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21. 发明授权

US4248791A 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol 失效
标题翻译： 25-羟基-26,26,26,27,27,27-六氟代胆钙化醇
公开(公告)号：US4248791A
公开(公告)日：1981-02-03
申请号：US118149
申请日：1980-02-04
申请人： Hector F. DeLuca , Yoko Tanaka , Nobuo Ikekawa , Yoshiro Kobayashi
发明人： Hector F. DeLuca , Yoko Tanaka , Nobuo Ikekawa , Yoshiro Kobayashi
IPC分类号： C07J9/00 , C07J17/00 , A61K31/59
CPC分类号： C07J9/00 , C07J17/00
摘要： The invention provides a new derivative of vitamin D, 25-hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol and a process for preparing the same.The compound is characterized by vitamin D-like activity in their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiencies.
摘要翻译：本发明提供维生素D，25-羟基-26,26,26,27,27,27-六氟代胆钙化醇的新衍生物及其制备方法。该化合物的特征在于维生素D样活性增加肠钙运输能力，增加血清钙并防止r the病的发展。这些化合物可以作为维生素D的替代物和治疗代谢钙和磷缺乏症的疾病状态得到准备。

22. 发明授权

US4226788A 24,24-Difluoro-1.alpha.,25-dihydroxycholecalciferol 失效
标题翻译： 24,24-二氟-1α，25-二羟基胆钙化甾醇
公开(公告)号：US4226788A
公开(公告)日：1980-10-07
申请号：US64254
申请日：1979-08-06
申请人： Hector F. DeLuca , Heinrich K. Schnoes , Nobuo Ikekawa , Yoko Tanaka , Yoshiro Kobayashi
发明人： Hector F. DeLuca , Heinrich K. Schnoes , Nobuo Ikekawa , Yoko Tanaka , Yoshiro Kobayashi
IPC分类号： C07C35/32 , C07C401/00 , C07J9/00
CPC分类号： C07C401/00 , C07C35/52 , C07C2102/18 , C07C2102/24
摘要： The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiences.
摘要翻译：本发明提供维生素D，24,24-二氟-1α，25-二羟基胆钙化甾醇和24,24-二氟-1α，25-二羟基-5,6-反式胆钙化甾醇的新衍生物及其制备方法。该化合物的特征在于维生素D样活性，其基本上等同于被认为是维生素D的激素形式和最活泼的衍生物的1α，25-二氢胆钙化醇的维生素D样活性。本发明的化合物的特征在于增加肠钙运输能力，增加血清钙，防止r the病的发展。这些化合物可以作为维生素D的替代物和治疗代谢钙和磷缺乏症的疾病状态得到准备。

23. 发明授权

US4196133A 24,24-Difluoro-25-hydroxycholecalciferol 失效
标题翻译： 24,24-二氟-25-羟基胆钙化甾醇
公开(公告)号：US4196133A
公开(公告)日：1980-04-01
申请号：US17168
申请日：1979-03-05
申请人： Hector F. DeLuca , Nobuo Ikekawa , Yoko Tanaka , Yoshiro Kobayashi
发明人： Hector F. DeLuca , Nobuo Ikekawa , Yoko Tanaka , Yoshiro Kobayashi
IPC分类号： C07J1/00 , A61K31/59 , A61P3/00 , A61P3/02 , A61P3/14 , C07C67/00 , C07C401/00 , C07J9/00
CPC分类号： C07J9/00
摘要： The invention provides a new derivative of vitamin D.sub.3, 24,24-difluoro-25-hydroxycholecalciferol.The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D.sub.3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are non-responsive to vitamin D.sub.3 therapy.
摘要翻译：本发明提供维生素D3,24,24-二氟-25-羟基胆钙化甾醇的新衍生物。该化合物的特征在于维生素D样活性增加肠钙运输能力，增加血清钙和无机磷浓度，并防止r the病的发展。它可以找到适合作为维生素D3替代品的替代品，以及治疗显示钙 - 磷不平衡的疾病状态，对维生素D3治疗无反应。

24. 发明授权

US5319915A Steel cord for reinforcing rubber product 失效
标题翻译：用于增强橡胶制品的钢丝绳
公开(公告)号：US5319915A
公开(公告)日：1994-06-14
申请号：US4630
申请日：1993-01-14
申请人： Yoshiro Kobayashi , Koichi Hinoura , Akihiro Nagamoto , Toshiaki Shimizu , Takanori Kobayashi
发明人： Yoshiro Kobayashi , Koichi Hinoura , Akihiro Nagamoto , Toshiaki Shimizu , Takanori Kobayashi
IPC分类号： B60C9/00 , D07B1/06 , D07B3/04 , D07B3/10 , D07B7/02 , D02G3/48
CPC分类号： D07B1/0646 , B60C9/0007 , B60C9/0057 , D07B3/04 , D07B3/10 , D07B7/025 , D07B2201/2007 , D07B2201/2022 , D07B2201/2024 , D07B2201/2025 , D07B2201/2039 , D07B2201/204 , D07B2207/204 , D07B2501/2046 , Y10S57/902
摘要： A steel cord comprising a number (between 3 and 27) of element steel wires tightly twisted at a regular pitch P between 5 and 20 mm in the same direction. Each wire has a diameter d between 0.1 and 0.4 mm. At least one of the wires includes a spiral portion having a spiral pitch P1 between 0.1P and 0.7P and a spiral diameter d1 between d+2/100 mm and d+2/10 mm. At least one other wire includes a straight portion. At any cross section of the cord, 1/4 through 2/3 of the wires is/are spiral and the other wire/s is/are straight. The stretch of the cord under a load of 5 kg is between 0.10 and 0.40%. A method of producing a steel cord comprises supplying a number of element steel wires, forming at least part of at least one of the wires to be spiral, and tightly twisting the wires. An apparatus for producing a steel cord comprises feeders supported by a frame, each feeding an element steel wire along an axis, a tension device for applying a tension to the wire from at least one of the feeders, a spiral device having pins which extend across and are spaced along an axis, so that at least one of the wires from the tension device turns alternately over and under the pins, a strand device rotatable on the axis, so that the wires are twisted to form a strand, and a take-up device to take up the strand.
摘要翻译：一种钢帘线，包括以相同方向以5至20mm之间的规则间距P紧密地扭曲的多个（3至27个）元素钢丝。每根线的直径d在0.1和0.4mm之间。至少一根电线包括具有0.1P和0.7P之间的螺旋间距P1和d + 2 / 100mm和d + 2 / 10mm之间的螺旋直径d1的螺旋部分。至少另一根线包括直线部分。在电线的任何横截面处，1/4至2/3的电线是螺旋形的，另一根电线是/是直的。在5kg载荷下，绳索的伸长率在0.10至0.40％之间。一种生产钢帘线的方法包括：供给若干元素钢线，形成要被螺旋形的至少一根电线的至少一部分，并且紧紧地扭曲线。一种用于生产钢帘线的装置，包括由框架支撑的馈送器，每个馈送器沿着轴线馈送元件钢丝;张紧装置，用于从至少一个馈送器向线材施加张力;螺旋装置，并且沿着轴线间隔开，使得来自张力装置的至少一根电线交替地在销上方和下方转动，可在轴线上旋转的绞线装置，使得电线被扭曲以形成绞线，收起装置来收起绳子。

25. 发明授权

US4451674A Substituted benzene derivatives having at least one benzene ring substituted by 3,3,3-trifluoropropyl group and process for their production 失效
标题翻译：具有至少一个苯环被3,3,3-三氟丙基取代的取代的苯衍生物及其制备方法
公开(公告)号：US4451674A
公开(公告)日：1984-05-29
申请号：US412963
申请日：1982-08-30
申请人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
发明人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
IPC分类号： C07C17/278 , C07C17/32 , C07C17/383 , C07C22/08 , C07C25/13 , C07C37/14 , C07C39/24 , C07C43/29 , C07C43/263 , C07C21/24
CPC分类号： C07C43/29 , C07C17/278 , C07C17/32 , C07C17/383 , C07C22/08 , C07C25/13 , C07C37/14 , C07C39/24
摘要： A novel trifluoropropyl derivative of mono-substituted benzene represented by the general formula: ##STR1## wherein R is halogen atom, trifluoromethyl, n-octyl, n-dodecyl, or phenoxy group not substituted or mono-substituted by 3,3,3-trifluoropropyl group, and n is an integer of 1, 2 or 3, with the proviso that the total number of 3,3,3-trifluoropropyl group of the derivative of mono-substituted benzene is at most 3, and a process for producing the derivative of mono-substituted benzene.
摘要翻译：由通式：其中R是卤素原子，三氟甲基，正辛基，正十二烷基或未被3,3,3-三唑基取代或单取代的苯氧基的单取代苯的新三氟丙基衍生物，三氟丙基，n为1,2或3的整数，条件是单取代苯衍生物的3,3,3-三氟丙基总数为3以下，制造方法单取代苯衍生物。

26. 发明授权

US4423259A Process for producing phenyl-[3,3,3-trifluoropropyl)phenyl]methane 失效
标题翻译：苯基 - [3,3,3-三氟丙基]苯基]甲烷的制备方法
公开(公告)号：US4423259A
公开(公告)日：1983-12-27
申请号：US347728
申请日：1982-02-10
申请人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
发明人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
IPC分类号： C07C17/26 , C07C17/278 , C07C17/32 , C07C17/383 , C07C22/08 , C07C37/14 , C07C39/24 , C07C43/29 , H01B3/24
CPC分类号： H01B3/24 , C07C17/269 , C07C17/275 , C07C17/383 , C07C22/08
摘要： Novel trifluoropropyl-substituted aryl- or aralkylbenzene of the formula: ##STR1## wherein R is a not-substituted or ring-substituted phenyl-, benzyl-, phenethyl- or alpha-methylbenzyl group by one 3,3,3-trifluoropropyl group, and n is an integer of 1,2 or 3, provided that the total number of 3,3,3-trifluoropropyl group of the above-mentioned trifluoropropyl-substituted aryl- or aralkylbenzene is at most 3, and a process for producing thereof are disclosed.
摘要翻译：下式的新型三氟丙基取代的芳基 - 或芳烷基苯：其中R是一个3,3,3-三氟丙基的未取代或环取代的苯基 - ，苄基 - ，苯乙基 - 或α-甲基苄基，并且n为1,2或3的整数，条件是上述三氟丙基取代的芳基 - 或芳烷基苯的3,3,3-三氟丙基的总数为3以下，其制造方法为披露

27. 发明授权

US4396785A 3,3,3-Trifluoropropyl derivatives of naphthalene or methylnaphthalene and process for preparing the same 失效
标题翻译：萘或甲基萘的3,3,3-三氟丙基衍生物及其制备方法
公开(公告)号：US4396785A
公开(公告)日：1983-08-02
申请号：US290931
申请日：1981-08-07
申请人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
发明人： Yoshiro Kobayashi , Itsumaro Kumadaki , Masaaki Takahashi , Takashi Yamauchi
IPC分类号： C07C17/32 , C07C22/08 , H01B3/24 , H01G4/22
CPC分类号： H01G4/222 , C07C17/32 , C07C22/08 , H01B3/24
摘要： Novel 3,3,3-trifluoropropyl derivatives of naphthalene or methylnaphthalene of the general formula ##STR1## wherein R.sup.1 and R.sup.2 respectively represent hydrogen atom or methyl group, with the proviso that R.sup.1 and R.sup.2 do not simultaneously represent methyl group; m and n respectively represent zero or 1, with the proviso that the sum of m and n is 1, and a process for preparing the derivatives are disclosed. The derivatives are suitable as a dielectric material.
摘要翻译：新颖的通式为“IMAGE”的萘或甲基萘的3,3,3-三氟丙基衍生物，其中R1和R2分别表示氢原子或甲基，条件是R1和R2不同时表示甲基; m和n分别表示0或1，条件是m和n的和为1，并且公开了制备衍生物的方法。该衍生物适合作为介电材料。

28. 发明授权

US4305880A Process for preparing 24-fluoro-25-hydroxycholecalciferol 失效
标题翻译：制备24-氟-25-羟基胆钙化甾醇的方法
公开(公告)号：US4305880A
公开(公告)日：1981-12-15
申请号：US189513
申请日：1980-09-22
申请人： Hector F. DeLuca , Yoko Tanaka , Nobuo Ikekawa , Yoshiro Kobayashi
发明人： Hector F. DeLuca , Yoko Tanaka , Nobuo Ikekawa , Yoshiro Kobayashi
IPC分类号： C07J9/00
CPC分类号： C07J9/00 , C07J9/005
摘要： The invention provides a new derivative of vitamin D.sub.3, 24-fluoro-25-hydroxycholecalciferol.The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D.sub.3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are nonresponsive to vitamin D.sub.3 therapy.
摘要翻译：本发明提供维生素D3，24-氟-25-羟基胆钙化甾醇的新衍生物。该化合物的特征在于维生素D样活性增加肠钙运输能力，增加血清钙和无机磷浓度，并防止r the病的发展。它可以作为维生素D3的替代品和治疗表现出钙磷不平衡的疾病状态，并且对维生素D3治疗无反应。

29. 发明授权

US5200536A Fluorine-containing vitamin D3 analogues 失效
标题翻译：含氟维生素D3类似物
公开(公告)号：US5200536A
公开(公告)日：1993-04-06
申请号：US832888
申请日：1992-02-10
申请人： Nobuo Ikekawa , Takeo Taguchi , Yoko Tanaka , Yoshiro Kobayashi , Yutaka Ohira
发明人： Nobuo Ikekawa , Takeo Taguchi , Yoko Tanaka , Yoshiro Kobayashi , Yutaka Ohira
IPC分类号： A61K31/59 , A61P35/00 , A61P35/02 , C07C35/52 , C07C401/00 , C07F7/18
CPC分类号： C07F7/1856 , C07C35/52 , C07C401/00 , Y02P20/55
摘要： Fluorine-containing vitamin D.sub.3 analogues of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen atom, a hydroxy-protecting group, having excellent pharmacological activities, such as tumor cell differentiation-inducing activity, which are useful as a medicament.
摘要翻译：含有下式的含氟维生素D 3类似物：其中R 1，R 2和R 3独立地为氢原子，具有优异的药理活性，例如肿瘤细胞分化诱导活性的羟基保护基，其可用于作为药物。

30. 发明授权

US5047564A Fluorine-containing vitamin D.sub.2 derivatives 失效
标题翻译：含氟维生素D2衍生物
公开(公告)号：US5047564A
公开(公告)日：1991-09-10
申请号：US151931
申请日：1988-02-03
申请人： Yoshiro Kobayashi , Takeo Taguchi , Nobuo Ikekawa
发明人： Yoshiro Kobayashi , Takeo Taguchi , Nobuo Ikekawa
IPC分类号： A61K31/59 , A61P5/38 , A61P13/02 , A61P15/00 , A61P43/00 , C07C67/00 , C07C401/00 , C07J9/00 , C07J17/00 , C07J31/00
CPC分类号： C07J9/00 , C07C401/00 , C07J17/00 , C07J31/006
摘要： A fluorine-containing vitamin D.sub.2 derivative represented by the following formula ##STR1## wherein R.sup.1 represents a methyl or trifluoromethyl group, and R.sup.2 represents a trifluoromethyl group when R.sup.1 is a methyl group, and a hydrogen atom or a methyl group when R.sup.1 is a trifluoromethyl group. This compound is useful for the prevention or treatment of calcium pathobolism or osteoporosis.

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