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21. 发明申请

WO2013009909A3 CELL INCLUDING CLEAN AND DIRTY SECTIONS FOR FABRICATING COMPOSITE PARTS 审中-公开
公开(公告)号：WO2013009909A3
公开(公告)日：2013-01-17
申请号：PCT/US2012/046303
申请日：2012-07-11
申请人： THE BOEING COMPANY , MILLER, Jeffrey L.
发明人： MILLER, Jeffrey L.
IPC分类号： B29C73/04 , B29C35/02 , B29C70/00
摘要： A cell for fabricating a part having reinforcing fibers embedded in a matrix, includes a clean section for performing clean operations including laying up the reinforcing fibers on a mandrel tool. The clean section satisfies clean room requirements for processing uncured composite materials. The cell further includes an adjacent dirty section for performing dirty operations including machining the layup after curing; a common end effector positioning system movable between the clean and dirty sections; and means for preventing contaminants in the dirty section from entering the clean section.

22. 发明申请

WO2012134935A3 DYNAMICALLY DETECTING A DEFECTIVE CONNECTOR AT A PORT 审中-公开
标题翻译：在端口动态检测缺陷连接器
公开(公告)号：WO2012134935A3
公开(公告)日：2013-01-03
申请号：PCT/US2012030065
申请日：2012-03-22
申请人： ADC TELECOMMUNICATIONS INC , ANNE LAXMAN R , MILLER JEFFREY J , SWAM STEVEN M , SYBESMA ERIC W
发明人： ANNE LAXMAN R , MILLER JEFFREY J , SWAM STEVEN M , SYBESMA ERIC W
IPC分类号： H04L29/02 , H04L12/26 , H04L29/04 , H04L29/12
CPC分类号： G06F11/2221
摘要： A connector assembly comprises a plurality of ports. Each of the plurality of ports is configured to receive a respective connector attached to a respective segment of physical communication media. Each of the plurality of ports comprises a respective media interface configured to receive data from a respective storage device attached to the respective connector. The connector assembly is configured to determine if a first connector attached to a first port included in the plurality of ports is defective by determining if a signal level received on the respective media interface associated with the first port has stabilized after a first predetermined amount of time has elapsed since the first connecter was connected to the first port. If the signal level has not stabilized after the first predetermined amount of time has elapsed since the first connecter was connected to the first port, the first connector is considered defective.
摘要翻译：连接器组件包括多个端口。多个端口中的每一个被配置为接收附接到物理通信介质的相应段的相应连接器。多个端口中的每一个包括被配置为从连接到相应连接器的相应存储装置接收数据的相应介质接口。连接器组件被配置为通过确定在与第一端口相关联的各个媒体接口上接收到的信号电平在第一预定时间量之后是否已经稳定来确定附接到包括在多个端口中的第一端口的第一连接器是否有故障从第一个连接器连接到第一个端口已经过去了。如果在从第一连接器连接到第一端口开始经过第一预定时间后信号电平没有稳定，则认为第一连接器有缺陷。

23. 发明申请

WO2012134934A2 IDENTIFIER ENCODING SCHEME FOR USE WITH MULTI-PATH CONNECTORS 审中-公开
标题翻译：识别程序使用多路连接器编写程序
公开(公告)号：WO2012134934A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030064
申请日：2012-03-22
申请人： ADC TELECOMMUNICATIONS, INC. , SYBESMA, Eric W. , MILLER, Jeffrey J.
发明人： SYBESMA, Eric W. , MILLER, Jeffrey J.
IPC分类号： H04L29/02 , H04L29/12 , H04L12/28
CPC分类号： G06F1/16 , G06F3/00 , H04L49/10 , H04Q1/00 , H04Q1/136 , H05K7/00
摘要： One exemplary embodiment is directed to a method of tracking a plurality of communication paths in a connector assembly having a plurality of first attachment points and a plurality of second attachment points. The plurality of first attachment points and the plurality of second attachment points are configured to attach physical communication media to the connector assembly. The method comprises reading, from a storage device associated with the connector assembly first, information indicative of a plurality of communication paths formed within the connector assembly between the first attachment points and the second attachment points. The method further comprises reading second information stored on or in physical communication media that is attached to the connector assembly and communicating the first and second information to an aggregation point that is communicatively coupled to the connector assembly.
摘要翻译：一个示例性实施例涉及一种在具有多个第一附接点和多个第二附接点的连接器组件中跟踪多个通信路径的方法。多个第一附接点和多个第二附接点被配置为将物理通信介质附接到连接器组件。所述方法包括从与所述连接器组件相关联的存储设备首先读取表示在所述连接器组件内形成的在所述第一连接点和所述第二附接点之间的多个通信路径的信息。该方法还包括读取存储在物理通信介质上的物理通信介质中附加到连接器组件的第二信息，并将第一和第二信息传送到通信地耦合到连接器组件的聚合点。

24. 发明申请

WO2012058494A3 ISOPRENE SYNTHASE VARIANTS FOR IMPROVED PRODUCTION OF ISOPRENE 审中-公开
标题翻译：用于改善异丙酚生产的异丙肾上腺素改变剂
公开(公告)号：WO2012058494A3
公开(公告)日：2012-09-20
申请号：PCT/US2011058188
申请日：2011-10-27
申请人： DANISCO US INC , GOODYEAR TIRE & RUBBER , BECK ZACHARY Q , ESTELL DAVID A , RIFE CHRISTOPHER LEE , WELLS DEREK H , MILLER JEFFREY V
发明人： BECK ZACHARY Q , ESTELL DAVID A , RIFE CHRISTOPHER LEE , WELLS DEREK H , MILLER JEFFREY V
IPC分类号： C12N9/88 , C12N15/52
CPC分类号： C12N9/88 , C12N15/63 , C12N15/74 , C12N15/79 , C12P5/005 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved specific productivity. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in host cells.
摘要翻译：本发明提供包含至少一种具有提高的比生产率的异戊二烯合酶的方法和组合物。特别地，本发明提供用于增加宿主细胞中异戊二烯生产的变体植物异戊二烯合成酶。

25. 发明申请

WO2012085516A2 DRILLING FLUIDS HAVING REDUCED SAG POTENTIAL AND RELATED METHODS 审中-公开
标题翻译：具有减少潜力的钻井液和相关方法
公开(公告)号：WO2012085516A2
公开(公告)日：2012-06-28
申请号：PCT/GB2011/001769
申请日：2011-12-23
申请人： HALLIBURTON ENERGY SERVICES, INC. , MILLER, Jeffrey James , BRALEY, Nicholas , SIEMS, Donald, R , BAKER, Patrick, Chris , JAMISON, Dale , COTTRILL, Emiliy Elizabeth Helen
发明人： MILLER, Jeffrey James , BRALEY, Nicholas , SIEMS, Donald, R , BAKER, Patrick, Chris , JAMISON, Dale
CPC分类号： C09K8/05 , C09K8/03 , C09K8/36
摘要： Invert emulsion drilling fluids that have extended emulsion stability and reduced sag potential are described herein. The drilling fluids comprise an invert emulsion, a weighting agent, and a plurality of colloidal particles. The invert emulsion comprises an oleaginous fluid continuous phase, an aqueous fluid internal phase, and a surfactant. At least a portion of the plurality of colloidal particles interact with the surfactant to form an associative supporting structure that inhibits sag of the weighting agent. In some embodiments, the weighting agent comprises barite particles, particularly barite particles that are less than about 45 microns in size. Methods for placing the invert emulsion drilling fluids in a subterranean formation via a wellbore are also disclosed.
摘要翻译：本文描述了具有延长的乳液稳定性和降低的下垂潜力的反相乳液钻井液。钻井流体包括反相乳液，增重剂和多种胶体颗粒。反相乳液包括油性流体连续相，含水流体内相和表面活性剂。多个胶体颗粒的至少一部分与表面活性剂相互作用以形成抑制加重剂下垂的缔合支持结构。在一些实施方案中，加重剂包括重晶石颗粒，特别是尺寸小于约45微米的重晶石颗粒。还公开了通过井眼将反相乳液钻井液置于地层中的方法。

26. 发明申请

WO2012078669A1 QUILTED IMPLANTABLE GRAFT 审中-公开
标题翻译：带有可植入的花纹
公开(公告)号：WO2012078669A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063588
申请日：2011-12-06
申请人： COOK BIOTECH INCORPORATED , PATEL, Umesh, H. , MILLER, Jeffrey , FEARNOT, Neal, E. , BLEYER, Mark, W.
发明人： PATEL, Umesh, H. , MILLER, Jeffrey , FEARNOT, Neal, E. , BLEYER, Mark, W.
IPC分类号： A61L27/36
CPC分类号： A61L27/3633 , A61F2/0063 , A61F2/0077 , A61F2/02 , A61L27/3625 , A61L27/3629 , A61L27/50 , A61L31/005
摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.
摘要翻译：描述了具有包含可重塑胶原片材料的说明性移植物的多层或多层可植入手术移植物的实施方案，所述移植物包括一个或多个交织构件以将移植物缝合在一起以帮助防止层在处理期间分层或分离，并且初始重塑阶段。交织构件可以包括以期望的图案编织穿过生物材料层的缝合线，线，单个线迹，材料条等。在一个实施方案中，交织构件包含药理学活性物质，例如药物，生长因子等，以在宿主组织中引发所需的生物反应。在另一个实施方案中，移植物还包括在可重塑生物材料层内的增强材料，例如合成网，并由一个或多个交织构件缝合在一起。

27. 发明申请

WO2012012667A2 METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS 审中-公开
标题翻译：用于修饰HLA基因的方法和组合物
公开(公告)号：WO2012012667A2
公开(公告)日：2012-01-26
申请号：PCT/US2011044902
申请日：2011-07-21
申请人： SANGAMO BIOSCIENCES INC , UNIV TEXAS , COLLINGWOOD TREVOR , COOPER LAURENCE J N , GREGORY PHILIP D , HOLMES MICHAEL C , MILLER JEFFREY C , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR
发明人： COLLINGWOOD TREVOR , COOPER LAURENCE J N , GREGORY PHILIP D , HOLMES MICHAEL C , MILLER JEFFREY C , REBAR EDWARD J , REIK ANDREAS , URNOV FYODOR
IPC分类号： A61K48/00 , A01K67/027 , A61P3/00 , A61P5/14 , A61P5/38 , A61P7/02 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P29/00 , A61P31/14 , A61P37/00 , C07K7/06 , C12N1/19 , C12N5/071 , C12N5/0735 , C12N5/0775 , C12N5/0797 , C12N5/10 , C12N9/96 , C12N15/11 , C12N15/63
CPC分类号： C07K14/70539 , A61K35/17 , C07K2319/81 , C12N15/907 , C12N2800/80
摘要： Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
摘要翻译：本文公开了用于调节HLA基因座的表达或用于选择性删除或操纵HLA基因座或HLA调节剂的方法和组合物。

28. 发明申请

WO2011146121A1 NOVEL DNA-BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：新型DNA结合蛋白及其用途
公开(公告)号：WO2011146121A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/000885
申请日：2011-05-17
申请人： SANGAMO BIOSCIENCES, INC. , GREGORY, Philip, D. , MILLER, Jeffrey, C. , PASCHON, David , REBAR, Edward, J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
发明人： GREGORY, Philip, D. , MILLER, Jeffrey, C. , PASCHON, David , REBAR, Edward, J. , TAN, Siyuan , URNOV, Fyodor , ZHANG, Lei
IPC分类号： A61K38/16
CPC分类号： C12N15/907 , A61K38/00 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/52 , C12N15/62 , C12N15/8213 , C12N15/85 , C12Y301/21004
摘要： Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
摘要翻译：本文公开了编码包含新型DNA结合结构域（包括TALE DNA结合结构域）的多肽，多核苷酸，细胞和生物体。还公开了使用这些新的DNA结合结构域来调节内源细胞序列的基因表达和/或基因组编辑的方法。

29. 发明申请

WO2010107493A2 MODIFICATION OF CXCR4 USING ENGINEERED ZINC FINGER PROTEINS 审中-公开
标题翻译：用工程化锌指蛋白修饰CXCR4
公开(公告)号：WO2010107493A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/000807
申请日：2010-03-18
申请人： SANGAMO BIOSCIENCES, INC. , HOLMES, Michael C. , MILLER, Jeffrey C. , WANG, Jianbin
发明人： HOLMES, Michael C. , MILLER, Jeffrey C. , WANG, Jianbin
IPC分类号： A61K48/00
CPC分类号： A61K35/17 , A61K48/00 , C07K14/70596 , C07K14/7158 , C07K2319/81
摘要： Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZF-TFs or ZFNs, vectors comprising polynucleotides encoding ZF-TFs or ZFNs and cells comprising polynucleotides encoding ZF-TFs or ZFNs and/or cells comprising ZF-TF or ZFNs are also provided.
摘要翻译：本文公开了用于调节CXCR4基因活性的方法和组合物，例如使用锌指转录因子（ZF-TF）或锌指核酸酶（ZFN），其包含锌手指蛋白和切割结构域或切割半结构域。还提供了编码ZF-TF或ZFN的多核苷酸，包含编码ZF-TF或ZFN的多核苷酸的载体和包含编码ZF-TF或ZFN的多核苷酸和/或包含ZF-TF或ZFN的细胞的细胞。

30. 发明申请

WO2009154686A1 COMPOSITIONS FOR LINKING DNA-BINDING DOMAINS AND CLEAVAGE DOMAINS 审中-公开
标题翻译：用于连接DNA结合域和CLEAVAGE域的组合物
公开(公告)号：WO2009154686A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/003249
申请日：2009-05-28
申请人： SANGAMO BIOSCIENCES, INC. , MILLER, Jeffrey, C.
发明人： MILLER, Jeffrey, C.
IPC分类号： C12N15/09 , C12N9/22
CPC分类号： C12N9/22 , C07K2319/00 , C07K2319/80 , C12N15/907
摘要： Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.
摘要翻译：本文公开了用于连接DNA结合结构域和切割结构域（或切割半结构域）以形成非天然存在的核酸酶的组合物。还描述了制备和使用包含这些接头的组合物的方法。

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