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21. 发明申请

WO2007081596A3 HIGH EFFICIENCY METHOD OF PREPARING POLYALKYLENE OXIDE CARBOXYLIC ACIDS 审中-公开
标题翻译：制备聚氧乙烯羧酸的高效方法
公开(公告)号：WO2007081596A3
公开(公告)日：2007-12-13
申请号：PCT/US2006049706
申请日：2006-12-28
申请人： ENZON PHARMACEUTICALS INC , ZHAO HONG , MARTINEZ ANTHONY J
发明人： ZHAO HONG , MARTINEZ ANTHONY J
IPC分类号： C08F255/06 , C08F279/00
CPC分类号： C08G65/329 , C08G65/3322
摘要： A new method of preparing a tertiary alkyl ester of a polyalkylene oxide is provided. The new method employs milder conditions that avoid the back reaction to the starting polyalkylene oxide. The tertiary alkyl ester of a polyalkylene oxide is then reacted with a suitable acid to produce a polyalkylene oxide acid.
摘要翻译：提供了一种制备聚环氧烷的叔烷基酯的新方法。新方法采用较轻的条件，避免了起始聚环氧烷的反应。然后使聚环氧烷的叔烷基酯与合适的酸反应以产生聚环氧烷酸。

22. 发明申请

WO2007084808A3 METHODS OF PREPARING ACTIVATED POLYMERS HAVING ALPHA NITROGEN GROUPS 审中-公开
标题翻译：制备具有α氮化物基团的活性聚合物的方法
公开(公告)号：WO2007084808A3
公开(公告)日：2007-11-22
申请号：PCT/US2007060205
申请日：2007-01-08
申请人： ENZON PHARMACEUTICALS INC , ZHAO HONG , WU DECHUN
发明人： ZHAO HONG , WU DECHUN
IPC分类号： A61K38/16
CPC分类号： C08G65/329 , C08G18/797 , C08G65/333
摘要： Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：公开了制备具有高纯度孤立电子对部分的基本上非抗原性聚合物的方法。该聚合物可用作合成胺基聚合物和形成用于与亲核试剂缀合的活化聚合物的中间体。还公开了偶联物和制备和用偶联物处理的方法。所得到的聚合物 - 胺具有足够的纯度，从而避免了药用级聚合物所需的昂贵和耗时的纯化步骤。

23. 发明申请

WO2007084808A2 METHODS OF PREPARING ACTIVATED POLYMERS HAVING ALPHA NITROGEN GROUPS 审中-公开
标题翻译：制备具有氨基酸组的活性聚合物的方法
公开(公告)号：WO2007084808A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/060205
申请日：2007-01-08
申请人： ENZON PHARMACEUTICALS, INC. , ZHAO, Hong , WU, Dechun
发明人： ZHAO, Hong , WU, Dechun
IPC分类号： C12P17/00 , C12N9/64 , C08F20/00
CPC分类号： C08G65/329 , C08G18/797 , C08G65/333
摘要： Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.
摘要翻译：公开了制备基本上具有高纯度的含有电子对的部分的非抗原性聚合物的方法。聚合物可用作合成基于胺的聚合物的中间体和用于与亲核试剂缀合的活化聚合物的形成。还公开了共轭物的共轭物和制备和处理方法。得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

24. 发明申请

WO1995019963A1 NEW PHARMACOTHERAPEUTICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：新药物活性化合物
公开(公告)号：WO1995019963A1
公开(公告)日：1995-07-27
申请号：PCT/NL1995000031
申请日：1995-01-23
申请人： DUPHAR INTERNATIONAL RESEARCH B.V. , KUTNER, Andrzej , ZHAO, Hong , FITAK, Hanna , CHODYN'SKI, Michael , HALKES, Sebastianus, J. , WILSON, Stephen, R. , VAN DEL VELDE, Jan-Paul
发明人： DUPHAR INTERNATIONAL RESEARCH B.V.
IPC分类号： C07C403/08
CPC分类号： C07C403/08 , C07B2200/07 , C07C45/30 , C07C401/00 , C07C2601/14 , C07C2601/16 , C07F9/532 , C07C47/19
摘要： The invention relates to a compound of general formula (I), wherein R1, R2, R4, R5 and R6 are each individually hydrogen atoms or methyl groups; R3 represents a methyl group or a methylene group; R7 and R8 are each individually straight or branched alkyl groups having 1 to 4 carbon atoms or cycloalkyl groups having 3 to 6 carbon atoms; Z is a hydrogen atom or a hydroxy group; n is an integer from 0 to 3; and the (a) bonds represent single or double carbon - carbon bonds; with the provisos: (1) that no cumulated double bonds are present in the molecule; (2) that either R3-C10, C5-C6 and C7-C8 or C10-C5, C6-C7 and C8-C9 form double bonds, with which optionally present additional double bonds are conjugated; and (3) that R3 represents a methyl group if R3-C10 is a single bond, and a methylene group if R3-C10 is a double bond. The invention also relates to a method of preparing this compound and to its use for the treament and/or prevention of certain disorders and diseases.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1，R 2，R 4，R 5和R 6各自为氢原子或甲基; R3表示甲基或亚甲基; R 7和R 8各自为具有1至4个碳原子的直链或支链烷基或具有3至6个碳原子的环烷基; Z是氢原子或羟基; n为0〜3的整数。（a）债券代表单一或双重碳 - 碳键; 条件是：（1）分子中不存在累积双键; （2）R3-C10，C5-C6和C7-C8或C10-C5，C6-C7和C8-C9形成双键，任选地存在额外的双键被共轭; 和（3）如果R3-C10是单键，则R3表示甲基，如果R3-C10是双键，则表示亚甲基。本发明还涉及一种制备该化合物的方法及其用于治疗和/或预防某些疾病和疾病的用途。

25. 发明申请

WO2019013906A1 VISCO-PSEUDO-ELASTIC TTI FWI/RTM FORMULATION AND IMPLEMENTATION 审中-公开
公开(公告)号：WO2019013906A1
公开(公告)日：2019-01-17
申请号：PCT/US2018/036173
申请日：2018-06-06
申请人： EXXONMOBIL UPSTREAM RESEARCH COMPANY , NAKSHATRALA, Praveen , MULLUR, Anoop, A. , ZHAO, Hong , BRYTIK, Valeriy, V.
发明人： NAKSHATRALA, Praveen , MULLUR, Anoop, A. , ZHAO, Hong , BRYTIK, Valeriy, V.
IPC分类号： G01V1/28
摘要： A method, including: obtaining, with a computer, an initial geophysical model; modeling, with a computer, a forward wavefield based on the initial geophysical model with wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium; modeling, with a computer, an adjoint wavefield with adjoint wave equations including a second order z-derivative in a rotated coordinate system that accounts for a tilted transverse isotropic (TTI) medium, wherein the wave equations and the adjoint wave equations include relaxation terms accounting for anelasticity of earth in an update of a primary variable and an evolution relationship for the relaxation terms; and obtaining, with a computer, a gradient of a cost function based on a combination of a model of the forward wavefield and a model of the adjoint wavefield.

26. 发明申请

WO2015171374A1 METHOD AND SYSTEM FOR TREATING WASTEWATER IN AN INTEGRATED FIXED FILM ACTIVATED SLUDGE SEQUENCING BATCH REACTOR 审中-公开
标题翻译：一体化固定膜活化污泥排序反应器处理废水的方法和系统
公开(公告)号：WO2015171374A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/028129
申请日：2015-04-29
申请人： VEOLIA WATER SOLUTIONS & TECHNOLOGIES SUPPORT , ZHAO, Hong , GUTSHALL, Michael Leon , THESING, Glenn , DIMASSIMO, Richard , CHRISTENSSON, Magnus
发明人： ZHAO, Hong , GUTSHALL, Michael Leon , THESING, Glenn , DIMASSIMO, Richard , CHRISTENSSON, Magnus
IPC分类号： C02F3/12 , C02F3/08 , C02F3/30
CPC分类号： C02F11/04 , C02F3/085 , C02F3/1263 , C02F3/301 , C02F3/308 , C02F2305/12 , Y02W10/15
摘要： An integrated fixed film activated sludge sequencing batch reactor is provided where both suspended biomass and biomass supported on biofilm carriers are utilized to biologically treat wastewater received by the sequencing batch reactor. The sequencing batch reactor includes two hydraulically connected tanks with suspended biomass being contained in at least one tank and biomass supported on biofilm carriers in the other tank.
摘要翻译：提供了一种综合的固定膜活性污泥排序间歇反应器，其中利用生物膜载体上的悬浮生物质和生物质两者来生物处理由间歇反应器接收的废水。排序间歇反应器包括两个液压连接的罐，其中悬浮的生物质被包含在至少一个罐中，并且生物质被支撑在另一个罐中的生物膜载体上。

27. 发明申请

WO2012082322A1 METHOD AND APPARATUS FOR ACTIVATING A FUNCTION OF AN ELECTRONIC DEVICE 审中-公开
标题翻译：用于激活电子设备功能的方法和装置
公开(公告)号：WO2012082322A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/061602
申请日：2011-11-21
申请人： MOTOROLA MOBILITY, INC. , ZHAO, Hong , OLLEY, Michael F. , VALENTINE, Mark F.
发明人： ZHAO, Hong , OLLEY, Michael F. , VALENTINE, Mark F.
IPC分类号： G06F3/01 , G06F3/048 , H04M1/00 , G06F1/16
CPC分类号： G06F3/041 , G06F1/1626 , G06F1/1694 , G06F3/017 , G06F3/0488 , G06F2200/1636 , H04M1/72563 , H04M2250/12
摘要： A method (300) and apparatus for activating a function of the electronic device (102) is disclosed herewith. The method (300) includes detecting (302) a first input by a motion sensor (202). Further, the method (300) activates a touch sensor (204) of the electronic device (102) in response to detecting the first input. The method (300) then detects (306) a second input by the motion sensor (202) within a predetermined time period from the first input. Next, the method (300) determines (308), in response to detecting the second input, whether contact has occurred at the touch sensor (204) and activates (310) a function of the electronic device (102) in response to determining that contact has occurred at the touch sensor (204) when the second input is detected.
摘要翻译：本文公开了一种用于激活电子设备（102）的功能的方法（300）和装置。方法（300）包括通过运动传感器（202）检测（302）第一输入。此外，方法（300）响应于检测到第一输入而激活电子设备（102）的触摸传感器（204）。然后，方法（300）在距离第一输入的预定时间段内检测（306）运动传感器（202）的第二输入。接下来，方法（300）响应于检测到第二输入而确定（308）是否在触摸传感器（204）发生了联系，并且响应于确定所述电子设备（102）的功能激活（310）功能当检测到第二输入时，触摸传感器（204）发生接触。

28. 发明申请

WO2011103311A2 TREATMENTS FOR GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：治疗胃肠疾病
公开(公告)号：WO2011103311A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025274
申请日：2011-02-17
申请人： IRONWOOD PHARMACEUTICALS, INC , FRETZEN, Angelika , ZHAO, Hong , KESSLER, Marco
发明人： FRETZEN, Angelika , ZHAO, Hong , KESSLER, Marco
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , A61K38/08 , A61K38/10 , A61K45/06 , C07K7/06
摘要： The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗胃肠病症和病症的肽，组合物和相关方法，所述胃肠病症和病症包括但不限于肠易激综合征（IBS），胃肠动力障碍，功能性胃肠病症，胃食管反流病（GERD），十二指肠胃逆流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良，内脏痛，胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻），与便秘相关的病症和其他病症本文描述了使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的病症。

29. 发明申请

WO2010138452A8 APPARATUS AND METHOD FOR MODEL QUALITY ESTIMATION AND MODEL ADAPTATION IN MULTIVARIABLE PROCESS CONTROL 审中-公开
标题翻译：多变量过程控制中模型质量估计和模型适应的装置和方法
公开(公告)号：WO2010138452A8
公开(公告)日：2011-08-11
申请号：PCT/US2010035960
申请日：2010-05-24
申请人： ASPEN TECHNOLOGY INC , ZHENG QINGSHENG Q , ZHAO HONG
发明人： ZHENG QINGSHENG Q , ZHAO HONG
IPC分类号： G05B13/04
CPC分类号： G05B13/048
摘要： Apparatuses and methods for model quality estimation and model adaptation in multivariable process control are disclosed. A method for updating a multiple input multiple output (MIMO) dynamical model of a process includes perturbing the process, auditing the controller model, identifying poor performing submodels and re-testing the relevant process variables, re-identifying submodels and adapting the model online while the process continues to operate within normal operating parameters. An apparatus comprises an online multivariable controller, a tester, a database to store data corresponding to manipulated variables and controlled variables, and a performance diagnosis module configured to identify problematic submodels and adapt a model used by the controller.
摘要翻译：公开了多变量过程控制中的模型质量估计和模型适应的装置和方法。用于更新过程的多输入多输出（MIMO）动态模型的方法包括扰动过程，审核控制器模型，识别执行不良的子模型并重新测试相关过程变量，重新识别子模型并在线适配模型该过程继续在正常操作参数内运行。一种装置包括在线多变量控制器，测试器，用于存储与操作变量和受控变量相对应的数据的数据库，以及性能诊断模块，被配置为识别有问题的子模型并适应控制器使用的模型。

30. 发明申请

WO2011017502A3 LINACLOTIDE-CONTAINING FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的含LINACLOTIDE的制剂
公开(公告)号：WO2011017502A3
公开(公告)日：2011-05-19
申请号：PCT/US2010044522
申请日：2010-08-05
申请人： IRONWOOD PHARMACEUTICALS INC , FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN , FOREST LAB HOLDINGS LTD
发明人： FRETZEN ANGELIKA , WITOWSKI STEVEN , GROSSI ALFREDO , ZHAO HONG , DEDHIYA MAHENDRA , MO YUN
IPC分类号： A61K38/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/50
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising imaciotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含伊马替尼的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

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