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21. 发明申请

WO0156500A2 IMPLANTABLE VASCULAR DEVICE 审中-公开
标题翻译：可植入血管装置
公开(公告)号：WO0156500A2
公开(公告)日：2001-08-09
申请号：PCT/US0103766
申请日：2001-02-05
申请人： COOK INC
发明人： PAVCNIK DUSAN , KELLER FREDERICK S , ROSCH JOSEF , OSBORNE THOMAS A , BATES BRIAN L , DEFORD JOHN A , DIXON CHRISTOPHER G , HOFFA ANDREW K , LEONARD RAYMOND B II , OBERMILLER JOSEPH F
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01 , A61F2/06 , A61F2/24 , A61L27/00
CPC分类号： A61B17/12022 , A61B17/12172 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/005 , A61F2230/0058 , A61F2230/0095
摘要： A multiple-sided medical device (10) comprises a frame (11) comprising wire or other resilient material and having a series of bends (12) and interconnecting sides. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs (16) for anchoring purposes. A full or partial covering (45) of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device (51), a stent graft (75), or an implantable, intraluminal valve (43) such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置（10）包括包括线或其它弹性材料并具有一系列弯曲部（12）和互连侧的框架（11）。将装置从输送导管推入管道或容器的内腔，并且可以包括用于锚固目的的一个或多个倒钩（16）。织物或其他柔性材料如DACRON，PTFE或胶原基材料如小肠粘膜下层（SIS）的全部或部分覆盖物（45）可以被缝合或附着到框架上以形成闭塞装置（51 ），支架移植物（75）或可植入的管腔内阀（43），例如用于矫正小腿和脚部的无能力的静脉。

22. 发明申请

WO9933515A3 APPARATUS FOR SUPPLYING RADIOACTIVE GAS TO A DELIVERY DEVICE 审中-公开
标题翻译：将放射性气体供应给送货装置的装置
公开(公告)号：WO9933515A3
公开(公告)日：1999-09-16
申请号：PCT/US9825129
申请日：1998-12-01
申请人： COOK INC , MED INST INC , APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10 , A61M36/06
CPC分类号： A61M25/10182 , A61M25/10185 , A61N5/1002 , A61N2005/1021
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).
摘要翻译：公开了一种填充有诸如惰性放射性气体的辐射载体材料用于治疗血管成形术后的再狭窄的导管装置和恶性肿瘤。膨胀的导管包括单个单元或者可替换地，用于运输放射性载体材料的多个离散室，并且血液可以在用规定的辐射治疗期间继续流动。当放射性载体是诸如氙133的气体时，可以使用注射装置（1400），其允许使用可装载到放射源小瓶外壳或室（1403）中的标准放射性气体源小瓶（1401）。用于封闭小瓶（1404）的装置还可以用作推动机构（1442），以将源小瓶（1401）推向一个或多个允许将放射性气体输送到导管的刺穿套管（1406,1454）。在一系列实施例中，放射性气体通过诸如多位置阀的选择器装置（1409）被抽出到诸如注射器的气密可变容积腔室（1411）中，然后将其放置以将气体输送到导管。在处理之后，将气体取出到注射器中并返回到源小瓶（1401）。在另一系列实施例中，使用填充有液体的注射器将气体直接置换到输送导管（1422）中，或者进入将气体注射到输送导管（1422）的第二注射器中。

23. 发明专利

ES2229490T3 INJERTO ENDOVASCULAR PARA REPARAR ANEURISMAS AORTICOS ABDOMINALES. 未知
公开(公告)号：ES2229490T3
公开(公告)日：2005-04-16
申请号：ES98918112
申请日：1998-04-09
申请人： COOK INC , WILLIAM COOK EUROPE AS
发明人： PAPAZOGLOU KONSTANTINOS , DEBRUYNE MICHAEL P , DEFORD JOHN A , RASMUSSEN ERIK E
IPC分类号： A61F2/07 , A61F2/06 , A61F2/848 , A61F2/89
摘要： La invención se refiere a un tipo de dispositivo dirigido al posicionamiento endovascular, de forma más simple que las técnicas ya existentes, de un extensor en la aorta abdominal, justo en su punto de bifurcación (26).

24. 发明专利

DK0971646T3 未知
公开(公告)号：DK0971646T3
公开(公告)日：2005-01-17
申请号：DK98918112
申请日：1998-04-09
申请人： COOK INC , WILLIAM COOK EUROPE AS
发明人： PAPAZOGLOU KONSTANTINOS , DEBRUYNE MICHAEL P , DEFORD JOHN A , RASMUSSEN ERIK E
IPC分类号： A61F2/07 , A61F2/06 , A61F2/848 , A61F2/89
摘要： This is regarding a type of device aimed at a simpler, in relation to already existing techniques, endovascular positioning of a stent-graft in the abdominal aorta for the therapy of aneurysms up to the point of its bifurcation (26). This device is comprised of a system of three cylinders: a "main" (1) centrally placed and two "limbs" (4, 5) peripherally placed. Each of these cylinders has a central (14, 9, 8) and a peripheral (12, 10, 11) orifice. The cylinders are comprised of a cylindrical metallic skeleton which is self-expanding (2, 7) and made out of stainless steel or nitinol and which is externally covered with a cylinder (3, 8) made out of thin-layered PTFE, Dacron or some other elastic biocompatible material, refolded (18) around the peripheral orifice (12) of the skeleton of the main cylinder. These cylinders can be compressed into small diameter tubules (23, 27, 38) and enter the vascular lumen. After their insertion into the desired position, they expand, regaining their original diameter. The main cylinder (1) is placed inside the aorta becoming more circular when it comes in contact with the healthy part of the aorta (13) central to the aneurysm at the center of the orifice (14). The peripheral orifice of the main cylinder sits upon the expanded aortic bifurcation (26). The two limbs have a central orifice (8, 9) with a diameter equal to or approximately about 2 mm smaller than the diameter of the peripheral orifice (12) of the main cylinder. The branching of the main cylinder is accomplished by the entrance of the main ends of the two limbs inside the peripheral end of the main cylinder. Both limbs are at the same height in such a manner that they compress each other at the center of the cylinder. Each limb exerts equal pressure, whereas equal pressure is also exerted on the internal surface of the main cylinder from their external surface (FIG. 5) and together they both occupy at the height of their orifices the entire perimeter of the main cylinder (43). Alternatively, as limbs (peripheral cylinders), tubes of different diameters and types of skeletons can be used (28, 27).

25. 发明专利

AU738093B2 Medical radiation treatment delivery apparatus 未知
公开(公告)号：AU738093B2
公开(公告)日：2001-09-06
申请号：AU9479898
申请日：1998-09-11
申请人： COOK INC , MED INST INC , MARC G APPLE
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

26. 发明专利

AU1604099A Apparatus for supplying radioactive gas to a delivery device 未知
公开(公告)号：AU1604099A
公开(公告)日：1999-07-19
申请号：AU1604099
申请日：1998-12-01
申请人： COOK INC , MED INSTITUTE INC
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E , PURDY JAMES D
IPC分类号： A61M36/04 , A61F2/958 , A61M36/12 , A61N5/10
摘要： Disclosed is a catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a single unit or alternatively, a plurality of discrete chambers for transporting the radioactive carrier material and through which, blood may continue to flow during treatment with the prescribed radiation. When the radioactive carrier is a gas such as Xenon 133, an injection apparatus (1400) may be used that permits use of a standard radioactive gas source vial (1401) that may be loaded into the radioactive source vial enclosure or chamber (1403). The means for enclosing the vial (1404) may also serve as an urging mechanism (1442) to urge the source vial (1401) toward one or more piercing cannulae (1406, 1454) which permit delivery of the radioactive gas to the catheter. In one series of embodiments, the radioactive gas is withdrawn through a selector means (1409) such as a multiple position valve into a gas-tight variable volume chamber (1411) such as a syringe which then is deployed to deliver the gas into the catheter. Following treatment, the gas is withdrawn into the syringe and returned to the source vial (1401). In another series of embodiments a syringe filled with a liquid is used to displace the gas either directly into the delivery catheter (1422), or into a second syringe which injects the gas to the delivery catheter (1422).

27. 发明专利

AU9479898A Medical radiation treatment delivery apparatus 未知
公开(公告)号：AU9479898A
公开(公告)日：1999-03-29
申请号：AU9479898
申请日：1998-09-11
申请人： APPLE MARC G , COOK INC , MED INSTITUTE INC
发明人： APPLE MARC G , BATES BRIAN L , DEFORD JOHN A , FEARNOT NEAL E
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

28. 发明专利

CA2303193A1 MEDICAL RADIATION TREATMENT DELIVERY APPARATUS 未知
公开(公告)号：CA2303193A1
公开(公告)日：1999-03-18
申请号：CA2303193
申请日：1998-09-11
申请人： COOK INC , APPLE MARC G , MED INST INC
发明人： APPLE MARC G , DEFORD JOHN A , BATES BRIAN L , FEARNOT NEAL E
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons travelling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.

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