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21. 发明申请

US20190083799A1 CROSSOVER ADAPTER AND CROSSOVER LEAD 审中-公开
公开(公告)号：US20190083799A1
公开(公告)日：2019-03-21
申请号：US16038660
申请日：2018-07-18
申请人： Morton M. MOWER
发明人： Morton M. MOWER
IPC分类号： A61N1/375 , A61N1/36
摘要： An adapter includes a first connector, a second connector, and a circuit that reverses a polarity of a signal received at the first connector. Moreover, a lead includes a connector including a cathode terminal and an anode terminal, an electrode including a tip and a ring, and a circuit that connects the anode terminal of the connector to the tip of the electrode and that connects the cathode terminal of the connector to the ring of the electrode.

22. 发明授权

US06332096B1 Augmentation of electrical conduction and contractility by biphasic cardiac pacing 有权
标题翻译：通过双相心脏起搏增强电传导和收缩
公开(公告)号：US06332096B1
公开(公告)日：2001-12-18
申请号：US09504710
申请日：2000-02-16
申请人： Morton M. Mower
发明人： Morton M. Mower
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/368
摘要： Augmentation of electrical conduction and contractility by biphasic cardiac pacing. A first stimulation phase is administered to the muscle tissue. This first stimulation phase has a predefined polarity, amplitude and duration. A second stimulation phase is then administered to the muscle tissue. This second phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with the increase in contractility. The technique can also be applied to large muscle tissue stimulation other than cardiac muscle.
摘要翻译：通过双相心脏起搏增强电传导和收缩。向肌肉组织施用第一刺激阶段。该第一刺激阶段具有预定义的极性，幅度和持续时间。然后将第二刺激期施用于肌肉组织。该第二阶段也具有预定义的极性，幅度和持续时间。顺序应用两个阶段。与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。以这种方式，通过心肌的脉冲传导随着收缩性的增加而提高。该技术也可应用于心肌以外的大肌肉组织刺激。

23. 发明授权

US6136019A Augmentation of electrical conduction and contractility by biphasic cardiac pacing administered via the cardiac blood pool 失效
标题翻译：通过心脏血库施用双相心脏起搏来增强电传导和收缩
公开(公告)号：US6136019A
公开(公告)日：2000-10-24
申请号：US8636
申请日：1998-01-16
申请人： Morton M. Mower
发明人： Morton M. Mower
IPC分类号： A61N1/36 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3622 , A61N1/362 , A61N1/368 , A61N1/3712 , A61N1/36514
摘要： Augmentation of electrical conduction and contractility by biphasic cardiac pacing. A first stimulation phase is administered to the cardiac blood pool This first stimulation phase has a predefined polarity, amplitude and duration A second stimulation phase is then administered to the cardiac blood pool. This second phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is unproved together with the increase in contractility.
摘要翻译：通过双相心脏起搏增强电传导和收缩。向心脏血液池施用第一刺激阶段。该第一刺激阶段具有预定义的极性，幅度和持续时间。然后将第二刺激阶段施用于心脏血液池。该第二阶段也具有预定义的极性，幅度和持续时间。顺序应用两个阶段。与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。以这种方式，通过心肌的脉冲传导与收缩性的增加一起没有改善。

24. 发明授权

US5417717A Implantable cardiac function monitor and stimulator for diagnosis and therapy delivery 失效
标题翻译：可植入的心脏功能监测和刺激器用于诊断和治疗
公开(公告)号：US5417717A
公开(公告)日：1995-05-23
申请号：US243069
申请日：1994-05-16
申请人： Rodney W. Salo , Bruce A. Tockman , Morton M. Mower
发明人： Rodney W. Salo , Bruce A. Tockman , Morton M. Mower
IPC分类号： A61M5/172 , A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61N1/36042 , A61N1/36585 , A61M5/1723 , A61N1/3627
摘要： An implantable monitor/stimulator is disclosed that monitors and assesses indices of cardiac function, including the strength and timing of cardiac contraction, then automatically executes a physician-selected mode of therapy. It accomplishes this by assessing impedance, electrocardiogram, and/or pressure measurements, then calculating various cardiac parameters. The results of these calculations may be stored within the device, telemetered to an external monitor or display and/or may be used by the physician to determine the mode of therapy to be chosen. If indicated, therapy is administered by the device itself or by telemetering control signals to various peripheral devices for the purpose of enhancing either contraction or relaxation of the heart. The cardiac parameters that are calculated all provide an assessment of level of cardiac function by monitoring changes in ventricular filling and ejection or by calculating isovolumic phase indices of heart contraction. Examples of such parameters are ejection fraction, cardiac output, stroke work, and/or various pressure-volume relationships. These parameters determine the mode of therapy that will be selected by a physician. Choices of therapy include several forms of pacing of cardiac or skeletal muscle, and telemetry to implanted or external units for drug infusion or for monitoring by a central data system.
摘要翻译：公开了一种监测和评估心脏功能指标（包括心脏收缩的强度和时间）的植入式监测器/刺激器，然后自动执行医师选择的治疗模式。它通过评估阻抗，心电图和/或压力测量，然后计算各种心脏参数来实现。这些计算的结果可以存储在设备内，遥测到外部监视器或显示器，和/或可被医师用来确定要选择的治疗方式。如果指示，治疗由装置本身施用或通过将控制信号遥测到各种外围装置，以增强心脏的收缩或放松的目的。计算的心脏参数都通过监测心室充盈和排出的变化或通过计算心脏收缩的等容性相位指数来提供心脏功能水平的评估。这些参数的实例是射血分数，心输出量，中风工作量和/或各种压力 - 体积关系。这些参数决定了医生选择的治疗方式。治疗选择包括心脏或骨骼肌的几种形式的起搏，以及用于药物输注或由中央数据系统监测的植入或外部单元的遥测。

25. 发明授权

US4559946A Method and apparatus for correcting abnormal cardiac activity by low energy shocks 失效
标题翻译：通过低能量冲击矫正心脏活动异常的方法和装置
公开(公告)号：US4559946A
公开(公告)日：1985-12-24
申请号：US389907
申请日：1982-06-18
申请人： Morton M. Mower
发明人： Morton M. Mower
IPC分类号： A61N1/365 , A61N1/38 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3956 , A61N1/3987
摘要： The present invention relates to a method and apparatus for delivering two or more individual low-level pulses to correct certain cardiac arrhythmias such as high-rate ventricular tachycardia and ventricular fibrillation; at least the latter shocks are delivered in synchronism with a repeatable characteristic of the heart's electrical activity. Basically, the apparatus comprises an electrode sensor placed in the right ventricle of the heart or in the coronary sinus to act as a detector for the electrical activity of the heart. Connected to the electrode sensor is an arrhythmia detector chosen to detect such arrhythmias as ventricular tachycardia and ventricular fibrillation. Upon detection of one of these arrhythmias, the detector issues a signal which is interpreted by a programmable logic device to activate an energy storage device for delivering a first low-level shock to the heart through a shock delivering electrode. A slew rate detector is then activated by the logic device. The output of the slew rate detector is fed to a comparator to be compared with a continually updated reference signal supplied by the logic device. When the slew rate output equals or exceeds the value of the reference signal, the comparator issues a signal which activates the energy storage device to issue a second low-level shock to the heart through the shock delivering electrode. Additional shocks may be delivered in a manner similar to the delivery of the second shock under the control of the logic device.
摘要翻译：本发明涉及一种用于递送两个或多个单独的低电平脉冲以校正某些心律不齐的方法和装置，例如高速心室心动过速和心室颤动; 至少后面的冲击与心脏的电活动的可重复的特征同步传递。基本上，该装置包括放置在心脏的右心室或冠状窦中的电极传感器，用作心脏电活动的检测器。连接到电极传感器是一种心律失常检测器，被选择用于检测心律失常与室性心动过速和心室颤动。在检测到这些心律失常之一时，检测器发出由可编程逻辑器件解释的信号，以激活用于通过冲击输送电极向心脏递送第一低电平冲击的能量存储装置。然后，逻辑器件激活转换速率检测器。转换速率检测器的输出被馈送到比较器，以与逻辑器件提供的连续更新的参考信号进行比较。当转换速率输出等于或超过参考信号的值时，比较器发出一个信号，激活能量存储装置，通过冲击输送电极向心脏发出第二次低电平冲击。额外的冲击可以以类似于在逻辑设备的控制下传送第二冲击的方式来传送。

26. 发明授权

US4184493A Circuit for monitoring a heart and for effecting cardioversion of a needy heart 失效
标题翻译：监测心脏和进行心脏复律的电路
公开(公告)号：US4184493A
公开(公告)日：1980-01-22
申请号：US878006
申请日：1978-02-15
申请人： Alois A. Langer , Marlin S. Heilman , Morton M. Mower , Mieczyslaw Mirowski
发明人： Alois A. Langer , Marlin S. Heilman , Morton M. Mower , Mieczyslaw Mirowski
IPC分类号： A61B5/046 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3621 , A61B5/046 , A61B5/7239 , A61N1/3956 , A61N1/3987
摘要： Disclosed are two embodiments of a circuit for analyzing the ECG signals of a heart and for delivering a cardioverting pulse of energy to the heart if the heart is in an arrhythmic state in need of cardioversion. In the first embodiment, the ECG is filtered by a high pass filter to provide the derivative of the ECG, is reviewed by a window detector to determine the average time that the input ECG spends at high slope, and then the average occurrence of high slope segments is compared with a predetermined reference to determine whether the ECG is normal. Cardioversion is effected if the ECG is abnormal. In the second embodiment, an absolute value circuit and a level comparator is used in place of the window detector. The input ECG is normalized by an automatic gain control where the AGC voltage is derived from the ECG signals after high pass filtration.
摘要翻译：公开了用于分析心脏的ECG信号的电路的两个实施例，并且如果心脏处于需要心脏复律的心律失调状态，则将心脏的心脏转复脉冲递送到心脏。在第一实施例中，通过高通滤波器对ECG进行滤波以提供ECG的导数，由窗口检测器进行检查，以确定输入ECG在高斜率处花费的平均时间，然后平均出现高斜率将段与预定参考值进行比较，以确定ECG是否正常。如果心电图异常，则进行心脏复律。在第二实施例中，使用绝对值电路和电平比较器代替窗口检测器。输入ECG通过自动增益控制进行归一化，其中AGC电压从高通滤波后的ECG信号导出。

27. 发明申请

US20220113306A1 SYSTEM, APPARATUS, AND METHOD FOR VIRAL MONITORING IN EFFLUENT 有权
公开(公告)号：US20220113306A1
公开(公告)日：2022-04-14
申请号：US17539763
申请日：2021-12-01
申请人： Morton M. MOWER
发明人： Morton M. MOWER
IPC分类号： G01N33/543 , G01N27/414
摘要： A system for viral monitoring in effluent includes at least one graphene-based field-effect transistor and circuitry, wherein the circuitry is configured to repeatedly monitor and determine presence of SARS-CoV-2 (COVID virus) in the effluent. The circuitry is configured to apply a gate voltage and measure a conductance across each of the at least one graphene-based field-effect transistor, compare the measured conductance across each of the at least one graphene-based field-effect transistor to a threshold conductance, and determine whether levels of the COVID virus exceed a predetermined threshold in the effluent. If levels of the COVID virus exceed the predetermined threshold in the effluent, the circuitry is configured to remove at least a portion of the bound COVID virus from the proteins of the at least one graphene-based field-effect transistor.

28. 发明申请

US20220096836A1 BIPHASIC NEURAL STIMULATION TO IMPROVE CEREBRAL CONDUCTION SPEED AND MITOCHONDRIAL FUNCTIONING 有权
公开(公告)号：US20220096836A1
公开(公告)日：2022-03-31
申请号：US17243633
申请日：2021-04-29
申请人： Morton M. MOWER
发明人： Morton M. MOWER
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05
摘要： Methods, devices and systems to improve neural stimulation by applying biphasic waveforms including a positive anodal pulse followed by a negative cathodal pulse to speed conduction and improve mitochondrial function in conditions such as cerebellar dysfunction (such as gluten ataxia, spinocerebellar ataxia, and Alzheimer's disease). Improved neural stimulation of more distal brain structures may interrupt epileptic seizures. Additionally, biphasic waveforms including a positive anodal pulse followed by a negative cathodal pulse speed wound healing by lowering the cell membrane potential of the skin, and may stimulate the release of hormonal secretions or insulin by proper placement of electrodes.

29. 发明授权

US09566444B2 Methods, apparatus, and systems for multiple stimulation from a single stimulator 有权
标题翻译：来自单个刺激器的多次刺激的方法，装置和系统
公开(公告)号：US09566444B2
公开(公告)日：2017-02-14
申请号：US14272730
申请日：2014-05-08
申请人： Morton M. Mower
发明人： Morton M. Mower
IPC分类号： A61N1/36 , A61N1/368 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684
摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.
摘要翻译：提供方法，装置和系统以刺激心脏中的多个部位。控制器感测与心脏窦性心律相关的电活动。信号发生器被配置为产生用于刺激心脏的电信号。基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

30. 发明授权

US08249725B2 Methods, apparatus, and systems for multiple stimulation from a single stimulator 有权
标题翻译：来自单个刺激器的多次刺激的方法，装置和系统
公开(公告)号：US08249725B2
公开(公告)日：2012-08-21
申请号：US11745593
申请日：2007-05-08
申请人： Morton M Mower
发明人： Morton M Mower
IPC分类号： A61N1/08
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684
摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.
摘要翻译：提供方法，装置和系统以刺激心脏中的多个部位。控制器感测与心脏窦性心律相关的电活动。信号发生器被配置为产生用于刺激心脏的电信号。基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

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