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21. 发明授权

US07460900B1 Method and apparatus for detecting ischemia using changes in QRS morphology 有权
标题翻译：使用QRS形态变化检测缺血的方法和装置
公开(公告)号：US07460900B1
公开(公告)日：2008-12-02
申请号：US11227856
申请日：2005-09-14
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/024 , A61N1/3627 , A61N1/36507
摘要： A method for operating an implantable medical device includes determining the difference of the absolute value of the voltage of a test QRS complex and the voltage of a baseline QRS template at a plurality of corresponding sample points and detecting ischemia if the sum of the differences at the plurality of sample points is greater than an ischemia detection threshold.
摘要翻译：一种用于操作可植入医疗装置的方法包括确定测试QRS复合物的电压的绝对值与基准QRS模板在多个对应采样点的电压之间的差异，并检测缺血，如果在多个采样点大于缺血检测阈值。

22. 发明授权

US07386343B1 Spectrum-driven arrhythmia treatment method 有权
标题翻译：频谱驱动心律失常治疗方法
公开(公告)号：US07386343B1
公开(公告)日：2008-06-10
申请号：US11240950
申请日：2005-09-30
申请人： Mark W. Kroll , Peter Boileau
发明人： Mark W. Kroll , Peter Boileau
IPC分类号： A61N1/36
CPC分类号： A61N1/3622
摘要： A method and apparatus for treating an arrhythmia is provided. The method includes the steps of: (a) sensing at least one electrical signal from the patient's heart; (b) calculating a frequency spectrum of each electrical signal; (c) calculating a center frequency for each frequency spectrum; and (d) selecting an electro-therapy for delivery to the patient's heart based on the center frequency. The electro-therapy can be a pre-programmed anti-tachycardia pacing (ATP) therapy, a shock therapy, or no therapy at all. The method is performed through the use of an implantable cardioverter defibrillator (ICD). Also provided is a method of determining the optimal location to deliver the electro-therapy.
摘要翻译：提供了一种治疗心律失常的方法和装置。该方法包括以下步骤：（a）感测来自患者心脏的至少一个电信号; （b）计算每个电信号的频谱; （c）计算每个频谱的中心频率; 以及（d）根据中心频率选择电疗以传送到患者的心脏。电疗可以是预先编程的抗心动过速起搏（ATP）治疗，休克疗法，或根本没有治疗。该方法通过使用植入式心律转复除颤器（ICD）进行。还提供了确定递送电疗的最佳位置的方法。

23. 发明授权

US07308306B1 System and method for dynamic ventricular overdrive pacing 有权
标题翻译：动态心室超速起搏的系统和方法
公开(公告)号：US07308306B1
公开(公告)日：2007-12-11
申请号：US10456060
申请日：2003-06-06
申请人： Euljoon Park , Peter Boileau , Joseph J. Florio , Gene A. Bornzin , Eric Falkenberg
发明人： Euljoon Park , Peter Boileau , Joseph J. Florio , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3621 , A61N1/365
摘要： Techniques are provided for overdrive pacing the ventricles using a pacemaker wherein an increase in an overdrive pacing rate is performed primarily to achieve a high degree of rate smoothing. The ventricles are paced at an overdrive pacing rate selected to permit the detection of the least some intrinsic ventricular pulses and then the overdrive pacing rate is dynamically adjusted based on the detected intrinsic ventricular pulses. In one example, an increase in the ventricular overdrive rate is performed only in response to detection of at least two intrinsic ventricular beats within a predetermined search period. If at least two intrinsic ventricular beats are not detected within the search period, the overdrive pacing rate is decreased. Various techniques are also provided for determining when to activate ventricular overdrive pacing depending, in part, on the capabilities of the particular pacemaker, the current mode of operation, the density of premature ventricular contractions, the degree of heart rate stability, and the presence of atrial fibrillation. Adaptive techniques for automatically adjusting ventricular overdrive pacing control parameters are also described.
摘要翻译：提供技术用于使用起搏器超速起搏心室，其中主要执行超速起搏速率的增加以实现高程度的速率平滑。心室以选择的超速起搏速度进行起搏，以允许检测至少一些内在的心室脉冲，然后基于检测到的内在心室脉冲来动态地调整超速起搏速率。在一个示例中，仅在响应于在预定搜索周期内检测到至少两个本征心室搏动来执行心室超速率的增加。如果在搜索期内未检测到至少两个内在心室搏动，则超速起搏速率降低。还提供了各种技术来确定何时激活心室过度起搏起搏，其部分取决于特定起搏器的能力，当前的手术方式，早期心室收缩的密度，心率稳定程度以及是否存在心房颤动。还描述了用于自动调节心室超速起搏控制参数的自适应技术。

24. 发明授权

US08886319B2 MRI signal filtering for implantable medical device 有权
标题翻译：可植入医疗器械的MRI信号滤波
公开(公告)号：US08886319B2
公开(公告)日：2014-11-11
申请号：US12617532
申请日：2009-11-12
申请人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
发明人： Jin Zhang , J. Christopher Moulder , George I. Isaac , Gabriel A. Mouchawar , Peter Boileau , Ingmar Viohl
IPC分类号： A61N1/08 , G01R33/28 , A61N1/37 , A61N1/375 , A61N1/365 , G01R33/36
CPC分类号： G01R33/288 , A61N1/36521 , A61N1/3718 , A61N1/3754 , G01R33/3685
摘要： A filtering scheme for an implantable medical device mitigates potentially adverse effects that may be caused by MRI-induced signals. In some aspects filtering is provided to attenuate MRI-induced signals on an implanted cardiac lead that is coupled to an implanted device. In some aspects the filter may be configured to complement a capacitor circuit (e.g., a feedthrough capacitor) that reduces the amount of EMI that enters the implanted device via the cardiac lead. In some implementations the filter consists of a LC tank circuit and a series LC circuit, where the LC tank circuit is in series with the cardiac lead and a cardiac stimulation circuit and the series LC circuit is in a shunt configuration across the cardiac stimulation circuit.
摘要翻译：用于可植入医疗装置的过滤方案减轻了可能由MRI诱导的信号引起的潜在的不利影响。在一些方面，提供过滤以减少与植入装置耦合的植入心脏引线上的MRI诱导信号。在一些方面，滤波器可以被配置为补充通过心脏引线减少进入植入装置的EMI量的电容器电路（例如，馈通电容器）。在一些实施方式中，滤波器由LC谐振电路和串联LC电路组成，其中LC谐振电路与心脏引线和心脏刺激电路串联，并且串联LC电路处于穿过心脏刺激电路的分流配置。

25. 发明授权

US08725256B2 Implantable medical device voltage divider circuit for mitigating electromagnetic interference 有权
标题翻译：可植入医疗器械分压器电路，用于减轻电磁干扰
公开(公告)号：US08725256B2
公开(公告)日：2014-05-13
申请号：US12968563
申请日：2010-12-15
申请人： J. Christopher Moulder , Peter Boileau
发明人： J. Christopher Moulder , Peter Boileau
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36125 , A61N1/36142 , A61N1/362 , A61N1/37 , A61N1/3718
摘要： An RF protection circuit mitigates potentially adverse effects that may otherwise result from electromagnetic interference (e.g., due to MRI scanning of a patient having an implanted medical device). The RF protection circuit may comprise a voltage divider that is deployed across a pair of cardiac electrodes that are coupled to internal circuitry of the implantable medical device. Each leg of the voltage divider may be referenced to a ground of the internal circuit, whereby the different legs are deployed in parallel across different circuits of the internal circuitry. In this way, when an EMI-induced (e.g., MRI-induced) signal appears across the cardiac electrodes, the voltages appearing across these circuits and the currents flowing through these circuits may be reduced. The RF protection circuit may be used in an implantable medical device that employs a relatively low capacitance feedthrough to reduce EMI-induced (e.g., MRI-induced) current flow in a cardiac lead.
摘要翻译： RF保护电路减轻了可能由电磁干扰引起的潜在不利影响（例如，由于具有植入的医疗装置的患者的MRI扫描）。 RF保护电路可以包括分压器，其分布在耦合到可植入医疗装置的内部电路的一对心脏电极上。分压器的每个支路可以参考内部电路的接地，由此不同的支路并联地布置在内部电路的不同电路上。以这种方式，当在心电极上出现EMI诱发（例如，MRI诱发的）信号时，可以减少跨越这些电路的电压和流过这些电路的电流。 RF保护电路可以用在可植入医疗装置中，其采用相对低电容的馈通以减少心脏导联中的EMI诱发（例如，MRI诱发的）电流。

26. 发明授权

US08321020B1 System and method for detecting and correcting atrial undersensing 有权
标题翻译：用于检测和纠正心房不足的系统和方法
公开(公告)号：US08321020B1
公开(公告)日：2012-11-27
申请号：US11549494
申请日：2006-10-13
申请人： Gene A. Bornzin , Peter Boileau , Jeffery D. Snell
发明人： Gene A. Bornzin , Peter Boileau , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3624 , A61N1/3704 , A61N1/371
摘要： A method for operating an implantable medical device includes delivering a plurality of pacing pulses to an atria of a patient's heart and monitoring intrinsic atrial activity to detect intrinsic atrial contractions between one or more of the plurality of pacing pulses. The method further includes detecting atrial undersensing as a function of the detection of intrinsic atrial contractions.
摘要翻译：一种用于操作可植入医疗装置的方法包括将多个起搏脉冲输送到患者心脏的心房并监测内在心房活动以检测多个起搏脉冲中的一个或多个之间的固有心房收缩。该方法还包括检测心房不足，作为内在心房收缩的检测的函数。

27. 发明授权

US08150512B2 Use of impedance to assess electrode locations 有权
标题翻译：使用阻抗来评估电极位置
公开(公告)号：US08150512B2
公开(公告)日：2012-04-03
申请号：US12273286
申请日：2008-11-18
申请人： Gene A. Bornzin , Peter Boileau , John W. Poore
发明人： Gene A. Bornzin , Peter Boileau , John W. Poore
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/3706
摘要： A process for determining whether the location of a stimulation electrode meets a selected heart performance criteria includes providing stimulation to the heart through the electrode and obtaining an impedance measurement during stimulation delivery using an impedance sensing vector formed by electrodes that do not include the stimulation electrode. The impedance measurements are processed, either alone or in combination with an electrogram, also obtained during stimulation, to obtain a measure of hemodynamic performance.
摘要翻译：用于确定刺激电极的位置是否满足所选择的心脏性能标准的过程包括通过电极向心脏提供刺激，并且使用由不包括刺激电极的电极形成的阻抗感测向量在刺激递送期间获得阻抗测量。阻抗测量单独地或与刺激期间获得的电描绘图结合进行处理，以获得血液动力学性能的量度。

28. 发明授权

US08090435B2 System and method for distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device 有权
公开(公告)号：US08090435B2
公开(公告)日：2012-01-03
申请号：US12360826
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/0402
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

29. 发明申请

US20110004111A1 ISCHEMIA DETECTION USING INTRA-CARDIAC SIGNALS 有权
标题翻译： ISCHEMIA检测使用内部信号
公开(公告)号：US20110004111A1
公开(公告)日：2011-01-06
申请号：US12846387
申请日：2010-07-29
申请人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
发明人： Jong Gill , Peter Boileau , Gene A. Bornzin , Joseph J. Florio , Mohssen Fard
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/7203 , A61B5/7264 , Y10S128/92
摘要： An implanted cardiac rhythm management device is disclosed that is operative to detect myocardial ischemia. This is done by evaluating electrogram features to detect an electrocardiographic change; specifically, changes in electrogram segment during the early part of an ST segment. The early part of the ST segment is chosen to avoid the T-wave.
摘要翻译：公开了可用于检测心肌缺血的植入式心律管理装置。这通过评估电描记图特征来检测心电图变化来完成; 具体来说，在ST段的早期部分的电描绘片段的变化。选择ST段的早期部分以避免T波。

30. 发明申请

US20090177105A1 System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device 有权
公开(公告)号：US20090177105A1
公开(公告)日：2009-07-09
申请号：US12360826
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

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