专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

ZA201204806B BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：ZA201204806B
公开(公告)日：2013-02-27
申请号：ZA201204806
申请日：2012-06-27
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , O'GARRA ANNE , KON ONN MIN , CHAUSSABEL DAMIEN , BERRY MATTHEW
IPC分类号： C12N20060101 , C12Q20060101 , C12R20060101 , G01N20060101
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting the patient gene expression dataset into one or more gene modules associated with Mycobacterium tuberculosis infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active Mycobacterium tuberculosis infection.

22. 发明专利

AU2010325179A1 Blood transcriptional signature of active versus latent Mycobacterium tuberculosis infection 未知
公开(公告)号：AU2010325179A1
公开(公告)日：2012-07-05
申请号：AU2010325179
申请日：2010-08-19
申请人： MEDICAL RES COUNCIL , BAYLOR RES INST , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12N15/31 , C12Q1/68 , C12R1/32 , G01N33/15
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent infection in a patient suspected of being infected with , the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with ; sorting the patient gene expression dataset into one or more gene modules associated with infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active infection.

23. 发明专利

PE20110386A1 PATRON DE TRANSCRIPCION SANGUINEA DE LA INFECCION POR MYCOBACTERIUM TUBERCULOSIS 未知
公开(公告)号：PE20110386A1
公开(公告)日：2011-07-03
申请号：PE2010001182
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
摘要： REFERIDA A UN METODO PARA DIFERENCIAR UNA INFECCION POR MYCOBACTERIUM TUBERCULOSIS ACTIVA DE UNA LATENTE EN UN PACIENTE, QUE COMPRENDE OBTENER UN CONJUNTO DE DATOS DE EXPRESION GENICA DE UNA MUESTRA DE SANGRE ENTERA DE UN PACIENTE Y DETERMINAR LA EXPRESION DIFERENCIAL DE UNO O MAS MODULOS DE EXPRESION GENICA QUE DISTINGUEN ENTRE INDIVIDUOS INFECTADOS Y NO INFECTADOS, DONDE EL CONJUNTO DE DATOS DEMUESTRA UN CAMBIO AGREGADO EN LOS NIVELES DE POLINUCLEOTIDOS EN UNO O MAS MODULOS DE EXPRESION GENICA DE TRANSCRIPCION PARA INDIVIDUOS INFECTADOS. EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.2, M1.3, M1.4, M1.5, M1.8, M2.1, M2.4, M2.8, M3.1, M3.2, M3.3, M3.4, M3.6, M3.7, M3.8 O M3.9 PARA DETECTAR LA INFECCION PULMONAR ACTIVA Y PARA DETECTAR UNA INFECCION LATENTE, EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.5, M2.1, M2.6, M2.10, M3.2 O M3.3

24. 发明专利

CA2729000A1 BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：CA2729000A1
公开(公告)日：2009-12-30
申请号：CA2729000
申请日：2009-06-25
申请人： BAYLOR RES INST , IMP COLLEGE HEALTHCARE NHS TRUST , NAT INST FOR MEDICAL RES
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.

25. 发明专利

PE20121690A1 SIGNATURA TRANSCRIPCIONAL EN LA SANGRE DE INFECCIONES DE MYCOBACTERIUM TUBERCULOSIS ACTIVAS VERSUS LATENTES 未知
公开(公告)号：PE20121690A1
公开(公告)日：2012-12-16
申请号：PE2012000735
申请日：2010-08-19
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12N15/31 , C12Q1/68 , C12R1/32 , G01N33/15
摘要： SE REFIERE A UN METODO PARA DETECTAR UNA INFECCION ACTIVA POR MYCOBACTERIUM TUBERCULOSIS QUE ESTA LATENTE Y ASINTOMATICA QUE COMPRENDE A) OBTENER UN CONJUNTO DE DATOS DE LA EXPRESION GENETICA DE PACIENTES CON UNA INFECCION LATENTE Y ASINTOMATICA POR MYCOBACTERIUM TUBERCULOSIS; B) CLASIFICAR EL CONJUNTO DE DATOS DE LA EXPRESION GENETICA OBTENIDO EN EL PASO (A) EN MODULOS GENETICOS ASOCIADOS CON UNA INFECCION POR MYCOBACTERIUM TUBERCULOSIS; C) COMPARAR EL CONJUNTO DE DATOS DE LA EXPRESION GENETICA DE UN PACIENTE NO CLASIFICADO CON LOS MODULOS GENETICOS DESCRITOS EN (B), EN DONDE UN INCREMENTO O DISMINUCION EN LA TOTALIDAD DE LA EXPRESION GENETICA INDICA UNA INFECCION ACTIVA POR MYCOBACTERIUM TUBERCULOSIS EN LUGAR DE UNA INFECCION LATENTE Y ASINTOMATICA

26. 发明专利

PE16902012A1 SIGNATURA TRANSCRIPCIONAL EN LA SANGRE DE INFECCIONES DE MYCOBACTERIUM TUBERCULOSIS ACTIVAS VERSUS LATENTES 未知
公开(公告)号：PE16902012A1
公开(公告)日：2012-12-16
申请号：PE0007352012
申请日：2010-08-19
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12N15/31 , C12Q1/68 , C12R1/32 , G01N33/15
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： SE REFIERE A UN METODO PARA DETECTAR UNA INFECCION ACTIVA POR MYCOBACTERIUM TUBERCULOSIS QUE ESTA LATENTE Y ASINTOMATICA QUE COMPRENDE A) OBTENER UN CONJUNTO DE DATOS DE LA EXPRESION GENETICA DE PACIENTES CON UNA INFECCION LATENTE Y ASINTOMATICA POR MYCOBACTERIUM TUBERCULOSIS; B) CLASIFICAR EL CONJUNTO DE DATOS DE LA EXPRESION GENETICA OBTENIDO EN EL PASO (A) EN MODULOS GENETICOS ASOCIADOS CON UNA INFECCION POR MYCOBACTERIUM TUBERCULOSIS; C) COMPARAR EL CONJUNTO DE DATOS DE LA EXPRESION GENETICA DE UN PACIENTE NO CLASIFICADO CON LOS MODULOS GENETICOS DESCRITOS EN (B), EN DONDE UN INCREMENTO O DISMINUCION EN LA TOTALIDAD DE LA EXPRESION GENETICA INDICA UNA INFECCION ACTIVA POR MYCOBACTERIUM TUBERCULOSIS EN LUGAR DE UNA INFECCION LATENTE Y ASINTOMATICA

27. 发明专利

SG182951A1 BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：SG182951A1
公开(公告)日：2012-08-30
申请号：SG2012039715
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
摘要： OF THE INVENTIONThe present invention includes methods, systems and kits for distinguishing between active and latent mycobaCterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosk,and distinguishing such patients from uninfected individuals, the method including the steps of5 obtaining a gate expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non-infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection. 87The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non-infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection,(Figure I)

28. 发明专利

BR112012013029A2 sinal transcricional de sangue de ativo versus infecção latente mycobacterium tuberculosis 未知
公开(公告)号：BR112012013029A2
公开(公告)日：2016-10-04
申请号：BR112012013029
申请日：2010-08-19
申请人： BAYLOR RES INST , IMP COLLEGE HEALTHCARE NHS TRUST , MEDICAL RES COUNCIL
发明人： O'GARRA ANNE , CHAUSSABEL DAMIEN , BANCHEREAU JACQUES F , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12N15/31 , C12Q1/68 , C12R1/32 , G01N33/15
摘要： sinal transcional de sangue de ativo o versus infecção latente mycobacterium tuberculosis. a presente invenção inclui métodos, sistemas e kits para distinguir entre a infecção mycobacterium tuberculosis ativa e latente em um paciente suspeito de estar infectado com mycobacterium tuberculosis, o método inclui as etapas de obtenção de um conjunto de dados de expressão dos genes do paciente a partir de um paciente suspeito de estar infectado com mycobacterium tuberculosis; classificando o conjunto de dados de expressão dos genes do paciente em um ou mais módulos associados do genes a infecção por mycobacterium tuberculosis; e comparar o conjunto de dados de expressão dos genes do paciente para cada um dos um ou mais módulos de genes para um conjunto de dados de expressão dos genes a partir de um não-paciente; em que um aumento ou diminuição na totalidade de expressão dos genes no conjunto de dados de expressão dos genes do paciente para um ou mais módulos de genes é indicativo de infecção por mycobacterium tuberculosis ativa.

29. 发明专利

CA2867118A1 EARLY DETECTION OF TUBERCULOSIS TREATMENT RESPONSE 未知
公开(公告)号：CA2867118A1
公开(公告)日：2013-09-19
申请号：CA2867118
申请日：2013-03-13
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： O'GARRA ANNE , BLOOM CHLOE , BERRY MATTHEW PAUL REDDOCH , WILKINSON ROBERT , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , PASCUAL MARIA VIRGINIA
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/68
摘要： The present invention includes methods for early detection of a treatment response in a patient suspected of being infected with Mycobacterium tuberculosis. Changes in the blood transcriptome are detectable within two weeks of the initiation of antituberculosis therapy.

30. 发明申请

WO2007044566A3 DIAGNOSIS OF SYSTEMIC ONSET JUVENILE IDIOPATHIC ARTHRITIS THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 审中-公开
标题翻译：系统性遗传性肾小球性肾炎通过血液白细胞微阵列分析诊断
公开(公告)号：WO2007044566A3
公开(公告)日：2007-11-08
申请号：PCT/US2006039230
申请日：2006-10-06
申请人： BAYLOR RES INST , PASCUAL MARIA VIRGINIA , BANCHEREAU JACQUES , CHAUSSABEL DAMIEN , ALLANTAZ FLORENCE
发明人： PASCUAL MARIA VIRGINIA , BANCHEREAU JACQUES , CHAUSSABEL DAMIEN , ALLANTAZ FLORENCE
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) usin microarrays.
摘要翻译：本发明包括用于在微阵列中早期检测和一致确定全身性发病的幼年特发性关节炎（SoJIA）的组合物，系统和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式