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21. 发明授权

US5574069A Substituted benzenesulfonylureas and -thioureas- process for their preparation and their use as pharmaceuticals 失效
标题翻译：取代苯磺酰脲和硫脲 - 其制备方法及其作为药物的用途
公开(公告)号：US5574069A
公开(公告)日：1996-11-12
申请号：US393027
申请日：1995-02-23
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/10 , C07C303/40 , C07C311/46 , C07C311/58 , C07C323/67 , C07C335/42 , A61K31/17
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto) alk (oxy) yl, E is O or S; Y is --[CR(3).sub.2 ]n-, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译：苯基磺酰脲和式I的硫脲，其中R（1）是H或（氟）甲基，R（2）是H，Hal或（氟）（巯基）烷基（氧）），E是O或 S; Y是 - [CR（3）2] n - ，其中R（3）= H或烷基，n = 1-4，X是H，Hal或烷基，Z是Hal，NO 2或烷基（yl）描述。化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。

22. 发明授权

US5364868A Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them 失效
标题翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物
公开(公告)号：US5364868A
公开(公告)日：1994-11-15
申请号：US16535
申请日：1993-02-11
申请人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
发明人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
IPC分类号： A61K31/155 , A61K31/165 , A61K31/445 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , C07C279/22 , C07D213/65 , C07D295/14 , C07D295/155 , C07C279/10 , C07D207/06 , C07D211/28
CPC分类号： C07D295/155 , C07C279/22 , C07D213/65
摘要： Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing themBenzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH.sub.2).sub.p -- where p=0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF.sub.3, C.sub.m F.sub.2m+1 --CH.sub.2 --, benzyl or phenoxy, and their pharmaceutically tolerable salts.The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
摘要翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物描述了其中R（1）或R（2）是氨基-NR（ 3）R（4）其中R（3）和R（4）是H或（环）烷基或R（3）是苯基 - （CH 2）p - ，其中p = 0,1,2,3或4，或苯基或R（3）和R（4）也可以一起为亚甲基链，其中每种情况下其它取代基R（1）或R（2）为H，F，Cl，烷基，烷氧基， CF3，CmF2m + 1-CH2-，苄基或苯氧基，及其药学上可耐受的盐。根据本发明的化合物具有非常好的抗心律失常性质，例如在缺氧症状的情况下发生。该化合物被用作具有用于梗塞预防和梗塞治疗的心脏保护组分以及用于治疗心绞痛的抗心律失常药物，其中它们也预防性地抑制或大大降低缺血诱导的损伤形成中的病理生理过程，特别是在产生缺血诱导的心律失常。

23. 发明授权

US5310753A Ethanol adducts of 6-sulfonyl-substituted 3-hydroxy-chromans and their use as inhalants in diseases 失效
标题翻译： 6-磺酰基取代的3-羟基 - 黑色素的乙醇加合物及其作为吸入剂在疾病中的用途
公开(公告)号：US5310753A
公开(公告)日：1994-05-10
申请号：US988839
申请日：1992-12-10
申请人： Heinrich Englert , Dieter Mania , Paul-Gerhard Kibat , Doris Gehring , Erich Paulus
发明人： Heinrich Englert , Dieter Mania , Paul-Gerhard Kibat , Doris Gehring , Erich Paulus
IPC分类号： A61K31/35 , A61K9/12 , A61K31/352 , A61K31/353 , A61K31/40 , A61K31/4025 , A61K31/445 , A61P11/00 , A61P11/06 , A61P11/08 , C07D207/12 , C07D311/68 , C07D311/74 , C07D405/04
CPC分类号： C07D405/04
摘要： The invention relates to ethanol adducts of the compounds of the formula I ##STR1## to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.
摘要翻译：本发明涉及式I化合物的乙醇加合物，其制备方法及其作为疾病，特别是哮喘中的吸入剂。

24. 发明申请

US20110201590A1 SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF 有权
标题翻译：取代氨基酸及其类似物及其药物用途
公开(公告)号：US20110201590A1
公开(公告)日：2011-08-18
申请号：US13061805
申请日：2009-08-25
申请人： Nils Rackelmann , Laurent Bialy , Heinrich Englert , Klaus Wirth , Petra Arndt , John Weston , Uwe Heinelt , Markus Follmann
发明人： Nils Rackelmann , Laurent Bialy , Heinrich Englert , Klaus Wirth , Petra Arndt , John Weston , Uwe Heinelt , Markus Follmann
IPC分类号： A61K31/454 , A61K31/4025 , A61K31/5377 , A61K31/4995 , A61K31/496 , A61K31/4439 , A61K31/4178 , A61K31/407 , C07D243/08 , C07D413/12 , C07D403/12 , C07D401/12 , C07D487/04 , A61P25/00 , A61P11/00 , A61P13/12 , A61P1/00 , A61P9/12 , A61P9/00 , A61P3/06 , A61P3/10 , A61P3/00
CPC分类号： C07D487/10 , C07D205/04 , C07D207/08 , C07D211/56 , C07D243/08 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D487/08
摘要： The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders.
摘要翻译：本发明涉及式（I）的取代氨基茚子及其类似物及其药物用途。包含这种类型化合物的药物适用于预防或治疗多种疾病，例如呼吸系统疾病，囊性纤维化疾病，急性或慢性肾脏疾病或排便障碍。

25. 发明授权

US6090981A Substituted benzenesulfonylureas and -thioureas--process for their preparation and their use as pharmaceuticals 失效
标题翻译：取代苯磺酰脲和硫脲制备方法及其作为药物的用途
公开(公告)号：US6090981A
公开(公告)日：2000-07-18
申请号：US81143
申请日：1998-05-19
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David W. Laufer
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David W. Laufer
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/10 , C07C303/40 , C07C311/46 , C07C311/58 , C07C323/67 , C07C335/42 , C07C311/16
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(ozy)yl, E is O or S; Y is --[CR(3).sub.2 ].sub.n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z in Hal, NO.sub.2 or alk(yl)oxy, are described.The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译：其中R（1）为H或（氟）甲基，R（2）为H，Hal或（氟）（巯基）烷基（ozy）），E为O或S的式I的苯磺酰脲和硫脲， Y是 - [CR（3）2] n - ，其中R（3）= H或烷基且n = 1-4，X是H，Hal或烷基，Hal在Hal，NO 2或烷基（yl）描述。化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。

26. 发明授权

US5880155A Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them 失效
标题翻译：取代苯磺酰脲和硫脲，其制备和使用基于这些化合物的药物制剂及其含有药物的方法
公开(公告)号：US5880155A
公开(公告)日：1999-03-09
申请号：US602018
申请日：1996-02-15
申请人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
发明人： Heinrich Englert , Uwe Gerlach , Dieter Mania , Heinz Gogelein , Joachim Kaiser
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07C233/00 , C07C303/36 , C07C303/40 , C07C311/57 , C07C311/58 , C07C311/59 , C07C327/40 , C07C335/00 , C07C335/42 , A61K31/17 , C07C311/16
CPC分类号： C07C335/42 , C07C311/58 , C07C2101/02 , C07C2101/14 , Y10S514/821
摘要： This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
摘要翻译：本发明涉及取代的苯磺酰脲和硫脲，其制备和使用基于这些化合物的药物制剂及其含有药物的方法。式I的取代苯磺酰脲和硫脲显示出对心血管系统的作用。

27. 发明授权

US5516805A 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them 失效
标题翻译： 3,5-取代的氨基苯甲酰基胍，它们用作药物或诊断剂以及含有它们的药物
公开(公告)号：US5516805A
公开(公告)日：1996-05-14
申请号：US450225
申请日：1995-05-25
申请人： Hans-Jochen Lang , Heinrich Englert , Andreas Weichert , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
发明人： Hans-Jochen Lang , Heinrich Englert , Andreas Weichert , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
IPC分类号： A61K31/165 , A61K31/155 , A61K49/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P35/00 , A61P43/00 , C07C279/22 , C07C311/16
CPC分类号： C07C279/22
摘要： 3,5-Substituted aminobenzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing themThere are described benzoylguanidines of the formula I ##STR1## where one of the substituents R(1), R(2), R(3) or R(4) is: an amino group ##STR2## where R(5), R(6)=inter alia, H or alkyl, or alternatively R(5) and R(6), together with the nitrogen atom, are a 5-7-membered ring, and the other substituents R(1), R(2), R(3) and R(4) in each case are: H, Hal, CN, CF.sub.3, NO.sub.2, CF.sub.3 --O--, C.sub.m F.sub.2m+1 --CH.sub.2 --O--, R(11)--C.sub.q H.sub.2q --X.sub.p --, X=O or NR(12), R(11)=H, (cyclo)alkyl, phenyl, and where R(1) and R(4) are not simultaneously hydrogen.The compounds I have very good antiarrhythmic and cardio-protective properties, but no undesired salidiuretic properties. They additionally exhibit protective properties against is chemically induced damage in vivo and in vitro in different organs and gastroprotective properties as a result of inhibition of gastric acid secretion. Moreover, they are distinguished by inhibitory action on the proliferation of cells.
摘要翻译： 3,5-取代的氨基苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途和含有它们的药物描述了式I（I）的苯甲酰胍，其中取代基R（1），R（2 ），R（3）或R（4）是：氨基，其中R（5），R（6）=特别是H或烷基，或者R（5）和R（6）与氮原子一起为5-7元环，其他取代基R（1），R（2），R（3）和R（4）分别为：H，Hal，CN，CF 3， NO2，CF3-O-，CmF2m + 1-CH2-O-，R（11）-CqH2q-Xp-，X = O或NR（12），R（11）= H，（环）烷基，苯基和其中R（1）和R（4）不同时为氢。化合物I具有非常好的抗心律失常和心脏保护作用，但没有不希望的耐盐性。它们另外表现出防止由于抑制胃酸分泌而导致的体内和体外在不同器官和胃保护性质中的化学诱导的损伤的保护性。此外，它们通过对细胞增殖的抑制作用来区分。

28. 发明授权

US5373024A 3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them 失效
标题翻译： 3,5-取代的苯甲酰胍，其制备方法，它们作为含有它们的诊断药物和药物的用途
公开(公告)号：US5373024A
公开(公告)日：1994-12-13
申请号：US15926
申请日：1993-02-10
申请人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
发明人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
IPC分类号： A61K31/155 , A61K31/18 , A61K31/275 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , A61P35/04 , C07C217/44 , C07C311/16 , C07C311/37 , C07C311/39 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/65 , C07C279/22
CPC分类号： C07C217/44 , C07C311/16 , Y10S514/821
摘要： Benzoylguanidines of the formula I ##STR1## are described where R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.z --, where R(4) and R(5) are alk(en)yl or --C.sub.n H.sub.2n --R(7), and where R(7) is a cycloalkyl or phenyl, where R(5) also has the meaning of H, and R(6) is H or C.sub.1 -C.sub.4 -alkyl, R(2) is hydrogen, halogen, alkyl, O--(CH.sub.2).sub.m C.sub.p F.sub.2p+1, --X--R(10), where X is O, S or NR(11), R(10) is H, (cyclo)alkyl(methyl) or --C.sub.n H.sub.2n --R(12) where R(12) is phenyl, and R(3) is defined, inter alia, as R(1), and their pharmaceutically tolerable salts.The compounds I are obtained by reaction of compounds of the formula II ##STR2## with guanidine, in which L is a leaving group which can be easily nucleophilically substituted.Compounds I are outstandingly suitable as antiarrythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris, where they also preventively inhibit or greatly reduce the pathophysiological processes during the formation of ischemically induced damage. They are moreover distinguished by strong inhibitory action on the proliferation of cells. They can therefore be used as antiatherosclerotics, agents against late-onset diabetic complications, cancers, and fibrotic diseases such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys.They are effective inhibitors of the cellular sodium/proton antiporter (Na.sup.+ /H.sup.+ exchanger).
摘要翻译：其中R（1）为R（4）-SOm或R（5）R（6）N-SOz-，其中R（4）和R（5）为烷基（烯）或-C n H 2n-R（7），其中R（7）为环烷基或苯基，其中R（5）也为H，R（6）为H或C 1 -C 4 - 烷基，R（2）为氢，卤素，烷基，O-（CH2）mCpF2p + 1，-XR（10）其中X为O，S或NR（11），R（10）为H，（环）烷基（甲基）或-CnH2n-R（12）其中R（12）为苯基，R（3）特别定义为R（1）及其药学上可耐受的盐。化合物I通过式II化合物（II）与胍反应而获得，其中L是可容易地亲核取代的离去基团。化合物I非常适合作为具有用于梗死预防和梗塞治疗的心脏保护组分和用于治疗心绞痛的抗焦虑药物，其中它们还预防性地抑制或大大降低在缺血诱导的损伤形成期间的病理生理过程。此外，它们通过对细胞增殖的强抑制作用而不同。因此，它们可以用作抗动脉粥样硬化，抗晚发性糖尿病并发症，癌症和纤维化疾病如肺纤维化，肝纤维化或肾纤维化的药物。它们是细胞钠/质子反转录酶（Na + / H +交换剂）的有效抑制剂。

29. 发明授权

US5360808A Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production and their use 失效
标题翻译：芳基羰基氨基烷基 - 二氢 - 氧代 - 吡啶，其生产及其用途
公开(公告)号：US5360808A
公开(公告)日：1994-11-01
申请号：US19296
申请日：1993-02-18
申请人： Heinrich Englert , Dieter Mania , David Wettlaufer , Erik Klaus
发明人： Heinrich Englert , Dieter Mania , David Wettlaufer , Erik Klaus
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61P9/00 , A61P21/00 , C07D213/64 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/89 , C07D401/12
CPC分类号： C07D213/80 , C07D213/81 , C07D401/12
摘要： Arylcarbonylaminoalkyl-dihydro-oxo-pyridines of Formula I ##STR1## are disclosed wherein aryl is an aromatic or heteroaromatic system, n is zero through 5; R and R(1), are hydrogen, or loweralkyl; W is hydrogen, (hetero)-(aryl)-loweralkyl; Z is hydrogen, CH.sub.2 OR(2.sub.), CHO, (CO)OR(2), (CO)NR(2).sub.2.Processes for the preparation of compound I are also disclosed.Compounds I are suitable for the treatment of disorders of the cardiovascular system, for example of hypertension, of cardiac insufficiency or of disturbances of blood flow in the coronary systems such as, for example, angina. Disturbances of cerebral and peripheral blood flow are likewise influenced beneficially. Furthermore, compounds I are able to influence smooth-muscle organs such as uterus, bronchi, intestines and biliary system, the urinary tract (ureter, bladder and urethra) in the sense of spasmolysis. They are therefore also suitable for the treatment of diseases associated with spasms of these organs, for example for the treatment of premature labor in pregnancy, of ureteral or biliary colic, of obstructive airway diseases such as asthma, of disturbances of intestinal motility such as, for example, of irritable colon or of bladder incontinence. Additionally, compounds of formula 1 can serve as anticonvulsants in the treatment of epilepsy.
摘要翻译：公开了式I的芳基羰基氨基烷基 - 二氢 - 氧代 - 吡啶，其中芳基是芳族或杂芳族体系，n为0至5; R和R（1）是氢或低级烷基; W是氢，（杂） - （芳基） - 低级烷基; Z是氢，CH2OR（2），CHO，（CO）OR（2），（CO）NR（2）2。还公开了制备化合物I的方法。化合物I适用于治疗冠状动脉系统（例如心绞痛）的心脏功能不全或血液流动紊乱的心血管系统疾病，例如高血压。脑和周围血流紊乱同样受到有利影响。此外，化合物I能够影响平滑肌器官如子宫，支气管，肠和胆汁系统，尿道（输尿管，膀胱和尿道）在解剖意义上。因此，它们也适用于治疗与这些器官的痉挛有关的疾病，例如用于治疗怀孕期间的输尿管或胆道绞痛，阻塞性气道疾病如哮喘，肠蠕动紊乱，例如，肠易激综合症或膀胱失禁。此外，式1的化合物可用作治疗癫痫的抗惊厥药。

30. 发明授权

US06506937B2 Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals 失效
标题翻译：取代苯磺酰脲和硫脲制备方法及其作为药物的用途
公开(公告)号：US06506937B2
公开(公告)日：2003-01-14
申请号：US09995782
申请日：2001-11-29
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
IPC分类号： C07C31116
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Benzenesulfonylureas and -thioureas of the formula I where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro) (mercapto)alk(oxy)yl, E is O or S; Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO3 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used an antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译：苯基磺酰脲和式I的硫脲，其中R（1）为H或（氟）甲基，R（2）为H，Hal或（氟）（巯基）烷（氧）基，E为O或S; Y是 - [CR（3）2] n-，其中R（3）= H或烷基，n = 1-4，X是H，Hal或烷基，Z是Hal，NO 3或烷基（yl）化合物I用于治疗心律紊乱和预防心律失常引起的心脏猝死，因此可用于抗心律失常药物。它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。

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