专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20100143949A1 BIOMARKERS FOR COLORECTAL CANCER 审中-公开
标题翻译：生物标志物为彩色癌
公开(公告)号：US20100143949A1
公开(公告)日：2010-06-10
申请号：US12446937
申请日：2007-10-31
申请人： Emanuel Petricoin , Weidong Zhou , Serena Camerini , Maria Letizia Polci , Lance Liotta
发明人： Emanuel Petricoin , Weidong Zhou , Serena Camerini , Maria Letizia Polci , Lance Liotta
IPC分类号： G01N33/53 , G01N33/00 , C12Q1/37 , C07K16/18
CPC分类号： G01N33/57419
摘要： Low molecular weight (LMW) peptides have been discovered that are indicative of colorectal cancer. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting colorectal cancer and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting colorectal cancer during its early stages.
摘要翻译：已经发现指示结肠直肠癌的低分子量（LMW）肽。评估患者样本中存在这样的LMW肽是检测结直肠癌和监测疾病进展的有效手段。 LMW肽在早期阶段检测结肠直肠癌特别有用。

22. 发明申请

US20050260671A1 Process for discriminating between biological states based on hidden patterns from biological data 审中-公开
公开(公告)号：US20050260671A1
公开(公告)日：2005-11-24
申请号：US11189808
申请日：2005-07-27
申请人： Ben Hitt , Peter Levine , Emanuel Petricoin , Lance Liotta
发明人： Ben Hitt , Peter Levine , Emanuel Petricoin , Lance Liotta
IPC分类号： G01N27/62 , G01N33/48 , G06F19/00 , C12Q1/68 , G01N33/50
CPC分类号： G16H10/40 , G16B25/00 , G16B40/00 , G16H50/70 , Y10S707/99933 , Y10S707/99943
摘要： The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e.g., a biological sample from a human, e.g., serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate.), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e.g., patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

23. 发明申请

US20050042636A1 Compositions and methods for detecting abnormal cell proliferation 审中-公开
标题翻译：用于检测异常细胞增殖的组合物和方法
公开(公告)号：US20050042636A1
公开(公告)日：2005-02-24
申请号：US10835531
申请日：2004-04-28
申请人： Lance Liotta , Elizabeth Woodhouse , Emanuel Petricoin
发明人： Lance Liotta , Elizabeth Woodhouse , Emanuel Petricoin
IPC分类号： A61K39/00 , C07K16/30 , C12Q1/68
CPC分类号： A61K39/0011 , A61K2039/505 , C07K16/3076 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides compositions for the detection and treatment of cells misexpressing (e.g., overexpressing) or expressing altered forms of SEMA 5 as well as methods for using the compositions. In a further aspect, high throughput screens are provided for identifying modulators of SEMA 5
摘要翻译：本发明提供用于检测和治疗错误表达（例如，过表达）或表达SEMA 5的改变形式的细胞的组合物以及使用该组合物的方法。在另一方面，提供了用于识别SEMA 5的调制器的高吞吐量屏幕

24. 发明申请

US20080103063A1 Quality Assurance/Quality Control for High Throughput Bioassay Process 审中-公开
标题翻译：高通量生物测定过程的质量保证/质量控制
公开(公告)号：US20080103063A1
公开(公告)日：2008-05-01
申请号：US11968262
申请日：2008-01-02
申请人： Ben Hitt , Peter Levine , Emanuel Petricoin
发明人： Ben Hitt , Peter Levine , Emanuel Petricoin
IPC分类号： C40B50/02
CPC分类号： G01N33/6848 , C40B30/04 , G01N33/6803 , G16B25/00 , G16B40/00 , Y10T436/24
摘要： The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to the bioassay process model to determine if the test sample and the bioassay process are producing acceptable data. Alternatively, the method may include comparing spectral data based on a combination of serum and diluents used in an electrospray process to the bioassay process model. If the bioassay process and test sample fall within the model, then the spectrum produced may be further analyzed.
摘要翻译：本发明涉及高通量生物测定方法的质量保证/质量控制方法。该方法包括生成生物测定过程模型，然后将基于生物芯片和测试血清的组合的光谱数据与生物测定过程模型进行比较，以确定测试样品和生物测定过程是否产生可接受的数据。或者，该方法可以包括将基于电喷雾过程中使用的血清和稀释剂的组合的光谱数据与生物测定过程模型进行比较。如果生物测定过程和测试样品落在模型中，则可以进一步分析产生的光谱。

25. 发明申请

US20110046039A1 POST-EXPOSURE PROPHYLAXIS AND TREATMENT OF INFECTIONS 审中-公开
标题翻译：暴露后预防和治疗感染
公开(公告)号：US20110046039A1
公开(公告)日：2011-02-24
申请号：US12530538
申请日：2008-03-06
申请人： Serguei G. Popov , Taissia Popov , Virginia Espina , Charles Bailey , Lance A. Liotta , Emanuel Petricoin
发明人： Serguei G. Popov , Taissia Popov , Virginia Espina , Charles Bailey , Lance A. Liotta , Emanuel Petricoin
IPC分类号： A61K38/07 , A61P31/04
CPC分类号： A61K45/06 , A61K31/496 , A61K2300/00
摘要： The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying non-lethal and lethal exposure to anthrax and similar disease vectors. Embodiments provide materials and methods for using the strains and model systems for differential profiling, such as proteomic profiling, such as differentiation phosphorylation profiling, to target identification and therapeutics discovery and development. Embodiments provide pharmaceutically acceptable compositions, and methods for using them to prevent and/or treat anthrax and similar diseases comprising an agent that decreases the activity of caspase ¼, such as YVAD, and/or an agent that increases the phosphorylation of AKT, such as IB-MECA or Cl-IB-MECA, together with, in particular embodiments, an antibiotic, such as ciprofloxacin. Kits comprising the same are provided as well, among other things.
摘要翻译：本发明提供用于鉴定用于预防和/或治疗炭疽和类似疾病的药剂的方法和材料。实施例提供用于研究非致死和致死性暴露于炭疽和类似疾病载体的菌株和模型系统。实施例提供了用于使用菌株和模型系统进行差异分析的材料和方法，例如蛋白质组学分析，例如分化磷酸化分析，以靶向鉴定和治疗发现和发展。实施方案提供了药学上可接受的组合物，以及使用它们来预防和/或治疗炭疽和类似疾病的方法，其包括降低半胱天冬酶（例如YVAD）的活性的试剂和/或增加AKT磷酸化的试剂，例如在特定实施方案中，IB-MECA或Cl-IB-MECA，以及抗生素，如环丙沙星。还提供了包括其的套件，以及其他。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式