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21. 发明授权

US06340774B1 Non-steroidal estrogen-receptor antagonists 失效
标题翻译：非甾体雌激素受体拮抗剂
公开(公告)号：US06340774B1
公开(公告)日：2002-01-22
申请号：US09773816
申请日：2001-01-31
申请人： Chaitan Khosla , Zhihao Hu , Thomas Marti
发明人： Chaitan Khosla , Zhihao Hu , Thomas Marti
IPC分类号： C07C49115
CPC分类号： C07C49/737
摘要： This invention relates generally to non-steroidal estrogen-receptor (ER) antagonists that are useful as therapeutics in the treatment of advanced stage breast cancer. More particularly, this invention relates to the cloning and heterologous expression of genes encoding ER antagonists. This invention also relates to the use of such expression to overproduce the ER antagonist and analogs thereof.
摘要翻译：本发明一般涉及可用作治疗晚期乳腺癌的治疗剂的非甾体雌激素受体（ER）拮抗剂。更具体地，本发明涉及编码ER拮抗剂的基因的克隆和异源表达。本发明还涉及使用这种表达来过量产生ER拮抗剂及其类似物。

22. 发明授权

US11066682B2 Methods and compositions for improved production of fatty acids and derivatives thereof 有权
公开(公告)号：US11066682B2
公开(公告)日：2021-07-20
申请号：US14007857
申请日：2012-04-02
申请人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
发明人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
IPC分类号： C12P7/62 , C12P7/64 , C07K14/245 , C07K14/195 , C07C31/125 , C07C33/02 , C07C53/126 , A61K38/00
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.

23. 发明申请

US20150167033A1 PRODUCTION OF ODD CHAIN FATTY ACID DERIVATIVES IN RECOMBINANT MICROBIAL CELLS 审中-公开
标题翻译：在重组微生物细胞中生产链状脂肪酸衍生物
公开(公告)号：US20150167033A1
公开(公告)日：2015-06-18
申请号：US14344658
申请日：2012-03-08
申请人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
发明人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
IPC分类号： C12P7/64 , C07C57/03 , C07C53/126
CPC分类号： C12P7/6409 , C07C53/126 , C07C57/03 , C12N9/0006 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/18 , C12N9/88 , C12N9/90 , C12Y101/01003 , C12Y101/01085 , C12Y201/03001 , C12Y203/01041 , C12Y207/02004 , C12Y301/02001 , C12Y401/01041 , C12Y401/03022 , C12Y402/01033 , C12Y402/03001 , C12Y403/01019 , C12Y504/99002
摘要： Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
摘要翻译：提供了重组微生物细胞，其已被工程化以通过脂肪酸生物合成途径产生具有含有奇数个碳原子的直链的脂肪酸衍生物。还提供了使用重组微生物细胞制备奇数链脂肪酸衍生物的方法，以及包含通过这些方法产生的奇数链脂肪酸衍生物的组合物。

24. 发明申请

US20150125933A1 PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF HAVING IMPROVED ALIPHATIC CHAIN LENGTH AND SATURATION CHARACTERISTICS 审中-公开
标题翻译：具有改善的脂肪链长度和饱和度特征的脂肪酸及其衍生物的生产
公开(公告)号：US20150125933A1
公开(公告)日：2015-05-07
申请号：US14236883
申请日：2012-08-17
申请人： Eli S. Groban , Vikranth Arlagadda , Scott A. Frykman , Derek L. Greenfield , Zhihao Hu
发明人： Eli S. Groban , Vikranth Arlagadda , Scott A. Frykman , Derek L. Greenfield , Zhihao Hu
IPC分类号： C12N15/70 , C12N9/02 , C12N9/20 , C12N9/00 , C12N9/88 , C12N9/10
CPC分类号： C12N15/70 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/16 , C12N9/18 , C12N9/20 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12Y102/01042 , C12Y203/01041 , C12Y203/01179 , C12Y301/01005 , C12Y402/01059 , C12Y602/01003 , Y02E50/13
摘要： The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods provide for high titers, high yields, and high productivities of fatty acids and derivatives thereof.
摘要翻译：本发明涉及组合物，包括多核苷酸序列，氨基酸序列，重组微生物和重组微生物培养物，其产生具有目标脂肪链长度和/或优选饱和饱和度的脂肪酸和衍生物的组合物。此外，本发明涉及制备和使用组合物的方法。组合物和方法提供高滴度，高产率和高生产率的脂肪酸及其衍生物。

25. 发明申请

US20140179940A1 METHODS AND COMPOSITIONS FOR IMPROVED PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF 审中-公开
标题翻译：改善脂肪酸及其衍生物生产的方法和组合物
公开(公告)号：US20140179940A1
公开(公告)日：2014-06-26
申请号：US14007857
申请日：2012-04-02
申请人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
发明人： Derek L. Greenfield , Louis G. Hom , Fernando A. Sanchez-Riera , Zhihao Hu , Vikranth Arlagadda , Eli S. Groban , Scott A. Frykman
IPC分类号： C12P7/64 , C07C31/125 , C07C33/02 , C07C53/126
CPC分类号： C12P7/6409 , C07C31/125 , C07C33/02 , C07C53/126 , C07K14/195 , C07K14/245 , Y02E50/13
摘要： The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
摘要翻译：本发明涉及组合物和方法，包括多核苷酸序列，氨基酸序列和用于产生脂肪酸的工程化宿主细胞和脂肪酸衍生物，例如酰基辅酶A，末端烯烃，脂肪醛，脂肪醇，烷烃，烯烃，蜡酯，酮和内烯，通过改变转录因子fadR的表达。

26. 发明申请

US20140005855A1 DEVICE AND METHOD FOR CALCULATING A REMAINING MILEAGE OF AN ELECTRIC VEHICLE 审中-公开
标题翻译：用于计算电动车的剩余空间的装置和方法
公开(公告)号：US20140005855A1
公开(公告)日：2014-01-02
申请号：US13552796
申请日：2012-07-19
申请人： Zhihao Hu , Falong Li
发明人： Zhihao Hu , Falong Li
IPC分类号： G06F7/00
CPC分类号： B60L3/12 , B60L58/12 , B60L2200/12 , B60L2240/12 , B60L2250/16 , B60L2260/52 , B60L2260/54 , Y02T10/7005 , Y02T10/7044 , Y02T10/705
摘要： A device for calculating mileage is disclosed. The device includes an estimation calculator, a mileage calculator, and a filter. The estimation calculator is configured for determining a first battery power consumed over a first predetermined distance, wherein the first battery power is determined based on a velocity and an initial remaining power. The mileage calculator is coupled to the estimation calculator, and is configured for determining an estimated remaining mileage based on the first battery power, the first predetermined distance, and a power balance. A filter is coupled to the estimation calculator and the mileage calculator, and is configured for smoothing the estimated remaining mileage and outputting a smoothed estimated remaining mileage.
摘要翻译：公开了一种计算里程的装置。该装置包括估计计算器，里程计算器和滤波器。估计计算器被配置为确定在第一预定距离上消耗的第一电池电力，其中基于速度和初始剩余电力来确定第一电池电力。所述里程计算器耦合到所述估计计算器，并且被配置为基于所述第一电池电力，所述第一预定距离和功率平衡来确定估计的剩余里程。滤波器耦合到估计计算器和里程计算器，并且被配置为平滑估计的剩余里程并输出平滑的估计剩余里程。

27. 发明申请

US20130335036A1 BALANCE CHARGING DETECTOR 审中-公开
标题翻译：平衡充电检测器
公开(公告)号：US20130335036A1
公开(公告)日：2013-12-19
申请号：US13537820
申请日：2012-06-29
申请人： Tao ZHANG , Jiangiang RUI , Falong LI , Zhihao HU
发明人： Tao ZHANG , Jiangiang RUI , Falong LI , Zhihao HU
IPC分类号： H02J7/00
CPC分类号： H02J7/0021 , H02J7/0014
摘要： A balance charging detector is configured to detect a balance charging condition for a battery. The balance charging detector includes a controller and a comparing module. The controller is configured to monitor a status of the battery, access battery parameters for the battery that correspond to the status, and generate a group of balance charging parameters based on the battery parameters. The comparing module is configured to set a balance charging flag based on a comparison of the group of balance charging parameters and a set of thresholds. A balance charging signal can be generated if the balance charging flag is set to indicate presence of a condition to perform a balance charging of the battery.
摘要翻译：平衡充电检测器被配置为检测电池的平衡充电状态。平衡充电检测器包括控制器和比较模块。控制器被配置为监视电池的状态，访问对应于状态的电池的电池参数，并且基于电池参数生成一组平衡充电参数。比较模块被配置为基于所述一组平衡充电参数和一组阈值的比较来设置平衡充电标志。如果平衡充电标志被设置为指示执行电池的平衡充电的条件的存在，则可以产生平衡充电信号。

28. 发明授权

US08283143B2 Enhanced production of fatty acid derivatives 有权
标题翻译：增强脂肪酸衍生物的生产
公开(公告)号：US08283143B2
公开(公告)日：2012-10-09
申请号：US13099986
申请日：2011-05-03
申请人： Zhihao Hu , Fernando Valle
发明人： Zhihao Hu , Fernando Valle
IPC分类号： C07C31/125 , C12P7/04 , C12N1/15 , C12N1/21
CPC分类号： C07C69/533 , C07C69/34 , C07C69/52 , C10L1/02 , C10L1/026 , C10L1/19 , C11C3/003 , C12N1/12 , C12N1/14 , C12N1/16 , C12N1/20 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/16 , C12N9/93 , C12P7/6409 , C12P7/6436 , C12P7/6463 , C12P7/649 , C12Y102/01 , C12Y301/02 , C12Y602/01 , C12Y604/01 , Y02E50/13 , Y02E50/343
摘要： Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
摘要翻译：提供了从脂肪酸生物合成途径产生脂肪醇的基因工程细胞和微生物以及它们使用的方法。

29. 发明申请

US20120070868A1 PRODUCTION OF ODD CHAIN FATTY ACID DERIVATIVES IN RECOMBINANT MICROBIAL CELLS 有权
标题翻译：在重组微生物细胞中生产链状脂肪酸衍生物
公开(公告)号：US20120070868A1
公开(公告)日：2012-03-22
申请号：US13232927
申请日：2011-09-14
申请人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
发明人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
IPC分类号： C07C53/126 , C12P7/04 , C12P5/02 , C07C31/02 , C12N1/21 , C12N15/63 , C12N1/19 , C12N1/13 , C12N5/10 , C07C57/03 , C07C9/00 , C12P7/64 , C12N1/15
CPC分类号： C12P7/6409 , C07C53/126 , C07C57/03 , C12N9/0006 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/18 , C12N9/88 , C12N9/90 , C12Y101/01003 , C12Y101/01085 , C12Y201/03001 , C12Y203/01041 , C12Y207/02004 , C12Y301/02001 , C12Y401/01041 , C12Y401/03022 , C12Y402/01033 , C12Y402/03001 , C12Y403/01019 , C12Y504/99002
摘要： Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
摘要翻译：提供了重组微生物细胞，其已被工程化以通过脂肪酸生物合成途径产生具有含有奇数个碳原子的直链的脂肪酸衍生物。还提供了使用重组微生物细胞制备奇数链脂肪酸衍生物的方法，以及包含通过这些方法产生的奇数链脂肪酸衍生物的组合物。

30. 发明授权

US08097439B2 Methods and compositions for producing fatty aldehydes 有权
标题翻译：用于生产脂肪醛的方法和组合物
公开(公告)号：US08097439B2
公开(公告)日：2012-01-17
申请号：US12575427
申请日：2009-10-07
申请人： Murtaza F. Alibhai , Zhihao Hu
发明人： Murtaza F. Alibhai , Zhihao Hu
IPC分类号： C12P7/24
CPC分类号： C12N9/16 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/90 , C12N9/93 , C12N15/52 , C12P7/24 , Y02P30/10
摘要： Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty aldehydes are described.
摘要翻译：描述了用于产生脂肪醛的方法和组合物，包括核苷酸序列，氨基酸序列和宿主细胞。

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