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    • 22. 发明专利
    • Spray drying apparatus and methods of use.
    • ZA200109553B
    • 2003-06-06
    • ZA200109553
    • 2001-11-20
    • ACUSPHERE INC
    • CHICKERING DONALD EKEEGAN MARK JRANDALL GREGBERNSTEIN HOWARDSTRAUB JULIE
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10B01DB01J
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.
    • 24. 发明专利
    • NO20015351D0
    • 2001-11-01
    • NO20015351
    • 2001-11-01
    • ACUSPHERE INC
    • CHICKERING DONALD EKEEGAN MARK JRANDALL GREGBERNSTEIN HOWARDSTRAUB JULIE
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10B01J
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.
    • 25. 发明专利
    • NO20015351L
    • 2001-01-02
    • NO20015351
    • 2001-11-01
    • ACUSPHERE INC
    • CHICKERING DONALD EKEEGAN MARK JRANDALL GREGBERNSTEIN HOWARDSTRAUB JULIE
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.
    • 26. 发明专利
    • DK1180020T3
    • 2006-03-27
    • DK00939365
    • 2000-05-25
    • ACUSPHERE INC
    • KHATAK SARWATSTRAUB JULIEBERNSTEIN HOWARDRANDALL GREGCHICKERING DONALD E III
    • A61K9/14A61K9/16A61K9/02A61K9/08A61K9/10A61K9/20A61K9/48A61K47/02A61K47/12A61K47/26A61K47/34
    • Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solutions, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral admisnistration. Paclitaxel or docetaxel can be provided in a porous matrix form, which allows the drug to be formulated without solubilizing agents and administered as a bolus. rocessed using standard techniques into tablets or capsules for oral administration. Paclitaxel or docetaxel can be provided in a porous matrix form, which allows the drug to be formulated without solubilizing agents and administered as a bolus.
    • 27. 发明专利
    • AT312601T
    • 2005-12-15
    • AT00939365
    • 2000-05-25
    • ACUSPHERE INC
    • STRAUB JULIEBERNSTEIN HOWARDCHICKERING DONALD E IIIKHATAK SARWATRANDALL GREG
    • A61K9/14A61K9/02A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61K47/02A61K47/12A61K47/26A61K47/34
    • Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solutions, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral admisnistration. Paclitaxel or docetaxel can be provided in a porous matrix form, which allows the drug to be formulated without solubilizing agents and administered as a bolus. rocessed using standard techniques into tablets or capsules for oral administration. Paclitaxel or docetaxel can be provided in a porous matrix form, which allows the drug to be formulated without solubilizing agents and administered as a bolus.
    • 28. 发明专利
    • SPRAY DRYING APPARATUS AND METHODS OF USE
    • CA2372194C
    • 2005-01-18
    • CA2372194
    • 2000-04-26
    • ACUSPHERE INC
    • RANDALL GREGKEEGAN MARK JBERNSTEIN HOWARDSTRAUB JULIECHICKERING DONALD E
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber (20) and a secondary drying apparatus (10) which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying witho ut the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield. The ratio of the length of tubing to t he length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easi ly be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of microparticles, between about 1 and 200 .mu.m in diameter, whi ch can be used to deliver therapeutic and diagnostic agents.
    • 29. 发明专利
    • DK1175257T3
    • 2004-07-05
    • DK00928391
    • 2000-04-26
    • ACUSPHERE INC
    • KEEGAN MARK JCHICKERING DONALD ERANDALL GREGBERNSTEIN HOWARDSTRAUB JULIE
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.
    • 30. 发明专利
    • AT260707T
    • 2004-03-15
    • AT00928391
    • 2000-04-26
    • ACUSPHERE INC
    • CHICKERING DONALD EKEEGAN MARK JRANDALL GREGBERNSTEIN HOWARDSTRAUB JULIE
    • F26B3/06A61K9/16B01D1/18B01J2/04F26B17/10F26B17/16F26B23/10
    • Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.