细胞毒性剂缀合的抗-CD30抗体。还提供了与本发明的抗体的治疗方式。

22. 发明申请

US20100158910A1 TREATMENT OF RENAL CELL CARCINOMA WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES 有权
标题翻译：用抗CD70抗体药物联合治疗肾细胞癌
公开(公告)号：US20100158910A1
公开(公告)日：2010-06-24
申请号：US12635607
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。

23. 发明申请

US20050261478A1 Compositions and methods for regulating lymphocyte activation 审中-公开
标题翻译：用于调节淋巴细胞活化的组合物和方法
公开(公告)号：US20050261478A1
公开(公告)日：2005-11-24
申请号：US11128440
申请日：2005-05-12
申请人： Jeffrey Ledbetter , Martha Hayden Ledbetter , William Brady , Laura Grosmaire , Che-Leung Law , Raj Dua
发明人： Jeffrey Ledbetter , Martha Hayden Ledbetter , William Brady , Laura Grosmaire , Che-Leung Law , Raj Dua
IPC分类号： C12N15/09 , A61K38/00 , A61P37/02 , C07K14/47 , C07K14/705 , C07K14/725 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N5/06 , C12N5/10
CPC分类号： C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2818 , C07K16/2878 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2319/00
摘要： The present invention relates to regulation of lymphocyte activation. In particular, it relates to compositions and methods for regulating lymphocyte activation by selectively binding multiple cell surface antigens expressed by the same lymphocyte.
摘要翻译：本发明涉及淋巴细胞活化的调节。特别地，本发明涉及通过选择性结合由相同淋巴细胞表达的多种细胞表面抗原来调节淋巴细胞活化的组合物和方法。

24. 发明申请

US20130209496A1 Synergistic Effects Between Auristatin-Based Antibody Drug Conjugates And Inhibitors Of The PI3K-AKT mTOR Pathway 有权
标题翻译：基于Auristatin的抗体药物结合物和PI3K-AKT mTOR通路抑制剂的协同效应
公开(公告)号：US20130209496A1
公开(公告)日：2013-08-15
申请号：US13879012
申请日：2011-10-20
申请人： Timothy S. Lewis , Che-Leung Law , Julie A. McEarchern
发明人： Timothy S. Lewis , Che-Leung Law , Julie A. McEarchern
IPC分类号： A61K47/48 , A61K31/4745 , A61K31/5377 , A61K31/4375 , A61K31/498 , A61K31/436 , A61K31/519
CPC分类号： A61K47/48561 , A61K31/436 , A61K31/4375 , A61K31/4745 , A61K31/498 , A61K31/519 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/48415 , A61K47/4863 , A61K47/6811 , A61K47/6849 , A61K47/6867
摘要： The present invention is directed to methods for treating cancer comprising administering to a subject in need thereof an auristatin-based antibody drug conjugate and an inhibitor of the PI3K-AKT-mTOR pathway.
摘要翻译：本发明涉及用于治疗癌症的方法，包括向有需要的受试者施用基于阿司他丁的抗体药物缀合物和PI3K-AKT-mTOR途径的抑制剂。

25. 发明申请

US20050180972A1 Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders 审中-公开
标题翻译：抗CD20抗体 - 药物共轭物，用于治疗癌症和免疫疾病
公开(公告)号：US20050180972A1
公开(公告)日：2005-08-18
申请号：US10632151
申请日：2003-07-30
申请人： Alan Wahl , Peter Senter , Che-Leung Law , Charles Cerveny
发明人： Alan Wahl , Peter Senter , Che-Leung Law , Charles Cerveny
IPC分类号： A61K39/395 , A61K47/48 , C07K16/46
CPC分类号： A61K47/6851 , A61K47/6849
摘要： The present invention relates to methods and compositions for the treatment of CD20-expressing cancers and immune disorders involving CD20-expressing cells. The present methods comprise administering to a subject an anti CD20 antibody-drug conjugate that has a high potency and/or is capable of internalizing into CD20-expressing cells. The present invention further provides pharmaceutical compositions and kits comprising such conjugates. The present invention yet further provides methods of and compositions relating to combination therapy of cancer and immune disorders involving CD20-expressing cells using the anti-CD20 antibody-drug conjugates of the invention.
摘要翻译：本发明涉及用于治疗表达CD20的癌症和涉及CD20表达细胞的免疫疾病的方法和组合物。本发明的方法包括向受试者施用具有高效力和/或能够内化成CD20表达细胞的抗CD20抗体 - 药物偶联物。本发明还提供了包含这种缀合物的药物组合物和试剂盒。本发明还进一步提供了使用本发明的抗CD20抗体 - 药物共轭物的癌症和涉及CD20表达细胞的免疫疾病的组合疗法的方法和组合物。

26. 发明授权

US09345785B2 Treatment of renal cell carcinoma with anti-CD70 antibody-drug conjugates 有权
标题翻译：用抗CD70抗体 - 药物偶联物治疗肾细胞癌
公开(公告)号：US09345785B2
公开(公告)日：2016-05-24
申请号：US12635607
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , C07K16/28
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达癌症的CD70的方法，包括向受试者施用所公开的药物组合物。

27. 发明申请

US20120288512A1 Anti-CD70 Antibody-Drug Conjugates and Their Use for the Treatment of Cancer and Immune Disorders 有权
标题翻译：抗CD70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途
公开(公告)号：US20120288512A1
公开(公告)日：2012-11-15
申请号：US13485536
申请日：2012-05-31
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/44 , A61P29/00 , A61P31/06 , A61P17/06 , A61P5/16 , A61P1/16 , A61P37/06 , A61P25/00
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

28. 发明申请

US20100150925A1 TREATMENT OF B-CELL CANCERS WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES 审中-公开
标题翻译：用抗CD70抗体药物联合治疗B细胞癌
公开(公告)号：US20100150925A1
公开(公告)日：2010-06-17
申请号：US12635571
申请日：2009-12-10
申请人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
发明人： Che-Leung Law , Alan F. Wahl , Nathalie Scholler , Linda A. Pestano
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体和抗体衍生物 - 药物偶联物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症的方法，包括向受试者施用所公开的药物组合物。

29. 发明申请

US20060233794A1 Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders 有权
标题翻译：抗cd70抗体 - 药物偶联物及其用于治疗癌症和免疫疾病的用途
公开(公告)号：US20060233794A1
公开(公告)日：2006-10-19
申请号：US10546304
申请日：2004-02-20
申请人： Che-Leung Law , Alan Wahl , Nathalie Scholler , Linda Pestano
发明人： Che-Leung Law , Alan Wahl , Nathalie Scholler , Linda Pestano
IPC分类号： A61K39/395
CPC分类号： A61K47/48561 , A61K47/65 , A61K47/6803 , A61K47/6849 , A61K49/0041 , A61K49/0058 , C07K16/2875 , C07K2317/56 , C07K2317/565
摘要： Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
摘要翻译：公开了与细胞毒性，免疫抑制或其它治疗剂缀合的抗CD70抗体及其衍生物，以及包含抗体 - 和抗体衍生物 - 药物共轭物的药物组合物和试剂盒。还公开了用于治疗表达CD70的癌症和免疫学疾病的方法，包括向受试者施用所公开的药物组合物。

30. 发明申请

US20060121476A1 Cancer associated antigens, sga-56m and sga-56mv, and uses thereof 审中-公开
标题翻译：癌症相关抗原，sga-56m和sga-56mv及其用途
公开(公告)号：US20060121476A1
公开(公告)日：2006-06-08
申请号：US10527572
申请日：2003-09-12
申请人： Joseph Petroziello , Che-Leung Law , Andrew Yamane , Alan Wahl
发明人： Joseph Petroziello , Che-Leung Law , Andrew Yamane , Alan Wahl
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57415 , C07K14/4748
摘要： The present invention relates to nucleic and amino acid sequences of SGA-56M and variants thereof. An exemplary variant of SGA-56M is SGA-56Mv. SGA-56M and SGA-56Mv are differentially expressed in cancer tissues and transformed cell lines. In particular, these genes are expressed at elevated levels in breast cancer and lung cancer tissues and cell lines. The present invention is also directed to methods for diagnosing a cancer in a subject, determining the prognosis of a cancer patient, and/or monitoring the efficacy of a treatment regimen for a cancer patient. The present invention further provides methods for screening and identifying modulators (e.g., antagonists or agonists) of SGA-56M and/or SGA-56Mv expression and/or activity. Antagonists identified using the methods of the invention are useful for the treatment of cancer patients. Also encompassed by the present invention are compositions including nucleic and/or amino acid sequences of SGA-56M and SGA-56Mv or SGA-56M/SGA-56Mv modulators and a pharmaceutically acceptable carrier. Such compositions may be used to advantage to treat a subject with a cancer to ameliorate the symptoms of the cancer or reduce the cancer cell burden in the subject. These compositions may also be utilized to prevent or delay the onset of a cancer in a subject exhibiting a predisposition to developing a cancer.
摘要翻译：本发明涉及SGA-56M的核酸和氨基酸序列及其变体。 SGA-56M的示例性变体是SGA-56Mv。 SGA-56M和SGA-56Mv在癌组织和转化细胞系中差异表达。特别地，这些基因在乳腺癌和肺癌组织和细胞系中以升高的水平表达。本发明还涉及用于诊断受试者中的癌症的方法，确定癌症患者的预后和/或监测癌症患者的治疗方案的功效。本发明还提供筛选和鉴定SGA-56M和/或SGA-56Mv表达和/或活性的调节剂（例如拮抗剂或激动剂）的方法。使用本发明方法鉴定的拮抗剂可用于治疗癌症患者。本发明还包括包含SGA-56M和SGA-56Mv或SGA-56M / SGA-56Mv调节剂的核酸和/或氨基酸序列和药学上可接受的载体的组合物。这样的组合物可用于治疗患有癌症的受试者以改善癌症的症状或降低受试者的癌细胞负担。也可以利用这些组合物来预防或延迟患有发展为癌症倾向的受试者的癌症的发作。

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