专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2006051314A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2006051314A2
公开(公告)日：2006-05-18
申请号：PCT/GB2005004361
申请日：2005-11-11
申请人： UCL BIOMEDICA PLC , VALLANCE PATRICK JOHN THOMPSON , LEIPER JAMES MITCHELL , SELWOOD DAVID LAWRENCE , ROSSITER SHARON , HARTZOULAKIS BASIL
发明人： VALLANCE PATRICK JOHN THOMPSON , LEIPER JAMES MITCHELL , SELWOOD DAVID LAWRENCE , ROSSITER SHARON , HARTZOULAKIS BASIL
IPC分类号： C07C279/14 , A61K31/16 , A61K31/198 , A61K31/223 , A61K31/40 , A61K31/445 , A61K31/5375 , A61P9/10 , A61P11/06 , A61P19/02 , C07C279/16 , C07C279/18 , C07C323/52 , C07D295/215
CPC分类号： C07C279/14 , A61K31/16 , A61K31/198 , A61K31/223 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/5375 , C07C279/16 , C07C279/18 , C07C323/44 , C07C2601/02 , C07D295/215 , C07D295/32
摘要： Compounds of formula (I) have been found to be useful as inhibitors of DDAH use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a disease whose pathology is affected by DDAH formula (I) wherein: either - (a) R 1 is C 3 -C 12 alkyl, C 3 -C 12 alkenyl, C 3 -C 12 alkynyl, C 6 -C 10 aryl, C 3 -C 8 carbocyclyl, 5- to 10-membered heterocyclyl, 5- to 10-membered heteroaryl, -L-A, -L-Het-L', -L-Y-L', -L-Het-A or -L-Y-A, wherein: L is C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; L' is C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; A is C 6 -C 10 aryl, C 3 -C 8 carbocyclyl, 5- to 10-membered heterocyclyl or 5- to 10-membered heteroaryl; Het is -O-, -S- or -NR'-, wherein R' is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl; and Y is -CO-, -SO-, -SO 2 -, -CO-O-, -CO-NR'-, -O-CO- or -NR'-CO-, wherein R' is as defined above; - R 2 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; and - R 3 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, - or (b) R 1 and R 2 form, together with the nitrogen to which they are attached, a 5- to 10-membered heterocyclic or heteroaryl ring, and R 3 is as defined above, - or (c) R 1 and R 3 form, together with the -N-C=N- moiety to which they are attached, a 5- to 10-membered heterocyclic or heteroaryl ring, and R 2 is as defined above; - R 4 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; B is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, -O-L-, -S-L- or-L-Het-L'-, wherein L, L' and Het are as defined above; - X is -O-, -S- or -NR'-, wherein R' is as defined above; -R 5 is hydrogen, C 1 -C 6 alkyl, C 2 - 6 alkenyl, C 2 -C 6 alkynyl, aryl, C 3 -C 8 carbocyclyl, 5- to 10-membered heterocyclyl, 5- to 10-membered heteroaryl, -L-A, -L-Het-L', -L-Y-L', -L-Het-A, -L-Y-A, -L-A-Het-A, -L-A-L'-A or -L-A-Het-L'-A, wherein L, L', Het and Y are as defined above and wherein each A is the same or different and is as defined above; -R 6 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; - R 7 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, or R 7 is a bond, a C 1 -C 4 alkyl or C 2 -C 4 alkenyl moiety which is joined to one of the carbon atoms of B to form, together with the -N-C- moiety to which R 7 and B are attached, a 5- to 10-membered heterocyclic ring; and - R 8 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl.
摘要翻译：已经发现式（I）化合物可用作DDAH抑制剂用于式（I）化合物或其药学上可接受的盐在制备用于治疗病症为受DDAH式（I）影响，其中： - （a）R 1是C 3 -C 12烷基，C 3 C 12 - 12链烯基，C 3 -C 12炔基，C 6-C≡N C 10 -C 10芳基，C 3 -C 8碳环基，5至10元杂环基，5至10元杂芳基，-LA，-L -Het-L'，-LY-L'，-L-Het-A或-LYA，其中：L为C 1 -C 6烷基，C _{如上所定义; R 4是氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，烯基或C 2 -C 6 - 炔基; B是C 1 -C 6烷基，C 2 -C 6链烯基，-OL-，-SL - 或-L-Het-L'-，其中L，L'和Het如上所定义; -X是-O - ， - S-或-NR'-，其中R'如上定义; R 5是氢，C 1 -C 6烷基，C 2 -C 6 - 亚烷基，C 2 -C 6炔基，芳基，C 3 -C 8碳环基，5- 至10元杂环基，5至10元杂芳基，-LA，-L-Het-L'，-LY-L'，-L-Het-A，-LYA，-LA-Het-A，-LA -L'-A或-LA-Het-L'-A，其中L，L'，Het和Y如上所定义，并且其中每个A相同或不同，如上所定义; R 6是氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基，烯基或C 2 -C 6 - 炔基; R 7是氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， C 1 -C 12烷基或C 2 -C 6 - 炔基，或R 7是键，C 1〜 -C 4烷基或C 2 -C 4亚烷基部分，其与B的一个碳原子连接形成，与 R 7和B连接的-NC-部分，5至10元杂环; 和 - R 8是氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基，烯基或C 2 -C 6炔基。}

22. 发明申请

WO2005104928A1 FLUID PROPELLED ENDOSCOPE 审中-公开
标题翻译：流体螺旋内窥镜
公开(公告)号：WO2005104928A1
公开(公告)日：2005-11-10
申请号：PCT/GB2005/001617
申请日：2005-04-27
申请人： UCL BIOMEDICA PLC , SWAIN, Christopher, Paul , MOSSE, Charles, Alexander
发明人： SWAIN, Christopher, Paul , MOSSE, Charles, Alexander
IPC分类号： A61B1/31
CPC分类号： A61B1/31 , A61B1/00091 , A61B1/00156 , A61B1/12
摘要： An endoscope, more particularly a colonoscope, is provided for introduction into and along a passageway in a human or animal body in a desired direction of travel, the endoscope having a fluid propulsion device for effecting introduction. The fluid propulsion device comprises a conduit having an inlet for fluid under pressure and at least one outlet for expelling the fluid in a direction at least partly opposed to the desired direction of travel of the endoscope. The outlets may be atomising nozzles. The conduit may be movable lengthwise of the endoscope, but constrained to substantially follow the path of the endoscope. In one embodiment the endoscope is caused to travel over a pre-installed guidewire.
摘要翻译：提供内窥镜，更具体地是结肠镜，用于沿着所需行进方向引入人体或动物体中的通道并沿其中的通道，该内窥镜具有用于引入的流体推进装置。流体推进装置包括具有用于在压力下的流体的入口的导管和用于沿至少部分地与内窥镜的行进方向相对的方向排出流体的至少一个出口。出口可以是雾化喷嘴。导管可以在内窥镜的纵向上可移动，但被限制为基本上沿着内窥镜的路径。在一个实施例中，使内窥镜在预先安装的导丝上移动。

23. 发明申请

WO2005070998A1 POLYMER FOR USE IN CONDUITS AND MEDICAL DEVICES 审中-公开
标题翻译：聚合物用于配方和医疗器械
公开(公告)号：WO2005070998A1
公开(公告)日：2005-08-04
申请号：PCT/GB2005/000204
申请日：2005-01-20
申请人： UCL BIOMEDICA PLC , SEIFALIAN, Alexander , SALACINSKI, Henryk , HANCOCK, Steve
发明人： SEIFALIAN, Alexander , SALACINSKI, Henryk , HANCOCK, Steve
IPC分类号： C08G77/448
CPC分类号： C08G77/452 , C08G18/12 , C08G18/44 , C08G18/61 , C08G18/643 , C08G64/18 , C08G77/448 , C08G77/458 , C08L83/10 , C08G18/3228 , C08G18/64
摘要： A copolymer comprising (a) one or more polysiloxane-containing segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments, which may be the saure or different, via urea or urethane linkages, wherein said polysiloxane-containing segment(s) are in the backbone of the copolymer. The copolymer is useful in the production of implantable devices such as vascular grafts.
摘要翻译：一种共聚物，其包含（a）一种或多种含聚硅氧烷的链段和（b）一种或多种多元醇链段，每个所述链段通过尿素或氨基甲酸酯键连接到一个或多个另外的片段，其可以是固化的或不同的，其中所述含聚硅氧烷的区段在共聚物的主链中。共聚物可用于生产可植入装置如血管移植物。

24. 发明申请

WO2005031357A2 CELL SAMPLE ANALYSIS 审中-公开
标题翻译：细胞样本分析
公开(公告)号：WO2005031357A2
公开(公告)日：2005-04-07
申请号：PCT/GB2004004010
申请日：2004-09-21
申请人： UCL BIOMEDICA PLC , JANOSSY GEORGE
发明人： JANOSSY GEORGE
IPC分类号： G01N33/50 , G01N33/569
CPC分类号： G01N33/56966 , G01N33/5008 , G01N33/5047 , G01N33/5091 , G01N33/5094 , G01N33/56972
摘要： The present invention provides a flow cytometric method for analysing a cell sample by enumeration of the CD4+, CD38+ and CD8+ populations of the cell sample. The method is particularly useful for monitoring HIV infection. The present invention also provides a method for gating CD8+ T cells into normal CD38+ cells and pathogenic CD38++ cells in a flow cytometric method, by indentifying the monocyte population in a reference cell sample and setting a gate based on the CD38 expression of this population.
摘要翻译：本发明提供了通过计数细胞样品的CD4 +，CD38 +和CD8 +群体来分析细胞样品的流式细胞术方法。该方法对监测HIV感染特别有用。本发明还提供了通过鉴定参考细胞样品中的单核细胞群并基于该群的CD38表达设定一个门，在流式细胞术方法中将CD8 + T细胞选通为正常CD38 +细胞和致病性CD38 ++细胞的方法。

25. 发明申请

WO2006051314A8 GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH 审中-公开
标题翻译：作为DDAH的抑制剂的胍衍生物
公开(公告)号：WO2006051314A8
公开(公告)日：2006-09-28
申请号：PCT/GB2005004361
申请日：2005-11-11
申请人： UCL BIOMEDICA PLC , VALLANCE PATRICK JOHN THOMPSON , LEIPER JAMES MITCHELL , SELWOOD DAVID LAWRENCE , ROSSITER SHARON , HARTZOULAKIS BASIL
发明人： VALLANCE PATRICK JOHN THOMPSON , LEIPER JAMES MITCHELL , SELWOOD DAVID LAWRENCE , ROSSITER SHARON , HARTZOULAKIS BASIL
IPC分类号： C07C279/14 , A61K31/16 , A61K31/198 , A61K31/223 , A61K31/40 , A61K31/4453 , A61K31/5375 , A61P9/10 , A61P11/06 , A61P19/02 , C07C279/16 , C07C279/18 , C07C323/44 , C07D295/215
CPC分类号： C07C279/14 , A61K31/16 , A61K31/198 , A61K31/223 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/5375 , C07C279/16 , C07C279/18 , C07C323/44 , C07C2601/02 , C07D295/215 , C07D295/32
摘要： Compounds of formula (I) have been found to be useful as inhibitors of DDAH. The present invention thus provides the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a disease whose pathology is affected by DDAH.
摘要翻译：已经发现式（I）化合物可用作DDAH的抑制剂。因此，本发明提供式（I）化合物或其药学上可接受的盐在制备用于治疗其病理学受DDAH影响的疾病的药物中的用途。

26. 发明申请

WO2006090096A1 COMPOSITION, KIT AND METHOD FOR FIXING CELLS 审中-公开
标题翻译：用于固定细胞的组合物，组合物和方法
公开(公告)号：WO2006090096A1
公开(公告)日：2006-08-31
申请号：PCT/GB2005/000750
申请日：2005-02-28
申请人： SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST , UCL BIOMEDICA PLC , JANOSSY, George , GRANGER, Vivian , BARNETT, David
发明人： JANOSSY, George , GRANGER, Vivian , BARNETT, David
IPC分类号： G01N1/30 , G01N33/50 , C12Q1/24 , A61K39/00 , C07K16/00
CPC分类号： G01N33/5094 , G01N1/30 , G01N2001/305 , G01N2333/705
摘要： The present invention provides a composition for mixing with a cell sample to fix and stain the cell sample. The composition comprises a mixture of a fixative and one or more antibodies. The fixative may be a fluid or in a lyophilised form. The fluid form (and the lyophilised form before lyophilisation or after reconstitution) comprises a sterile buffered aqueous solution having a pH in the range of 6.8 to 8.0, which comprises (i) an aliphatic aldehyde, at a molar concentration of 0.15 to 3.4M; and (ii) one or more heavy metal salts, at a total molar concentration of 0.2x10 -3 M to 0.2M, the solution. The present invention also provides a container, such as a sample collection container, comprising an aliquot of the composition, in fluid or lyophilised form.
摘要翻译：本发明提供了用于与细胞样品混合以固定和染色细胞样品的组合物。组合物包含固定剂和一种或多种抗体的混合物。固定剂可以是流体或冻干形式。流体形式（以及冻干前或冻干后的冻干形式）包含pH在6.8至8.0范围内的无菌缓冲水溶液，其包含（i）摩尔浓度为0.15至3.4M的脂族醛; 和（ii）一种或多种重金属盐，其总摩尔浓度为0.2×10 -3 M至0.2M，溶液。本发明还提供一种容器，例如样品收集容器，其包含流体或冻干形式的组合物的等分试样。

27. 发明申请

WO2006051314A3 GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH 审中-公开
公开(公告)号：WO2006051314A3
公开(公告)日：2006-05-18
申请号：PCT/GB2005/004361
申请日：2005-11-11
申请人： UCL BIOMEDICA PLC , VALLANCE, Patrick, John, Thompson , LEIPER, James, Mitchell , SELWOOD, David, Lawrence , ROSSITER, Sharon , HARTZOULAKIS, Basil
发明人： VALLANCE, Patrick, John, Thompson , LEIPER, James, Mitchell , SELWOOD, David, Lawrence , ROSSITER, Sharon , HARTZOULAKIS, Basil
IPC分类号： C07C279/14 , C07C279/16 , C07C279/18 , C07C323/44 , C07D295/215 , A61P9/10 , A61P11/06 , A61P19/02 , A61K31/40 , A61K31/4453 , A61K31/5375 , A61K31/198 , A61K31/223 , A61K31/16
摘要： Compounds of formula (I) have been found to be useful as inhibitors of DDAH. The present invention thus provides the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a disease whose pathology is affected by DDAH.

28. 发明申请

WO2006003442A3 CELL-INDEPENDENT FABRICATION OF TISSUE EQUIVALENTS 审中-公开
标题翻译：细胞独立制备组织等效物
公开(公告)号：WO2006003442A3
公开(公告)日：2006-02-23
申请号：PCT/GB2005002631
申请日：2005-07-05
申请人： UCL BIOMEDICA PLC , BROWN ROBERT , NAZHAT SHOWAN , MUDERA VIVEK , WISEMAN MIKE
发明人： BROWN ROBERT , NAZHAT SHOWAN , MUDERA VIVEK , WISEMAN MIKE
IPC分类号： A61L27/24 , A61L27/38 , A61L27/52
CPC分类号： A61L27/52 , A61L27/24 , A61L27/38
摘要： This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organised biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibres of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
摘要翻译：本发明涉及模拟细胞生物重建和产生具有适合用作功能性组织植入物的机械性质和活细胞密度的组织生物材料的细胞非依赖性过程。生物材料通过提供包含支架纤维基质和间质液的凝胶来生产; 并且塑性地压实凝胶以产生生物材料。生物材料可以包括3D结构，例如模拟天然组织结构的细胞和基质的分层，比对和中尺度区带异质性。具有本文所述的仿生结构的生物材料可用于一系列治疗应用。

29. 发明申请

WO2005070988A1 POLYMER FOR USE IN CONDUITS, MEDICAL DEVICES AND BIOMEDICAL SURFACE MODIFICATION 审中-公开
标题翻译：聚合物用于导管，医疗器械和生物医学表面改性
公开(公告)号：WO2005070988A1
公开(公告)日：2005-08-04
申请号：PCT/GB2005/000189
申请日：2005-01-20
申请人： UCL BIOMEDICA PLC , SEIFALIAN, Alexander , SALACINSKI, Henryk , SRAI, Kaila , RAMESH, Bala , DARBYSHIRE, Arnold , HANCOCK, Steve
发明人： SEIFALIAN, Alexander , SALACINSKI, Henryk , SRAI, Kaila , RAMESH, Bala , DARBYSHIRE, Arnold , HANCOCK, Steve
IPC分类号： C08G18/76
CPC分类号： A61L27/18 , C08G18/3893 , C08G18/44 , C08L75/04
摘要： A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments, and one or more of the pendant group segments being selected from: (i) siloxane segments; (ii) segments containing phosphoryl choline or a derivative or analogue thereof; (iii) segments containing a di- or trifluoromethyl group; (iv) heparin-like segments containing a group of formula: (XII) D-N=N-Ar-SO 3 - (v) segments containing a group of formula: (I) [P] n’ -[Lys] n -Lys-[Spacer]-Lys-[Al] x in which D, Ar, P, Lys, Al, Spacer, x, n and n’ are as defined herein, and wherein at least a part of each of said pendant group segment(s) is on a side chain of the copolymer. The copolymer is useful in the production of implantable devices such as vascular grafts.
摘要翻译：一种共聚物，其包含（a）一个或多个侧基基团链段和（b）一个或多个多元醇部分，所述链段中的每一个链接至一个或多个其它链段，并且所述侧链基团片段中的一个或多个选自：（i ）硅氧烷片段（ii）含有磷酸胆碱或其衍生物或类似物的片段; （iii）含有二或三氟甲基的链段; （Ⅳ）含有下列基团的肝素样片段：（Ⅻ）Ⅳ= N-Ar-SO3>（ⅴ）含有下列基团的片段：（I）[P] n' - [Lys] 其中D，Ar，P，Lys，Al，间隔物，x，n和n'如本文所定义的Lys- [间隔] -Lys- [Al] x，并且其中每个所述侧链基团片段的至少一部分（s）在共聚物的侧链上。共聚物可用于生产可植入装置如血管移植物。

30. 发明申请

WO2005051134A1 MATTRESS PROTECTION 审中-公开
标题翻译： MATTRESS保护
公开(公告)号：WO2005051134A1
公开(公告)日：2005-06-09
申请号：PCT/GB2004/004942
申请日：2004-11-22
申请人： UCL BIOMEDICA PLC , BAIN, Duncan , PELL, Martin, Ferguson , NICHOLSON, Graham
发明人： BAIN, Duncan , PELL, Martin, Ferguson , NICHOLSON, Graham
IPC分类号： A47C21/06
CPC分类号： A61F5/48 , A47C27/006
摘要： The present invention seeks to address the chronic and worsening problem of mattress management in hospitals by providing a mattress protector to shield a mattress or mattress core from body fluids, the protector not only comprising a shielding cover for the mattress (1) or mattress core but also a detector in an inter or under-layer (2) of the cover to detect body fluid that has passed into or through the cover. The detector may be chemical, with the cover being a transparent cover (3) and the under-layer being absorbent and having a dye that is activated by a body fluid to provide a visual indication of presence of the body fluid. In an alternative embodiment the detector may be an apparatus monitoring electrical conductivity. This suitably uses threads of electrically conductive yarn forming either the warp or weft of a thin flexible under layer of the protective cover (5) and which are linked to a small processor (7) which monitors the electrical conductivity between neighbouring conductive threads in the sensing layer.
摘要翻译：本发明旨在通过提供床垫保护器来将床垫或床垫芯与体液屏蔽，来解决医院床垫管理的长期和恶化问题，保护器不仅包括用于床垫（1）或床垫芯的屏蔽罩，而且也是盖子的中间层或下层（2）中的检测器，以检测已经通过或穿过盖的体液。检测器可以是化学的，其中盖是透明盖（3），底层是吸收性的，并且具有被体液激活的染料以提供体液存在的视觉指示。在替代实施例中，检测器可以是监测导电性的装置。这适当地使用形成保护盖（5）的薄柔性底层的经线或纬线的导电纱线，并且连接到小型处理器（7），该小处理器（7）监测感测中相邻导电丝之间的导电性层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式