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21. 发明申请

US20080108745A1 Irreversible immobilization of enzymes into polyurethane coatings 失效
标题翻译：不可逆地将酶固定在聚氨酯涂料中
公开(公告)号：US20080108745A1
公开(公告)日：2008-05-08
申请号：US12002841
申请日：2007-12-19
申请人： Alan Russell , Geraldine Drevon , Douglas Wicks , Karsten Danielmeier
发明人： Alan Russell , Geraldine Drevon , Douglas Wicks , Karsten Danielmeier
IPC分类号： C08G18/00
CPC分类号： C12N11/08 , C08G18/0866 , C08G18/3278 , C08G18/42 , C08G18/6446 , C08G18/706 , C08G18/798 , C09D175/04 , C12N11/04
摘要： A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of the enzyme to the polymeric matrix. The distribution of immobilized enzyme as well as activity retention are homogeneous within the polyurethane. Decreasing ECC hydrophobicity, via the use of a less hydrophobic polyisocyanate prepolymer during polymerization, significantly enhanced the intrinsic activity of the ECC.
摘要翻译：一种不可逆地将酶固定在聚氨酯中的方法和具有约100％酶固定度的含酶聚氨酯。在存在酶的情况下水性聚氨酯的合成使得酶不可逆连接到聚合物基质上。固定化酶的分布以及活性保留在聚氨酯中是均匀的。通过在聚合过程中通过使用较少疏水性的多异氰酸酯预聚物来降低ECC疏水性，显着提高了ECC的内在活性。

22. 发明申请

US20080014622A1 Devices, systems and methods for reducing the concentration of a chemical entity in fluids 有权
标题翻译：减少流体中化学物质浓度的装置，系统和方法
公开(公告)号：US20080014622A1
公开(公告)日：2008-01-17
申请号：US11811265
申请日：2007-06-08
申请人： William Federspiel , Alan Russell , Heung-II Oh , Joel Kaar
发明人： William Federspiel , Alan Russell , Heung-II Oh , Joel Kaar
IPC分类号： C12N11/04 , C12M3/00
CPC分类号： B01D69/144 , A61M1/1698 , A61M1/28 , A61M1/3679 , B01D19/0031 , B01D53/229 , B01D67/009 , B01D67/0093 , B01D69/08 , B01D69/145 , B01D71/26 , B01D71/70 , B01D2311/2653 , B01D2323/30 , B01D2325/10 , Y02C10/10
摘要： A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to be contacted with the fluid such that the immobilized carbonic anhydrase comes into contact with the fluid. The first surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the first surface of the membrane based on monolayer surface coverage of carbonic anhydrase in the case that the carbonic anhydrase is immobilize on the first surface.
摘要翻译：用于从水性流体中去除至少一部分二氧化碳的装置包括至少一个膜，二氧化碳可以通过该膜从流体中除去，并将固定的碳酸酐酶固定在膜的第一表面上或其附近，至与流体接触，使得固定的碳酸酐酶与流体接触。在碳酸酐酶固定在第一表面的情况下，第一表面基于碳酸酐酶的单层表面覆盖，显示出膜的第一表面的最大理论活性的至少20％的碳酸酐酶活性。

23. 发明申请

US20060116451A1 Stabilization of antioxidants 审中-公开
标题翻译：抗氧化剂稳定
公开(公告)号：US20060116451A1
公开(公告)日：2006-06-01
申请号：US11288925
申请日：2005-11-29
申请人： Bhalchandra Lele , Alan Russell
发明人： Bhalchandra Lele , Alan Russell
IPC分类号： C08K5/34
CPC分类号： C08K5/005
摘要： A composition includes at least one antioxidant moiety and at least one UV-absorbing moiety. The antioxidant moiety and the UV-absorbing moiety are maintained in proximity to each other. The UV-absorbing moiety and the antioxidant moiety can, for example, be attached to a common entity. The antioxidant moiety and the UV-absorbing moiety can, for example, be covalently attached within a single molecule. The UV-absorbing moiety can be attached sufficiently closely to the antioxidant moiety to enhance the stability of the antioxidant in an environment in which photooxidation can occur. In one embodiment, the UV-absorbing moiety is attached to the molecule to be juxtapositioned to the antioxidant moiety.
摘要翻译：组合物包含至少一种抗氧化剂部分和至少一种UV吸收部分。抗氧化剂部分和UV吸收部分保持彼此接近。 UV吸收部分和抗氧化剂部分可以例如连接到共同的实体。抗氧化剂部分和UV吸收部分可以例如共价连接在单个分子内。紫外线吸收部分可以充分接近抗氧化剂部分，以增强抗氧化剂在可能发生光氧化的环境中的稳定性。在一个实施方案中，UV吸收部分连接到分子以与抗氧化剂部分并置。

24. 发明授权

US06642037B2 Preparation of enzymatically active sponges or foams for detoxification of hazardous compounds 失效
标题翻译：制备用于有毒化合物解毒的酶活性海绵或泡沫
公开(公告)号：US06642037B2
公开(公告)日：2003-11-04
申请号：US09558512
申请日：2000-04-26
申请人： Richard K. Gordon , Bhupendra P. Doctor , Ashima Saxena , Shawn R. Feaster , Donald Maxwell , Michelle Ross , David Lenz , Keith Lejeune , Alan Russell
发明人： Richard K. Gordon , Bhupendra P. Doctor , Ashima Saxena , Shawn R. Feaster , Donald Maxwell , Michelle Ross , David Lenz , Keith Lejeune , Alan Russell
IPC分类号： C12N1104
CPC分类号： A62D3/00 , A61L2/16 , A61L2/235 , A62D3/02 , A62D2101/02 , A62D2101/26 , A62D2101/28 , C08G18/10 , C08G2101/0083 , C12N11/04 , C12N11/18 , C08G18/3821
摘要： An enzymatically active reusable sponge or foam, capable of regeneration with oximes, made of a polymer such as polyurethane is prepared for detoxification of hazardous compounds such as organophosphorus and organosulfur compounds. The foam or sponge contains a plurality of enzymes including enzymes selected from acetylcholinesterase, butyrylcholinesterase, triesterase, pseudocholinesterase, organophosphate hydrase, phosphotriesterase, paraoxonase and organophosphorus and organosulfur hydrolyzing enzymes. The sponge or foam may additionally contain activated carbon and an enzyme reactivation compound. A kit can be formed containing the sponge or foam and the compound for enzyme reactivation. The enzymatically active foam or sponge may be prepared using a two chamber device where enzymes and prepolymer are passed from separate chambers into a static mixing stator and are subjected to low shear mixing and extrusion to form by the sponge or foam.
摘要翻译：制备能够由诸如聚氨酯的聚合物制成的能够用肟再生的酶活性可重复使用的海绵或泡沫，用于有机磷和有机硫化合物等有害化合物的解毒。泡沫或海绵含有多种酶，包括选自乙酰胆碱酯酶，丁酰胆碱酯酶，三酯酶，假胆碱酯酶，有机磷酸盐水解酶，磷酸三酯酶，对氧磷酶和有机磷和有机硫水解酶的酶。海绵或泡沫可另外含有活性炭和酶再活化化合物。可以形成包含海绵或泡沫的试剂盒和用于酶再活化的化合物。酶活性泡沫或海绵可以使用两室装置制备，其中酶和预聚物从分离的室进入静态混合定子，并经受低剪切混合和挤出以由海绵或泡沫形成。

25. 发明授权

US06406876B1 Immobilized enzymes biosensors for chemical toxins 有权
标题翻译：固定化酶作为化学毒素的生物传感器
公开(公告)号：US06406876B1
公开(公告)日：2002-06-18
申请号：US09558511
申请日：2000-04-26
申请人： Richard K. Gordon , Bhupendra P. Doctor , Ashima Saxena , Shawn R. Feaster , Donald Maxwell , Michelle Ross , David Lenz , Keith LeJeune , Alan Russell
发明人： Richard K. Gordon , Bhupendra P. Doctor , Ashima Saxena , Shawn R. Feaster , Donald Maxwell , Michelle Ross , David Lenz , Keith LeJeune , Alan Russell
IPC分类号： C12Q146
CPC分类号： C12Q1/34 , C12Q1/26 , C12Q1/28 , C12Q1/42 , C12Q1/44 , C12Q1/46 , Y10S435/963 , Y10S435/97
摘要： Methods, compositions and materials useful in the detection of organophosphorous and organosulfur compounds are disclosed. In particular, biosensors wherein a porous or a non-porous support having an enzyme immobilized upon or within are disclosed. The biosensors exhibit enzymatic stability at extreme temperatures and/or denaturing conditions, and similar kinetic characteristics of the soluble form of the enzymes utilized. The enzyme does not leach from the porous or non-porous support and the material retains enzymatic activity after prolonged storage. Differential biosensors are also disclosed.
摘要翻译：公开了用于检测有机磷和有机硫化合物的方法，组合物和材料。特别地，公开了其中固定有或内部固定有酶的多孔或无孔载体的生物传感器。生物传感器在极端温度和/或变性条件下表现出酶稳定性，以及所用酶的可溶形式的类似动力学特征。该酶不会从多孔或非多孔载体中浸出，并且材料在长时间储存后保留酶活性。还公开了差示生物传感器。

26. 发明授权

US4657595A Quick setting anionic bituminous emulsions 失效
标题翻译：快速设定阴离子沥青乳液
公开(公告)号：US4657595A
公开(公告)日：1987-04-14
申请号：US776278
申请日：1985-09-16
申请人： Alan Russell
发明人： Alan Russell
IPC分类号： E01C7/08 , C08K5/42 , C08K7/16 , C08K7/18 , C08L11/02 , C08L21/00 , C08L95/00
CPC分类号： C08K5/42
摘要： Quick setting anionic bituminous emulsions in which the emulsifier is an alkylbenzenesulfonic acid which has been neutralized with specified alkyl or hydroxyalkyl amines.
摘要翻译：快速设定阴离子沥青乳液，其中乳化剂是用特定的烷基或羟烷基胺中和的烷基苯磺酸。

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