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21. 发明专利

DK456585D0 未知
公开(公告)号：DK456585D0
公开(公告)日：1985-10-07
申请号：DK456585
申请日：1985-10-07
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02 , C07F
摘要： PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.

22. 发明专利

IE59017B1 Cytostatically active titanocene complexes 未知
公开(公告)号：IE59017B1
公开(公告)日：1993-12-15
申请号：IE135186
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
IPC分类号： A61K31/28 , C07F7/28 , A61P35/00 , C07F17/00
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

23. 发明专利

FI81358B Process for preparing ferricenium trichloroacetate- mono(trichloroacetic acid) 未知
公开(公告)号：FI81358B
公开(公告)日：1990-06-29
申请号：FI853818
申请日：1985-10-02
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02
摘要： PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.

24. 发明专利

NO862006L 未知
公开(公告)号：NO862006L
公开(公告)日：1986-11-24
申请号：NO862006
申请日：1986-05-21
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT
IPC分类号： A61K31/28 , C07F7/28 , A61P35/00 , C07F17/00
摘要： 1. Titanocene complexes having the general formula I see diagramm : EP0202673,P17,F1 wherein A represents the group see diagramm : EP0202673,P17,F2 in which X is an oxygen atom or sulfur atom, R is hydrogen or a C1-4 -alkyl group, and Y is a halide ; or A represents the group -O-CO-R', in which R' is the group -CF3 , -CCI3 , -CBr3 , -CHCI2 , -CH2 CI, -CH=CH-COOH or -(CH2 )n COOH, and n has the value 0, 1, 2, 3 or 4, and B is a halide or is defined as the radical A ; for use as pharmaceuticals.

25. 发明专利

FI853818L 未知
公开(公告)号：FI853818L
公开(公告)日：1985-10-02
申请号：FI853818
申请日：1985-10-02
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02 , C07F
摘要： The invention relates to metallicenium salts of the formula (I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopentadienyl rings which, independently of each other, can be unsubstituted (x, y = 0) or substituted 1-5 times (x, y = 1, 2, 3, 4 or 5), where R and R', independently of each other, represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl or triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge containing 2-4 bridge atoms; a, b, m and n are integers, where m has the value 1 or 2 and n the value 1, 2 or 3, and a.m = b.n; and A is a complex-forming or highly space-filling anion which stabilizes metallicenium cations; and solvates of these salts for use as medicaments, in particular as cytostatic agents for controlling cancer.

26. 发明专利

FI853818A0 未知
公开(公告)号：FI853818A0
公开(公告)日：1985-10-02
申请号：FI853818
申请日：1985-10-02
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
发明人： KOEPF-MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02 , C07F
摘要： PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.

27. 发明专利

DE3404443A1 未知
公开(公告)号：DE3404443A1
公开(公告)日：1985-08-08
申请号：DE3404443
申请日：1984-02-08
申请人： KOEPF MAIER PETRA , KOEPF HARTMUT , NEUSE EBERHARD WILHELM PROF DR
发明人： KOEPF-MAIER PETRA PROF DR , KOEPF HARTMUT PROF DR , NEUSE EBERHARD WILHELM PROF DR
IPC分类号： C07F17/00 , A61K31/28 , A61K31/295 , A61P35/00 , C07F17/02 , A61K45/05
摘要： PCT No. PCT/EP85/00047 Sec. 371 Date Oct. 3, 1985 Sec. 102(e) Date Oct. 3, 1985 PCT Filed Feb. 8, 1985 PCT Pub. No. WO85/03507 PCT Pub. Date Aug. 15, 1985.Metallicenium salts of the general formula I [( eta 5-C5H-xRx)M( eta 5-C5H5-yR'y)]am+[A]bn-(I) in which M is Fe, Co, Ni, Ru or Os; C5H5-xRx and C5H5-yR'y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and axm=bxn; and A is a complexating or very bulky anion which stabilizes the metallicenium cation; and solvates of these salts, for use as medicaments, in paticular as cytostatics in combating tumors susceptible thereto.

28. 发明专利

DE2923334C2 未知
公开(公告)号：DE2923334C2
公开(公告)日：1985-03-07
申请号：DE2923334
申请日：1979-06-08
申请人： KOEPF, HARTMUT, PROF. DIPL.-CHEM. DR. , KOEPF-MAIER, PETRA, DR., 1000 BERLIN, DE
发明人： KOEPF, HARTMUT, PROF. DIPL.-CHEM. DR. , KOEPF-MAIER, PETRA, DR., 1000 BERLIN, DE
IPC分类号： A61K31/28 , A61K31/695 , A61P35/00
摘要： This disclosure relates to the use of cytostatically active cyclopentadienyl metal-acido complexes for the treatment of transplanted tumor and pharmaceutical compositions containing said complexes. The organometallic compounds employed in the invention have the general formula: wherein M is Ti, Zr, Hf, V, Nb, Ta, Mo or W, Cp and Cp' are, e.g., cyclopentadienyl or substituted cyclopentadienyl radicals, Z is an optional straight-chain or branched bridging group having 1 to 3 C, Si or Ge atoms in the bridging chain and X and X' are, e.g., halogen, cyanate, isocyanate, thiocyanate, isothiocyanate, azide or phenylacetylide.

29. 发明申请

WO1985003507A1 METALLICENIUM SALTS AND UTILIZATION THEREOF AS CYTOSTATIC AGENTS FOR COMBATTING CANCER 审中-公开
标题翻译：金属盐及其应用作为癌症治疗剂
公开(公告)号：WO1985003507A1
公开(公告)日：1985-08-15
申请号：PCT/EP1985000047
申请日：1985-02-08
申请人： KÖPF-MAIER, Petra , KÖPF, Hartmut , NEUSE, Eberhard, Wilhelm
IPC分类号： C07F17/00

30. 发明专利

DE4135291A1 Use of ionic metallocene complexes - as cytostatic agents to treat tumours, esp. solid tumours of lung, breast, gastrointestinal, neck and head 未知
公开(公告)号：DE4135291A1
公开(公告)日：1993-04-29
申请号：DE4135291
申请日：1991-10-25
申请人： KOEPF MAIER PETRA , KLAPOETKE THOMAS DR
发明人： KOEPF-MAIER PETRA PROF DR , KLAPOETKE THOMAS DR
IPC分类号： C07F17/00
摘要： Ionic metallocene complexes of formula ((C5H5)2MX2)a(m+)(Y)b(n-) (I) can be used as pharmaceuticals. M = V, Nb, Mo or Re; X = each halide or pseudohalide ligands; Y = a pharmaceutically acceptable anion; a, b, m and n are integers and m = 1 or 2 and n = 1, 2 or 3 and a.m = b.n. USE/ADVANTAGE - (I) are chemotherapeutics which broaden the spectrum of therapeutically useful metallocenes. As (I) are highly water-soluble, dosing and application is easy. They show good to very good cytostatic properties in animal experiments on account of their high therapeutic index (quotient of toxicity and activity) they are safer to use than corresponding neutral complexes. (I) can be used to treat a variety of tumours, esp. solid tumours, such as lung, breast, urogenital, gastrointestinal, neck and head tumours

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