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21. 发明申请

WO2005014032A2 USES OF SECRETAGOGUES 审中-公开
标题翻译： SECRETAGOGUES的用途
公开(公告)号：WO2005014032A2
公开(公告)日：2005-02-17
申请号：PCT/DK2004/000529
申请日：2004-08-06
申请人： GASTROTECH PHARMA A/S , LANGE, Birgitte, Holst , HANSEN, Christian , NILSSON, Henrik
发明人： LANGE, Birgitte, Holst , HANSEN, Christian , NILSSON, Henrik
IPC分类号： A61K38/25
CPC分类号： A61K38/25 , G01N2333/4745 , G01N2333/475 , G01N2333/65
摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.
摘要翻译：本发明一方面涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。另一方面，本发明涉及生长激素释放肽样化合物在制备用于预防或治疗个体恶病质的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。另一方面，本发明涉及生长激素释放肽样化合物或其药学上可接受的盐在制备用于刺激个体食欲的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。此外，本发明涉及许多新的生长素释放肽样化合物及其用途，以及包含新型生长素释放肽样化合物的药物组合物和医药包装。

22. 发明申请

WO2007028394A2 USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT 审中-公开
标题翻译：用于治疗胆汁淤积症和/或胆汁淤积/分泌的GLP-1分子的使用
公开(公告)号：WO2007028394A2
公开(公告)日：2007-03-15
申请号：PCT/DK2006/000496
申请日：2006-09-06
申请人： GASTROTECH PHARMA A/S , NIELSEN, Tina, Geritz , NILSSON, Henrik , HANSEN, Christian , SCHAMBYE, Hans, T.
发明人： NIELSEN, Tina, Geritz , NILSSON, Henrik , HANSEN, Christian , SCHAMBYE, Hans, T.
CPC分类号： A61K38/26 , G01N2333/605 , G01N2500/02 , G01N2800/08
摘要： The present invention relates to molecules, compositions and methods suitable for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree. The peptide hormone glucagon-like peptide-1 (GLP-1) has both anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract. GLP-1 exists in several forms, where the natural occurring GLP-1 molecules are GLP-1 (1- 37), GLP-1 (7-37), and the amidated versions GLP-1 (1-36)amide, GLP-1 (7- 36)amide. Other molecules capable of binding to and activating the GLP-1 receptor is herein included in the tern GLP-1 molecules. GLP-1 molecules may be naturally occurring or homologues of GLP-1 having one or more amino acid substitutions or modifications. The GLP-1 molecules are used for the manufacture of a medicament for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree.
摘要翻译：本发明涉及适用于治疗或预防来自胆道树的胆汁运动障碍和/或疼痛和/或不适的分子，组合物和方法。肽激素胰高血糖素样肽-1（GLP-1）在胃肠道中具有抗分泌作用和平滑肌松弛性质。 GLP-1以几种形式存在，其中天然存在的GLP-1分子是GLP-1（1-37），GLP-1（7-37）和酰胺化GLP-1（1-36）酰胺，GLP -1（7-36）酰胺。在GLP-1分子中包括能够结合并激活GLP-1受体的其它分子。 GLP-1分子可以是具有一个或多个氨基酸取代或修饰的GLP-1的天然存在或同源物。 GLP-1分子用于制造用于治疗或预防胆汁运动障碍和/或来自胆道树的疼痛和/或不适的药物。

23. 发明申请

WO2006111169A1 PHARMACEUTICAL PREPARATIONS OF A GLP-1 MOLECULE AND AN ANTI-EMETIC DRUG 审中-公开
标题翻译： GLP-1分子和抗静脉药物的药物制备
公开(公告)号：WO2006111169A1
公开(公告)日：2006-10-26
申请号：PCT/DK2006/000211
申请日：2006-04-21
申请人： GASTROTECH PHARMA A/S , SCHAMBYE, Hans, T. , NILSSON, Henrik , HANSEN, Christian
发明人： SCHAMBYE, Hans, T. , NILSSON, Henrik , HANSEN, Christian
IPC分类号： A61K38/26
CPC分类号： A61K45/06 , A61K38/26 , A61K2300/00
摘要： The present invention relates to a kit of parts comprising a GLP-1 molecule and an anti-emetic drug, said kit of parts being suitable for separate, sequential or/and simultaneous administration to a subject, preferably a human being. Also provided are combinations of GLP-1 or a GLP-1 analog with one or more anti-emetic drugs, as well as uses of the combinations in the manufacture of medicaments.
摘要翻译：本发明涉及包含GLP-1分子和抗呕吐药物的试剂盒，所述试剂盒适用于对受试者，优选人类的单独，连续或/和同时施用。还提供了GLP-1或GLP-1类似物与一种或多种抗呕吐药物的组合，以及组合制备药物的用途。

24. 发明申请

WO2005123192A2 A METHOD OF IMPROVING THE MEDICAL TREATMENT OF PAIN 审中-公开
标题翻译：改善疼痛的药物治疗方法
公开(公告)号：WO2005123192A2
公开(公告)日：2005-12-29
申请号：PCT/DK2005/000401
申请日：2005-06-17
申请人： OSTEOLOGIX A/S , CHRISTGAU, Stephan , HANSEN, Christian , NILSSON, Henrik
发明人： CHRISTGAU, Stephan , HANSEN, Christian , NILSSON, Henrik
IPC分类号： A61P29/00
CPC分类号： A61K31/192 , A61K31/415 , A61K33/24 , A61K2300/00
摘要： Methods for improving pain management in a mammal, the methods comprising administering a combination of a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents to the mammal. Pharmaceutical compositions for use in such methods, comprising a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents.
摘要翻译：用于改善哺乳动物疼痛管理的方法，所述方法包括向哺乳动物施用含锶化合物和选自镇痛剂，抗炎药和姑息治疗剂的第二治疗和/或预防活性物质的组合物。用于这种方法的药物组合物，其包含含锶化合物和选自止痛剂，抗炎剂和姑息治疗剂的第二治疗和/或预防活性物质。

25. 发明申请

WO2005110454A2 PROTECTIVE BINDING MEMBERS OF PYY FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译： PYY保护性结合成分治疗代谢性疾病
公开(公告)号：WO2005110454A2
公开(公告)日：2005-11-24
申请号：PCT/DK2005/000329
申请日：2005-05-18
申请人： ADITECH PHARMA AB , NILSSON, Henrik , HANSEN, Christian
发明人： NILSSON, Henrik , HANSEN, Christian
IPC分类号： A61K38/02
CPC分类号： C07K14/57545 , C07K14/72
摘要： The present invention relates to a binding member of PYY or a functional equivalent thereof for use in pharmaceutical compositions. The pharmaceutical compositions are in particular useful in the treatment of metabolic disorders e.g. obesity, eating disorders, such as disorders characterised by cravings and binges and functional gastrointestinal disorders such as irritable bowel syndrome and functional dyspepsia. The invention further relates to methods of treatment using said compositions. Further included is the combination of a binding member of PYY or a functional equivalent thereof with a secondary active ingredient such as PYY or functional equivalents thereof. The invention further describes the use of a binding member of PYY or a functional equivalent thereof for diagnostic purposes.
摘要翻译：本发明涉及用于药物组合物的PYY的结合成员或其功能等同物。该药物组合物特别适用于治疗代谢紊乱，例如肥胖症，进食障碍，如以渴望和暴食为特征的疾病和功能性胃肠疾病如肠易激综合征和功能性消化不良。本发明还涉及使用所述组合物的治疗方法。还包括PYY的结合成员或其功能等同物与第二活性成分例如PYY或其功能等同物的组合。本发明进一步描述了PYY的结合成员或其功能等价物用于诊断目的的用途。

26. 发明申请

WO2004098617A3 CONTROLLED RELEASE COMPOSITION CONTAINING A STRONTIUM SALT 审中-公开
标题翻译：含锶盐的控制释放组合物
公开(公告)号：WO2004098617A3
公开(公告)日：2005-03-31
申请号：PCT/DK2004000326
申请日：2004-05-06
申请人： OSTEOLOGIX AS , HANSEN CHRISTIAN , NILSSON HENRIK , ANDERSEN JENS E T , CHRISTGAU STEPHAN
发明人： HANSEN CHRISTIAN , NILSSON HENRIK , ANDERSEN JENS E T , CHRISTGAU STEPHAN
IPC分类号： A61K31/28 , A61K33/24 , A61K45/06 , A61P19/08
CPC分类号： A61K33/00 , A61K31/28 , A61K31/592 , A61K31/593 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A controlled release pharmaceutical composition comprising a strontium salt. The invention also relates to the use of a strontium salt for treating a male suffering from diseases and conditions affecting metabolism and/or structural integrity of cartilage and/or bone. The invention also relates to the use of a strontium-containing compound for preventing a cartilage and/or bone condition in a subject, and for the treatment and/or prophylaxis of secondary osteoporosis.
摘要翻译：包含锶盐的控释药物组合物。本发明还涉及锶盐用于治疗患有软骨和/或骨的代谢和/或结构完整性的疾病和病症的男性。本发明还涉及含锶化合物用于预防受试者的软骨和/或骨骼状况以及用于治疗和/或预防继发性骨质疏松症的用途。

27. 发明申请

WO2005014032A3 USE OF SECRETAGOGUES LIKE GHRELIN IN CANCER CACHEXIA AND FOR STIMULATING APPETITE 审中-公开
标题翻译：使用胃肠激素在胃癌中的作用和刺激胃癌
公开(公告)号：WO2005014032A3
公开(公告)日：2005-03-17
申请号：PCT/DK2004000529
申请日：2004-08-06
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
发明人： LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
IPC分类号： A61K38/25 , A61P1/14 , C07K14/60 , G01N33/74
CPC分类号： A61K38/25 , G01N2333/4745 , G01N2333/475 , G01N2333/65
摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.
摘要翻译：一方面，本发明涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。另一方面，本发明涉及生长激素释放肽样化合物在制备用于预防或治疗个体恶病质的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。另一方面，本发明涉及生长激素释放肽样化合物或其药学上可接受的盐在制备用于刺激个体食欲的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。此外，本发明涉及许多新的生长激素释放肽样化合物及其用途，以及包含新生长素释放肽样化合物的药物组合物和医药包装。

28. 发明申请

WO9821924A3 CONTROL EQUIPMENT FOR AN ACTIVE FILTER 审中-公开
标题翻译：主动过滤器的控制设备
公开(公告)号：WO9821924A3
公开(公告)日：1998-09-11
申请号：PCT/SE9800421
申请日：1998-03-10
申请人： ASEA BROWN BOVERI , GOERANSSON TOR , NILSSON HENRIK , AABERG ANDERS
发明人： GOERANSSON TOR , NILSSON HENRIK , AABERG ANDERS
IPC分类号： H02J1/02 , H02J3/01 , H02J3/36 , H02M1/15 , H02M7/06
CPC分类号： H02J3/36 , Y02E60/60
摘要： An active filter (2) is connected to a dc circuit (L1, L2) in a converter (SR1) in an installation for transmission of high-voltage direct current. Control equipment (5) generates, in dependence on a control signal, a control order (SCF) for the active filter which, in dependence thereon, generates and supplies to the dc connection one of a filter voltage (UF) and a filter current (IF) for reducing at least one tone of a chosen tone frequency in a current (Id) in the dc connection. The control equipment comprises a controlling unit which forms a controller signal in dependence on a supplied current measurement value (IM) of the current in the dc connection, and an identification unit. The identification unit forms a first compensating parameter in dependence on the current measurement value and on an excitation signal generated by the control equipment and added to the control order. The control equipment forms the control signal in dependence on the controlling signal and the compensating parameter, which has been formed such that the sum thereof and of the phase shift for a transfer function from the control signal to the current measurement value at the chosen tone frequency is at least approximately equal to a preselected value.

29. 发明申请

WO2007042035A2 COMBINATION THERAPY FOR TREATMENT OF AN AUTOIMMUNE AND/OR INFLAMMATORY DISORDER AND RELATED CONDITIONS 审中-公开
标题翻译：治疗自身免疫和/或炎症性疾病及相关情况的联合治疗
公开(公告)号：WO2007042035A2
公开(公告)日：2007-04-19
申请号：PCT/DK2006000563
申请日：2006-10-06
申请人： ADITECH PHARMA AB , NILSSON HENRIK
发明人： NILSSON HENRIK
IPC分类号： A61K31/225 , A61P17/00 , A61P17/06 , A61P25/28
CPC分类号： A61K9/2846 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/4891 , A61K9/5047 , A61K31/215 , A61K31/225 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compositions, kits and methods for administration of a first component of fumaric acid ester(s), or a pharmaceutically acceptable salt thereof, and a second component which is a substance that reduces or eliminates flushing.
摘要翻译：本发明涉及用于施用富马酸酯的第一组分或其药学上可接受的盐的组合物，试剂盒和方法，以及作为减少或消除冲洗的物质的第二组分。

30. 发明申请

WO2005123192A3 IMPROVING PAIN TREATMENT WITH STRONTIUM COMBINATIONS 审中-公开
标题翻译：改善痤疮组合治疗疼痛
公开(公告)号：WO2005123192A3
公开(公告)日：2006-12-28
申请号：PCT/DK2005000401
申请日：2005-06-17
申请人： OSTEOLOGIX AS , CHRISTGAU STEPHAN , HANSEN CHRISTIAN , NILSSON HENRIK
发明人： CHRISTGAU STEPHAN , HANSEN CHRISTIAN , NILSSON HENRIK
IPC分类号： A61P29/00 , A61K31/192 , A61K31/415 , A61K33/24
CPC分类号： A61K31/192 , A61K31/415 , A61K33/24 , A61K2300/00
摘要： The present invention relates to methods for improving pain management in a mammal, the methods comprising administering a combination of a strontium- containing compound and a second therapeutically and/or prophylactically active substance selected from the group consjsting of analgesic agents, anti-inflammatory agents and palliative agents to the mammal. The invention also relates to pharmaceutical compositions for use in such methods.
摘要翻译：本发明涉及用于改善哺乳动物疼痛管理的方法，所述方法包括施用含锶化合物和选自以下的治疗和/或预防活性物质的组合：镇痛剂组，抗炎剂组和姑息治疗剂给哺乳动物。本发明还涉及用于这些方法的药物组合物。

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