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21. 发明授权

US08753606B2 Multimodal imaging method using nano-emulsion comprising optical nano-particles and perfluorocarbons 有权
标题翻译：使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法
公开(公告)号：US08753606B2
公开(公告)日：2014-06-17
申请号：US13000197
申请日：2009-06-19
申请人： Bong Hyun Chung , Yong Taik Lim
发明人： Bong Hyun Chung , Yong Taik Lim
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K49/0002 , A61K49/0017 , A61K49/0067 , A61K49/1806
摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.
摘要翻译：本发明涉及使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳组成的纳米乳液用于多光谱磁共振成像（MRI）和用于多色荧光检测的纳米颗粒。在多模式成像方法中，通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合，可以获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

22. 发明申请

US20120202703A1 METHOD FOR DETECTING AND QUANTIFYING A TARGET SUBSTANCE USING A BIOCHIP 审中-公开
标题翻译：使用BIOCHIP检测和定量目标物质的方法
公开(公告)号：US20120202703A1
公开(公告)日：2012-08-09
申请号：US13395414
申请日：2010-08-27
申请人： Bong Hyun Chung , Sang Kyu Kim , Hyun Min Cho
发明人： Bong Hyun Chung , Sang Kyu Kim , Hyun Min Cho
IPC分类号： C40B30/04 , B82Y15/00
CPC分类号： C12Q1/6837 , C12Q2565/113 , C12Q2563/155 , C12Q2563/137 , C12Q2523/31
摘要： The present invention relates to a method for detecting and quantifying a target substance using a biochip having a substrate onto which probe molecules are fixed, and more particularly, to a method for detecting and quantifying a target substance with the naked eye by using a biochip, comprising the steps of preparing a biochip having a substrate onto which probe molecules are fixed, contacting the biochip with a sample containing a target substance having electric charges, reacting the target substance with nanoparticles having electric charges that are opposite to those of the target substance, and then reacting with a metal enhancing solution so as to amplify the size of the nanoparticles.
摘要翻译：本发明涉及使用具有固定有探针分子的基板的生物芯片来检测和定量目标物质的方法，更具体地，涉及使用生物芯片用肉眼检测和定量目标物质的方法，包括以下步骤：制备具有固定有探针分子的基板的生物芯片，使生物芯片与含有具有电荷的目标物质的样品接触，使目标物质与具有与目标物质相反电荷的纳米粒子反应，然后与金属增强溶液反应，以扩大纳米颗粒的尺寸。

23. 发明申请

US20110201027A1 BIOSENSOR FOR DETECTING A TRACE AMOUNT OF SAMPLE AND PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：用于检测样品量的生物传感器及其生产方法
公开(公告)号：US20110201027A1
公开(公告)日：2011-08-18
申请号：US12933114
申请日：2009-03-18
申请人： Min Gon Kim , Yong Beom Shin , Bong Hyun Chung , Jun Hyoung Ahn
发明人： Min Gon Kim , Yong Beom Shin , Bong Hyun Chung , Jun Hyoung Ahn
IPC分类号： G01N33/53 , C12M1/34 , G01N1/28
CPC分类号： G01N33/5438
摘要： The present invention relates to a biosensor capable of a trace amount of sample and a fabrication method thereof. More specifically, the invention relates to a method for fabricating a biosensor, the method comprising: immobilizing a receptor molecule, which binds selectively to a target substance, on an electrically insulated nano-electrode chip; binding an enzyme to the receptor molecule; and treating the bound enzyme with metal ions and depositing the metal ions on the nano-electrode surface, and to a biosensor fabricated thereby. According to the invention, a precipitate is produced on the nano-electrode surface by a precipitation between the enzyme and the metal ions, and the produced precipitate electrically connects the nano-electrodes together, thereby increasing electrical conductivity. Thus, the invention is useful for quantitative analysis of trace amounts and/or various concentrations of target substances.
摘要翻译：本发明涉及能够追踪微量样品的生物传感器及其制造方法。更具体地说，本发明涉及一种制造生物传感器的方法，该方法包括：在电绝缘的纳米电极芯片上固定与靶物质选择性结合的受体分子; 将酶与受体分子结合; 并用金属离子处理结合的酶并将金属离子沉积在纳米电极表面上，以及由其制造的生物传感器。根据本发明，通过酶和金属离子之间的沉淀在纳米电极表面上产生沉淀物，并且所产生的沉淀物将纳米电极电连接在一起，从而增加导电性。因此，本发明可用于痕量和/或各种浓度的目标物质的定量分析。

24. 发明申请

US20100203653A1 Protein G-Oligonucleotide Conjugate 审中-公开
标题翻译：蛋白G-寡核苷酸缀合物
公开(公告)号：US20100203653A1
公开(公告)日：2010-08-12
申请号：US12665397
申请日：2008-05-16
申请人： Bong Hyun Chung , Yong Won Jung , Jeong Min Lee
发明人： Bong Hyun Chung , Yong Won Jung , Jeong Min Lee
IPC分类号： G01N33/543 , C07K14/00
CPC分类号： C07K19/00 , C07K14/315 , G01N33/54393
摘要： The present invention relates to a protein G conjugate, which is prepared by linking an N-terminal cysteine-tagged protein G variant with an oligonucleotide via a linker. The conjugate binds in a directional manner on the surface of a biochip and biosensor, thereby providing a biochip and biosensor having improved antibody immobilization ability.
摘要翻译：本发明涉及蛋白G缀合物，其通过将N-末端半胱氨酸标记的蛋白G变体与寡核苷酸通过接头连接来制备。缀合物以有向的方式结合在生物芯片和生物传感器的表面上，从而提供具有改进的抗体固定能力的生物芯片和生物传感器。

25. 发明申请

US20090022765A1 COSMETIC PIGMENT COMPOSITION CONTAINING GOLD OR SILVER NANO-PARTICLES 审中-公开
标题翻译：包含金或银纳米颗粒的化妆品颜料组合物
公开(公告)号：US20090022765A1
公开(公告)日：2009-01-22
申请号：US11995847
申请日：2006-02-13
申请人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim , Jin Young Jeong , Tai Hwan Ha
发明人： Bong Hyun Chung , Yong Taik Lim , Jin Kyeong Kim , Jin Young Jeong , Tai Hwan Ha
IPC分类号： A61K8/19 , A61K8/00 , A61Q1/00 , A61Q1/04 , A61Q1/10
CPC分类号： B82Y5/00 , A61K8/0241 , A61K8/19 , A61K8/8176 , A61K2800/413 , A61Q1/02 , A61Q1/06
摘要： The present invention relates to a cosmetic pigment composition exhibiting colors in the visible region, which comprises an effective amount of nanoparticles or a mixture of two or more nanoparticles selected from the group consisting of (a) gold nanoparticles exhibiting red color; (b) silver nanoparticles exhibiting yellow color; (c) gold-silver alloy nanoparticles exhibiting flame color; and (d) gold nanoparticles exhibiting blue color, and a color cosmetic composition and a color lotion comprising the pigment composition. According to the present invention, it is possible to prepare pigments exhibiting various colors in the visible region using gold or silver nanoparticles, and a cosmetic pigment composition which can exhibit various colors by mixing the pigments in various compositional ratios, in which precipitation or agglomeration of particles does not occur, and whose color can be maintained for a long time. Also, since the pigment of the present invention is not harmful to the human body unlike conventional metal pigments, and contains gold or silver that is beneficial to health, the pigment can be used in various applications as functional raw materials.
摘要翻译：本发明涉及一种在可见光区域显示颜色的化妆品颜料组合物，其包含有效量的纳米颗粒或选自（a）显示红色的金纳米颗粒的两种或更多种纳米颗粒的混合物; （b）呈现黄色的银纳米颗粒; （c）显示火焰色的金 - 银合金纳米颗粒; 和（d）显示蓝色的金纳米颗粒，以及着色化妆品组合物和包含该颜料组合物的色乳液。根据本发明，可以使用金或银纳米颗粒制备在可见区域中显示各种颜色的颜料，以及可以通过以各种组成比混合颜料来显示各种颜色的化妆品颜料组合物，其中沉淀或聚集颗粒不会发生，并且其颜色可以长时间保持。此外，由于本发明的颜料与常规金属颜料不同，对人体无害，并且含有有益于健康的金或银，所以颜料可用作各种用途的功能性原料。

26. 发明授权

US5698104A Purification process for hirudin using affinity chromatography 失效
标题翻译：使用亲和色谱法对水蛭素进行纯化
公开(公告)号：US5698104A
公开(公告)日：1997-12-16
申请号：US524311
申请日：1995-09-06
申请人： Sang Ki Rhee , Bong Hyun Chung , Eui Sung Choi , Jung Hoon Sohn , Deok Joong Youn , Myung Kuk Kim , Hae Don Lee
发明人： Sang Ki Rhee , Bong Hyun Chung , Eui Sung Choi , Jung Hoon Sohn , Deok Joong Youn , Myung Kuk Kim , Hae Don Lee
IPC分类号： C07K1/22 , C07K1/14 , C07K14/815 , B01D15/08
CPC分类号： C07K14/815 , Y10S530/855
摘要： Disclosed herein is a process for purifying hirudin from a solution containing hirudin and other substances, characterized in that the process comprises a step of subjecting the solution to a metal ion affinity chromatography wherein copper ion (Cu.sup.++) is used as a metal ion and a phosphate buffer is used as an eluent.
摘要翻译：本文公开了一种从含有水蛭素和其他物质的溶液中净化水蛭素的方法，其特征在于该方法包括使溶液进行金属离子亲和层析的步骤，其中使用铜离子（Cu ++）作为金属离子和磷酸盐缓冲液用作洗脱液。

27. 发明授权

US09022997B2 Microneedle unit capable of controlling fluid delivery 有权
标题翻译：能够控制流体输送的微针单元
公开(公告)号：US09022997B2
公开(公告)日：2015-05-05
申请号：US13263306
申请日：2010-04-08
申请人： Bong Hyun Chung , Nyeon Sik Eum
发明人： Bong Hyun Chung , Nyeon Sik Eum
IPC分类号： A61M5/00 , A61M37/00 , A61M5/178
CPC分类号： A61M37/0015 , A61M5/178 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2037/0061
摘要： Provided is a microneedle unit comprising a case having a space accommodating a fluid and a fluid channel through which the fluid is discharged, a microneedle coupled to a lower portion of the case, a base cover disposed at the lower portion of the case, having a hole through which the microneedle passes, and being vertically movable, a guide pin coupled to the base cover and configured to open and close the fluid channel, and an elastic member configured to impart a restoring force such that the base cover is moved upward by an external pressure and then returns downward again. Therefore, the microneedle unit, which is provided to deliver a fluid into the skin with no pain and no scar, can control injection of the fluid using the guide pin, and repeatedly and conveniently control injection of the fluid using the elastic member.
摘要翻译：提供了一种微针单元，其包括具有容纳流体的空间和流体被排出的流体通道的壳体，连接到壳体的下部的微针，设置在壳体的下部的底盖，具有所述微针通过所述孔并且可垂直移动;引导销，其联接到所述基座盖并且构造成打开和关闭所述流体通道;以及弹性构件，其构造成赋予恢复力，使得所述底盖向上移动一个外部压力再次向下返回。因此，提供用于将流体输送到皮肤中而没有疼痛和无疤痕的微针单元可以使用导销来控制流体的注入，并且使用弹性构件重复且方便地控制流体的注入。

28. 发明授权

US08715738B2 Fullerene-silica nanoparticles with improved fluorescence, preparation method thereof and use thereof 有权
标题翻译：具有改进荧光的富勒烯二氧化硅纳米颗粒，其制备方法和用途
公开(公告)号：US08715738B2
公开(公告)日：2014-05-06
申请号：US12993908
申请日：2009-01-06
申请人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
发明人： Bong Hyun Chung , Jinyoung Jeong , Nam Woong Song
IPC分类号： A61K9/14
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/152 , C09K11/02 , C09K11/65
摘要： The present invention relates to fullerene-silica nanoparticles with improved fluorescence, a preparation method of the fullerene-silica nanoparticles, and use thereof. More specifically, the present invention relates to fullerene-silica nanoparticles with improved fluorescence in which fullerene and silica are covalently linked, a preparation method of the fullerene-silica nanoparticles, and use thereof. The preparation method of the fullerene-silica nanoparticles comprises the steps of: adding a surfactant to a non-polar organic solvent and a polar solvent and stirring them to form reverse micelles (step 1); adding fullerene to the reverse micelles formed in the step 1 and stirring them (step 2); and adding a silica precursor and a catalyst to a reaction solution containing the fullerene prepared in the step 2 and stirring them to prepare fullerene-silica nanoparticles (step 3). According to the present invention, fullerene-silica nanoparticles in the form of a uniform spherical shape of tens of nanometers can be prepared. As such prepared fullerene-silica nanoparticles have a large surface area due to a nanometer-sized structure, they have good reactivity. Compared with heavy metals or metal nanoparticles, the fullerene-silica nanoparticles, because of using silica, are harmless to a living body. Further, as the fullerene-silica nanoparticles exhibit strong fluorescence, they can be used as a contrast agent for in-vivo imaging or as a drug delivery carrier.
摘要翻译：本发明涉及具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯 - 二氧化硅纳米粒子的制备方法及其应用。更具体地，本发明涉及富勒烯和二氧化硅共价连接的具有改进荧光的富勒烯二氧化硅纳米粒子，富勒烯二氧化硅纳米粒子的制备方法及其用途。富勒烯二氧化硅纳米粒子的制备方法包括以下步骤：向非极性有机溶剂和极性溶剂中加入表面活性剂并搅拌形成反胶束（步骤1）。向步骤1中形成的反胶束中加入富勒烯并搅拌（步骤2）; 并将二氧化硅前体和催化剂加入到包含步骤2中制备的富勒烯的反应溶液中并搅拌以制备富勒烯二氧化硅纳米颗粒（步骤3）。根据本发明，可以制备数十纳米的均匀球形形式的富勒烯二氧化硅纳米颗粒。由于这种制备的富勒烯二氧化硅纳米颗粒由于纳米尺寸的结构而具有大的表面积，所以它们具有良好的反应性。与重金属或金属纳米粒子相比，由于使用二氧化硅，富勒烯二氧化硅纳米粒子对生物体无害。此外，由于富勒烯二氧化硅纳米粒子表现出强烈的荧光，因此它们可以用作体内成像的造影剂或药物递送载体。

29. 发明授权

US08697389B2 Cell labeling and imaging using multifunctional perfluorocarbon nanoemulsion 有权
标题翻译：使用多功能全氟化碳纳米乳液的细胞标记和成像
公开(公告)号：US08697389B2
公开(公告)日：2014-04-15
申请号：US12937875
申请日：2009-03-24
申请人： Bong Hyun Chung , Yong Taik Lim
发明人： Bong Hyun Chung , Yong Taik Lim
IPC分类号： C12Q1/02
CPC分类号： G01N33/532 , B82Y15/00 , G01N33/5005 , G01N33/582 , G01N33/587 , G01N33/588
摘要： The present invention relates to cell labeling and imaging using a multifunctional perfluorocarbon (PFC) nanoemulsion. In particular, the perfluorocarbon nanoemulsion containing optical nanoparticle is provided with both optical characteristics and 19F magnetic resonance characteristics, thus can be used for magnetic resonance imaging (MRI) and optical imaging (OI) simultaneously. Cell labeling and imaging using the perfluorocarbon nanoemulsion containing quantum dot nanoparticle exerted no effect on cell viability. Therefore, perfluorocarbon nanoemulsion can be applied to methods for multifunctional and effectively cell labeling and imaging.
摘要翻译：本发明涉及使用多功能全氟化碳（PFC）纳米乳液的细胞标记和成像。特别是，含有光学纳米颗粒的全氟化碳纳米乳液具有光学特性和19F磁共振特性，因此可同时用于磁共振成像（MRI）和光学成像（OI）。使用含有量子点纳米颗粒的全氟化碳纳米乳液的细胞标记和成像对细胞活力没有影响。因此，全氟化碳纳米乳液可用于多功能，有效的细胞标记和成像方法。

30. 发明授权

US08642356B2 Cascade enzyme-linked immunosorbent assay 失效
标题翻译：级联酶联免疫吸附测定
公开(公告)号：US08642356B2
公开(公告)日：2014-02-04
申请号：US12679830
申请日：2008-05-30
申请人： Sang Jeon Chung , Young-mi Lee , Yu-Jin Jeong , Hyo Jin Kang , Bong Hyun Chung
发明人： Sang Jeon Chung , Young-mi Lee , Yu-Jin Jeong , Hyo Jin Kang , Bong Hyun Chung
IPC分类号： G01N33/553 , G01N33/573
CPC分类号： G01N33/54326 , G01N33/581 , G01N33/587 , G01N2333/976
摘要： The present invention relates to a cascade enzyme-linked immunosorbent assay, more precisely a cascade enzyme-linked immunosorbent assay using magnetic microparticles (MMPs) immobilized with the target antigen specific primary antibody and silica nanoparticles (SPs) immobilized with a cascade reaction initiator and the antigen-specific secondary antibody. When the method of the present invention is applied in the detection of an antigen in biosamples, the detection sensitivity can be significantly increased.
摘要翻译：本发明涉及级联酶联免疫吸附测定法，更确切地说，使用固定有靶抗原特异性一级抗体的磁性微粒（MMP）和固定有级联反应引发剂的二氧化硅纳米颗粒（SP）的级联酶联免疫吸附测定法，抗原特异性二抗。当将本发明的方法应用于生物样品中的抗原检测时，可以显着提高检测灵敏度。

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