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    • 28. 发明授权
    • Indane compounds and their pharmaceutical use
    • 吲哚化合物及其药物用途
    • US06433021B1
    • 2002-08-13
    • US09453444
    • 1999-12-03
    • Neil FrankishHelen SheridanJohn WalshMichael Jordan
    • Neil FrankishHelen SheridanJohn WalshMichael Jordan
    • A61K3112
    • C07C49/835C07C35/32C07C45/64C07C45/72C07C49/252C07C49/683C07C49/747C07C49/798
    • Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, cyclopentyl, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxyamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, indane, indene, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitirile, heterocyclic groups containing hetero atoms selected from one or more of N, O or S, aralkyl groups, aryl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, carboxylic acid groups of C1 to C10 which may be substituted or unsubstituted, alkyl, substituted alkyl groups, acyl groups, substituted acyl groups; where R1 and R3 may together represent a double bond and wherein in (CH2)n, n is 0 to 8.
    • 描述了通式(1)至(4)的茚满化合物及其药物用途,特别是实现肥大细胞稳定活性和/或抗炎活性。 在这些式中,R 1至R 7可以选自:H,卤素,羟基,烷氧基,芳氧基,乙酰氧基,羧基,环戊基,烷基羰基,氢羰基,氨基,酰氨基,烷基氨基,羟基氨基,氧化胺基,偶氮基,氰基, 肼基,酰肼基,腙基,茚满,茚,酰亚胺基,亚氨基醚基,脲基,肟,硝基,硝酸根,亚硝酸根,亚硝基,亚硝基,含有选自N,O中的一个或多个的杂原子的杂环基, S,芳烷基,芳基,单和多亚苄基芳基,取代的芳基,硫醇,硫脲基,苯硫醇基,磺酸基,亚砜基,砜基,可被取代或未取代的C1至C10的羧酸基,烷基 取代的烷基,酰基,取代的酰基; 其中R 1和R 3可以一起表示双键,并且其中在(CH 2)n中,n是0至8。