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21. 发明专利

ES2053578T3 未知
公开(公告)号：ES2053578T3
公开(公告)日：1994-08-01
申请号：ES87810045
申请日：1987-01-26
申请人： CIBA GEIGY AG
发明人： BENCZE WILLIAM DR , FROSTL WOLFGANG DR , WILHELM MAX DR
IPC分类号： C07D207/27 , A61K31/40 , A61K31/495 , A61P25/28 , C07D207/26 , C07D403/06
摘要： Substituted pyrrolidin-2-ones of the formula (I) wherein R1 represents a phenyl or naphthyl radical that is unsubstituted or substituted by lower alkyl, lower alkloxy, halogen and/or trifluoromethyl, X1 represents lower alkylidene, X2 represents methylene, ethylene or oxoethylene and R2 represents hydrogen, lower alkyl or a radical of the formula (Ia) wherein X4 represents lower alkylidene and R3 represents hydrogen or a phenyl or a phenyl naphthyl radical that is unsubstituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl, and their pharmaceutically acceptable salts, have nootropic properties and can be used as nootropic active ingredients in medicaments. They are prepared, for example, by condensing with one another compounds of the formulae (II) and (III) wherein Z1 represents a group of the formula -X1-(=O)-Z3 (IIa) and Z2 represents hydrogen, or Z1 represents hydrogen and Z2 represents a group of the formula -C(=O) -X1-Z4 (IIIa), wherein each of Z3 and Z4 represents a removable radical and R2' represnts a radical R2 or amino-protecting group, or their salts, and removing an amino-protecting R2' which may be present.

23. 发明专利

DE2341376A1 1-(3-Aryloxy-2-hydroxypropyl)-4-acylaminopiperidines - with antihyper-tensive, anti-tachycardia and alpha-sympatholytic activity 未知
公开(公告)号：DE2341376A1
公开(公告)日：1974-03-07
申请号：DE2341376
申请日：1973-08-16
申请人： CIBA GEIGY AG
发明人： EICHENBERGER KURT DR , OSTERMAYER FRANZ DR , SCHROETER HERBERT DR , WILHELM MAX DR
IPC分类号： C07D211/58 , C07D29/30
摘要： Cpds. of formula (I): (where R1 is opt. substd. aryl, R2 is H or lower alkyl; R3 is free or substd. OH; R4 is H or lower alkyl; n = 1-4; R5 is acyl) are prepd. by (a) reacting a cpd. (II): with R1OQ (where one of P and Q is CH2CHXCH2Z and the other is H; X is free or substd. OH and Z is a reactive ester gp., or X+Z is epoxy); by reducing the corresp. cpd. where CHR3 is replaced by C=O; (c) reducing the corresp. pyridinium cpd.; or (d) acylating (I; R5=H).

26. 发明专利

CH529722A Verfahren zur Herstellung von neuen 1-(sek.-Amino)-2-hydroxy-3-(aryloxy)-propanen 未知
公开(公告)号：CH529722A
公开(公告)日：1972-10-31
申请号：CH146971
申请日：1969-04-03
申请人： CIBA GEIGY AG
发明人： WILHELM MAX DR
IPC分类号： C07D263/06 , C07C93/02

27. 发明专利

CH513802A Verfahren zur Herstellung von neuen Aminen 未知
公开(公告)号：CH513802A
公开(公告)日：1971-10-15
申请号：CH1858870
申请日：1969-01-03
申请人： CIBA GEIGY AG
发明人： WILHELM MAX DR
IPC分类号： C07C211/61 , A47C3/18 , C07C15/28 , C07C211/31 , C07C213/06 , C07C213/08 , C07C217/58 , C07C85/14 , C07C87/28

28. 发明专利

CH513801A Verfahren zur Herstellung von neuen Aminen 未知
公开(公告)号：CH513801A
公开(公告)日：1971-10-15
申请号：CH1858770
申请日：1969-01-03
申请人： CIBA GEIGY AG
发明人： WILHELM MAX DR
IPC分类号： C07C211/61 , A47C3/18 , C07C15/28 , C07C211/31 , C07C213/06 , C07C213/08 , C07C217/58 , C07C85/12 , C07C87/28

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