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21. 发明申请

WO2006038022A1 METHODS FOR ANTIBODY LIBRARY SCREENING 审中-公开
标题翻译：抗体库筛选方法
公开(公告)号：WO2006038022A1
公开(公告)日：2006-04-13
申请号：PCT/GB2005/003866
申请日：2005-10-07
申请人： AFFITECH AS , OWEN, Deborah, Jane , STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
发明人： STASSAR, Marike, Josée, Janneke, Gertrud , REIERSEN, Herald
IPC分类号： G01N33/68
CPC分类号： C40B30/04 , C12N15/1086
摘要： The present invention provides an improved method of screening a library of molecules to identify or select one or more members thereof which are candidate binding partners for one or more target entities: (a) contacting an expression library with one or more target entities; (b) subjecting said target entities to at least one washing step; (c) separating target entities which have become bound to one or more members of the expression library from unbound members of the expression library by separation through an organic phase, thereby separating candidate binding partners for said target entities from other library members.
摘要翻译：本发明提供了一种筛选分子文库以鉴定或选择一个或多个成员的改进方法，所述成员是一个或多个目标实体的候选结合配偶体：（a）使表达文库与一个或多个目标实体接触; （b）对所述目标实体进行至少一个洗涤步骤; （c）通过分离有机相分离已经从表达文库的未结合成员绑定到表达文库的一个或多个成员的目标实体，从而将所述目标实体的候选绑定伙伴与其他库成员分离。

22. 发明申请

WO2005100991A2 ASSAY 审中-公开
公开(公告)号：WO2005100991A2
公开(公告)日：2005-10-27
申请号：PCT/GB2005/001455
申请日：2005-04-15
申请人： BIOSENSE LABORATORIES AS , OWEN, Deborah, Jane , GOKSØYR, Anders
发明人： GOKSØYR, Anders
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N33/566 , G01N2430/40 , G01N2520/00
摘要： The invention relates to an in vitro assay method for detecting dioxins and dioxin-like compounds comprising (a) providing assay reagents comprising: (i) an inactive Aryl-Hydrocarbon (Ah) receptor, or a fragment or mutant thereof, which is capable of binding to said dioxins and dioxin-like compounds; (ii) an Ah-Receptor Nuclear Translocator (ARNT), or a fragment or mutant thereof, which is capable of binding to the active Ah-receptor formed when the Ah-receptor becomes bound to the dioxin or dioxin-like compounds; (iii) one or more chaperones and/or co-chaperones; and (b) contacting a test sample with the assay reagents under conditions such that any dioxin or dioxin-like compounds present in the test sample become bound to the inactive Ah-receptor and transform it to an active form which can bind to ARNT; and (c) analysing the presence of the AH-receptor-ARNT complex. The invention also covers an assay method for detecting dioxins and dioxin like compounds comprising steps (a), (b) and (c) as above, wherein the Ah receptor is from a non-mammalian source and an assay method wherein the Ah-receptor is recombinant or mutated. Kits comprising reagents necessary to carry out the assay methods of the invention are further covered by the present invention.
摘要翻译：本发明涉及一种用于检测二恶英和二恶英样化合物的体外测定方法，其包括（a）提供测定试剂，其包含：（i）无活性芳基 - 烃（Ah）受体或其片段或突变体，其能够与所述二恶英和二恶英样化合物结合; （ii）Ah-受体核转运体（ARNT）或其片段或突变体，其能够结合当Ah-受体结合到二恶英或二恶英样化合物时形成的活性Ah受体; （iii）一个或多个伴侣和/或伴侣伴侣; 和（b）使测试样品与测定试剂接触，使得存在于测试样品中的任何二恶英或二恶英样化合物与无活性的Ah-受体结合并将其转化为可结合ARNT的活性形式; 和（c）分析AH-受体-ARNT复合物的存在。本发明还涉及用于检测包含如上所述的步骤（a），（b）和（c）的二恶英和二恶英类化合物的测定方法，其中所述Ah受体来自非哺乳动物来源，以及其中所述Ah-受体是重组的或突变的。包含实施本发明的测定方法所必需的试剂的试剂盒进一步被本发明覆盖。

23. 发明申请

WO2005042776A1 METHOD OF DETERMINING PREDISPOSITION TOWARDS ATHEROSCLEROSIS 审中-公开
标题翻译：确定ATHEROSCLEROSIS的预测方法
公开(公告)号：WO2005042776A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004471
申请日：2004-10-22
申请人： FORINNOVA AS , OWEN, Deborah , VEDELER, Christian, Alexander , MYHR, Kjell-Morten , NYGÅRD, Ottar
发明人： VEDELER, Christian, Alexander , MYHR, Kjell-Morten , NYGÅRD, Ottar
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , G01N2333/70535
摘要： The invention provides a method of determining predisposition towards atherosclerosis and other vessel diseases, e.g. other cerebrovascular or cardiovascular diseases which involves determining the genotype of a human or non-human mammalian subject for at least one Fc receptor and identifying whether the determined genotype signifies or corresponds to a positive or negative disposition towards said disease. Methods of prognosis are also provided. A preferred Fc receptor genotype to be determined in accordance with the methods of the invention is the FcγRIIIA receptor.
摘要翻译：本发明提供了确定对动脉粥样硬化和其它血管疾病的倾向的方法，例如，涉及确定至少一种Fc受体的人或非人哺乳动物受试者的基因型的其他脑血管或心血管疾病，并鉴定所确定的基因型是否表示或对应于所述疾病的阳性或阴性倾向。还提供了预后方法。根据本发明方法测定的优选的Fc受体基因型是FcγRIIIA受体。

24. 发明申请

WO2004056995A1 PROCESS FOR PRODUCING AN IN VITRO PEPTIDE EXPRESSION LIBRARY 审中-公开
标题翻译：生产体外肽表达图谱的方法
公开(公告)号：WO2004056995A1
公开(公告)日：2004-07-08
申请号：PCT/GB2002/005909
申请日：2002-12-23
申请人： AFFITECH AS , OWEN, Deborah , MARVIK, Ole, Jørgen , REIERSEN, Herald , BREKKE, Ole, Henrik
发明人： MARVIK, Ole, Jørgen , REIERSEN, Herald , BREKKE, Ole, Henrik
IPC分类号： C12N15/10
CPC分类号： C12N15/1075
摘要： The present invention provides a method of producing a peptide expression library which displays a plurality of different peptides, wherein displayed peptides coupled to the genetic material encoding them, said method comprising the following steps: (a) preparing a library of nucleic acid molecules wherein each member of the library comprises a nucleotide sequence encoding a nucleic acid binding amino acid sequence, an oligonucleotide tag and a nucleotide sequence encoding the peptide which is to be displayed said nucleic acid binding sequence being capable of coupling to the nucleic acid molecule which encodes it; (b) attaching said library or a subpopulation thereof to one or more solid supports, wherein said attachment occurs by specific hybridisation of the oligonucleotide tag of a library member to a complementary tag which is attached to a solid support or a discrete area of a solid support so that each solid support or discrete area of a solid support has attached a distinct type of individual library members; and (c) translating the library members. Nucleic acid and peptide expression libraries and the members thereof form yet further aspects of the invention, as do kits comprising these libraries and members thereof. Further aspects involve the use of said libraries to screen and identify peptides or proteins or other entities exhibiting desired properties or the use of said library to screen against another library.
摘要翻译：本发明提供了一种产生肽表达文库的方法，其显示多个不同的肽，其中显示的肽与编码它们的遗传物质偶联，所述方法包括以下步骤：（a）制备核酸分子文库，其中每个文库成员包括编码核酸结合氨基酸序列的核苷酸序列，寡核苷酸标签和编码该肽的核苷酸序列，该核苷酸序列将显示所述核酸结合序列，其能够与编码该核酸结合序列的核酸分子偶联; （b）将所述文库或其亚群连接至一种或多种固体支持物，其中所述附着通过文库成员的寡核苷酸标签与附着于固体支持物或固体的离散区域的互补标签的特异性杂交而发生支撑，使得固体支持物的每个固体支持物或离散区域附着有不同类型的单个文库成员; 和（c）翻译图书馆成员。核酸和肽表达文库及其成员形成本发明的进一步方面，以及包含这些文库及其成员的试剂盒。进一步的方面涉及使用所述文库来筛选和鉴定显示所需性质的肽或蛋白质或其他实体或使用所述文库筛选另一文库。

25. 发明申请

WO2011098762A2 ANTIBODIES 审中-公开
标题翻译：抗体
公开(公告)号：WO2011098762A2
公开(公告)日：2011-08-18
申请号：PCT/GB2011000175
申请日：2011-02-10
申请人： AFFITECH RES AS , KAVLIE ANITA , OWEN DEBORAH JANE , KIPRIJANOV SERGEJ MICHAILOVIC
发明人： KAVLIE ANITA , KIPRIJANOV SERGEJ MICHAILOVIC
IPC分类号： A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies which bind to CXC chemokine receptor (4) (CXCR4) and which do not induce significant apoptosis of CXCR4 expressing cells. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields.
摘要翻译：本发明提供与CXC趋化因子受体（4）（CXCR4）结合并且不诱导表达CXCR4的细胞的显着细胞凋亡的抗体。还提供了免疫缀合物和包含此类抗体的组合物，以及涉及这种抗体的方法和用途，特别是在医学和诊断领域。

26. 发明申请

WO2009060198A1 ANTI-VEGF ANTIBODY COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗VEGF抗体组合物和方法
公开(公告)号：WO2009060198A1
公开(公告)日：2009-05-14
申请号：PCT/GB2008/003745
申请日：2008-11-07
申请人： PEREGRINE PHARMACEUTICALS, INC. , AFFITECH AS , OWEN, Deborah Jane
发明人： KAVLIE, Anita , SCHLUNEGGER, Kyle
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22
CPC分类号： A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Disclosed are human antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two primary VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet have improved safety due to their specificity. The present invention thus provides new human antibody-based compositions, methods and combined protocols for treating cancer and other angiogenic diseases. Advantageous immunoconjugate compositions and methods using the new VEGF-specific human antibodies are also provided.
摘要翻译：公开了特异性抑制VEGF仅与两种主要VEGF受体中的一种（VEGFR2）结合的人抗体。抗体有效抑制血管生成并诱导肿瘤消退，但由于其特异性而具有改善的安全性。因此，本发明提供了新的基于人抗体的组合物，用于治疗癌症和其它血管生成疾病的方法和组合方案。还提供了有利的免疫缀合物组合物和使用新的VEGF特异性人抗体的方法。

27. 发明申请

WO2005100991A3 METHOD FOR DETECTING DIOXIN-LIKE COMPOUNDS 审中-公开
标题翻译：检测二氧化物化合物的方法
公开(公告)号：WO2005100991A3
公开(公告)日：2006-03-02
申请号：PCT/GB2005001455
申请日：2005-04-15
申请人： BIOSENSE LAB AS , OWEN DEBORAH JANE , GOKSOEYR ANDERS
发明人： GOKSOEYR ANDERS
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/5308 , G01N33/566 , G01N2430/40 , G01N2520/00
摘要： The invention relates to an
摘要翻译：本发明涉及一种

28. 发明申请

WO2005123121A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2005123121A2
公开(公告)日：2005-12-29
申请号：PCT/GB2005/002472
申请日：2005-06-22
申请人： FORINNOVA AS , OWEN, Deborah, Jane , NERLAND, Audun, Helge , LORENZEN, Niels , SOMMERSET, Ingunn
发明人： NERLAND, Audun, Helge , LORENZEN, Niels , SOMMERSET, Ingunn
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/552 , A61K2039/55561 , C12N2760/20022 , C12N2770/30034
摘要： The present invention provides the use of a DNA molecule encoding an antigen (and in particular encoding a bacteria or virus glycoprotein, preferably a rhabdovirus glycoprotein) which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a medicament for use as a vaccine adjuvant or to enhance the immune stimulating properties or vaccination properties of a vaccine molecule, or to enhance the immune response to a vaccine molecule. A composition comprising said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, and a vaccine molecule, is also provided. A further aspect of the present invention provides the use of said DNA molecule encoding an antigen which is expressed on the surface of a host cell, or variant, or a fragment thereof, in the manufacture of a composition which can improve or increase the elimination of other foreign DNA molecules from an organism.
摘要翻译：本发明提供编码抗原（特别是编码细菌或病毒糖蛋白，优选弹状病毒糖蛋白）的DNA分子在宿主细胞表面或其变体或片段上的表达的用途，制造用作疫苗佐剂或增强疫苗分子的免疫刺激性质或疫苗接种性质或增强对疫苗分子的免疫应答的药物。还提供了包含编码在宿主细胞或其变体或其片段表面上表达的抗原的DNA分子和疫苗分子的组合物。本发明的另一方面提供了编码在宿主细胞或其变体或片段的表面上表达的抗原的所述DNA分子在制备可以改善或增加来自生物体的其他外来DNA分子。

29. 发明申请

WO2005045071A1 METHODS OF IDENTIFYING ACTIVE GENES 审中-公开
标题翻译：鉴定活性基因的方法
公开(公告)号：WO2005045071A1
公开(公告)日：2005-05-19
申请号：PCT/GB2004/004577
申请日：2004-10-29
申请人： FORINNOVA AS , OWEN, Deborah , BECKER, Thomas , ELLINGSEN, Staale
发明人： BECKER, Thomas , ELLINGSEN, Staale
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897
摘要： This invention relates to a method of enhancer trapping in an organism, comprising introducing a retroviral vector into said organism, wherein said vector comprises a basal promoter and a detectably expressible gene. Retroviral vectors, transgenic organisms obtainable by introducing a retroviral vector into said organism and kits comprising the retroviral vectors or transgenic organisms are also included in the invention.
摘要翻译：本发明涉及一种增强剂捕获生物体的方法，包括将逆转录病毒载体导入所述生物体，其中所述载体包含基础启动子和可检测表达的基因。逆转录病毒载体，通过将逆转录病毒载体引入所述生物体获得的转基因生物体和包含逆转录病毒载体或转基因生物体的试剂盒也包括在本发明中。

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