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21. 发明专利

AU2014261101A1 Quinolone derivatives 未知
公开(公告)号：AU2014261101A1
公开(公告)日：2015-12-17
申请号：AU2014261101
申请日：2014-04-30
申请人： ACTELION PHARMACEUTICALS LTD
发明人： ENDERLIN-PAPUT STEPHANIE , HUBSCHWERLEN CHRISTIAN , RUEEDI GEORG , ZUMBRUNN CORNELIA
IPC分类号： C07D498/04 , A61K31/424 , A61K31/429 , A61K31/4353 , A61P31/04 , C07D513/04 , C07D519/00
摘要： The invention relates to antibacterial compounds of formula (I), wherein R

22. 发明专利

SG11201508479RA ANTIBACTERIAL BIAROMATIC DERIVATIVES 未知
公开(公告)号：SG11201508479RA
公开(公告)日：2015-11-27
申请号：SG11201508479R
申请日：2014-04-15
申请人： ACTELION PHARMACEUTICALS LTD
发明人： CREN SYLVAINE , FRIEDLI ASTRID , HUBSCHWERLEN CHRISTIAN , RUEEDI GEORG , ZUMBRUNN CORNELIA
IPC分类号： C07D413/14 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/542 , A61P31/00 , C07D413/04 , C07D417/04 , C07D417/14 , C07D498/04 , C07D513/04
摘要： The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (1-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-1-yl or 3,4-dihydroxycyclopentyl)methoxy; U1 is N or CR1, U2 is N or CR1, U3 is N or CR3 and U4 is N or CR1, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time; V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time; R1 is H, cyano, hydroxy or alkoxy; R2 is H, hydroxy or alkoxy; R3 is H, cyano, hydroxy, alkoxy or carboxamido; R4 is H or alkoxy; R5 is H, hydroxy or halogen; R6 is H, hydroxy or halogen; R7 is H; the dotted line “______” represents a bond or is absent; W represents CH or N when the dotted line “______” is a bond, or W represents CH2 when the dotted line “______” is absent; X represents CH or N; and Q represents O or S; and salts thereof.

23. 发明专利

AU2014255326A1 Antibacterial biaromatic derivatives 未知
公开(公告)号：AU2014255326A1
公开(公告)日：2015-11-26
申请号：AU2014255326
申请日：2014-04-15
申请人： ACTELION PHARMACEUTICALS LTD
发明人： CREN SYLVAINE , FRIEDLI ASTRID , HUBSCHWERLEN CHRISTIAN , RUEEDI GEORG , ZUMBRUNN CORNELIA
IPC分类号： C07D413/14 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/542 , A61P31/00 , C07D413/04 , C07D417/04 , C07D417/14 , C07D498/04 , C07D513/04
摘要： The invention relates to antibacterial compounds of formula I (I) wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (l-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-l-yl or 3,4-dihydroxycyclopentyl)methoxy; U

25. 发明专利

SI2344495T1 Spojine tricikličnega oksazolidinonskega antibiotika 未知
公开(公告)号：SI2344495T1
公开(公告)日：2015-03-31
申请号：SI200931132
申请日：2009-10-06
申请人： ACTELION PHARMACEUTICALS LTD
发明人： HUBSCHWERLEN CHRISTIAN , RITZ DANIEL , RUEEDI GEORG , SURIVET JEAN-PHILIPPE , ZUMBRUNN ACKLIN CORNELIA
IPC分类号： C07D471/00 , A61K31/00 , A61P31/00 , C07D487/00 , C07D519/00

26. 发明专利

CA2668369C 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE ANTIBACTERIALS 未知
公开(公告)号：CA2668369C
公开(公告)日：2015-03-31
申请号：CA2668369
申请日：2007-11-23
申请人： ACTELION PHARMACEUTICALS LTD
发明人： HUBSCHWERLEN CHRISTIAN , PANCHAUD PHILIPPE , SPECKLIN JEAN-LUC
IPC分类号： C07D498/14 , A61K31/5383 , A61P31/04
摘要： The invention relates to novel chimeric antibiotics of formula (I) wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; R3 represents H or halogen; R4 is H, (C1-C3) alkyl, or cycloalkyl; R5 represents piperidin-4-yl or R5 is the residue of a naturally occurring amino acid, of the enantiomer of a naturally occurring amino acid or of dimethylaminoglycine; n is O or 1; and to salts (in particular pharmaceutically acceptable salts) of compounds of formula (I). These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).

27. 发明专利

AU2009245351B2 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases 未知
公开(公告)号：AU2009245351B2
公开(公告)日：2015-01-22
申请号：AU2009245351
申请日：2009-05-08
申请人： ACTELION PHARMACEUTICALS LTD
发明人： LOCHER HANS , HUBSCHWERLEN CHRISTIAN
IPC分类号： A61K31/4375 , A61K31/4709 , A61P31/00
摘要： The invention relates to the compounds of formula I (I) wherein A is N or CH; and n is 0 or 1; or the pharmaceutically acceptable salts thereof, for preventing or treating intestinal diseases which are caused by bacteria selected from Clostridium difficile, Clostridium perfringens or Staphylococcus aureus.

29. 发明专利

ES2438742T3 Derivados de 2-hidroxietil-1H-quinolin-2-ona y sus análogos azaisostéricos con actividad antibacteriana 未知
公开(公告)号：ES2438742T3
公开(公告)日：2014-01-20
申请号：ES10714481
申请日：2010-04-08
申请人： ACTELION PHARMACEUTICALS LTD
发明人： HUBSCHWERLEN CHRISTIAN , RUEEDI GEORG , SURIVET JEAN-PHILIPPE , ZUMBRUNN ACKLIN CORNELIA
IPC分类号： C07D491/056 , A61K31/436 , A61K31/4365 , A61K31/498 , A61P31/04 , C07D497/04
摘要： Un compuesto de fórmula I en la que R1 representa alcoxi (C1-C4); cada uno de U y V representa CH y W representa CH o N, o U representa N, V representa CH y W representa CH o N, o cada uno de U y V representa N y W representa CH; R2 representa hidrógeno o flúor cuando W representa CH o R2 representa hidrógeno cuando W representa N; A representa O o CH2; Y representa CH o N; Q representa O o S; y n representa 0 o 1; o una sal de dicho compuesto.

30. 发明专利

MX2013011253A DERIVADOS DE 3-UREIDOISOQUINOLIN-8-ILO. 未知
公开(公告)号：MX2013011253A
公开(公告)日：2013-10-17
申请号：MX2013011253
申请日：2012-03-28
申请人： ACTELION PHARMACEUTICALS LTD
发明人： HUBSCHWERLEN CHRISTIAN , GUDE MARKUS , PANCHAUD PHILIPPE
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P31/04 , C07D401/04 , C07D401/12 , C07D401/14
摘要： La invención se refiere a derivados de 3-ureidoisoquinolin-8-ilo de la fórmula I; (Ver Formula) en donde R1 es alquilo, haloalquilo o ciclopropilo; R2 es H, halógeno, piridazin-4-ilo, pirimidin-5-ilo o un grupo piridin-3-ilo, piridin-4-ilo o fenilo opcionalmente sustituido; R3 es alquilo, alquinilo, aminoalquilo, carbamoiloalquilo, metilcarbamoiloalquilo, alcoxi, haloalcoxi, alquiniloxi, (4-hidroxibut-2-in-1-iI)oxi, (4-aminobut-2-in-1-il)ox i, dimetilaminoalcoxi, carbamoiloalcoxi, alquilamino, cicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, hidroxialquilo, hiroxialcoxi, alcoxialquilo, alcoxialcoxi, carboxialquilo, carboxialcoxi, alcoxicarbonilalcoxi, arilo, heteroarilo, bencilo, benciloxi, 2-cianoetoxi, 2,3-dihidroxipropoxi, 3,4-dihidroxibutoxi, CH2Ra, CH2CH2RLD, (CH2)C(O)ORd, (CH2)N(Rc)C(O)ORd, -O-(CH2)- N(Rc)C(O)ORd, (CH2)n-Re o o(CH2)n-Re; R es ciano, acetilamino o N,N-dimetilamino; Rb es ciano o carbamoilo; Rc es H o metilo; Rd es alquilo; R es pirrolidin-1-ilo, piperidin-1-ilo, piperidin-3-ilo, morfolin-1-ilo, 2-oxopirrolidin-1-ilo, 5-oxopirrolidin- 2-Ho, 2,5-dioxopirrolidin-1-ib, 2-oxoimidazoliden-1-ib, 4-(terc-butoxicarbonil)piperazin-1-ilo, 4-(aminometil)cicbohexibo o heteroaribo; es H o metilo; y a las sales de tales compuestos. Estos compuestos son útiles para la prevención o el tratamiento de infecciones bacterianas.

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