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21. 发明申请

WO2006009464A2 COMPOSITION COMPRISING PLANT AND/OR FISH OILS AND COMPOUNDS COMPRISING NON-OXIDIZABLE FATTY ACID ENTITIES 审中-公开
标题翻译：包含植物和/或鱼油的组合物和包含不可氧化的脂肪酸实体的化合物
公开(公告)号：WO2006009464A2
公开(公告)日：2006-01-26
申请号：PCT/NO2005000271
申请日：2005-07-19
申请人： THIA MEDICA AS , BERGE ROLF
发明人： BERGE ROLF
IPC分类号： A61K45/06 , A23J1/04 , A23J3/34 , A23K1/16 , A23K1/18 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/232 , A61K31/685 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P19/00 , A61P29/00 , A61P35/00
CPC分类号： A61K31/232 , A23K10/12 , A23K50/30 , A23K50/75 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/685 , A61K38/01 , A61K45/06 , A61K2300/00 , A23V2250/164 , A23V2250/70 , A23V2250/18
摘要： The present invention concerns a composition prepared from a combination of plant oil and/or fish oil and a compound comprising non ß-oxidizable fatty acid analogues, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. The present invention also concerns an animal feed prepared from a combination of plant oil and/or fish oil and a compound comprising non ß-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.
摘要翻译：本发明涉及由植物油和/或鱼油的组合和包含不可氧化的脂肪酸类似物的化合物制备的组合物，以及所述组合物用于制备药物或营养组合物用于预防和/ 或治疗胰岛素抵抗，肥胖，糖尿病，脂肪肝，高胆固醇血症，血脂异常，动脉粥样硬化，冠心病，血栓形成，狭窄，继发性狭窄，心肌梗死，中风，血压升高，内皮功能障碍，促凝血状态，多囊卵巢综合征代谢综合征，癌症，炎症性疾病和增殖性皮肤病。本发明还涉及由植物油和/或鱼油的组合和包含不可氧化的脂肪酸类似物的化合物制备的动物饲料，所述饲料用于改善动物的身体组成以及产生的产品从所说的动物。

22. 发明申请

WO2009108067A2 PREVENTION AND TREATMENT OF HSMI 审中-公开
标题翻译：预防和治疗HSMI
公开(公告)号：WO2009108067A2
公开(公告)日：2009-09-03
申请号：PCT/NO2009/000069
申请日：2009-02-27
申请人： THIA MEDICA AS , RØRVIK, Kjell-Arne , ALNE, Henriette , THOMASSEN, Magny , BERGE, Rolf, Kristian
发明人： RØRVIK, Kjell-Arne , ALNE, Henriette , THOMASSEN, Magny , BERGE, Rolf, Kristian
IPC分类号： A61K31/19 , A61K31/095 , A61P29/00
CPC分类号： A61K31/095 , A23K20/10 , A23K20/158 , A23K40/30 , A23K50/80 , A61K31/19
摘要： The present invention relates to the use of a compound for the preparation of a nutritional and/or pharmaceutical composition for reducing the mortality related to heart and skeletal muscle inflammation (HSMI) of a fish.
摘要翻译：本发明涉及化合物用于制备营养和/或药物组合物以减少与鱼和心脏和骨骼肌炎症（HSMI）有关的死亡率的用途。

23. 发明申请

WO2007061314A3 USE OF FATTY ACID ANALOGUES 审中-公开
公开(公告)号：WO2007061314A3
公开(公告)日：2007-05-31
申请号：PCT/NO2006/000424
申请日：2006-11-22
申请人： BERGE BIOMED AS , THIA MEDICA AS , RORVIK, Kjell-Arne , THOMASSEN, Magny , BERGE, Rolf
发明人： RORVIK, Kjell-Arne , THOMASSEN, Magny , BERGE, Rolf
IPC分类号： A23K1/18 , A23K1/16 , A61P31/12
摘要： Use of a fish feed comprising a compound represented by the general formula R"- COO-(CH 2 ) 2n+1 -X-R', (I) or (II), which comprise non β-oxidizable fatty acids, for feeding fish during time periods where the requirements for energy of said fish is increased, in order to improve the health of said fish.

24. 发明申请

WO2007011232A2 USE OF LIPID CLEARING AGENTS 审中-公开
标题翻译：使用脂肪清除剂
公开(公告)号：WO2007011232A2
公开(公告)日：2007-01-25
申请号：PCT/NO2006000263
申请日：2006-07-10
申请人： THIA MEDICA AS , BERGE ROLF
发明人： BERGE ROLF
IPC分类号： A61P19/08 , A61K20060101 , A61K31/192 , A61K31/216 , A61K31/505 , A61P19/10
CPC分类号： A61K31/216 , A61K31/192 , A61K31/505
摘要： The invention comprises the use of a fibrate and/or the compound Wyeth 14,643 for preparation of a pharmaceutical composition for the prevention and/or treatment of conditions associated with low/decreased bone mineral density (BMD), and/or for increasing the BMD by decreasing the bone resorption.
摘要翻译：本发明包括使用贝特类和/或化合物Wyeth 14,643来制备用于预防和/或治疗与低/低骨矿物质密度（BMD）有关的病症的药物组合物和/或用于通过减少骨吸收。

25. 发明申请

WO2007011231A2 USE OF COMPOUNDS COMPRISING FATTY ACID ENTITIES 审中-公开
标题翻译：使用包含脂肪酸实体的化合物
公开(公告)号：WO2007011231A2
公开(公告)日：2007-01-25
申请号：PCT/NO2006000262
申请日：2006-07-10
申请人： THIA MEDICA AS , BERGE ROLF
发明人： BERGE ROLF
IPC分类号： A61P19/08 , A61K20060101 , A61K31/00 , A61K31/19 , A61K31/20 , A61K31/28 , A61P19/10
CPC分类号： A61K31/00 , A61K31/19 , A61K31/20 , A61K31/28 , H05B41/042 , H05B41/2881 , H05B41/2882 , H05B41/2885 , Y02B20/202
摘要： The invention comprises the use of compounds comprising non ß-oxidizable fatty acid entities according to formula (I) or (II) for the preparation of a pharmaceutical composition for the prevention and/or treatment of conditions associated with low/decreased bone mineral density (BMD), and/or for increasing the BMD by decreasing the bone resorption.
摘要翻译：本发明包括使用包含根据式（I）或（II）的不可氧化的脂肪酸实体的化合物来制备用于预防和/或治疗与低/降低的骨矿物质密度相关的病症的药物组合物 BMD），和/或通过减少骨吸收来增加BMD。

26. 发明申请

WO2006009464A3 COMPOSITION COMPRISING PLANT AND/OR FISH OILS AND NON-OXIDIZABLE FATTY ACID ENTITIES 审中-公开
公开(公告)号：WO2006009464A3
公开(公告)日：2006-01-26
申请号：PCT/NO2005/000271
申请日：2005-07-19
申请人： THIA MEDICA AS , BERGE, Rolf
发明人： BERGE, Rolf
IPC分类号： A61K45/06 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/232 , A61K31/685 , A23K1/16 , A23K1/18 , A23J3/34 , A23J1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10
摘要： The present invention concerns a composition prepared from a combination of plant oil and/or fish oil and a compound comprising non β-oxidizable fatty acid analogues, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. The present invention also concerns an animal feed prepared from a combination of plant oil and/or fish oil and a compound comprising non β-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.

27. 发明申请

WO2004000854A1 SULFUR-CONTAINING PHOSPHOLIPID DERIVATIVES 审中-公开
标题翻译：含硫的磷脂衍生物
公开(公告)号：WO2004000854A1
公开(公告)日：2003-12-31
申请号：PCT/GB2003/002582
申请日：2003-06-16
申请人： IC VEC LIMITED , THIA MEDICA AS , MILLER, Andrew, David , JORGENSEN, Michael, Rael , BERGE, Rolf , SKORVE, Jon
发明人： MILLER, Andrew, David , JORGENSEN, Michael, Rael , BERGE, Rolf , SKORVE, Jon
IPC分类号： C07F9/09
CPC分类号： C07C329/06 , A61K9/1272 , C07C323/52 , C07F9/10
摘要： The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X-Y-Z-, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO 2 , SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[C(O)] m PHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.
摘要翻译：本发明提供了包含至少一个非极性部分和极性部分的脂质化合物，其中每个或至少一个非极性部分具有式XYZ-，其中X是烃基链，Y至少选自 S，Se，SO2，SO和O之一，Z是任选的烃基，其中极性部分具有式 - [C（O）] m PHG，其中PHG是极性头基，其中m是非极性部分的数量。

28. 发明申请

WO0226218A3 FATTY ACID ANALOGUES FOR THE TREATMENT OF PROLIFERATIVE SKIN DISORDERS 审中-公开
标题翻译：脂肪酸类似物治疗增生性皮肤病
公开(公告)号：WO0226218A3
公开(公告)日：2002-06-13
申请号：PCT/NO0100393
申请日：2001-09-27
申请人： THIA MEDICA AS , BERGE ROLF , KRISTIANSEN KARSTEN
发明人： BERGE ROLF , KRISTIANSEN KARSTEN
IPC分类号： A61K31/19 , A61K31/20 , A61K31/215 , A61P17/00 , A61P17/06 , A61P17/08 , A61P17/12 , A61P37/08 , A61K31/201 , A61K31/202
CPC分类号： A61K31/20
摘要： The present invention relates to fatty acid analogues of the general formula (I): R1- [xi - CH2]n - COOR2 wherein R1 is; a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1-C24 alkyne, and/or a C1-C24 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein X1 independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the ( omega -1) carbon and the ( omega -2) carbon, or between the ( omega -2) carbon and the ( omega -3) carbon, or between the ( omega -3) carbon and the ( omega -4) carbon, which can be used for the treatment and/or prevention of proliferative skin disorders. More specifically the invention relates to the inhibition of proliferation and/or differentiation of keratinocytes.
摘要翻译：本发明涉及通式（I）的脂肪酸类似物：R1- [xi-CH2] n-COOR2其中R1是; 具有一个或多个双键和/或具有一个或多个三键的C1-C24烯烃和/或C1-C24炔烃，和/或C1-C24烷基或被一个或多个与选自氟化物，氯化物，羟基，C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 2 -C 5酰氧基或C 1 -C 4烷基的组中的一种或多种化合物反应，并且其中R 2表示氢或C 1 -C 4烷基，并且其中 n是1至12的整数，并且其中i是奇数并且表示相对于COOR 2的位置，并且其中彼此独立的X 1选自组包括O，S，SO，SO 2，Se和CH 2，条件是至少一个X 1不是CH 2，并且条件是如果R 1是炔烃或烯烃，则碳 - 碳三键或双键键位于（ω-1）碳和（ω-2）碳之间，或（ω-2）碳和（ω-3）碳之间，或（ω-3）碳和（ω- 欧米茄-4）碳，whic h可以用于治疗和/或预防增殖性皮肤病。更具体地说，本发明涉及抑制角质形成细胞的增殖和/或分化。

29. 发明公开

EP2275140A3 Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities 有权转让
标题翻译：含有植物油或鱼油脂肪酸和含非可氧化组分组合物
公开(公告)号：EP2275140A3
公开(公告)日：2012-08-08
申请号：EP10183765.6
申请日：2005-07-19
申请人： Thia Medica AS
发明人： Berge, Rolf Kristian
IPC分类号： A61K45/06 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/232 , A61K31/685 , A23K1/16 , A23K1/18 , A23J3/34 , A23J1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P19/00 , A61P17/00 , A61P29/00 , A61P35/00
CPC分类号： A61K31/232 , A23K10/12 , A23K50/30 , A23K50/75 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/685 , A61K38/01 , A61K45/06 , A61K2300/00 , A23V2250/164 , A23V2250/70 , A23V2250/18
摘要： The present invention concerns a composition comprising a combination of a protein material, and a plant or fish oil, wherein the protein material is chosen from the group comprising single cell protein material (SCP), fish protein hydrolysate, or a fermented soy protein material, preferably Gendaxin®. The invention also relates to the use of such a composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of hypercholesterolemia and conditions negatively effected by high cholesterol levels, insulin resistance, obesity, diabetes, fatty liver, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders.

30. 发明公开

EP1784223A2 COMPOSITION COMPRISING PLANT AND/OR FISH OILS AND NON-OXIDIZABLE FATTY ACID ENTITIES 审中-公开
标题翻译：成分含有植物或鱼油和非脂肪酸氧化
公开(公告)号：EP1784223A2
公开(公告)日：2007-05-16
申请号：EP05772164.9
申请日：2005-07-19
申请人： Thia Medica AS
发明人： BERGE, Rolf
IPC分类号： A61K45/06 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/232 , A61K31/685 , A23K1/16 , A23K1/18 , A23J3/34 , A23J1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P19/00 , A61P17/00 , A61P29/00 , A61P35/00
CPC分类号： A61K31/232 , A23K10/12 , A23K50/30 , A23K50/75 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K31/10 , A61K31/19 , A61K31/231 , A61K31/685 , A61K38/01 , A61K45/06 , A61K2300/00 , A23V2250/164 , A23V2250/70 , A23V2250/18
摘要： The present invention concerns a composition prepared from a combination of plant oil and/or fish oil and a compound comprising non β-oxidizable fatty acid analogues, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. The present invention also concerns an animal feed prepared from a combination of plant oil and/or fish oil and a compound comprising non β-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.

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