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21. 发明专利

DK1501812T3 PNA-monomer og prækursor 未知
公开(公告)号：DK1501812T3
公开(公告)日：2010-03-22
申请号：DK03718981
申请日：2003-04-28
申请人： PANAGENE INC
发明人： LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , LEE SUNG HEE , YOON WON JUN , KIM SUNG KEE , AHN SANG YOUL
IPC分类号： C07D277/76 , C12N15/09 , A61K31/513 , A61K31/52 , A61K31/522 , A61P35/00 , C07D263/58 , C07D277/80 , C07D405/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D473/02 , C07D473/18 , C07D473/26 , C07D473/32 , C07D473/34

22. 发明专利

AT447569T 未知
公开(公告)号：AT447569T
公开(公告)日：2009-11-15
申请号：AT04726242
申请日：2004-04-07
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , LEE SUNG HEE
IPC分类号： C07D413/12 , A61K31/496 , C07D263/46 , C07D271/10 , C07D271/113 , C07D417/02 , C07D417/12
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 -C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 -C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C 1 -C 4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

23. 发明专利

DK1470114T3 未知
公开(公告)号：DK1470114T3
公开(公告)日：2009-11-02
申请号：DK03700408
申请日：2003-01-23
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , LEE SUNG HEE , AHN SANG YOUL
IPC分类号： C07D241/08 , C07H19/00 , C07C303/40 , C07C311/18 , C07D239/47 , C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/00
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein R1, R2, R3, R4, R5 is independently H, halogen, C 1 -C 4 alkyl, nitro, nitrile, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkyl, or halogenated C 1 -C 4 alkoxy, wherein at least one of R1, R3, and R5 is nitro; R6 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases.

24. 发明专利

DE60328866D1 未知
公开(公告)号：DE60328866D1
公开(公告)日：2009-10-01
申请号：DE60328866
申请日：2003-01-23
申请人： PANAGENE INC
发明人： KIM SUNG KEE , LEE HYUNIL , LIM JONG CHAN , CHOI HOON , JEON JAE HOON , AHN SANG YOUL , LEE SUNG HEE
IPC分类号： C07D241/08 , C07H19/00 , C07C303/40 , C07C311/18 , C07D239/47 , C07D239/54 , C07D403/06 , C07D473/18 , C07D473/30 , C07D473/34 , C07K14/00
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein R1, R2, R3, R4, R5 is independently H, halogen, C 1 -C 4 alkyl, nitro, nitrile, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkyl, or halogenated C 1 -C 4 alkoxy, wherein at least one of R1, R3, and R5 is nitro; R6 is H or protected or unprotected side chain of natural or unnatural alpha-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases.

25. 发明申请

WO2009072812A3 METHOD FOR SELECTIVE LABELING AND DETECTION OF TARGET NUCLEIC ACIDS USING IMMOBILIZED PEPTIDE NUCLEIC ACID PROBES 审中-公开
标题翻译：选择性标记方法和使用固定肽核酸探针检测目标核酸
公开(公告)号：WO2009072812A3
公开(公告)日：2009-08-20
申请号：PCT/KR2008007148
申请日：2008-12-04
申请人： PANAGENE INC , PARK HEE KYUNG , CHOI JAE JIN
发明人： PARK HEE KYUNG , CHOI JAE JIN
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6837 , C12Q2525/107 , G01N33/532 , G01N2333/9015 , G01N2333/9127 , C12Q2565/537 , C12Q2521/131 , C12Q2521/501
摘要： Disclosed are a method for selective labeling of target nucleic acids on an array having nucleic acid analogue, e.g. PNA (peptide nucleic acid), probes immobilized on a support or supports, comprising adding to the array a detectable label and an agent for introducing the label into the target nucleic acids, after hybridization between the target nucleic acids and the nucleic acid analogue probes, and a method for detection of target nucleic acids using the same.
摘要翻译：公开了在具有核酸类似物的阵列上选择性标记靶核酸的方法，例如， PNA（肽核酸），固定在载体或载体上的探针，包括在靶核酸和核酸类似物探针杂交后，向阵列中加入可检测标记和引入标记物到靶核酸中的试剂，以及使用其的靶核酸的检测方法。

26. 发明申请

WO2005009998A1 PNA MONOMER AND PRECURSOR 审中-公开
标题翻译： PNA单身和前辈
公开(公告)号：WO2005009998A1
公开(公告)日：2005-02-03
申请号：PCT/IB2004/050406
申请日：2004-04-07
申请人： PANAGENE INC. , KIM, Sung Kee , LEE, Hyunil , LIM, Jong Chan , LEE, Sung Hee
发明人： KIM, Sung Kee , LEE, Hyunil , LIM, Jong Chan , LEE, Sung Hee
IPC分类号： C07D413/12
CPC分类号： C07D271/113 , C07D263/46 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers,wherein E is sulfur or oxygen; J is nitrogen or C-R'; R1, R' is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae (A, B) wherein A 1 , A 2 , A 3 , A 4 , A 5 , is independently selected from H, halogen such as F, Cl, Br or I, CF 3 , alkyl, preferably C 1 ,-C 4 alkyl, nitro, nitrile, alkoxy, preferably C 1 ,-C 4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C 1 -C 4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated Ci-C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I) phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法，其中E为硫或氧; J为氮或C-R'; R1，R'独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基或具有以下通式之一（A，B）的官能团，其中A1，A2，A3，A4，A5为独立地选自H，卤素如F，Cl，Br或I，CF 3，烷基，优选C 1 -C 4烷基，硝基，腈，烷氧基，优选C 1 -C 4烷氧基，卤代（如F，Cl，Br和卤代（如F，Cl，Br和I）烷氧基，优选卤代C 1 -C 4烷氧基，苯基和卤代（如F，Cl，Br和I）苯基; R2是天然或非天然α-氨基酸的H或保护或未保护的侧链; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

27. 发明专利

TW201617458A 用於檢測人乳頭瘤病毒的基因型的肽核酸探針、試劑盒以及方法审中-公开
简体标题：用于检测人乳头瘤病毒的基因型的肽核酸探针、试剂盒以及方法
公开(公告)号：TW201617458A
公开(公告)日：2016-05-16
申请号：TW104135907
申请日：2015-10-30
申请人：帕那金股份有限公司 , PANAGENE INC.
发明人：崔寶蘿 , CHOI, BO RA , 姜在炫 , KANG, JAE HYUN , 崔在真 , CHOI, JAE JIN , 金成基 , KIM, SUNG KEE , 朴斗山 , PARK, DOO SAN
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/569
CPC分类号： C12Q1/68 , C12N2310/3181 , C12Q1/6816 , C12Q1/6818 , C12Q1/6851 , C12Q1/6888 , C12Q1/708 , C12Q2525/107 , C12Q2565/1015
摘要：本發明涉及利用肽核酸檢測探針的人乳頭瘤病毒基因型檢測方法，更詳細地涉及能夠以基因型特異性的方式與人乳頭瘤病毒(Human Papillomavirus，HPV)去氧核糖核酸(DNA，Deoxyribonucleic acid)相結合的檢測探針、包含其的檢測試劑盒及利用其的人乳頭瘤病毒基因型檢測方法。本發明可準確地檢測在子宮頸中發現的22種人乳頭瘤病毒的基因型，並且還可診斷一種以上的人乳頭瘤病毒基因型的多重感染，可檢測除了22種之外是否存在其他人乳頭瘤病毒的基因型，並且能夠以高的靈敏度和特異度檢測人乳頭瘤病毒基因型。
简体摘要：本发明涉及利用肽核酸检测探针的人乳头瘤病毒基因型检测方法，更详细地涉及能够以基因型特异性的方式与人乳头瘤病毒(Human Papillomavirus，HPV)去氧核糖核酸(DNA，Deoxyribonucleic acid)相结合的检测探针、包含其的检测试剂盒及利用其的人乳头瘤病毒基因型检测方法。本发明可准确地检测在子宫颈中发现的22种人乳头瘤病毒的基因型，并且还可诊断一种以上的人乳头瘤病毒基因型的多重感染，可检测除了22种之外是否存在其他人乳头瘤病毒的基因型，并且能够以高的灵敏度和特异度检测人乳头瘤病毒基因型。

28. 发明授权

US10227637B2 Melting curve analysis using PNA probe, method and kit for analyzing nucleotide polymorphism using melting curve analysis 有权
公开(公告)号：US10227637B2
公开(公告)日：2019-03-12
申请号：US15300771
申请日：2014-04-04
申请人： PANAGENE INC.
发明人： Goon Ho Joe , Sung-Kee Kim , Heekyung Park , Chwang Siek Park , Se Ryun Kim , Yongtae Kim , Su Nam Kim
IPC分类号： C12Q1/68 , C12Q1/6818
摘要： Provided are a PNA probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the PNA probe. It is characterized that the PNA probe according to the present invention contains negative charge molecules. The modified PNA probe according to the present invention contains the negative charge molecules to have a high recognition ability with respect to a target DNA and a high coupling ability to the target DNA and to be rapidly dissociated by heat, such that the nucleotide polymorphism analysis may be relatively easily performed even in a heterozygous sample showing two melting curve graphs, and two or more adjacent single nucleotide polymorphisms may be simultaneously analyzed.

29. 发明申请

US20170233818A1 MULTIPLE TARGET NUCLEIC ACID DETECTION METHOD USING CLAMPING PROBE AND DETECTION PROBE 审中-公开
公开(公告)号：US20170233818A1
公开(公告)日：2017-08-17
申请号：US15329050
申请日：2015-07-23
申请人： PANAGENE INC.
发明人： Jae Jin CHOI , Ji Hye YOON , Su Nam KIM , Sung Kee KIM , Jin Woo KIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/6818 , C12Q1/6858 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2537/163
摘要： The present invention relates to an application of a target nucleic acid detection method using a clamping probe and a detection probe. The method of the present invention can effectively detect a small amount of variation or a specific gene sequence contained in a sample by selective amplification and detection of a trace amount of a target gene to be detected while inhibiting amplification of wild-type genes or undesired genes. The method of the present invention comprises a step for evaluating the detection of biomarkers such as EGFR, KRAS, NRAS etc. and the presence of mutations of biomarkers using invasive specimens such as tissues as well as non-invasive specimens (blood, urine, sputum, stool, saliva, and cells). The presence of the biomarker and mutations provides a method used for monitoring of the entire cycle of a related disease, disease prognosis and prediction, decision of disease treatment strategy, disease diagnosis/early diagnosis, disease prevention, and development of disease therapeutics.

30. 发明申请

US20170067092A1 MELTING CURVE ANALYSIS USING PNA PROBE, METHOD AND KIT FOR ANALYZING NUCLEOTIDE POLYMORPHISM USING MELTING CURVE ANALYSIS 审中-公开
标题翻译：使用PNA探针的熔融曲线分析，使用熔融曲线分析分析核苷酸多态性的方法和工具包
公开(公告)号：US20170067092A1
公开(公告)日：2017-03-09
申请号：US15300771
申请日：2014-04-04
申请人： PANAGENE INC.
发明人： Goon Ho Joe , Sung-Kee Kim , Heekyung Park , Chwang Siek Park , Se Ryun Kim , Yongtae Kim , Su Nam Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2525/107 , C12Q2527/107 , C12Q2563/173
摘要： Provided are a PNA probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the PNA probe. It is characterized that the PNA probe according to the present invention contains negative charge molecules. The modified PNA probe according to the present invention contains the negative charge molecules to have a high recognition ability with respect to a target DNA and a high coupling ability to the target DNA and to be rapidly dissociated by heat, such that the nucleotide polymorphism analysis may be relatively easily performed even in a heterozygous sample showing two melting curve graphs, and two or more adjacent single nucleotide polymorphisms may be simultaneously analyzed.
摘要翻译：提供了用于检测靶基因的核苷酸多态性的PNA探针，使用该靶基因的靶基因的核苷酸多态性的检测的解链曲线分析方法，包含解链曲线分析法的靶基因的核苷酸多态性分析方法，以及用于检测含有PNA探针的靶基因的核苷酸多态性的试剂盒。其特征在于根据本发明的PNA探针含有负电荷分子。根据本发明的修饰的PNA探针含有相对于目标DNA具有高识别能力的负电荷分子和与目标DNA的高偶联能力并且通过热快速解离，使得核苷酸多态性分析可以即使在显示两个解链曲线图的杂合样品中也可以相对容易地进行，并且可以同时分析两个或更多个相邻的单核苷酸多态性。

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