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21. 发明授权

US5639638A DNA molecules encoding bone morpogenetic protein-11 失效
标题翻译： DNA分子编码骨形成蛋白-11
公开(公告)号：US5639638A
公开(公告)日：1997-06-17
申请号：US247907
申请日：1994-05-20
申请人： John M. Wozney , Anthony J. Celeste
发明人： John M. Wozney , Anthony J. Celeste
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P7/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/51 , C07K14/575 , C12N5/0793 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91 , C12N15/16 , C12N15/85
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C12N5/0619 , C07K2319/00 , C12N2501/155 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception, and for the induction of bone, cartilage and/or other connective tissue.
摘要翻译：公开了纯化骨形态发生蛋白-11蛋白及其生产方法。还公开了编码BMP-11蛋白的重组DNA分子。蛋白质可用于调节促卵泡激素，例如用于避孕，以及用于诱导骨，软骨和/或其它结缔组织。

22. 发明授权

US07378392B1 Bone and cartilage inductive proteins 失效
标题翻译：骨和软骨诱导蛋白
公开(公告)号：US07378392B1
公开(公告)日：2008-05-27
申请号：US08319831
申请日：1994-10-06
申请人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
发明人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
IPC分类号： A61K38/18 , C07K14/435 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的软骨和/或骨诱导蛋白及其制备方法。蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。

23. 发明授权

US06340668B1 Neuronal uses of BMP-11 失效
标题翻译：神经元使用BMP-11
公开(公告)号：US06340668B1
公开(公告)日：2002-01-22
申请号：US09414234
申请日：1999-10-07
申请人： Anthony J. Celeste , John M. Wozney , R. Scott Thies
发明人： Anthony J. Celeste , John M. Wozney , R. Scott Thies
IPC分类号： A61K3818
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
摘要翻译：公开了纯化的BMP-11蛋白质及其生产方法。还公开了编码BMP-11蛋白的重组DNA分子。蛋白质可用于调节促卵泡激素，例如用于避孕。此外，蛋白质可用于诱导和/或维持骨，软骨和/或其它结缔组织和/或神经元组织。

24. 发明授权

US06291206B1 BMP receptor proteins 失效
标题翻译： BMP受体蛋白
公开(公告)号：US06291206B1
公开(公告)日：2001-09-18
申请号：US08123934
申请日：1993-09-17
申请人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
发明人： John M. Wozney , Anthony J. Celeste , R. Scott Thies , Noboru Yamaji
IPC分类号： C12P2106
CPC分类号： C07K14/71 , A61K38/00 , C07K14/51
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
摘要翻译：公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。

25. 发明授权

US5703043A Bone morphogenetic protein-10 (BMP-10) compositions 失效
标题翻译：骨形态发生蛋白-10（BMP-10）组成
公开(公告)号：US5703043A
公开(公告)日：1997-12-30
申请号：US453942
申请日：1995-05-30
申请人： Anthony J. Celeste , John M. Wozney
发明人： Anthony J. Celeste , John M. Wozney
IPC分类号： A61K38/00 , A61P17/02 , A61P19/00 , C07K14/51 , C12N15/16 , A61K38/18
CPC分类号： C07K14/51 , A61K38/00 , C07K2319/02 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-10 (BMP-10) proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化骨形态发生蛋白-10（BMP-10）蛋白及其制备方法。还公开了编码BMP-10蛋白质的DNA分子。蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。

26. 发明授权

US5700911A Bone morphogenetic protein -11 (BMP-11) compositions 失效
标题翻译：骨形态发生蛋白-11（BMP-11）组成
公开(公告)号：US5700911A
公开(公告)日：1997-12-23
申请号：US452772
申请日：1995-05-30
申请人： John M. Wozney , Anthony J. Celeste
发明人： John M. Wozney , Anthony J. Celeste
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P7/00 , A61P13/02 , A61P15/00 , A61P15/18 , A61P19/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/495 , C07K14/51 , C07K14/575 , C12N5/0793 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C12N5/0619 , C07K2319/00 , C12N2501/155 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein-11(BMP-11) proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction of bone, cartilage and/or other connective tissue.
摘要翻译：公开了纯化骨形态发生蛋白-11（BMP-11）蛋白及其制备方法。还公开了编码BMP-11蛋白的重组DNA分子。蛋白质可用于调节促卵泡激素，例如用于避孕。此外，蛋白质可用于诱导骨，软骨和/或其他结缔组织。

27. 发明授权

US5688678A DNA encoding and methods for producing BMP-8 proteins 失效
标题翻译： DNA编码和产生BMP-8蛋白的方法
公开(公告)号：US5688678A
公开(公告)日：1997-11-18
申请号：US800364
申请日：1991-11-26
申请人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
发明人： Rodney M. Hewick , Jack H. Wang , John M. Wozney , Anthony J. Celeste
IPC分类号： A61K38/00 , C07K14/51 , C12N1/21 , C12N15/16
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified cartilage and/or bone inductive proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的软骨和/或骨诱导蛋白及其制备方法。蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。

28. 发明授权

US06492493B2 Bone morphogenetic protein (BMP)-17 and BMP-18 compositions 有权
标题翻译：骨形态发生蛋白（BMP）-17和BMP-18组合物
公开(公告)号：US06492493B2
公开(公告)日：2002-12-10
申请号：US09438623
申请日：1999-11-12
申请人： Anthony J. Celeste , Beth L. Murray
发明人： Anthony J. Celeste , Beth L. Murray
IPC分类号： C07K1451
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
摘要翻译：公开了纯化的BMP-17和BMP-18蛋白及其生产方法。还公开了编码BMP-17和BMP-18蛋白质的DNA分子。蛋白质可以用于治疗伤口愈合和相关组织修复中的骨，软骨，其他结缔组织缺陷和障碍，包括腱，韧带和半月板，以及用于治疗包括表皮的组织的病症和缺陷，神经，肌肉，包括心肌和其他组织和伤口，以及诸如肝，肺，上皮，脑，脾，心脏，胰腺和肾组织的器官。蛋白质也可用于诱导未分化胚胎和干细胞的生长和/或分化。

29. 发明授权

US07151086B2 Bone morphogenetic protein (BMP)-17 and BMP-18 compositions 有权
公开(公告)号：US07151086B2
公开(公告)日：2006-12-19
申请号：US10228808
申请日：2002-08-26
申请人： Anthony J. Celeste , Beth L. Murray
发明人： Anthony J. Celeste , Beth L. Murray
IPC分类号： A61K38/18
CPC分类号： C07K14/51 , A61K38/00
摘要： Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.

30. 发明授权

US6034229A BMP-15 compositions 失效
标题翻译： BMP-15组合物
公开(公告)号：US6034229A
公开(公告)日：2000-03-07
申请号：US982987
申请日：1997-12-02
申请人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
发明人： Anthony J. Celeste , Jennifer L. Dube , Karen M. Lyons , Brigid Hogan
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61L27/22 , A61L27/36 , A61P43/00 , C07K14/51 , C07K16/22 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/02 , C07H21/04
CPC分类号： C07K14/51 , A61L27/227 , A61K38/00 , C07K2319/00
摘要： Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
摘要翻译：公开了纯化的BMP-15相关蛋白质及其生产方法。还公开了编码BMP-15相关蛋白的DNA分子。蛋白质可用于治疗骨和软骨和/或其他结缔组织缺陷以及伤口愈合和相关组织修复。

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