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21. 发明申请

US20100121214A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于内分泌压力和患者运动的癫痫病症评估
公开(公告)号：US20100121214A1
公开(公告)日：2010-05-13
申请号：US12359055
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0476 , A61B5/03 , A61B5/11 , A61B5/053
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压，以评估癫痫发作障碍。在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间发生癫痫发作。除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

22. 发明申请

US20100010384A1 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 有权
标题翻译：使用可选择的系统控制参数进行姿态检测
公开(公告)号：US20100010384A1
公开(公告)日：2010-01-14
申请号：US12433029
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61B5/103
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动相关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以以可选择的方式处理一个或多个感测信号。该可选择方式可以基于描述患者以前被分类的姿势状态的当前姿势状态数据。或者或另外，该当前姿势状态数据可以描述先前由患者进行的姿势状态转换。然后可以将如此处理的一个或多个信号用于对患者的姿势状态进行分类。

23. 发明授权

US08688225B2 Posture state detection using selectable system control parameters 有权
标题翻译：姿态检测采用可选择的系统控制参数
公开(公告)号：US08688225B2
公开(公告)日：2014-04-01
申请号：US12433029
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61N1/00
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动相关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以以可选择的方式处理一个或多个感测信号。该可选择方式可以基于描述患者以前被分类的姿势状态的当前姿势状态数据。或者或另外，该当前姿势状态数据可以描述先前由患者进行的姿势状态转换。然后可以将如此处理的一个或多个信号用于对患者的姿势状态进行分类。

24. 发明授权

US08565864B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08565864B2
公开(公告)日：2013-10-22
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

25. 发明授权

US08515549B2 Associating therapy adjustments with intended patient posture states 有权
标题翻译：将治疗调整与预期的患者姿势状态相关联
公开(公告)号：US08515549B2
公开(公告)日：2013-08-20
申请号：US12433756
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61B5/00 , A61B5/02 , A61B5/103 , A61B5/11 , A61N1/00 , A61N1/05 , A61N1/372
CPC分类号： A61B5/1116 , A61B5/103 , A61B5/686 , A61B2560/0219 , A61B2562/0219 , A61N1/36071 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： The disclosure described techniques for associating therapy adjustments with intended patient posture states. The techniques may include receiving a patient therapy adjustment to a parameter of a therapy program that defines electrical stimulation therapy delivered to the patient, identifying a posture state of the patient, and associating the patient therapy adjustment with the posture state when the patient therapy adjustment is within a range determined based on stored adjustment information for the identified posture state.
摘要翻译：本公开描述了将治疗调整与预期患者姿势状态相关联的技术。这些技术可以包括接收患者治疗调整，该治疗程序的参数限定递送给患者的电刺激治疗，识别患者的姿势状态，以及当患者治疗调整为在基于所识别的姿势状态的存储的调整信息确定的范围内。

26. 发明授权

US08380314B2 Patient directed therapy control 有权
公开(公告)号：US08380314B2
公开(公告)日：2013-02-19
申请号：US11974931
申请日：2007-10-16
申请人： Eric J. Panken , Timothy J. Denison , Gregory F. Molnar
发明人： Eric J. Panken , Timothy J. Denison , Gregory F. Molnar
IPC分类号： A61N1/18
CPC分类号： A61N1/36139 , A61B5/048 , A61B5/4082 , A61B5/7475 , A61M5/14276 , A61M5/1723 , A61M2210/0693 , A61N1/36014 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/3605 , A61N1/3606 , A61N1/36071 , A61N1/36082 , A61N1/37252 , G06F3/015
摘要： A patient controls the delivery of therapy through volitional inputs that are detected by a biosignal within the brain. The volitional patient input may be directed towards performing a specific physical or mental activity, such as moving a muscle or performing a mathematical calculation. In one embodiment, a biosignal detection module monitors an electroencephalogram (EEG) signal from within the brain of the patient and determines whether the EEG signal includes the biosignal. In one embodiment, the biosignal detection module analyzes one or more frequency components of the EEG signal. In this manner, the patient may adjust therapy delivery by providing a volitional input that is detected by brain signals, wherein the volitional input may not require the interaction with another device, thereby eliminating the need for an external programmer to adjust therapy delivery. Example therapies include electrical stimulation, drug delivery, and delivery of sensory cues.

27. 发明授权

US08209019B2 System and method for utilizing brain state information to modulate cardiac therapy 有权
标题翻译：利用脑状态信息调制心脏治疗的系统和方法
公开(公告)号：US08209019B2
公开(公告)日：2012-06-26
申请号：US11796577
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3621 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.
摘要翻译：使用脑状态信息调节或调节心脏治疗的系统。调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是调节心脏的治疗输出。

28. 发明授权

US08108033B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08108033B2
公开(公告)日：2012-01-31
申请号：US11264974
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. Upon detection of a possible occurrence of a physiological event by one group of monitoring elements, an implanted device records data received from another group of monitoring elements. The implanted device obtains and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。在通过一组监测元件检测到生理事件的可能发生时，植入装置记录从另一组监测元件接收的数据。植入装置以基于年龄的第一数据结构获得并存储在数据记录中的数据。在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

29. 发明申请

US20110172562A1 AUTOMATED CALIBRATION OF POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 有权
标题翻译：自动校准医疗器械的状态分类
公开(公告)号：US20110172562A1
公开(公告)日：2011-07-14
申请号：US12769391
申请日：2010-04-28
申请人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
发明人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
IPC分类号： A61B5/103
CPC分类号： A61B5/4839 , A61B5/021 , A61B5/024 , A61B5/0476 , A61B5/0488 , A61B5/1116 , A61B5/1118 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2560/0475 , A61N1/36071 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/324 , G16H50/20
摘要： Techniques relate to operating a medical device by classifying a detected posture state of a patient. This classification may be performed by comparing the detected posture state of the patient to posture state definitions available within the system. Each definition may be described in terms of a parameter (e.g., vector) indicative of a direction in three-dimensional space. The posture state definitions may be calibrated by automatically estimating values for these parameters, thereby eliminating the need for the patient to assume each posture state during the calibration process to capture actual parameter values. According to another aspect, the estimated parameter values may be updated as the patient assumes various postures during a daily routine. For instance, estimated vectors initially used to calibrate the posture state definitions may be changed over time to more closely represent posture states the patient actually assumes, and to further adapt to changes in a patient's condition.
摘要翻译：技术涉及通过对检测到的患者的姿势状态进行分类来操作医疗装置。可以通过将检测到的患者的姿势状态与系统内可用的姿势状态定义进行比较来执行该分类。可以根据指示三维空间中的方向的参数（例如，矢量）来描述每个定义。可以通过自动估计这些参数的值来校准姿势状态定义，从而消除了在校准过程期间患者承担每个姿势状态以捕获实际参数值的需要。根据另一方面，当患者在日常例行程序中呈现各种姿势时，可以更新所估计的参数值。例如，最初用于校准姿势状态定义的估计矢量可以随着时间而改变以更加紧密地表示患者实际假定的姿势状态，并进一步适应患者状况的变化。

30. 发明申请

US20100121213A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
公开(公告)号：US20100121213A1
公开(公告)日：2010-05-13
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0478 , A61B5/03 , A61B5/103 , A61N1/36
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

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