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21. 发明授权

US5202563A Tandem time-of-flight mass spectrometer 失效
标题翻译： TANDEM飞行时间质谱仪
公开(公告)号：US5202563A
公开(公告)日：1993-04-13
申请号：US700697
申请日：1991-05-16
申请人： Robert J. Cotter , Timothy J. Cornish
发明人： Robert J. Cotter , Timothy J. Cornish
IPC分类号： G01N27/62 , H01J49/40
CPC分类号： H01J49/004 , H01J49/406
摘要： A tandem time-of-flight mass spectrometer comprises a grounded vacuum housing, two reflecting-type mass analyzers coupled via a collision chamber, and flight channels electrically floated with respect to the grounded vacuum housing. The first reflecting-type mass analyzer receives ionized molecules (ions). These ions pass through the flight channel of the first reflecting-type mass analyzer and are fragmented in the collision chamber. The fragmented ions pass through the flight channel of the second reflecting-type mass analyzer. Detectors disposed in the collision chamber and in the second reflecting-type mass analyzer detect the spectrum of the first reflecting-type mass analyzer and the spectra of the tandem time-of-flight mass analyzer, respectively.
摘要翻译：串联飞行时间质谱仪包括接地的真空壳体，通过碰撞室耦合的两个反射型质量分析器和相对于接地的真空壳体浮动的飞行通道。第一反射型质量分析仪接收电离分子（离子）。这些离子通过第一反射型质量分析器的飞行通道并在碰撞室中分段。碎片离子通过第二反射型质量分析仪的飞行通道。设置在碰撞室中的检测器和第二反射型质量分析器分别检测第一反射型质量分析器的光谱和串联飞行时间质量分析器的光谱。

22. 发明授权

US5159028A Process for the preparation of polycarbonate and/or polyarylate block copolymers with poly(aryl ethers) 失效
标题翻译：用聚（芳基醚）制备聚碳酸酯和/或聚芳酯嵌段共聚物的方法
公开(公告)号：US5159028A
公开(公告)日：1992-10-27
申请号：US700489
申请日：1991-05-15
申请人： Markus Matzner , George T. Kwiatkowski , Robert A. Clendinning , Selvaraj Savariar , Mohammad J. El-Hibri , Charles N. Merriam , Robert J. Cotter
发明人： Markus Matzner , George T. Kwiatkowski , Robert A. Clendinning , Selvaraj Savariar , Mohammad J. El-Hibri , Charles N. Merriam , Robert J. Cotter
IPC分类号： C08G81/00
CPC分类号： C08G81/00
摘要： The invention describes a novel process for the preparation of polycarbonate and/or polyarylate block copolymers with poly(aryl ethers). The process is comprised of the steps:(a) the reaction of a dihydroxy-terminated poly(aryl ether) oligomer with a high molecular weight polycarbonate, or a high molecular weight polyarylate, or a high molecular weight poly(arylate-carbonate) to yield a block copolymer; followed by(b) the coupling of the material obtained in step (a) to the required molecular weight, using a diaryl ester of carbonic acid or of a dicarboxylic acid.Both steps are performed in the presence of a catalyst. The copolymerizations can be run in bulk under vacuum in a single or twin screw extruder. Using the above conditions high molecular weight, high quality block copolymers having a combination of excellent properties are obtained in a matter of minutes.
摘要翻译：本发明描述了用聚（芳基醚）制备聚碳酸酯和/或聚芳酯嵌段共聚物的新方法。该方法包括以下步骤：（a）二羟基封端的聚（芳基醚）低聚物与高分子量聚碳酸酯或高分子量聚芳酯或高分子量聚芳基酯 - 碳酸酯的反应与得到嵌段共聚物; （b）使用碳酸或二羧酸的二芳基酯将步骤（a）中获得的材料与所需的分子量的偶联。两个步骤都在催化剂存在下进行。共聚可以在单螺杆或双螺杆挤出机中在真空下大量运行。使用上述条件可以在几分钟内获得具有优异性能的组合的高分子量的高质量嵌段共聚物。

23. 发明授权

US5077351A Process for the preparation of polycarbonate and/or polyarylate block copolymers with poly(aryl ethers) 失效
标题翻译：用聚芳醚（ARYL ETHERS）制备聚碳酸酯和/或多烯酸酯嵌段共聚物的方法
公开(公告)号：US5077351A
公开(公告)日：1991-12-31
申请号：US332880
申请日：1989-04-03
申请人： Markus Matzner , George T. Kwiatkowski , Robert A. Clendinning , Selvaraj Savariar , Mohammad J. El-Hibri , Charles N. Merriam , Robert J. Cotter
发明人： Markus Matzner , George T. Kwiatkowski , Robert A. Clendinning , Selvaraj Savariar , Mohammad J. El-Hibri , Charles N. Merriam , Robert J. Cotter
IPC分类号： C08G65/40 , C08G63/64 , C08G63/66 , C08G64/00 , C08G64/18 , C08G64/42 , C08G65/28 , C08G75/00 , C08G75/23 , C08G81/00
CPC分类号： C08G81/00
摘要： The invention describes a novel process for the preparation of polycarbonate and/or polyarylate block copolymers with poly(aryl ethers). The process is comprised of the steps:(a) the reaction of a dihydroxy-terminated poly(aryl ether) oligomer with a high molecular weight polycarbonate, or a high molecular weight polyarylate, or a high molecular weight poly(arylate-carbonate) to yield a block copolymer; followed by(b) the coupling of the material obtained in step (a) to the required molecular weight, using a diaryl ester of carbonic acid or of a dicarboxylic acid.Both steps are performed in the presence of a catalyst. The copolymerizations can be run in bulk under vacuum in a single or twin screw extruder. Using the above conditions high molecular weight, high quality block copolymers having a combination of excellent properties are obtained in a matter of minutes.
摘要翻译：本发明描述了用聚（芳基醚）制备聚碳酸酯和/或聚芳酯嵌段共聚物的新方法。该方法包括以下步骤：（a）二羟基封端的聚（芳基醚）低聚物与高分子量聚碳酸酯或高分子量多芳基化合物或高分子量聚芳基酯 - 碳酸酯的反应与得到嵌段共聚物; （b）使用碳酸或二羧酸的二芳基酯将步骤（a）中获得的材料与所需的分子量的偶联。两个步骤都在催化剂存在下进行。共聚可以在单螺杆或双螺杆挤出机中在真空下大量运行。使用上述条件可以在几分钟内获得具有优异性能的组合的高分子量的高质量嵌段共聚物。

24. 发明授权

US4814419A Polyarylether sulfones useful for molding into a circuit board substrate 失效
标题翻译：用于模制成电路板基底的聚芳醚砜
公开(公告)号：US4814419A
公开(公告)日：1989-03-21
申请号：US209014
申请日：1988-06-20
申请人： Robert J. Cotter , Stephen B. Rimsa , Robert Barclay, Jr.
发明人： Robert J. Cotter , Stephen B. Rimsa , Robert Barclay, Jr.
IPC分类号： C08G75/23 , H05K1/03
CPC分类号： H05K1/0333 , C08G75/23
摘要： Described herein are circuit board substrates prepared from certain poly(aryl ethers) based on 4,4'-dichlorodiphenyl sulfone.
摘要翻译：这里描述的是由基于4,4'-二氯二苯砜的某些聚（芳基醚）制备的电路板基底。

25. 发明授权

US4705822A Ordered, alternating sulfone polycarbonate composition 失效
标题翻译：有序，交替的砜聚碳酸酯组合物
公开(公告)号：US4705822A
公开(公告)日：1987-11-10
申请号：US872275
申请日：1986-06-10
申请人： James H. Kawakami , James E. Harris , Louis M. Maresca , Lloyd M. Robeson , Robert J. Cotter
发明人： James H. Kawakami , James E. Harris , Louis M. Maresca , Lloyd M. Robeson , Robert J. Cotter
IPC分类号： C08G64/08 , C08G63/62 , C08L69/00
CPC分类号： C08G64/081
摘要： This invention relates to moldable polycarbonate compositions and in particular to moldable polycarbonates which have ordered, alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl)sulfone (TMBS) and 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A) dihaloformate, or ordered, alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl) sulfone (TMBS) dihaloformate and a bisphenol compound such as 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A). Such polycarbonate exhibit improved hydrolytic stability and also excellent processability in molding applications.
摘要翻译：本发明涉及可模制的聚碳酸酯组合物，特别是涉及可衍生的聚碳酸酯，其具有衍生自双 - （3,5-二甲基-4-羟基苯基）砜（TMBS）和2,2-双 - （4-羟基苯基））丙二醇（双酚A）二卤代甲酸酯或有序的衍生自二 - （3,5-二甲基-4-羟基苯基）砜（TMBS）二卤代甲酸酯和双酚化合物的交替重复单元，例如2,2-双 - （4-羟基苯基））丙烷（双酚A）。这样的聚碳酸酯表现出改善的水解稳定性和在模塑应用中的优异加工性能。

26. 发明授权

US4229559A Novel bis(half ester) and compositions containing the same 失效
标题翻译：新型双（半酯）和含有它们的组合物
公开(公告)号：US4229559A
公开(公告)日：1980-10-21
申请号：US34996
申请日：1979-05-01
申请人： Robert J. Cotter , Hugh C. Gardner
发明人： Robert J. Cotter , Hugh C. Gardner
IPC分类号： C07C69/675 , C08F20/00 , C08F20/02 , C08F22/20 , C08F222/12 , C07C69/34
CPC分类号： C08F22/20 , Y10T428/2933 , Y10T428/2998 , Y10T442/2992
摘要： This invention is directed to a half ester characterized by the following empirical formula: ##STR1## wherein n is a number having an average value of 1.7 to 2, and m is equal to 2-n. Also described herein is a composition comprising said half ester, maleic anhydride and an ethylenically unsaturated monomer, wherein at least 75 mole percent of the half ester is in the maleate form.
摘要翻译：本发明涉及一种以下述经验式为特征的半酯：其中n为平均值为1.7〜2，m为2-n的数。本文还描述了包含所述半酯，马来酸酐和烯属不饱和单体的组合物，其中至少75摩尔％的半酯是马来酸盐形式。

27. 发明申请

US20100137420A1 Methods and Compositions for Diagnosis and Treatment of Multiple Sclerosis 失效
标题翻译：多发性硬化症诊断和治疗的方法和组成
公开(公告)号：US20100137420A1
公开(公告)日：2010-06-03
申请号：US11857742
申请日：2007-09-19
申请人： Avindra Nath , Caroline F. Anderson , David Irani , Robert J. Cotter , Joseph P. Steiner , Norman Haughey
发明人： Avindra Nath , Caroline F. Anderson , David Irani , Robert J. Cotter , Joseph P. Steiner , Norman Haughey
IPC分类号： G01N33/53 , C07K16/18 , A61K31/352
CPC分类号： G01N33/564 , C07K14/8139 , G01N2800/285
摘要： Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition comprising a modified terpenoid compound. Also described are isolated polypeptide biomarkers, polynucleotides encoding the polypeptide biomarkers, and antibodies that bind specifically to the polypeptide biomarkers. Further described are kits that include the above-mentioned isolated polypeptide biomarkers, the polynucleotides encoding them, or specific antibodies against the polypeptide biomarkers.
摘要翻译：描述了用于多发性硬化的生物标志物及其在该疾病的诊断和预后中的用途。还描述了通过施用组织蛋白酶B活性抑制剂治疗多发性硬化的方法或包含修饰的萜类化合物的神经保护组合物。还描述了分离的多肽生物标志物，编码多肽生物标志的多核苷酸，以及特异性结合多肽生物标志物的抗体。进一步描述的是包括上述分离的多肽生物标志物，编码它们的多核苷酸或针对多肽生物标志物的特异性抗体的试剂盒。

28. 发明授权

US5572025A Method and apparatus for scanning an ion trap mass spectrometer in the resonance ejection mode 失效
标题翻译：用于在共振喷射模式下扫描离子阱质谱仪的方法和装置
公开(公告)号：US5572025A
公开(公告)日：1996-11-05
申请号：US450464
申请日：1995-05-25
申请人： Robert J. Cotter , Vladimir M. Doroshenko
发明人： Robert J. Cotter , Vladimir M. Doroshenko
IPC分类号： H01J49/16 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/0009 , H01J49/429
摘要： A method of operation of an ion trap mass spectrometer having a ring electrode and pair of end-cap electrodes in a resonance ejection mode is disclosed. The method includes producing ions from a plurality of biomolecules, applying a trapping RF voltage to the ring electrode, applying an excitation voltage to the end-cap electrodes, scanning the trapping RF voltage in order to sequentially eject the ions, controlling a ration of the amplitude of the trapping RF voltage to the amplitude of the excitation voltage in order that the ratio is generally constant, and determining a ratio of mass to charge of the ejected ions. In one embodiment, a feedback voltage which is proportional to the trapping RF voltage is sensed, and the amplitude of the excitation voltage is controlled as a function of the amplitude of the feedback voltage. In another embodiment, a first value related to the amplitude of the trapping RF voltage and a second value, which is proportional to the first value and related to the amplitude of the excitation voltage, are determined. The amplitude of the trapping RF voltage is modulated employing the first value and the amplitude of the excitation voltage is modulated employing the second value. Preferably, the determined mass-to-charge ratio (m/z) of the ejected ions is equal to a constant (.alpha.) times the trapping RF voltage (V). Associated apparatus and method of calibration are also disclosed.
摘要翻译：公开了一种具有环形电极和一对端帽电极的共振喷射模式的离子阱质谱仪的操作方法。该方法包括从多个生物分子产生离子，向环形电极施加捕获RF电压，向端帽电极施加激发电压，扫描捕获RF电压以顺序地喷射离子，控制将捕获的RF电压的幅度调节到激励电压的幅度，以使该比率基本上恒定，并且确定所排出的离子的质量与电荷的比率。在一个实施例中，感测与捕获RF电压成比例的反馈电压，并且激励电压的幅度被控制为反馈电压的幅度的函数。在另一个实施例中，确定与捕获RF电压的幅度相关的第一值和与第一值成比例并且与激励电压的幅度相关的第二值。使用第一值调制捕获RF电压的幅度，并且使用第二值调制激励电压的幅度。优选地，所确定的喷射离子的质荷比（m / z）等于捕获RF电压（V）的常数（α）。还公开了相关装置和校准方法。

29. 发明授权

US5101105A Neutralization/chemical reionization tandem mass spectrometry method and apparatus therefor 失效
标题翻译：中和/化学反离子串联质谱法及其设备
公开(公告)号：US5101105A
公开(公告)日：1992-03-31
申请号：US608435
申请日：1990-11-02
申请人： Catherine Fenselau , Robert J. Cotter
发明人： Catherine Fenselau , Robert J. Cotter
IPC分类号： H01J49/14
CPC分类号： H01J49/145 , H01J49/14
摘要： A mass spectrometer system including a device for supplying a protonated ion species; a single chamber having an entrance and an exit slit, the chamber receiving the supplied protonated ion and transmitting a reprotonated ion through the exit slit; a device for supplying a predetermined reagent gas within the chamber; a device for supplying an electron beam in said chamber such that the electron beam reacts with the supplied predetermined reagent gas to provide neutral reagent gas and protonated reagent gas within the chamber, the supplied ion species reacting with the neutral reagent gas to neutralize the ion species, thereby providing neutral species within the chamber, the neutral species reacting with the protonated reagent gas to provide reionized species within the chamber; and a device, coupled to the exit slit of the chamber, for extracting the reionized species.
摘要翻译：一种质谱仪系统，包括用于提供质子化离子物质的装置; 具有入口和出口狭缝的单个室，所述室接收所提供的质子离子并将再现离子透过出口狭缝; 用于在所述室内供应预定的反应气体的装置; 用于在所述室中供应电子束的装置，使得电子束与所提供的预定反应气体反应以在室内提供中性反应气体和质子化反应气体，所供应的离子物质与中性反应气体反应以中和离子种类从而在室内提供中性物质，中性物质与质子化的反应气体反应以在室内提供去离子物质; 以及耦合到所述室的出口狭缝的用于提取所述再离子化物质的装置。

30. 发明授权

US5096997A Copoly arylate from hydroquinone and dihydroxy diphenyl sulfone 失效
标题翻译：来自氢醌和二羟基二苯砜的共聚芳基化物
公开(公告)号：US5096997A
公开(公告)日：1992-03-17
申请号：US83153
申请日：1987-08-10
申请人： James H. Kawakami , Lloyd M. Robeson , Robert J. Cotter
发明人： James H. Kawakami , Lloyd M. Robeson , Robert J. Cotter
IPC分类号： C08G63/19
CPC分类号： C08G63/19
摘要： Described herein are novel polyarylates derived from mixtures of terephthalic and isophthalic acids, hydroquinone and 4,4'-dihydroxydiphenyl sulfone. The instant polyarylates exhibit excellent stress-crack resistance in a wide variety of solvents. Moreover, the materials display very good mechanical and thermal properties.
摘要翻译：本文描述了衍生自对苯二甲酸和间苯二甲酸，氢醌和4,4'-二羟基二苯砜的混合物的新型聚芳酯。本发明的多芳基化合物在各种溶剂中表现出优异的抗应力开裂性。此外，材料显示出非常好的机械和热性能。

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