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21. 发明申请

WO2005044785A1 ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS 审中-公开
标题翻译： ARALKYL AMINES作为CANNABINOID受体调节剂
公开(公告)号：WO2005044785A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/035846
申请日：2004-10-27
申请人： MERCK & CO., INC. , SHAH, Shrenik, K. , TRUONG, Quang, T. , QI, Hongbo , HAGMANN, William, K.
发明人： SHAH, Shrenik, K. , TRUONG, Quang, T. , QI, Hongbo , HAGMANN, William, K.
IPC分类号： C07C255/59
CPC分类号： C07D213/74 , C07C255/58 , C07C317/28 , C07C317/48 , C07C323/63 , C07C2601/04 , C07C2601/14 , C07D207/32 , C07D207/325 , C07D213/38 , C07D213/57 , C07D213/61 , C07D213/64 , C07D231/12 , C07D231/38 , C07D239/26 , C07D249/06 , C07D249/08 , C07D249/14
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson’s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, including alcohol and nicotine addiction, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。该化合物还可用于治疗药物滥用障碍，包括酒精和尼古丁成瘾，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

22. 发明申请

WO2004109106A3 PUMP AND PUMP CONTROL CIRCUIT APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2004109106A3
公开(公告)日：2004-12-16
申请号：PCT/US2004/017524
申请日：2004-06-03
申请人： SHURFLO PUMP MANUFACTURING COMPANY, INC. , MEZA, Humberto , GANDHI, Nikhil, Jitendra , TRUONG, Quang, Ming
发明人： MEZA, Humberto , GANDHI, Nikhil, Jitendra , TRUONG, Quang, Ming
IPC分类号： F04B43/00 , F04B43/02 , F04B49/06
摘要： A method and apparatus for a pump (10) and a pump control system (200). The apparatus includes pistons integrally formed in a diaphragm (54) and coupled to the diaphragm (54) by convolutes (128). The convolutes (128) have a bottom surface angled with respect to a top surface of the pistons (62). The apparatus also includes an outlet port positioned tangentially with respect to the perimeter of an outlet chamber (94). The apparatus further includes a non-mechanical pressure sensor (116) and a temperature sensor coupled to a pump control system (200). For the method of the invention, the microcontroller provides a pulse-width modulation control signal to an output power stage in order to selectively control the power provided to the pump (10). The control signal is based on the pressure within the pump (10), the current being provided to the pump (10), the voltage level of the battery (202), and the temperature of the pump (10).

23. 发明申请

WO2004109106A2 PUMP AND PUMP CONTROL CIRCUIT APPARATUS AND METHOD 审中-公开
标题翻译：泵和泵控制电路设备及方法
公开(公告)号：WO2004109106A2
公开(公告)日：2004-12-16
申请号：PCT/US2004017524
申请日：2004-06-03
申请人： SHURFLO PUMP MFG CO INC , MEZA HUMBERTO , GANDHI NIKHIL JITENDRA , TRUONG QUANG MING
发明人： MEZA HUMBERTO , GANDHI NIKHIL JITENDRA , TRUONG QUANG MING
IPC分类号： F04B43/00 , F04B43/02 , F04B43/04 , F04B49/06 , F04B
CPC分类号： F04B43/026 , F04B43/0054 , F04B43/04 , F04B49/065 , F04B2205/04 , F04B2205/09
摘要： A method and apparatus for a pump and a pump control system. The apparatus includes pistons integrally formed in a diaphragm and coupled to the diaphragm by convolutes. The convolutes have a bottom surface angled with respect to a top surface of the pistons. The apparatus also includes an outlet port positioned tangentially with respect to the perimeter of an outlet chamber. The apparatus further includes a non-mechanical pressure sensor and a temperature sensor coupled to a pump control system. For the method of the invention, the microcontroller provides a pulse-width modulation control signal to an output power stage in order to selectively control the power provided to the pump. The control signal is based on the pressure within the pump, the current being provided to the pump, the voltage level of the battery, and the temperature of the pump.
摘要翻译：一种用于泵和泵控制系统的方法和装置。该装置包括一体地形成在隔膜中的活塞，通过卷曲连接到隔膜。卷轴具有相对于活塞顶表面成角度的底面。该装置还包括相对于出口室的周边切向定位的出口。该装置还包括耦合到泵控制系统的非机械压力传感器和温度传感器。对于本发明的方法，微控制器向输出功率级提供脉宽调制控制信号，以选择性地控制提供给泵的功率。控制信号基于泵内的压力，提供给泵的电流，电池的电压水平和泵的温度。

24. 发明申请

WO2014204831A1 CYCLIC PHOSPHONATE SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：环状磷酸酯取代的核苷类衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：WO2014204831A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/042463
申请日：2014-06-16
申请人： MERCK SHARP & DOHME CORP. , BOGEN, Stephane , GIRIJAVALLABHAN, Vinay , TRUONG, Quang , CHEN, Ping , BENNETT, Frank , KEREKES, Angela , DANG, Qun , OLSEN, David, B. , DAVIES, Ian
发明人： BOGEN, Stephane , GIRIJAVALLABHAN, Vinay , TRUONG, Quang , CHEN, Ping , BENNETT, Frank , KEREKES, Angela , DANG, Qun , OLSEN, David, B. , DAVIES, Ian
IPC分类号： A61K31/66 , A61K31/712 , A61K31/7105
CPC分类号： C07H19/10 , A61K31/661 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07F9/65586 , C07F9/65744 , C07H19/11 , A61K2300/00
摘要： The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein, as well as to compositions and methods of using the Cyclic Phosphonate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的环磷酸酯取代的核苷衍生物：（结构）及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义，以及使用用于治疗或预防患者HCV感染的环磷酸酯取代的核苷衍生物。

25. 发明申请

WO2012068187A1 POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES 审中-公开
标题翻译：用于交付寡核苷酸的聚（酰胺）聚合物
公开(公告)号：WO2012068187A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060893
申请日：2011-11-16
申请人： MERCK SHARP & DOHME CORP. , BARRETT, Stephanie, E. , BUSUEK, Marina , COLLETTI, Steven, L. , GARBACCIO, Robert, M. , GUIDRY, Erin, N. , KOWTONIUK, Robert, A. , LIAO, Jing , PARISH, Craig, A. , PARMAR, Rubina, G. , PEI, Tao , SCHLOSSER, Kevin, M. , TELLERS, David, M. , TOBIAS, Sandra, C. , TRUONG, Quang, T. , WALDMAN, Jacob, H. , WANG, Weimin , WILLIAMS, J. Michael
发明人： BARRETT, Stephanie, E. , BUSUEK, Marina , COLLETTI, Steven, L. , GARBACCIO, Robert, M. , GUIDRY, Erin, N. , KOWTONIUK, Robert, A. , LIAO, Jing , PARISH, Craig, A. , PARMAR, Rubina, G. , PEI, Tao , SCHLOSSER, Kevin, M. , TELLERS, David, M. , TOBIAS, Sandra, C. , TRUONG, Quang, T. , WALDMAN, Jacob, H. , WANG, Weimin , WILLIAMS, J. Michael
IPC分类号： A61K31/7088
CPC分类号： A61K47/48092 , A61K47/549 , C08G69/10 , C08G73/028 , C08L79/02
摘要： The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
摘要翻译：本发明提供用于递送用于治疗目的的寡核苷酸的聚（酰胺）聚合物，多偶联物，组合物和方法。

26. 发明申请

WO2011088025A1 OXADIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：作为抗菌化合物的奥沙唑苯甲酰胺衍生物
公开(公告)号：WO2011088025A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/020796
申请日：2011-01-11
申请人： MERCK SHARP & DOHME CORP. , GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , LIU, Jian , NARGUND, Ravi, P. , SHAH, Shrenik, K. , TRUONG, Quang, T.
发明人： GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , LIU, Jian , NARGUND, Ravi, P. , SHAH, Shrenik, K. , TRUONG, Quang, T.
IPC分类号： A01N43/42
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
摘要翻译：结构式I的β-咔啉衍生物是生长抑素亚型受体3（SSTR3）的选择性拮抗剂，可用于治疗2型糖尿病和通常与该疾病相关的病症，包括高血糖症，胰岛素抵抗，肥胖症，脂质障碍和高血压。这些化合物也可用于治疗抑郁症和焦虑症。

27. 发明申请

WO2007098131A3 PUMP AND PUMP CONTROL CIRCUIT APPARATUS AND METHOD 审中-公开
标题翻译：泵和泵控制电路设备及方法
公开(公告)号：WO2007098131A3
公开(公告)日：2008-01-24
申请号：PCT/US2007004314
申请日：2007-02-16
申请人： SHURFLO LLC , MEZA HUMBERTO V , GANDHI NIKHIL JITENDRA , TRUONG QUANG MINH
发明人： MEZA HUMBERTO V , GANDHI NIKHIL JITENDRA , TRUONG QUANG MINH
IPC分类号： F04B49/06 , F04B43/00 , F04B43/02 , F04B43/04
CPC分类号： F04B43/0081 , F04B43/0054 , F04B43/026 , F04B43/04 , F04B49/065 , F04B2203/0201 , F04B2203/0208 , F04B2205/04
摘要： A method and apparatus for a pump and a pump control system. The apparatus includes a pressure sensor and a temperature sensor coupled to a pump control system. For the method of the invention, the microcontroller provides a pulse-width modulation control signal to an output power stage in order to selectively control the power provided to the pump.
摘要翻译：一种用于泵和泵控制系统的方法和装置。该装置包括压力传感器和耦合到泵控制系统的温度传感器。对于本发明的方法，微控制器向输出功率级提供脉宽调制控制信号，以选择性地控制提供给泵的功率。

28. 发明申请

WO2003007887A2 SUBSTITUTED IMIDAZOLES AS CANNABINOID RECEPTOR MODULATORS 审中-公开
标题翻译：取代的咪唑作为大麻素受体调节剂
公开(公告)号：WO2003007887A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/023230
申请日：2002-07-16
申请人： MERCK & CO., INC. , FINKE, Paul, E. , MILLS, Sander, G. , PLUMMER, Christopher, W. , SHAH, Shrenik, K. , TRUONG, Quang, T.
发明人： FINKE, Paul, E. , MILLS, Sander, G. , PLUMMER, Christopher, W. , SHAH, Shrenik, K. , TRUONG, Quang, T.
IPC分类号： A61K
CPC分类号： C07D405/12 , C07D233/90
摘要： The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1)receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.
摘要翻译：本发明化合物作为大麻素-1（CB1）受体的拮抗剂和/或反向激动剂的用途，特别是在治疗，预防和抑制由大麻素-1（CB1）介导的疾病）受体。本发明涉及这些新型化合物选择性拮抗大麻素-1（CB1）受体的用途。因此，本发明化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化症和格林 - 巴利综合征的神经炎症和病毒性脑炎，脑炎的炎性后遗症的精神药物血管意外，头部创伤，焦虑症，压力，癫痫，帕金森病和精神分裂症。这些化合物还可用于治疗物质滥用障碍，特别是阿片类药物，酒精和尼古丁。该化合物还可用于治疗与过量食物摄入和与之相关的并发症相关的肥胖症或进食障碍。结构式（I）的新化合物也被要求保护。

29. 发明授权

US07992496B2 Decoys for infra-red radiation seeking missiles and methods of producing and using the same 有权
标题翻译：用于红外辐射寻找导弹的诱饵及其生产和使用方法
公开(公告)号：US07992496B2
公开(公告)日：2011-08-09
申请号：US12205987
申请日：2008-09-08
申请人： David P. Dillard , Jason A. Fischer , Rajesh D. Shah , John J. Scanlon , Eric M. Smith , Truong Quang Dinh , David L. Machamer
发明人： David P. Dillard , Jason A. Fischer , Rajesh D. Shah , John J. Scanlon , Eric M. Smith , Truong Quang Dinh , David L. Machamer
IPC分类号： F42B12/70 , F42B4/26
CPC分类号： F42B12/70 , F41J2/02 , F42B4/26 , F42B12/36
摘要： The present invention relates to decoys for heat-seeking missiles and methods of producing and using the same. The decoys are designed to be kinematic or pseudo-kinematic, producing one or more infra-red radiation emitting clouds that give the appearance of a moving infra-red target in the airspace in which the decoy has been released.
摘要翻译：本发明涉及用于寻热导弹的诱饵及其制造和使用方法。诱饵被设计为运动学或伪运动学，产生一个或多个红外线辐射云，使得在诱捕器已被释放的空域中出现移动的红外目标。

30. 发明申请

US20140208973A1 DECOYS FOR INFRA-RED RADIATION SEEKING MISSILES AND METHODS OF PRODUCING AND USING THE SAME 有权
标题翻译：用于红外辐射探测器的解决方案及其生产和使用方法
公开(公告)号：US20140208973A1
公开(公告)日：2014-07-31
申请号：US13632668
申请日：2012-10-01
申请人： David Dillard , Jason A. Fischer , Rajesh D. Shah , John J. Scanlon , Eric M. Smith , Truong Quang Dinh , David L. Machamer
发明人： David Dillard , Jason A. Fischer , Rajesh D. Shah , John J. Scanlon , Eric M. Smith , Truong Quang Dinh , David L. Machamer
IPC分类号： F42B12/70 , F42B4/26
CPC分类号： F42B12/70 , F41J2/02 , F42B4/26 , F42B12/36
摘要： The present invention relates to decoys for heat-seeking missiles and methods of producing and using the same. The decoys axe designed to be kinematic or pseudo-kinematic, producing one or more infra-red radiation emitting clouds that give the appearance of a moving infra-red target in the airspace in which the decoy has been released.
摘要翻译：本发明涉及用于寻热导弹的诱饵及其制造和使用方法。设计为运动学或伪运动学的诱饵轴，产生一个或多个红外线辐射云，使得在诱饵被释放的空域中出现移动的红外目标。

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