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21. 发明授权

US09067048B2 Medication liquid supporting jig and method of applying medication to micro-needle using same 有权
标题翻译：药物液体支持夹具及使用其的微针施用药物的方法
公开(公告)号：US09067048B2
公开(公告)日：2015-06-30
申请号：US13265997
申请日：2010-04-24
申请人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
发明人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto
IPC分类号： B01L3/00 , G01N31/16 , A61M37/00 , A61K9/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053
摘要： Provided are a jig for uniformly applying a drug liquid to a microneedle, and a method of applying a drug to a microneedle using same. Grooves of a number corresponding to the number of rows of small needles of a microneedle are formed in the surface of a flat plate jig or of a roller-like jig, and a drug liquid is filled and held in the grooves. The drug liquid is applied to the microneedle by inserting the small needles of the microneedle into the surface of the drug liquid held in the narrow grooves, and immersing the small needles in the drug liquid. By this, the drug liquid is uniformly applied to the small needles of the microneedle without unevenness between the central section and the peripheral section of each microneedle, and thus the microneedles having good quality can be easily manufactured.
摘要翻译：提供了用于将药液均匀地施加到微针的夹具，以及使用其将药物施加到微针的方法。在平板夹具或辊状夹具的表面上形成与微针的小针数相对应的数字的槽，并且将药液填充并保持在槽中。通过将微针的小针插入保持在窄槽中的药液的表面，并将小针浸入药液中，将药液施加到微针上。由此，将药液均匀地施加到微针的小针上，而在每个微针的中心部和周边部之间没有不均匀，因此可以容易地制造质量好的微针。

22. 发明授权

US06488648B1 Device for feeding a powder in a predetermined amount and method thereof 有权
标题翻译：用于以预定量供给粉末的装置及其方法
公开(公告)号：US06488648B1
公开(公告)日：2002-12-03
申请号：US09646159
申请日：2000-09-14
申请人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima
发明人： Hideo Matsugi , Yuji Makino , Masahiko Dohi , Yasuhide Uejima
IPC分类号： A61M3100
CPC分类号： A61M15/0065 , A61M11/001 , A61M2202/064 , A61M2205/075
摘要： A powdered medicine multi-dose administering device has a medicine container unit (5b) for containing a unit-dose of medicine under the lower surface of the medicine storage chamber (5a) storing the medicine in a multi-dose amount. A medicine guiding unit (2) moves between a filling position and an administering position while maintaining a contact with the bottom surface. At the filling position, the medicine container unit is opened to the medicine storage chamber and is filled with the medicine. As the medicine container unit moves from the filling position to the administering position, the powdered medicine in the medicine container unit is swept and metered. At the administering position, the medicine in the medicine container unit is injected by the action of the pump unit (3) through a filter (6) and a pipe (2g, 2d, 2c).
摘要翻译：粉末药物多剂量给药装置具有药剂容纳单元（5b），用于在药物储存室（5a）的下表面容纳多剂量的药剂，以多剂量存储药物。药物引导单元（2）在保持与底面的接触的同时在填充位置和给药位置之间移动。在填充位置，药剂容器单元向药剂储存室开口并填充药剂。当药剂容器单元从填充位置移动到给药位置时，将药剂容器单元中的粉末药片扫过并计量。在给药位置，药剂容器单元中的药物通过泵单元（3）的作用通过过滤器（6）和管（2g，2d，2c）注入。

23. 发明授权

US06222590B1 Phase-locked loop circuit 失效
标题翻译：锁相环电路
公开(公告)号：US06222590B1
公开(公告)日：2001-04-24
申请号：US09141719
申请日：1998-08-27
申请人： Yuji Makino
发明人： Yuji Makino
IPC分类号： H04N510
CPC分类号： H04N5/126 , G09G5/12
摘要： In a phase-locked loop circuit, a vertical synchronous separation circuit separates a vertical sync signal from a composite synchronizing signal to detect part of a vertical synchronizing period. A mask circuit masks the composite synchronizing signal during a predetermined period. A selector selects a reference signal or the composite synchronizing signal in accordance with the detection output from the vertical synchronous separation circuit. A phase comparator detects a phase difference between the output from the selector and the reference signal. A voltage-controlled oscillator changes an oscillation frequency upon receiving the output from the phase comparator through a low-pass filter. A counter counts the oscillation output from the voltage-controlled oscillator. A decoder circuit decodes the output from the counter to generate the reference signal, supplies it to the selector and the phase comparator, and resets the counter at a predetermined period. A mask pulse decoder generates a mask pulse to control a mask period of the mask circuit. The composite synchronizing signal is replaced with the reference signal in accordance with the detection output from the vertical synchronous separation circuit and supplied to an input of the phase comparator.
摘要翻译：在锁相环电路中，垂直同步分离电路将垂直同步信号与复合同步信号分离，以检测垂直同步周期的一部分。掩模电路在预定时段期间掩蔽复合同步信号。选择器根据来自垂直同步分离电路的检测输出来选择参考信号或复合同步信号。相位比较器检测来自选择器的输出和参考信号之间的相位差。压控振荡器通过低通滤波器从相位比较器接收到输出时改变振荡频率。计数器对来自压控振荡器的振荡输出进行计数。解码器电路对来自计数器的输出进行解码以产生参考信号，将其提供给选择器和相位比较器，并以预定周期复位计数器。掩模脉冲解码器产生掩模脉冲以控制掩模电路的屏蔽周期。根据来自垂直同步分离电路的检测输出，将复合同步信号替换为参考信号，并提供给相位比较器的输入端。

24. 发明授权

US6008206A Sodium alendronate preparation for local administration 失效
标题翻译：阿仑膦酸钠用于局部给药
公开(公告)号：US6008206A
公开(公告)日：1999-12-28
申请号：US86173
申请日：1998-05-28
申请人： Masahiko Dohi , Yuji Makino , Takao Hujii
发明人： Masahiko Dohi , Yuji Makino , Takao Hujii
IPC分类号： A61K31/66
CPC分类号： A61K31/663
摘要： The object of the present invention is to provide a preparation for local administration to permit selective delivery of an effective amount of sodium alendronate to the bone site where bone resorption is accentuated.
摘要翻译：本发明的目的是提供一种用于局部给药的制剂，以允许有选择地将有效量的阿仑膦酸钠递送到骨吸收增强的骨部位。

25. 发明授权

US5182274A Stabilized aqueous preparation of active form of vitamin D.sub.3 失效
标题翻译：维生素D 3的活性形式的稳定水分准备
公开(公告)号：US5182274A
公开(公告)日：1993-01-26
申请号：US490637
申请日：1990-05-25
申请人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
发明人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
IPC分类号： A61K9/00 , A61K31/59 , A61K47/12 , A61K47/26 , A61K47/44
CPC分类号： A61K31/59 , A61K47/12 , A61K47/26 , A61K47/44 , A61K9/0019
摘要： An aqueous preparation of active form of vitamin D.sub.3 which is solubilized with a nonionic surface active agent and stabilized with a combination of a specific chelating agent such as citric acid with an antioxidant. Stabilized oral and parenteral preparations of active form of vitamin D.sub.3 can be provided.

26. 发明授权

US5158944A Solid pharmaceutical preparations of active form of vitamin D3 of improved stability 失效
标题翻译：维生素D3有效形式的固体药物制剂改进稳定性
公开(公告)号：US5158944A
公开(公告)日：1992-10-27
申请号：US601775
申请日：1990-10-31
申请人： Yuji Makino , Yoshiki Suzuki
发明人： Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/14 , A61K9/16 , A61K31/59 , A61K47/02 , A61K47/04 , A61K47/12 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/38
CPC分类号： A61K47/02 , A61K31/59 , A61K47/12 , A61K9/145 , A61K9/146 , A61K9/1676 , Y10S514/96 , Y10S514/97
摘要： A pharmaceutical solid preparation of active form of vitamin D.sub.3 of improved stability which comprises a composition of active form of vitamin D.sub.3 dispersed in an excipient readily soluble in organic solvent and a basic substance.As a basic substance, are cited sodium citrate, magnesium oxide or the like.
摘要翻译： PCT No.PCT / JP90 / 00255 Sec。 371 1990年10月31日第 102（e）1990年10月31日PCT PCT 1990年2月28日PCT公布。出版物WO90 / 09796 1990年9月7日。一种具有改善的稳定性的维生素D3活性形式的药物固体制剂，其包含分散在易溶于有机溶剂的赋形剂中的活性形式的维生素D3的组合物和碱性物质。作为碱性物质，可以举出柠檬酸钠，氧化镁等。

27. 发明授权

US4948788A Composition for injection of active type vitamins D.sub.3 失效
标题翻译：用于注射活性型维生素D3的组合物
公开(公告)号：US4948788A
公开(公告)日：1990-08-14
申请号：US904125
申请日：1986-09-05
申请人： Yuji Makino , Yoshiki Suzuki
发明人： Yuji Makino , Yoshiki Suzuki
IPC分类号： A61K9/14 , A61K31/59 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/32 , A61K47/38
CPC分类号： A61K47/38 , A61K31/59 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/32 , A61K9/0019
摘要： A composition for the injection of active type vitamins D.sub.3 comprising a lyophilized product of active type vitamins D.sub.3 and an excipient. This composition has good stability of active type vitamins D.sub.3 and is effective as an injection preparation.
摘要翻译：用于注射活性型维生素D3的组合物，其包含活性型维生素D3和赋形剂的冻干产品。该组合物具有良好的活性型维生素D3的稳定性，作为注射剂有效。

28. 发明授权

US4871723A Method for treating psoriasis by externally administering to a patient a pharmaceutical composition containing active-type vitamin D 失效
标题翻译：通过向患者外部施用含有活性型维生素D的药物组合物来治疗银屑病的方法
公开(公告)号：US4871723A
公开(公告)日：1989-10-03
申请号：US933326
申请日：1986-11-21
申请人： Yuji Makino , Yoshiki Suzuki , Takashi Aoyagi
发明人： Yuji Makino , Yoshiki Suzuki , Takashi Aoyagi
IPC分类号： A61K9/06 , A61K31/59
CPC分类号： A61K9/06 , A61K31/59
摘要： A process for treating psoriasis by externally applying to the skin of a warm-blooded animal a composition comprising:(A) a pharmaceutically effective amount of an active-type vitamin D.sub.3,(B) a substantially water-free carrier containing the active-type vitamin D.sub.3 dissolved or uniformly dispersed therein, and(C) a solvent selected from fatty acid esters, higher alcohols with 10 or more carbons and propylene carbonate.
摘要翻译：一种通过向温血动物的皮肤外部施用银屑病的方法，该组合物包含：（A）药学有效量的活性型维生素D3，（B）基本上不含水的载体，其含有活性型维生素D3溶解或均匀分散在其中，和（C）选自脂肪酸酯，具有10个或更多个碳的高级醇和碳酸丙烯酯的溶剂。

29. 发明授权

US4755544A Sustained release preparation 失效
标题翻译：持续释放准备
公开(公告)号：US4755544A
公开(公告)日：1988-07-05
申请号：US870480
申请日：1986-06-04
申请人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
发明人： Yuji Makino , Hideo Matugi , Yoshiki Suzuki
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48 , C08L1/26 , A01N25/26 , A01N25/28 , A61F13/00
CPC分类号： A61K9/4866 , A61K9/2027 , A61K9/205 , A61K9/2054
摘要： A sustained release preparation comprising:(a) a non-anionic cellulose ether(b) a methoxyethylene-maleic anhydride copolymer or the hydrolyzate thereof, and(c) pharmaceutically active agents.This sustained release preparation can provide the desired sustained-release or dissolution of the pharmaceutically active agents in human organs irrespective of the acidity (i.e., pH conditions) therein.
摘要翻译：一种缓释制剂，其包含：（a）非阴离子纤维素醚（b）甲氧基亚乙基 - 马来酸酐共聚物或其水解产物，和（c）药用活性剂。这种持续释放制剂可以提供药物活性剂在人体器官中的期望的缓释或溶解，而与其中的酸度（即pH条件）无关。

30. 发明申请

US20130209660A1 MICRO-NEEDLE COATING METHOD 审中-公开
标题翻译：微针涂层法
公开(公告)号：US20130209660A1
公开(公告)日：2013-08-15
申请号：US13882056
申请日：2011-10-27
申请人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto , Katsunori Kobayashi
发明人： Yuji Makino , Takurou Kurita , Hidetoshi Hamamoto , Katsunori Kobayashi
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0053 , B05D1/18 , B05D1/28
摘要： Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves.
摘要翻译：由于将药液施加到微针的尖端部分的所有方法都是在开放系统中施用药液，所以溶剂从药液的蒸发是不可避免的，使得药物液体的浓度容易变化，并且大量的药液是必需的。本发明提供了通过使用少量的溶液并且不改变药液浓度的方式将药物施用于针状青蛙形微针。制造具有多个凹槽的构件，并且其一端浸入药液罐中以用药液填充凹槽。通过将销青蛙形的微针设置成通过槽内的药液，可以将药物均匀地施加到微针的前端部。

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