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    • 22. 发明专利
    • AT447569T
    • 2009-11-15
    • AT04726242
    • 2004-04-07
    • PANAGENE INC
    • KIM SUNG KEELEE HYUNILLIM JONG CHANLEE SUNG HEE
    • C07D413/12A61K31/496C07D263/46C07D271/10C07D271/113C07D417/02C07D417/12
    • This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 -C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 -C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C 1 -C 4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
    • 26. 发明申请
    • PNA MONOMER AND PRECURSOR
    • PNA单身和前辈
    • WO2005009998A1
    • 2005-02-03
    • PCT/IB2004/050406
    • 2004-04-07
    • PANAGENE INC.KIM, Sung KeeLEE, HyunilLIM, Jong ChanLEE, Sung Hee
    • KIM, Sung KeeLEE, HyunilLIM, Jong ChanLEE, Sung Hee
    • C07D413/12
    • C07D271/113C07D263/46C07D413/12C07D417/12Y02P20/55
    • This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers,wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae (A, B) wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 ,-C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 ,-C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated Ci-C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I) phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
    • 本申请涉及用于制备PNA(肽核酸)寡聚体的通式(I)的单体,并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法,其中E为硫或氧; J为氮或C-R'; R1,R'独立地为H,卤素,烷基,硝基,腈,烷氧基,卤代烷基,卤代烷氧基或具有以下通式之一(A,B)的官能团,其中A1,A2,A3,A4,A5为 独立地选自H,卤素如F,Cl,Br或I,CF 3,烷基,优选C 1 -C 4烷基,硝基,腈,烷氧基,优选C 1 -C 4烷氧基,卤代(如F,Cl,Br和 卤代(如F,Cl,Br和I)烷氧基,优选卤代C 1 -C 4烷氧基,苯基和卤代(如F,Cl,Br和I)苯基; R2是天然或非天然α-氨基酸的H或保护或未保护的侧链; 并且B是天然或非天然核碱基,其中当所述核碱基具有环外氨基功能时,所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。
    • 30. 发明申请
    • MELTING CURVE ANALYSIS USING PNA PROBE, METHOD AND KIT FOR ANALYZING NUCLEOTIDE POLYMORPHISM USING MELTING CURVE ANALYSIS
    • 使用PNA探针的熔融曲线分析,使用熔融曲线分析分析核苷酸多态性的方法和工具包
    • US20170067092A1
    • 2017-03-09
    • US15300771
    • 2014-04-04
    • PANAGENE INC.
    • Goon Ho JoeSung-Kee KimHeekyung ParkChwang Siek ParkSe Ryun KimYongtae KimSu Nam Kim
    • C12Q1/68
    • C12Q1/6818C12Q2525/107C12Q2527/107C12Q2563/173
    • Provided are a PNA probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the PNA probe. It is characterized that the PNA probe according to the present invention contains negative charge molecules. The modified PNA probe according to the present invention contains the negative charge molecules to have a high recognition ability with respect to a target DNA and a high coupling ability to the target DNA and to be rapidly dissociated by heat, such that the nucleotide polymorphism analysis may be relatively easily performed even in a heterozygous sample showing two melting curve graphs, and two or more adjacent single nucleotide polymorphisms may be simultaneously analyzed.
    • 提供了用于检测靶基因的核苷酸多态性的PNA探针,使用该靶基因的靶基因的核苷酸多态性的检测的解链曲线分析方法,包含解链曲线分析法的靶基因的核苷酸多态性分析方法,以及 用于检测含有PNA探针的靶基因的核苷酸多态性的试剂盒。 其特征在于根据本发明的PNA探针含有负电荷分子。 根据本发明的修饰的PNA探针含有相对于目标DNA具有高识别能力的负电荷分子和与目标DNA的高偶联能力并且通过热快速解离,使得核苷酸多态性分析可以 即使在显示两个解链曲线图的杂合样品中也可以相对容易地进行,并且可以同时分析两个或更多个相邻的单核苷酸多态性。